RBP Type
Canonical_RBPs
Diseases
Drug
N.A.
Main interacting RNAs
diverse
Moonlighting functions
N.A.
Localizations
Stress granucle
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000144535 Gene ID
129563 Accession
28648
Symbol
DIS3L2
Alias
FAM6A;PRLMNS;hDIS3L2
Full Name
DIS3 like 3'-5' exoribonuclease 2
Status
Confidence
Length
383106 bases
Strand
Plus strand
Position
2 : 231961245 - 232344350
RNA binding domain
OB_Dis3 , RNB
Summary
The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000273009
OB_Dis3
PF17849 7.7e-27
1
ENSP00000273009
RNB
PF00773 6e-52
2
ENSP00000374655
OB_Dis3
PF17849 8.1e-27
1
ENSP00000374655
RNB
PF00773 3.2e-59
2
ENSP00000315569
OB_Dis3
PF17849 1.2e-26
1
ENSP00000315569
RNB
PF00773 8.8e-96
2
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
33119769 Post-transcriptional control of cellular differentiation by the RNA exosome complex.
Isabela I Andrade Fraga
2020-12-02
Nucleic acids research
33719213 Co-occurrence of orofacial clefts and clubfoot phenotypes in a sub-Saharan African cohort: Whole-exome sequencing implicates multiple syndromes and genes.
J J Lord Gowans
2021-04-01
Molecular genetics & genomic medicine
26399619 Biogenesis and regulation of the let-7 miRNAs and their functional implications.
Hosuk Lee
2016-02-01
Protein & cell
30395968 Unraveling 3'-end RNA uridylation at nucleotide resolution.
Mehdi Pirouz
2019-02-15
Methods (San Diego, Calif.)
30638126 Regulation of RNA decay and cellular function by 3'-5' exoribonuclease DIS3L2.
Siyu Luan
2019-02-01
RNA biology
32070232 'High vault-age': non-coding RNA control of autophagy.
Magdalena Büscher
2020-02-01
Open biology
30715470 RNA surveillance by uridylation-dependent RNA decay in Schizosaccharomyces pombe.
Z Christina Chung
2019-04-08
Nucleic acids research
36823385 A shape-shifting nuclease unravels structured RNA.
Katarina Meze
2023-03-01
Nature structural & molecular biology
27881476 Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively.
Stanislaw Jakub Nowak
2017-03-01
RNA (New York, N.Y.)
27647875 TUT-DIS3L2 is a mammalian surveillance pathway for aberrant structured non-coding RNAs.
Dmytro Ustianenko
2016-10-17
The EMBO journal
30029005 LIN28 Selectively Modulates a Subclass of Let-7 MicroRNAs.
Dmytro Ustianenko
2018-07-19
Molecular cell
24141620 Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs.
Dmytro Ustianenko
2013-12-01
RNA (New York, N.Y.)
27498873 Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs.
Mehdi Pirouz
2016-08-16
Cell reports
29036353 Structural insights into RNA unwinding and degradation by RNase R.
Lee-Ya Chu
2017-11-16
Nucleic acids research
27729457 Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila.
M Madalena Reimão-Pinto
2016-11-15
The EMBO journal
33313834 Repeated Evolution of Inactive Pseudonucleases in a Fungal Branch of the Dis3/RNase II Family of Nucleases.
R Elizabeth Ballou
2021-05-04
Molecular biology and evolution
25119025 Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway.
R Christopher Faehnle
2014-10-09
Nature
Name
Transcript ID
bp
Protein
Translation ID
DIS3L2-201
ENST00000273009
3201
603aa
ENSP00000273009
DIS3L2-204
ENST00000409401
2048
249aa
ENSP00000386594
DIS3L2-203
ENST00000390005
3328
619aa
ENSP00000374655
DIS3L2-211
ENST00000445090
3250
249aa
ENSP00000388999
DIS3L2-210
ENST00000441279
570
144aa
ENSP00000390467
DIS3L2-202
ENST00000325385
3366
885aa
ENSP00000315569
DIS3L2-208
ENST00000433430
4671
356aa
ENSP00000391175
DIS3L2-212
ENST00000464554
585
No protein
-
DIS3L2-213
ENST00000470087
848
No protein
-
DIS3L2-214
ENST00000498319
564
No protein
-
DIS3L2-207
ENST00000429283
