Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000143194 Gene ID 84944 Accession 25929
Symbol MAEL Alias CT128;SPATA35 Full Name maelstrom spermatogenic transposon silencer
Status Confidence Length 46633 bases Strand Plus strand
Position 1 : 166975582 - 167022214 RNA binding domain Maelstrom
Summary Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in gamete generation; negative regulation of macromolecule metabolic process; and piRNA metabolic process. Predicted to act upstream of or within several processes, including homologous chromosome pairing at meiosis; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of macromolecule metabolic process. Predicted to be located in piP-body. Predicted to be active in P granule and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000402143 Maelstrom PF13017 1.2e-42 1
ENSP00000482771 Maelstrom PF13017 1.8e-42 1
ENSP00000356844 Maelstrom PF13017 2.1e-42 1
ENSP00000356846 Maelstrom PF13017 2.5e-42 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25778731 Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists. Kuan-Ming Chen 2015-05-01 RNA (New York, N.Y.)
19032786 Functional insight into Maelstrom in the germline piRNA pathway: a unique domain homologous to the DnaQ-H 3'-5' exonuclease, its lineage-specific expansion/loss and evolutionarily active site switch. Dapeng Zhang 2008-11-25 Biology direct
27926513 Mael is essential for cancer cell survival and tumorigenesis through protection of genetic integrity. Su-Hyeon Kim 2017-01-17 Oncotarget
33730017 Structural analysis of viral ExoN domains reveals polyphyletic hijacking events. Adrián Cruz-González 2021-01-01 PloS one

Transcripts

Name Transcript ID bp Protein Translation ID
MAEL-202 ENST00000367872 1737 434aa ENSP00000356846
MAEL-203 ENST00000447624 1013 316aa ENSP00000402143
MAEL-205 ENST00000491055 2355 No protein -
MAEL-204 ENST00000487826 416 No protein -
MAEL-206 ENST00000622874 1700 378aa ENSP00000482771
MAEL-201 ENST00000367870 1831 403aa ENSP00000356844

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
31419Erythrocyte Indices7.5220000E-006-
31450Erythrocyte Indices5.8590000E-005-
31456Erythrocyte Indices5.8550000E-006-
31571Erythrocyte Count1.5470000E-005-
31601Erythrocyte Count7.0390000E-005-
31609Erythrocyte Count1.3720000E-005-
36369Platelet Function Tests1.1100000E-006-
36394Platelet Function Tests3.7800000E-007-
36858Platelet Function Tests9.0700000E-008-
36944Platelet Function Tests5.0100000E-006-
38759Platelet Function Tests4.3800000E-006-
38781Platelet Function Tests3.3593800E-005-
40335Platelet Function Tests1.0387300E-005-
73453Astigmatism3E-625367360

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000143194

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000143194homo_sapiensENSP0000035684698.847997.9263nomascus_leucogenysENSNLEP0000001797198.847997.9263
ENSG00000143194homo_sapiensENSP0000035684699.308898.8479pan_paniscusENSPPAP0000003887699.308898.8479
ENSG00000143194homo_sapiensENSP0000035684699.539298.6175pongo_abeliiENSPPYP0000000064999.539298.6175
ENSG00000143194homo_sapiensENSP0000035684699.308898.8479pan_troglodytesENSPTRP0000005158399.308898.8479
