Ensembl ID ENSG00000144535 Gene ID 129563 Accession 28648
Gene Symbol DIS3L2 Alias FAM6A;PRLMNS;hDIS3L2 Full Name DIS3 like 3'-5' exoribonuclease 2
Position 2 : 231961245 - 232344350 Length 383106 bases Strand Plus strand
Status Confidence Main interacting RNAsdiverseRBP type Canonical_RBPs
Summary The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]

ENSG00000144535 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000144535 DIS3L2 -0.4 2.51e-11 HNSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000144535 DIS3L2 Wilms tumor 22306653
ENSG00000144535 DIS3L2 Wilms tumor 23613427
ENSG00000144535 DIS3L2 Wilms tumor 24755370
ENSG00000144535 DIS3L2 tumors 25670083
ENSG00000144535 DIS3L2 Wilms tumor 27647875
ENSG00000144535 DIS3L2 colorectal cancer 28496335
ENSG00000144535 DIS3L2 Wilms tumor 29950491
ENSG00000144535 DIS3L2 Wilms tumors 30057901
ENSG00000144535 DIS3L2 cancer 30638126
ENSG00000144535 DIS3L2 liver cancer 31331910
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000144535 DIS3L2 MESO 0.029 low
ENSG00000144535 DIS3L2 CHOL 0.033 high
ENSG00000144535 DIS3L2 UVM 0.0051 high
ENSG00000144535 DIS3L2 UCEC 0.016 low
ENSG00000144535 DIS3L2 ACC 0.003 high
ENSG00000144535 DIS3L2 LUSC 0.035 high
ENSG00000144535 DIS3L2 HNSC 0.041 low
ENSG00000144535 DIS3L2 PCPG 0.0022 high
ENSG00000144535 DIS3L2 THYM 0.00029 low
ENSG00000144535 DIS3L2 BRCA 0.013 low
ENSG00000144535 DIS3L2 OV 0.027 high
ENSG00000144535 DIS3L2 DLBC 0.021 low
ENSG00000144535 DIS3L2 KIRC 8e-04 high
ENSG00000144535 DIS3L2 TGCT 0.0032 low
ENSG00000144535 DIS3L2 LAML 0.0018 low
ENSG00000144535 DIS3L2 SKCM 0.00057 high
ENSG00000144535 DIS3L2 LIHC 0.0015 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000144535 DIS3L2 LUSC Del 18.311583 0.202916 0.392913 0.307385
ENSG00000144535 DIS3L2 LGG Del 11.828660 0.113963 0.516077 0.116959
ENSG00000144535 DIS3L2 CESC Del 40.218419 0.390121 0.538047 0.433898
ENSG00000144535 DIS3L2 KIRP Amp 1.259300 0.069729 0.551282 0.152778
ENSG00000144535 DIS3L2 KIRP Del 2.761897 0.046238 0.653407 0.041667
ENSG00000144535 DIS3L2 THYM Del 0.970980 0.045771 0.517711 0.048780
ENSG00000144535 DIS3L2 SARC Del 14.349098 0.349228 0.622378 0.385214
ENSG00000144535 DIS3L2 ESCA Del 2.668373 0.150041 0.381336 0.250000
ENSG00000144535 DIS3L2 SKCM Del 3.380388 0.104430 0.425477 0.201635
ENSG00000144535 DIS3L2 THCA Del 0.973661 0.010631 0.469303 0.026052
ENSG00000144535 DIS3L2 HNSC Del 24.460073 0.194753 0.388575 0.302682
ENSG00000144535 DIS3L2 BLCA Del 32.417754 0.325326 0.455355 0.502451
ENSG00000144535 DIS3L2 BRCA Del 6.153664 0.098341 0.358857 0.279630
ENSG00000144535 DIS3L2 STAD Del 1.441039 0.071195 0.326973 0.140590
ENSG00000144535 DIS3L2 UCEC Del 1.589928 0.059054 0.441904 0.087199
ENSG00000144535 DIS3L2 KIRC Del 12.007565 0.073612 0.542790 0.089015
ENSG00000144535 DIS3L2 UVM Del 1.063142 0.077139 0.955323 0.037500
ENSG00000144535 DIS3L2 OV Del 2.603134 0.212977 0.497551 0.259067