4332
No protein
-
DIS3L2-209
ENST00000434477
659
196aa
ENSP00000392754
DIS3L2-206
ENST00000418143
843
166aa
ENSP00000401700
DIS3L2-205
ENST00000417808
923
68aa
ENSP00000408764
Pathway ID
Pathway Name
Source
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000144535 homo_sapiens ENSP00000366997 41.023 26.5136 homo_sapiens ENSP00000315569 44.4068 28.7006 ENSG00000144535 homo_sapiens ENSP00000321711 37.1917 23.6243 homo_sapiens ENSP00000315569 44.2938 28.1356
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000144535 homo_sapiens ENSP00000315569 94.3503 92.9943 nomascus_leucogenys ENSNLEP00000034838 96.8678 95.4756 ENSG00000144535 homo_sapiens ENSP00000315569 99.774 99.548 pan_paniscus ENSPPAP00000017968 99.3251 99.1001 ENSG00000144535 homo_sapiens ENSP00000315569 99.435 98.7571 pongo_abelii ENSPPYP00000014839 99.0991 98.4234 ENSG00000144535 homo_sapiens ENSP00000315569 99.774 99.548 pan_troglodytes ENSPTRP00000042229 99.549 99.3236 ENSG00000144535 homo_sapiens ENSP00000315569 90.8475 90.6215 gorilla_gorilla ENSGGOP00000026562 99.1369 98.8903 ENSG00000144535 homo_sapiens ENSP00000315569 84.9717 75.1412 ornithorhynchus_anatinus ENSOANP00000038395 65.6769 58.0786 ENSG00000144535 homo_sapiens ENSP00000315569 82.4859 72.2034 sarcophilus_harrisii ENSSHAP00000037182 65.0045 56.9012 ENSG00000144535 homo_sapiens ENSP00000315569 74.2373 64.5198 notamacropus_eugenii ENSMEUP00000012863 75.6041 65.7077 ENSG00000144535 homo_sapiens ENSP00000315569 56.0452 52.9944 choloepus_hoffmanni ENSCHOP00000008542 65.0919 61.5486 ENSG00000144535 homo_sapiens ENSP00000315569 77.7401 72.5424 dasypus_novemcinctus ENSDNOP00000014694 91.3679 85.259 ENSG00000144535 homo_sapiens ENSP00000315569 41.1299 38.4181 echinops_telfairi ENSETEP00000010599 60.8696 56.8562 ENSG00000144535 homo_sapiens ENSP00000315569 96.9492 94.1243 callithrix_jacchus ENSCJAP00000025175 97.0588 94.2308 ENSG00000144535 homo_sapiens ENSP00000315569 96.2712 94.8023 cercocebus_atys ENSCATP00000043879 97.3714 95.8857 ENSG00000144535 homo_sapiens ENSP00000315569 98.5311 97.5141 macaca_fascicularis ENSMFAP00000057578 93.7634 92.7957 ENSG00000144535 homo_sapiens ENSP00000315569 98.4181 97.4011 macaca_mulatta ENSMMUP00000019888 93.6559 92.6882 ENSG00000144535 homo_sapiens ENSP00000315569 97.1751 96.0452 macaca_nemestrina ENSMNEP00000028350 96.7379 95.613 ENSG00000144535 homo_sapiens ENSP00000315569 62.4859 61.1299 papio_anubis ENSPANP00000037378 92.1667 90.1667 ENSG00000144535 homo_sapiens ENSP00000315569 98.5311 97.5141 mandrillus_leucophaeus ENSMLEP00000037540 98.3089 97.2943 ENSG00000144535 homo_sapiens ENSP00000315569 80.904 76.4972 tursiops_truncatus ENSTTRP00000008716 89.3883 84.5193 ENSG00000144535 homo_sapiens ENSP00000315569 93.7853 89.3785 vulpes_vulpes ENSVVUP00000035516 94.2111 89.7843 ENSG00000144535 homo_sapiens ENSP00000315569 91.4124 85.8757 mus_spretus MGP_SPRETEiJ_P0019855 91.5158 85.9728 ENSG00000144535 homo_sapiens ENSP00000315569 93.7853 88.5876 equus_asinus ENSEASP00005012533 88.5806 83.6713 ENSG00000144535 homo_sapiens ENSP00000315569 93.6723 88.3616 capra_hircus ENSCHIP00000025412 93.9909 88.6621 ENSG00000144535 homo_sapiens ENSP00000315569 19.209 16.7232 loxodonta_africana ENSLAFP00000023290 73.5931 64.0693 ENSG00000144535 homo_sapiens ENSP00000315569 20.678 18.9831 loxodonta_africana ENSLAFP00000024344 91.0448 83.5821 ENSG00000144535 homo_sapiens ENSP00000315569 94.9153 89.0396 panthera_leo ENSPLOP00000022240 95.2381 89.3424 ENSG00000144535 homo_sapiens ENSP00000315569 94.0113 89.1525 ailuropoda_melanoleuca ENSAMEP00000017526 94.4381 89.5573 ENSG00000144535 homo_sapiens ENSP00000315569 