ENSG00000143194homo_sapiensENSP0000035684699.308899.0783gorilla_gorillaENSGGOP0000001225881.939281.749
ENSG00000143194homo_sapiensENSP0000035684673.963162.4424ornithorhynchus_anatinusENSOANP0000004319356.914948.0496
ENSG00000143194homo_sapiensENSP0000035684685.714378.8018sarcophilus_harrisiiENSSHAP0000002163685.517278.6207
ENSG00000143194homo_sapiensENSP0000035684674.654468.2028notamacropus_eugeniiENSMEUP0000000153183.720976.4858
ENSG00000143194homo_sapiensENSP0000035684670.967768.4332choloepus_hoffmanniENSCHOP0000001052370.967768.4332
ENSG00000143194homo_sapiensENSP0000035684695.622191.4747dasypus_novemcinctusENSDNOP0000001270394.965790.8467
ENSG00000143194homo_sapiensENSP0000035684682.949379.0323erinaceus_europaeusENSEEUP0000001282684.309180.3279
ENSG00000143194homo_sapiensENSP0000035684673.963168.6636echinops_telfairiENSETEP0000000107076.428670.9524
ENSG00000143194homo_sapiensENSP0000035684697.23594.2396callithrix_jacchusENSCJAP0000003164397.23594.2396
ENSG00000143194homo_sapiensENSP0000035684698.847997.6959cercocebus_atysENSCATP0000002615498.847997.6959
ENSG00000143194homo_sapiensENSP0000035684699.078398.1567macaca_fascicularisENSMFAP0000000735799.078398.1567
ENSG00000143194homo_sapiensENSP0000035684699.308898.3871macaca_mulattaENSMMUP0000003772999.308898.3871
ENSG00000143194homo_sapiensENSP0000035684699.308898.1567macaca_nemestrinaENSMNEP0000003990099.308898.1567
ENSG00000143194homo_sapiensENSP0000035684696.082994.47papio_anubisENSPANP0000001019696.751795.1276
ENSG00000143194homo_sapiensENSP0000035684698.847997.9263mandrillus_leucophaeusENSMLEP0000002008998.847997.9263
ENSG00000143194homo_sapiensENSP0000035684685.714382.7189tursiops_truncatusENSTTRP0000000580387.735884.6698
ENSG00000143194homo_sapiensENSP0000035684694.009290.553vulpes_vulpesENSVVUP0000003682695.550492.0375
ENSG00000143194homo_sapiensENSP0000035684694.239689.8617mus_spretusMGP_SPRETEiJ_P002203294.239689.8617
ENSG00000143194homo_sapiensENSP0000035684694.930990.553equus_asinusENSEASP0000504648680.468876.7578
ENSG00000143194homo_sapiensENSP0000035684696.313492.6267capra_hircusENSCHIP0000003071696.313492.6267
ENSG00000143194homo_sapiensENSP0000035684695.622190.7834loxodonta_africanaENSLAFP0000001700994.748989.9543
ENSG00000143194homo_sapiensENSP0000035684695.161392.6267panthera_leoENSPLOP0000001504395.601993.0556
ENSG00000143194homo_sapiensENSP0000035684695.622191.4747ailuropoda_melanoleucaENSAMEP0000002151994.965790.8467
ENSG00000143194homo_sapiensENSP0000035684694.009290.0922bos_indicus_hybridENSBIXP0000504017895.550491.5691
ENSG00000143194homo_sapiensENSP0000035684694.700590.0922oryctolagus_cuniculusENSOCUP0000003432780.273476.3672
ENSG00000143194homo_sapiensENSP0000035684688.479383.871equus_caballusENSECAP0000005039395.285490.3226
ENSG00000143194homo_sapiensENSP0000035684696.543892.6267canis_lupus_familiarisENSCAFP0084500521496.543892.6267
ENSG00000143194homo_sapiensENSP0000035684696.543893.5484panthera_pardusENSPPRP0000000802996.543893.5484
ENSG00000143194homo_sapiensENSP0000035684695.852592.8571marmota_marmota_marmotaENSMMMP0000002348095.852592.8571