94.0113 88.7006 bos_indicus_hybrid ENSBIXP00005034451 94.3311 89.0023 ENSG00000144535 homo_sapiens ENSP00000315569 24.6328 22.2599 oryctolagus_cuniculus ENSOCUP00000026847 87.5502 79.1165 ENSG00000144535 homo_sapiens ENSP00000315569 92.0904 86.7797 equus_caballus ENSECAP00000025622 88.2035 83.1169 ENSG00000144535 homo_sapiens ENSP00000315569 92.2034 86.8927 canis_lupus_familiaris ENSCAFP00845034158 83.1804 78.3894 ENSG00000144535 homo_sapiens ENSP00000315569 94.3503 88.8136 panthera_pardus ENSPPRP00000000442 95.5378 89.9314 ENSG00000144535 homo_sapiens ENSP00000315569 93.4463 88.4746 marmota_marmota_marmota ENSMMMP00000001993 94.8394 89.7936 ENSG00000144535 homo_sapiens ENSP00000315569 90.7345 85.0847 balaenoptera_musculus ENSBMSP00010001107 91.1464 85.4711 ENSG00000144535 homo_sapiens ENSP00000315569 90.8475 84.0678 cavia_porcellus ENSCPOP00000004679 91.6762 84.8347 ENSG00000144535 homo_sapiens ENSP00000315569 92.4294 87.1186 felis_catus ENSFCAP00000054121 79.572 75 ENSG00000144535 homo_sapiens ENSP00000315569 90.9604 85.3107 ursus_americanus ENSUAMP00000026550 91.7902 86.0889 ENSG00000144535 homo_sapiens ENSP00000315569 72.6554 62.7119 monodelphis_domestica ENSMODP00000054398 77.4699 66.8675 ENSG00000144535 homo_sapiens ENSP00000315569 24.9718 23.2768 bison_bison_bison ENSBBBP00000002798 90.2041 84.0816 ENSG00000144535 homo_sapiens ENSP00000315569 93.3333 87.9096 monodon_monoceros ENSMMNP00015014878 93.6508 88.2086 ENSG00000144535 homo_sapiens ENSP00000315569 93.4463 88.2486 sus_scrofa ENSSSCP00000025465 88.7339 83.7983 ENSG00000144535 homo_sapiens ENSP00000315569 90.2825 86.2147 microcebus_murinus ENSMICP00000039458 87.4179 83.4792 ENSG00000144535 homo_sapiens ENSP00000315569 91.4124 85.3107 octodon_degus ENSODEP00000010529 92.5629 86.3844 ENSG00000144535 homo_sapiens ENSP00000315569 91.2994 85.6497 jaculus_jaculus ENSJJAP00000001755 91.5062 85.8437 ENSG00000144535 homo_sapiens ENSP00000315569 93.8983 88.5876 ovis_aries_rambouillet ENSOARP00020015010 94.2177 88.8889 ENSG00000144535 homo_sapiens ENSP00000315569 92.2034 87.4576 ursus_maritimus ENSUMAP00000021543 88.1209 83.5853 ENSG00000144535 homo_sapiens ENSP00000315569 87.3446 79.774 ochotona_princeps ENSOPRP00000014542 87.1477 79.5941 ENSG00000144535 homo_sapiens ENSP00000315569 90.6215 85.0847 delphinapterus_leucas ENSDLEP00000012754 87.2688 81.9369 ENSG00000144535 homo_sapiens ENSP00000315569 92.3164 87.0057 physeter_catodon ENSPCTP00005025871 92.6304 87.3016 ENSG00000144535 homo_sapiens ENSP00000315569 91.7514 86.4407 mus_caroli MGP_CAROLIEiJ_P0018843 91.8552 86.5385 ENSG00000144535 homo_sapiens ENSP00000315569 91.4124 85.9887 mus_musculus ENSMUSP00000132673 91.5158 86.086 ENSG00000144535 homo_sapiens ENSP00000315569 85.7627 77.8531 dipodomys_ordii ENSDORP00000012354 89.2941 81.0588 ENSG00000144535 homo_sapiens ENSP00000315569 93.4463 88.3616 mustela_putorius_furo ENSMPUP00000004853 93.552 88.4615 ENSG00000144535 homo_sapiens ENSP00000315569 97.1751 95.1412 aotus_nancymaae ENSANAP00000004488 97.7273 95.6818 ENSG00000144535 homo_sapiens ENSP00000315569 96.9492 94.3503 saimiri_boliviensis_boliviensis ENSSBOP00000017492 96.7306 94.1375 ENSG00000144535 homo_sapiens ENSP00000315569 63.5028 60 vicugna_pacos ENSVPAP00000003973 75.5376 71.371 ENSG00000144535 homo_sapiens ENSP00000315569 98.3051 97.4011 chlorocebus_sabaeus ENSCSAP00000002902 94.7712 93.8998 ENSG00000144535 homo_sapiens ENSP00000315569 55.3672 51.4124 tupaia_belangeri ENSTBEP00000003423 56.3867 52.359 ENSG00000144535 homo_sapiens ENSP00000315569 92.0904 86.5537 mesocricetus_auratus ENSMAUP00000010986 92.1946 86.6516 ENSG00000144535 homo_sapiens ENSP00000315569 93.1073 88.1356 phocoena_sinus ENSPSNP00000007155 93.424 88.4354 ENSG00000144535 homo_sapiens ENSP00000315569 92.8814 87.9096 camelus_dromedarius ENSCDRP00005010163 88.961 84.1991 ENSG00000144535 homo_sapiens ENSP00000315569 13.2203 12.7684 carlito_syrichta ENSTSYP00000019976 94.3548 91.129 ENSG00000144535 homo_sapiens ENSP00000315569 56.2712 52.7684 carlito_syrichta ENSTSYP00000010896 91.5441 85.8456 ENSG00000144535 homo_sapiens ENSP00000315569 94.5763 89.0396 panthera_tigris_altaica ENSPTIP00000019887 95.7666 90.1602 ENSG00000144535 homo_sapiens ENSP00000315569 92.2034 86.6667 rattus_norvegicus ENSRNOP00000073968 91.6854 86.1798 ENSG00000144535 homo_sapiens ENSP00000315569 93.8983 90.2825 prolemur_simus ENSPSMP00000037800 94.3246 90.6924 ENSG00000144535 homo_sapiens ENSP00000315569 91.7514 85.5367 microtus_ochrogaster ENSMOCP00000019556 92.9062 86.6133 ENSG00000144535 homo_sapiens ENSP00000315569 47.6836 42.2599 sorex_araneus ENSSARP00000002506 48.6175 43.0876 ENSG00000144535 homo_sapiens ENSP00000315569 92.7684 86.4407 peromyscus_maniculatus_bairdii ENSPEMP00000033014 92.7684 86.4407 ENSG00000144535 homo_sapiens ENSP00000315569 93.6723 87.9096 bos_mutus ENSBMUP00000000104 93.9909 88.2086 ENSG00000144535 homo_sapiens ENSP00000315569 58.1921 53.1073 mus_spicilegus ENSMSIP00000002645 82.7974 75.5627 ENSG00000144535 homo_sapiens ENSP00000315569 91.2994 85.7627 cricetulus_griseus_chok1gshd ENSCGRP00001004174 91.714 86.1521 ENSG00000144535 homo_sapiens ENSP00000315569 69.0396 65.0847 pteropus_vampyrus ENSPVAP00000004494 76.7588 72.3618 ENSG00000144535 homo_sapiens ENSP00000315569 90.7345 84.4068 myotis_lucifugus ENSMLUP00000015425 90.8371 84.5023 ENSG00000144535 homo_sapiens ENSP00000315569 83.1638 73.4463 vombatus_ursinus ENSVURP00010029569 65.4222 57.7778 ENSG00000144535 homo_sapiens ENSP00000315569 92.5424 86.7797 rhinolophus_ferrumequinum ENSRFEP00010017595 93.3865 87.5713 ENSG00000144535 homo_sapiens ENSP00000315569 93.3333 88.1356 neovison_vison ENSNVIP00000004203 93.5447 88.3352 ENSG00000144535 homo_sapiens ENSP00000315569 94.0113 88.7006 bos_taurus ENSBTAP00000037928 94.3311 89.0023 ENSG00000144535 homo_sapiens ENSP00000315569 91.5254 85.8757 heterocephalus_glaber_female ENSHGLP00000003279 90 84.4444 ENSG00000144535 homo_sapiens ENSP00000315569 92.6554 90.0565 rhinopithecus_bieti ENSRBIP00000020022 93.2878 90.6712 ENSG00000144535 homo_sapiens ENSP00000315569 93.7853 89.3785 canis_lupus_dingo ENSCAFP00020029706 94.4255 89.9886 ENSG00000144535 homo_sapiens ENSP00000315569 92.9943 88.3616 sciurus_vulgaris ENSSVLP00005018103 93.0995 88.4615 ENSG00000144535 homo_sapiens ENSP00000315569 79.774 69.4915 phascolarctos_cinereus ENSPCIP00000044809 57.5387 50.1222 ENSG00000144535 homo_sapiens ENSP00000315569 59.209 54.3503 procavia_capensis ENSPCAP00000008596 64.8515 59.5297 ENSG00000144535 homo_sapiens ENSP00000315569 92.7684 88.0226 nannospalax_galili ENSNGAP00000026662 93.508 88.7244 ENSG00000144535 homo_sapiens ENSP00000315569 93.7853 88.4746 bos_grunniens ENSBGRP00000031675 94.1043 88.7755 ENSG00000144535 homo_sapiens ENSP00000315569 92.5424 87.0057 chinchilla_lanigera ENSCLAP00000014789 91.9192 86.4198 ENSG00000144535 homo_sapiens ENSP00000315569 94.0113 89.0396 cervus_hanglu_yarkandensis ENSCHYP00000030081 94.3311 89.3424 ENSG00000144535 homo_sapiens ENSP00000315569 93.2203 87.6836 catagonus_wagneri ENSCWAP00000004890 93.4315 87.8822 ENSG00000144535 homo_sapiens ENSP00000315569 93.3333 88.5876 ictidomys_tridecemlineatus ENSSTOP00000005085 94.7248 89.9083 ENSG00000144535 homo_sapiens ENSP00000315569 94.3503 