ENSG00000143194homo_sapiensENSP0000035684695.622192.3963balaenoptera_musculusENSBMSP0001001120795.84392.6097
ENSG00000143194homo_sapiensENSP0000035684687.327280.8756cavia_porcellusENSCPOP0000000454090.453583.7709
ENSG00000143194homo_sapiensENSP0000035684696.082993.7788felis_catusENSFCAP0000000860996.082993.7788
ENSG00000143194homo_sapiensENSP0000035684695.391791.7051ursus_americanusENSUAMP0000002352695.391791.7051
ENSG00000143194homo_sapiensENSP0000035684679.493172.1198monodelphis_domesticaENSMODP0000000301476.837469.7105
ENSG00000143194homo_sapiensENSP0000035684696.543892.6267bison_bison_bisonENSBBBP0000001056896.543892.6267
ENSG00000143194homo_sapiensENSP0000035684693.778890.3226monodon_monocerosENSMMNP0001500454693.778890.3226
ENSG00000143194homo_sapiensENSP0000035684695.622191.7051sus_scrofaENSSSCP0000006048695.622191.7051
ENSG00000143194homo_sapiensENSP0000035684697.004694.9309microcebus_murinusENSMICP0000001821297.004694.9309
ENSG00000143194homo_sapiensENSP0000035684687.327280.6452octodon_degusENSODEP0000000296891.767684.7458
ENSG00000143194homo_sapiensENSP0000035684691.705185.7143jaculus_jaculusENSJJAP0000000716991.705185.7143
ENSG00000143194homo_sapiensENSP0000035684696.313492.8571ovis_aries_rambouilletENSOARP0002000336096.313492.8571
ENSG00000143194homo_sapiensENSP0000035684688.940184.1014ursus_maritimusENSUMAP0000002263387.330382.5792
ENSG00000143194homo_sapiensENSP0000035684685.483980.1843ochotona_princepsENSOPRP0000000484285.287480
ENSG00000143194homo_sapiensENSP0000035684694.239690.7834delphinapterus_leucasENSDLEP0000002975294.239690.7834
ENSG00000143194homo_sapiensENSP0000035684693.778890.0922physeter_catodonENSPCTP0000500352893.778890.0922
ENSG00000143194homo_sapiensENSP0000035684694.700589.8617mus_caroliMGP_CAROLIEiJ_P002096894.700589.8617
ENSG00000143194homo_sapiensENSP0000035684694.239689.8617mus_musculusENSMUSP0000004582894.239689.8617
ENSG00000143194homo_sapiensENSP0000035684693.548488.9401dipodomys_ordiiENSDORP0000002250393.548488.9401
ENSG00000143194homo_sapiensENSP0000035684695.391791.4747mustela_putorius_furoENSMPUP0000001557595.391791.4747
ENSG00000143194homo_sapiensENSP0000035684696.543892.6267aotus_nancymaaeENSANAP0000002737596.543892.6267
ENSG00000143194homo_sapiensENSP0000035684697.465494.9309saimiri_boliviensis_boliviensisENSSBOP0000002127497.465494.9309
ENSG00000143194homo_sapiensENSP0000035684679.032375.3456vicugna_pacosENSVPAP0000000457479.214875.5196
ENSG00000143194homo_sapiensENSP0000035684699.078397.9263chlorocebus_sabaeusENSCSAP0000000706998.850697.7011
ENSG00000143194homo_sapiensENSP0000035684667.741964.5161tupaia_belangeriENSTBEP0000000287368.691665.4206
ENSG00000143194homo_sapiensENSP0000035684694.700589.8617mesocricetus_auratusENSMAUP0000002489194.700589.8617
ENSG00000143194homo_sapiensENSP0000035684694.4790.7834phocoena_sinusENSPSNP0000002299194.4790.7834
ENSG00000143194homo_sapiensENSP0000035684695.852591.4747camelus_dromedariusENSCDRP0000500712895.852591.4747
ENSG00000143194homo_sapiensENSP0000035684693.548489.6313carlito_syrichtaENSTSYP0000000297693.333389.4253
ENSG00000143194homo_sapiensENSP0000035684687.096884.7926panthera_tigris_altaicaENSPTIP0000001022889.361786.9976