89.2655 otolemur_garnettii ENSOGAP00000008192 94.7787 89.6708 ENSG00000144535 homo_sapiens ENSP00000315569 90.7345 88.0226 cebus_imitator ENSCCAP00000036354 94.6934 91.8632 ENSG00000144535 homo_sapiens ENSP00000315569 91.4124 86.2147 urocitellus_parryii ENSUPAP00010006361 90.8989 85.7303 ENSG00000144535 homo_sapiens ENSP00000315569 94.1243 88.5876 moschus_moschiferus ENSMMSP00000014351 94.4444 88.8889 ENSG00000144535 homo_sapiens ENSP00000315569 98.6441 97.1751 rhinopithecus_roxellana ENSRROP00000028653 98.4216 96.956 ENSG00000144535 homo_sapiens ENSP00000315569 91.2994 85.9887 mus_pahari MGP_PahariEiJ_P0074149 91.2994 85.9887 ENSG00000144535 homo_sapiens ENSP00000315569 93.7853 90.3955 propithecus_coquereli ENSPCOP00000027297 93.9977 90.6002 ENSG00000144535 homo_sapiens ENSP00000315569 55.5932 38.1921 caenorhabditis_elegans F48E8.6.1 58.0189 39.8585 ENSG00000144535 homo_sapiens ENSP00000315569 46.3277 29.9435 drosophila_melanogaster FBpp0072388 39.272 25.3831 ENSG00000144535 homo_sapiens ENSP00000315569 48.4746 35.8192 ciona_intestinalis ENSCINP00000008123 57.8947 42.78 ENSG00000144535 homo_sapiens ENSP00000315569 26.6667 19.774 petromyzon_marinus ENSPMAP00000003045 63.4409 47.043 ENSG00000144535 homo_sapiens ENSP00000315569 61.3559 47.5706 eptatretus_burgeri ENSEBUP00000013404 53.2353 41.2745 ENSG00000144535 homo_sapiens ENSP00000315569 76.3842 63.2768 callorhinchus_milii ENSCMIP00000020784 67.3307 55.7769 ENSG00000144535 homo_sapiens ENSP00000315569 63.5028 53.5593 latimeria_chalumnae ENSLACP00000014529 80.5158 67.9083 ENSG00000144535 homo_sapiens ENSP00000315569 72.5424 61.3559 lepisosteus_oculatus ENSLOCP00000005770 63.6274 53.8157 ENSG00000144535 homo_sapiens ENSP00000315569 22.2599 11.0734 clupea_harengus ENSCHAP00000025038 42.6407 21.2121 ENSG00000144535 homo_sapiens ENSP00000315569 70.8475 57.8531 danio_rerio ENSDARP00000114941 63.0151 51.4573 ENSG00000144535 homo_sapiens ENSP00000315569 10.3955 8.24859 carassius_auratus ENSCARP00000020054 68.1481 54.0741 ENSG00000144535 homo_sapiens ENSP00000315569 56.9492 47.1186 carassius_auratus ENSCARP00000059318 82.6229 68.3607 ENSG00000144535 homo_sapiens ENSP00000315569 62.0339 49.9435 astyanax_mexicanus ENSAMXP00000020260 67.2794 54.1667 ENSG00000144535 homo_sapiens ENSP00000315569 71.9774 57.0621 ictalurus_punctatus ENSIPUP00000008652 64.6701 51.269 ENSG00000144535 homo_sapiens ENSP00000315569 72.5424 60.113 esox_lucius ENSELUP00000023908 60.7955 50.3788 ENSG00000144535 homo_sapiens ENSP00000315569 68.4746 56.8362 electrophorus_electricus ENSEEEP00000004794 65.6555 54.4962 ENSG00000144535 homo_sapiens ENSP00000315569 72.7684 60.678 oncorhynchus_kisutch ENSOKIP00005060834 61.4504 51.2405 ENSG00000144535 homo_sapiens ENSP00000315569 72.8814 60.678 oncorhynchus_mykiss ENSOMYP00000011557 61.4286 51.1429 ENSG00000144535 homo_sapiens ENSP00000315569 72.9943 60.678 salmo_salar ENSSSAP00000010245 61.5825 51.1916 ENSG00000144535 homo_sapiens ENSP00000315569 72.9943 60.678 salmo_trutta ENSSTUP00000080429 61.5825 51.1916 ENSG00000144535 homo_sapiens ENSP00000315569 67.7966 55.7062 gadus_morhua ENSGMOP00000053150 63.8978 52.5027 ENSG00000144535 homo_sapiens ENSP00000315569 70.9604 57.6271 fundulus_heteroclitus ENSFHEP00000032836 58.6368 47.619 ENSG00000144535 homo_sapiens ENSP00000315569 69.9435 56.4972 poecilia_reticulata ENSPREP00000003433 58.3962 47.1698 ENSG00000144535 homo_sapiens ENSP00000315569 66.8927 54.1243 xiphophorus_maculatus ENSXMAP00000032491 62.845 50.8493 ENSG00000144535 homo_sapiens ENSP00000315569 71.2994 57.1751 oryzias_latipes ENSORLP00000036024 61.0251 48.9362 ENSG00000144535 homo_sapiens ENSP00000315569 71.0734 57.7401 cyclopterus_lumpus ENSCLMP00005005773 59.2837 48.1621 ENSG00000144535 homo_sapiens ENSP00000315569 73.4463 60.565 oreochromis_niloticus ENSONIP00000076718 62.38 51.4395 ENSG00000144535 homo_sapiens ENSP00000315569 73.1073 60.452 haplochromis_burtoni ENSHBUP00000002782 62.0921 51.3436 ENSG00000144535 homo_sapiens ENSP00000315569 73.2203 60.339 astatotilapia_calliptera ENSACLP00000023316 62.1881 51.2476 ENSG00000144535 homo_sapiens ENSP00000315569 73.5593 61.0169 sparus_aurata ENSSAUP00010024256 61.8234 51.2821 ENSG00000144535 homo_sapiens ENSP00000315569 73.4463 60.226 lates_calcarifer ENSLCAP00010005848 61.8459 50.7136 ENSG00000144535 homo_sapiens ENSP00000315569 77.2881 64.1808 xenopus_tropicalis ENSXETP00000075290 64.0449 53.1835 ENSG00000144535 homo_sapiens ENSP00000315569 83.3898 70.8475 chrysemys_picta_bellii ENSCPBP00000022982 65.4255 55.5851 ENSG00000144535 homo_sapiens ENSP00000315569 81.6949 70.2825 sphenodon_punctatus ENSSPUP00000015501 64.3238 55.3381 ENSG00000144535 homo_sapiens ENSP00000315569 82.2599 69.9435 crocodylus_porosus ENSCPRP00005017260 64.3678 54.7303 ENSG00000144535 homo_sapiens ENSP00000315569 73.6723 61.9209 pseudonaja_textilis ENSPTXP00000022031 75.9022 63.7951 ENSG00000144535 homo_sapiens ENSP00000315569 45.3107 38.8701 anas_platyrhynchos_platyrhynchos ENSAPLP00000012707 71.7352 61.5385 ENSG00000144535 homo_sapiens ENSP00000315569 12.5424 10.7345 anas_platyrhynchos_platyrhynchos ENSAPLP00000032196 78.7234 67.3759 ENSG00000144535 homo_sapiens ENSP00000315569 81.9209 70.2825 gallus_gallus ENSGALP00010025169 64.273 55.1418 ENSG00000144535 homo_sapiens ENSP00000315569 77.2881 65.5367 meleagris_gallopavo ENSMGAP00000034557 59.2208 50.2164 ENSG00000144535 homo_sapiens ENSP00000315569 81.4689 68.7006 serinus_canaria ENSSCAP00000019955 63.6364 53.6628 ENSG00000144535 homo_sapiens ENSP00000315569 81.8079 68.9266 parus_major ENSPMJP00000000334 62.684 52.8139 ENSG00000144535 homo_sapiens ENSP00000315569 79.435 67.1186 anolis_carolinensis ENSACAP00000011772 62.656 52.9412 ENSG00000144535 homo_sapiens ENSP00000315569 73.1073 60.226 neolamprologus_brichardi ENSNBRP00000011418 62.0921 51.1516 ENSG00000144535 homo_sapiens ENSP00000315569 76.7232 64.1808 podarcis_muralis ENSPMRP00000031378 80.0708 66.9811 ENSG00000144535 homo_sapiens ENSP00000315569 81.1299 67.6836 geospiza_fortis ENSGFOP00000019326 63.5398 53.0089 ENSG00000144535 homo_sapiens ENSP00000315569 81.3559 68.2486 taeniopygia_guttata ENSTGUP00000010126 63.7733 53.4987 ENSG00000144535 homo_sapiens ENSP00000315569 39.435 30.6215 erpetoichthys_calabaricus ENSECRP00000009722 61.8794 48.0496 ENSG00000144535 homo_sapiens ENSP00000315569 9.49153 7.79661 erpetoichthys_calabaricus ENSECRP00000009710 23.0769 18.956 ENSG00000144535 homo_sapiens ENSP00000315569 71.7514 59.774 kryptolebias_marmoratus ENSKMAP00000010294 65.8031 54.8187 ENSG00000144535 homo_sapiens ENSP00000315569 79.774 66.2147 salvator_merianae ENSSMRP00000024153 62.8114 52.1352 ENSG00000144535 homo_sapiens ENSP00000315569 69.6045 56.0452 oryzias_javanicus ENSOJAP00000034591 59.6899 48.062 ENSG00000144535 homo_sapiens ENSP00000315569 68.0226 56.1582 amphilophus_citrinellus ENSACIP00000010786 60.6244 50.0504 ENSG00000144535 homo_sapiens ENSP00000315569 73.6723 61.6949 dicentrarchus_labrax ENSDLAP00005009457 61.7424 51.7045 ENSG00000144535 homo_sapiens ENSP00000315569 74.3503 60.791 amphiprion_percula ENSAPEP00000031898 62.0755 50.7547 ENSG00000144535 homo_sapiens ENSP00000315569 71.0734 57.0621 oryzias_sinensis ENSOSIP00000023518 60.8317 48.8395 ENSG00000144535 homo_sapiens