ENSG00000143194homo_sapiensENSP0000035684694.239690.3226rattus_norvegicusENSRNOP0000000506094.239690.3226
ENSG00000143194homo_sapiensENSP0000035684696.774294.47prolemur_simusENSPSMP0000001419696.774294.47
ENSG00000143194homo_sapiensENSP0000035684693.548488.2488microtus_ochrogasterENSMOCP0000000473293.764488.4527
ENSG00000143194homo_sapiensENSP0000035684694.4790.3226peromyscus_maniculatus_bairdiiENSPEMP0000002911694.4790.3226
ENSG00000143194homo_sapiensENSP0000035684696.543892.6267bos_mutusENSBMUP0000003577596.543892.6267
ENSG00000143194homo_sapiensENSP0000035684694.239689.8617mus_spicilegusENSMSIP0000001518294.239689.8617
ENSG00000143194homo_sapiensENSP0000035684694.930990.3226cricetulus_griseus_chok1gshdENSCGRP0000100676994.930990.3226
ENSG00000143194homo_sapiensENSP0000035684686.866483.1797pteropus_vampyrusENSPVAP0000001253786.866483.1797
ENSG00000143194homo_sapiensENSP0000035684693.548488.0184myotis_lucifugusENSMLUP0000000373492.906287.4142
ENSG00000143194homo_sapiensENSP0000035684685.483978.5714vombatus_ursinusENSVURP0001000456485.287478.3908
ENSG00000143194homo_sapiensENSP0000035684693.548488.0184rhinolophus_ferrumequinumENSRFEP0001002754093.333387.8161
ENSG00000143194homo_sapiensENSP0000035684692.396388.4793neovison_visonENSNVIP0000001041795.476291.4286
ENSG00000143194homo_sapiensENSP0000035684693.31889.4009bos_taurusENSBTAP0000003400496.428692.381
ENSG00000143194homo_sapiensENSP0000035684687.557682.9493heterocephalus_glaber_femaleENSHGLP0000001875592.23387.3786
ENSG00000143194homo_sapiensENSP0000035684698.847998.1567rhinopithecus_bietiENSRBIP0000002976398.847998.1567
ENSG00000143194homo_sapiensENSP0000035684696.543892.6267canis_lupus_dingoENSCAFP0002002926596.543892.6267
ENSG00000143194homo_sapiensENSP0000035684695.622191.7051sciurus_vulgarisENSSVLP0000500918295.622191.7051
ENSG00000143194homo_sapiensENSP0000035684684.792676.9585phascolarctos_cinereusENSPCIP0000004107784.403776.6055
ENSG00000143194homo_sapiensENSP0000035684647.695942.3963phascolarctos_cinereusENSPCIP0000003635884.836175.4098
ENSG00000143194homo_sapiensENSP0000035684664.97759.6774procavia_capensisENSPCAP0000001216578.551572.1448
ENSG00000143194homo_sapiensENSP0000035684692.396388.4793nannospalax_galiliENSNGAP0000001088192.824188.8889
ENSG00000143194homo_sapiensENSP0000035684696.543892.6267bos_grunniensENSBGRP0000001048196.543892.6267
ENSG00000143194homo_sapiensENSP0000035684688.248882.4885chinchilla_lanigeraENSCLAP0000000991191.408185.4415
ENSG00000143194homo_sapiensENSP0000035684696.313491.9355cervus_hanglu_yarkandensisENSCHYP0000001719596.313491.9355
ENSG00000143194homo_sapiensENSP0000035684696.082991.4747catagonus_wagneriENSCWAP0000001533896.082991.4747
ENSG00000143194homo_sapiensENSP0000035684696.082993.0876ictidomys_tridecemlineatusENSSTOP0000003056396.082993.0876
ENSG00000143194homo_sapiensENSP0000035684696.543894.47otolemur_garnettiiENSOGAP0000000682696.100994.0367
ENSG00000143194homo_sapiensENSP0000035684697.465495.3917cebus_imitatorENSCCAP0000003064097.465495.3917
ENSG00000143194homo_sapiensENSP0000035684695.852592.1659moschus_moschiferusENSMMSP0000002176095.852592.1659