ENSP00000315569 81.4689 69.8305 pelodiscus_sinensis ENSPSIP00000008353 83.4491 71.5278 ENSG00000144535 homo_sapiens ENSP00000315569 82.8249 70.6215 gopherus_evgoodei ENSGEVP00005027289 64.9823 55.4078 ENSG00000144535 homo_sapiens ENSP00000315569 82.4859 70.0565 chelonoidis_abingdonii ENSCABP00000016863 64.7163 54.9645 ENSG00000144535 homo_sapiens ENSP00000315569 74.0113 60.791 seriola_dumerili ENSSDUP00000007433 60.987 50.0931 ENSG00000144535 homo_sapiens ENSP00000315569 74.0113 60.113 cottoperca_gobio ENSCGOP00000038684 61.9678 50.3311 ENSG00000144535 homo_sapiens ENSP00000315569 77.6271 64.9717 struthio_camelus_australis ENSSCUP00000019093 85.3416 71.4286 ENSG00000144535 homo_sapiens ENSP00000315569 82.2599 70.3955 anser_brachyrhynchus ENSABRP00000007543 64.5963 55.2795 ENSG00000144535 homo_sapiens ENSP00000315569 72.6554 59.548 gasterosteus_aculeatus ENSGACP00000021702 78.7026 64.5043 ENSG00000144535 homo_sapiens ENSP00000315569 71.0734 57.4011 cynoglossus_semilaevis ENSCSEP00000029253 60.8317 49.1296 ENSG00000144535 homo_sapiens ENSP00000315569 70.5085 57.4011 poecilia_formosa ENSPFOP00000007867 58.8679 47.9245 ENSG00000144535 homo_sapiens ENSP00000315569 75.2542 62.0339 myripristis_murdjan ENSMMDP00005034080 62.8302 51.7925 ENSG00000144535 homo_sapiens ENSP00000315569 73.5593 60.452 sander_lucioperca ENSSLUP00000022899 61.8234 50.8072 ENSG00000144535 homo_sapiens ENSP00000315569 81.1299 69.1525 strigops_habroptila ENSSHBP00005020900 63.7655 54.3517 ENSG00000144535 homo_sapiens ENSP00000315569 74.3503 61.0169 amphiprion_ocellaris ENSAOCP00000009693 62.0755 50.9434 ENSG00000144535 homo_sapiens ENSP00000315569 83.1638 70.5085 terrapene_carolina_triunguis ENSTMTP00000000388 65.2482 55.3191 ENSG00000144535 homo_sapiens ENSP00000315569 72.5424 60.565 hucho_hucho ENSHHUP00000062856 61.2011 51.0963 ENSG00000144535 homo_sapiens ENSP00000315569 72.3164 59.548 betta_splendens ENSBSLP00000028120 61.244 50.4306 ENSG00000144535 homo_sapiens ENSP00000315569 73.2203 60.226 pygocentrus_nattereri ENSPNAP00000022245 62.8516 51.6974 ENSG00000144535 homo_sapiens ENSP00000315569 73.4463 60.565 anabas_testudineus ENSATEP00000004732 61.553 50.7576 ENSG00000144535 homo_sapiens ENSP00000315569 31.8644 23.1638 ciona_savignyi ENSCSAVP00000011395 61.3043 44.5652 ENSG00000144535 homo_sapiens ENSP00000315569 8.92655 5.9887 ciona_savignyi ENSCSAVP00000011389 30.5019 20.4633 ENSG00000144535 homo_sapiens ENSP00000315569 42.2599 24.9718 saccharomyces_cerevisiae YDR293C 29.92 17.68 ENSG00000144535 homo_sapiens ENSP00000315569 73.8983 60.678 seriola_lalandi_dorsalis ENSSLDP00000006438 62.0493 50.9488 ENSG00000144535 homo_sapiens ENSP00000315569 72.3164 59.322 labrus_bergylta ENSLBEP00000007074 61.0105 50.0477 ENSG00000144535 homo_sapiens ENSP00000315569 73.3333 60.565 pundamilia_nyererei ENSPNYP00000002800 62.2841 51.4395 ENSG00000144535 homo_sapiens ENSP00000315569 72.5424 58.6441 mastacembelus_armatus ENSMAMP00000027029 61.0847 49.3815 ENSG00000144535 homo_sapiens ENSP00000315569 74.0113 60.791 stegastes_partitus ENSSPAP00000028217 62.2624 51.1407 ENSG00000144535 homo_sapiens ENSP00000315569 72.7684 60.678 oncorhynchus_tshawytscha ENSOTSP00005039830 61.5091 51.2894 ENSG00000144535 homo_sapiens ENSP00000315569 74.3503 61.1299 acanthochromis_polyacanthus ENSAPOP00000017121 62.1341 51.0859 ENSG00000144535 homo_sapiens ENSP00000315569 82.4859 69.9435 aquila_chrysaetos_chrysaetos ENSACCP00020006032 64.5446 54.7303 ENSG00000144535 homo_sapiens ENSP00000315569 70.1695 53.8983 nothobranchius_furzeri ENSNFUP00015015977 56.8161 43.6414 ENSG00000144535 homo_sapiens ENSP00000315569 70.5085 