ENSG00000143194homo_sapiensENSP0000035684698.847998.1567rhinopithecus_roxellanaENSRROP0000003132898.847998.1567
ENSG00000143194homo_sapiensENSP0000035684694.4789.8617mus_pahariMGP_PahariEiJ_P007623594.4789.8617
ENSG00000143194homo_sapiensENSP0000035684696.313493.318propithecus_coquereliENSPCOP0000000239596.313493.318
ENSG00000143194homo_sapiensENSP0000035684636.175113.8249drosophila_melanogasterFBpp008857433.982712.987
ENSG00000143194homo_sapiensENSP0000035684614.28576.91244ciona_intestinalisENSCINP0000002018550.819724.5902
ENSG00000143194homo_sapiensENSP0000035684620.276513.1336eptatretus_burgeriENSEBUP0000002336955.345935.8491
ENSG00000143194homo_sapiensENSP0000035684642.626728.5714callorhinchus_miliiENSCMIP0000000044265.37143.8163
ENSG00000143194homo_sapiensENSP0000035684662.21247.9263latimeria_chalumnaeENSLACP0000002327663.231848.7119
ENSG00000143194homo_sapiensENSP0000035684660.829543.0876xenopus_tropicalisENSXETP0000004537763.614545.0602
ENSG00000143194homo_sapiensENSP0000035684672.811160.3687chrysemys_picta_belliiENSCPBP0000000774077.073263.9024
ENSG00000143194homo_sapiensENSP0000035684665.668255.0691sphenodon_punctatusENSSPUP0000002423672.519160.8143
ENSG00000143194homo_sapiensENSP0000035684665.668253.6866crocodylus_porosusENSCPRP0000501599271.969758.8384
ENSG00000143194homo_sapiensENSP0000035684660.829548.1567notechis_scutatusENSNSUP0000002225670.026555.4377
ENSG00000143194homo_sapiensENSP0000035684661.290348.1567pseudonaja_textilisENSPTXP0000000532869.090954.2857
ENSG00000143194homo_sapiensENSP0000035684664.516149.0783anas_platyrhynchos_platyrhynchosENSAPLP0000000632468.292751.9512
ENSG00000143194homo_sapiensENSP0000035684661.981647.4654gallus_gallusENSGALP0001001124065.450150.1217
ENSG00000143194homo_sapiensENSP0000035684640.322629.4931meleagris_gallopavoENSMGAP0000001528050.143336.6762
ENSG00000143194homo_sapiensENSP0000035684656.221242.6267serinus_canariaENSSCAP0000001690465.415649.5979
ENSG00000143194homo_sapiensENSP0000035684658.986244.0092parus_majorENSPMJP0000001618562.135946.3592
ENSG00000143194homo_sapiensENSP0000035684664.97750.9217anolis_carolinensisENSACAP0000002289461.171447.9393
ENSG00000143194homo_sapiensENSP0000035684639.170529.9539anolis_carolinensisENSACAP0000001838162.547.7941
ENSG00000143194homo_sapiensENSP0000035684661.290350.2304naja_najaENSNNAP0000000534371.505458.6021
ENSG00000143194homo_sapiensENSP0000035684667.972452.765podarcis_muralisENSPMRP0000001453869.905254.2654
ENSG00000143194homo_sapiensENSP0000035684649.539238.4793geospiza_fortisENSGFOP0000000810166.563551.7028
ENSG00000143194homo_sapiensENSP0000035684661.520747.0046taeniopygia_guttataENSTGUP0000001391165.60250.1228
ENSG00000143194homo_sapiensENSP0000035684668.202852.9954salvator_merianaeENSSMRP0000000255875.126958.3756
ENSG00000143194homo_sapiensENSP0000035684671.65958.2949pelodiscus_sinensisENSPSIP0000001091675.853761.7073
ENSG00000143194homo_sapiensENSP0000035684672.350258.9862gopherus_evgoodeiENSGEVP0000500453176.772662.5917
ENSG00000143194homo_sapiensENSP0000035684663.133653.2258chelonoidis_abingdoniiENSCABP0000000837773.854462.2642