57.5141 cyprinodon_variegatus ENSCVAP00000031443 61.5992 50.2468 ENSG00000144535 homo_sapiens ENSP00000315569 70.8475 58.9831 denticeps_clupeoides ENSDCDP00000032957 63.2694 52.6741 ENSG00000144535 homo_sapiens ENSP00000315569 72.6554 59.435 larimichthys_crocea ENSLCRP00005021820 62.4272 51.068 ENSG00000144535 homo_sapiens ENSP00000315569 71.5254 58.6441 takifugu_rubripes ENSTRUP00000015436 60.7486 49.8081 ENSG00000144535 homo_sapiens ENSP00000315569 81.017 68.8136 ficedula_albicollis ENSFALP00000030696 61.9171 52.5907 ENSG00000144535 homo_sapiens ENSP00000315569 66.1017 54.6893 hippocampus_comes ENSHCOP00000018075 61.8393 51.1628 ENSG00000144535 homo_sapiens ENSP00000315569 71.5254 57.1751 cyprinus_carpio_carpio ENSCCRP00000150815 61.6959 49.3177 ENSG00000144535 homo_sapiens ENSP00000315569 81.9209 69.3785 coturnix_japonica ENSCJPP00005016720 62.9887 53.3449 ENSG00000144535 homo_sapiens ENSP00000315569 70.2825 57.2881 poecilia_latipinna ENSPLAP00000016800 58.7347 47.8754 ENSG00000144535 homo_sapiens ENSP00000315569 65.9887 52.9944 sinocyclocheilus_grahami ENSSGRP00000049462 61.409 49.3165 ENSG00000144535 homo_sapiens ENSP00000315569 8.58757 7.11864 sinocyclocheilus_grahami ENSSGRP00000049464 71.028 58.8785 ENSG00000144535 homo_sapiens ENSP00000315569 73.2203 60.339 maylandia_zebra ENSMZEP00005013379 62.1881 51.2476 ENSG00000144535 homo_sapiens ENSP00000315569 72.0904 59.322 tetraodon_nigroviridis ENSTNIP00000010711 78.0906 64.2595 ENSG00000144535 homo_sapiens ENSP00000315569 73.7853 61.5819 paramormyrops_kingsleyae ENSPKIP00000021890 61.6038 51.4151 ENSG00000144535 homo_sapiens ENSP00000315569 75.2542 62.2599 scleropages_formosus ENSSFOP00015020647 63.3682 52.4263 ENSG00000144535 homo_sapiens ENSP00000315569 77.9661 63.9548 leptobrachium_leishanense ENSLLEP00000035975 65.9026 54.0592 ENSG00000144535 homo_sapiens ENSP00000315569 71.9774 57.8531 scophthalmus_maximus ENSSMAP00000058335 77.7778 62.5153 ENSG00000144535 homo_sapiens ENSP00000315569 69.8305 56.1582 oryzias_melastigma ENSOMEP00000006208 60 48.2524
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000175 enables 3-5-RNA exonuclease activity 2 IBA,IDA Homo_sapiens(9606) Function GO:0000278 involved_in mitotic cell cycle 1 IMP Homo_sapiens(9606) Process GO:0000287 enables magnesium ion binding 1 IDA Homo_sapiens(9606) Function GO:0000291 involved_in nuclear-transcribed mRNA catabolic process, exonucleolytic 1 IMP Homo_sapiens(9606) Process GO:0000932 is_active_in P-body 2 IBA,IDA Homo_sapiens(9606) Component GO:0004540 enables RNA nuclease activity 1 IDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005737 located_in cytoplasm 1 IDA Homo_sapiens(9606) Component GO:0005844 part_of polysome 1 TAS Homo_sapiens(9606) Component GO:0006402 involved_in mRNA catabolic process 1 IBA Homo_sapiens(9606) Process GO:0008266 enables poly(U) RNA binding 1 IDA Homo_sapiens(9606) Function GO:0008285 involved_in negative regulation of cell population proliferation 1 IMP Homo_sapiens(9606) Process GO:0010587 involved_in miRNA catabolic process 3 IBA,IDA,ISS Homo_sapiens(9606) Process GO:0019827 involved_in stem cell population maintenance 1 ISS Homo_sapiens(9606) Process GO:0034427 involved_in nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5 1 IEA Homo_sapiens(9606) Process GO:0051301 involved_in cell division 1 IEA Homo_sapiens(9606) Process GO:0051306 involved_in mitotic sister chromatid separation 1 IMP Homo_sapiens(9606) Process GO:1990074 involved_in polyuridylation-dependent mRNA catabolic process 1 ISS Homo_sapiens(9606) Process
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