ENSG00000143194homo_sapiensENSP0000035684649.539238.9401struthio_camelus_australisENSSCUP0000002281871.428656.1462
ENSG00000143194homo_sapiensENSP0000035684665.437850anser_brachyrhynchusENSABRP0000000158569.268352.9268
ENSG00000143194homo_sapiensENSP0000035684658.755847.0046strigops_habroptilaENSSHBP0000500926866.062252.8497
ENSG00000143194homo_sapiensENSP0000035684671.65959.2166terrapene_carolina_triunguisENSTMTP0000000510375.853762.6829
ENSG00000143194homo_sapiensENSP0000035684624.193512.6728ciona_savignyiENSCSAVP0000001548645.851524.0175
ENSG00000143194homo_sapiensENSP0000035684658.064546.3134aquila_chrysaetos_chrysaetosENSACCP0002000903460.431748.2014
ENSG00000143194homo_sapiensENSP0000035684662.672847.9263ficedula_albicollisENSFALP0000000161566.341550.7317
ENSG00000143194homo_sapiensENSP0000035684663.364147.6959coturnix_japonicaENSCJPP0000500311561.659246.4126
ENSG00000143194homo_sapiensENSP0000035684660.138243.318leptobrachium_leishanenseENSLLEP0000000108555.179739.7463

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0000785part_of chromatin1IEAHomo_sapiens(9606)Component
GO:0000902involved_in cell morphogenesis1IEAHomo_sapiens(9606)Process
GO:0001673located_in male germ cell nucleus1IEAHomo_sapiens(9606)Component
GO:0001741located_in XY body1IEAHomo_sapiens(9606)Component
GO:0005634is_active_in nucleus2IBA,ISSHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1ISSHomo_sapiens(9606)Component
GO:0007129involved_in homologous chromosome pairing at meiosis1IEAHomo_sapiens(9606)Process
GO:0007140involved_in male meiotic nuclear division1IBAHomo_sapiens(9606)Process
GO:0007283involved_in spermatogenesis2IBA,ISSHomo_sapiens(9606)Process
GO:0008630involved_in intrinsic apoptotic signaling pathway in response to DNA damage1IEAHomo_sapiens(9606)Process
GO:0009566involved_in fertilization1IEAHomo_sapiens(9606)Process
GO:0030849located_in autosome1IEAHomo_sapiens(9606)Component
GO:0031047involved_in regulatory ncRNA-mediated gene silencing1ISSHomo_sapiens(9606)Process
GO:0033391located_in chromatoid body1IEAHomo_sapiens(9606)Component
GO:0034587involved_in piRNA processing2IBA,ISSHomo_sapiens(9606)Process
GO:0035234involved_in ectopic germ cell programmed cell death1IEAHomo_sapiens(9606)Process
GO:0043066involved_in negative regulation of apoptotic process1IEAHomo_sapiens(9606)Process
GO:0043186is_active_in P granule2IBA,ISSHomo_sapiens(9606)Component
GO:0043565enables sequence-specific DNA binding1IBAHomo_sapiens(9606)Function
GO:0045892involved_in negative regulation of DNA-templated transcription1IBAHomo_sapiens(9606)Process
GO:0046620involved_in regulation of organ growth1IEAHomo_sapiens(9606)Process
GO:0048471located_in perinuclear region of cytoplasm1IEAHomo_sapiens(9606)Component
GO:0051093involved_in negative regulation of developmental process1IEAHomo_sapiens(9606)Process
GO:0060964involved_in regulation of miRNA-mediated gene silencing1IEAHomo_sapiens(9606)Process
GO:0071514involved_in genomic imprinting1ISSHomo_sapiens(9606)Process
GO:0071547located_in piP-body1ISSHomo_sapiens(9606)Component
GO:2000242involved_in negative regulation of reproductive process1IEAHomo_sapiens(9606)Process

Expression