RBP Type
Non-canonical_RBPs
Diseases
Drug
N.A.
Main interacting RNAs
snRNA
Moonlighting functions
N.A.
Localizations
N.A.
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000141759 Gene ID
10907 Accession
30551
Symbol
TXNL4A
Alias
BMKS;DIB1;DIM1;TXNL4;SNRNP15;U5-15kD
Full Name
thioredoxin like 4A
Status
Confidence
Length
63137 bases
Strand
Minus strand
Position
18 : 79970813 - 80033949
RNA binding domain
N.A.
Summary
The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
Name
Transcript ID
bp
Protein
Translation ID
TXNL4A-201
ENST00000269601
3472
142aa
ENSP00000269601
TXNL4A-203
ENST00000585474
1185
71aa
ENSP00000465572
TXNL4A-208
ENST00000588162
752
57aa
ENSP00000465321
TXNL4A-212
ENST00000592957
546
71aa
ENSP00000465493
TXNL4A-202
ENST00000355491
803
91aa
ENSP00000347678
TXNL4A-204
ENST00000585769
988
54aa
ENSP00000466266
TXNL4A-206
ENST00000586612
448
No protein
-
TXNL4A-211
ENST00000592837
611
71aa
ENSP00000468761
TXNL4A-210
ENST00000591711
669
103aa
ENSP00000468493
TXNL4A-207
ENST00000586825
586
54aa
ENSP00000467304
TXNL4A-205
ENST00000586295
706
86aa
ENSP00000466694
TXNL4A-209
ENST00000589926
535
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000141759 homo_sapiens ENSP00000268483 61.745 35.5705 homo_sapiens ENSP00000269601 64.7887 37.3239
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000141759 homo_sapiens ENSP00000269601 100 100 nomascus_leucogenys ENSNLEP00000033707 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 pan_paniscus ENSPPAP00000022778 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 pongo_abelii ENSPPYP00000010397 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 pan_troglodytes ENSPTRP00000074214 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 gorilla_gorilla ENSGGOP00000005173 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 ornithorhynchus_anatinus ENSOANP00000020454 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 64.0845 63.3803 choloepus_hoffmanni ENSCHOP00000006395 100 98.9011 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 dasypus_novemcinctus ENSDNOP00000016795 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 64.0845 63.3803 erinaceus_europaeus ENSEEUP00000008246 100 98.9011 ENSG00000141759 homo_sapiens ENSP00000269601 64.0845 63.3803 echinops_telfairi ENSETEP00000011808 100 98.9011 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 callithrix_jacchus ENSCJAP00000080424 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 cercocebus_atys ENSCATP00000033471 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 macaca_fascicularis ENSMFAP00000007759 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 macaca_mulatta ENSMMUP00000002155 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 macaca_nemestrina ENSMNEP00000008368 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 papio_anubis ENSPANP00000054868 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 50 50 mandrillus_leucophaeus ENSMLEP00000002589 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 75.3521 74.6479 tursiops_truncatus ENSTTRP00000008547 75.3521 74.6479 ENSG00000141759 homo_sapiens ENSP00000269601 62.6761 54.9296 vulpes_vulpes ENSVVUP00000025838 39.2071 34.3612 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 mus_spretus MGP_SPRETEiJ_P0049178 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 equus_asinus ENSEASP00005037179 66.3551 65.8878 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 capra_hircus ENSCHIP00000020620 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 loxodonta_africana ENSLAFP00000002649 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 92.9577 85.2113 loxodonta_africana ENSLAFP00000013992 92.9577 85.2113 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 panthera_leo ENSPLOP00000027758 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 ailuropoda_melanoleuca ENSAMEP00000010917 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 98.5916 97.8873 bos_indicus_hybrid ENSBIXP00005020517 60.3448 59.9138 ENSG00000141759 homo_sapiens ENSP00000269601 63.3803 62.6761 oryctolagus_cuniculus ENSOCUP00000039510 92.7835 91.7526 ENSG00000141759 homo_sapiens ENSP00000269601 56.338 51.4085 equus_caballus ENSECAP00000063111 57.1429 52.1429 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 canis_lupus_familiaris ENSCAFP00845000026 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 panthera_pardus ENSPPRP00000023930 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 marmota_marmota_marmota ENSMMMP00000021717 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 balaenoptera_musculus ENSBMSP00010013086 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 cavia_porcellus ENSCPOP00000021303 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 66.9014 53.5211 felis_catus ENSFCAP00000032333 26.5363 21.229 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 ursus_americanus ENSUAMP00000004180 75.5319 75 ENSG00000141759 homo_sapiens ENSP00000269601 61.2676 61.2676 bison_bison_bison ENSBBBP00000020724 85.2941 85.2941 ENSG00000141759 homo_sapiens ENSP00000269601 92.9577 88.7324 monodon_monoceros ENSMMNP00015024601 94.964 90.6475 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 monodon_monoceros ENSMMNP00015005338 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 sus_scrofa ENSSSCP00000037560 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 73.9437 70.4225 microcebus_murinus ENSMICP00000012591 92.1053 87.7193 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 microcebus_murinus ENSMICP00000024531 99.3007 99.3007 ENSG00000141759 homo_sapiens ENSP00000269601 89.4366 85.9155 microcebus_murinus ENSMICP00000039953 88.8112 85.3147 ENSG00000141759 homo_sapiens ENSP00000269601 87.3239 81.6901 microcebus_murinus ENSMICP00000016839 77.0186 72.0497 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 octodon_degus ENSODEP00000004214 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 jaculus_jaculus ENSJJAP00000014352 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 ovis_aries_rambouillet ENSOARP00020014810 63.6771 63.2287 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 ursus_maritimus ENSUMAP00000006181 59.4142 58.9958 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 ochotona_princeps ENSOPRP00000010110 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 delphinapterus_leucas ENSDLEP00000006634 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 67.6056 64.7887 delphinapterus_leucas ENSDLEP00000000601 97.9592 93.8775 ENSG00000141759 homo_sapiens ENSP00000269601 68.3099 64.7887 physeter_catodon ENSPCTP00005010337 80.8333 76.6667 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 physeter_catodon ENSPCTP00005021822 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 mus_caroli MGP_CAROLIEiJ_P0047222 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 mus_musculus ENSMUSP00000115320 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 41.5493 40.8451 dipodomys_ordii ENSDORP00000027310 84.2857 82.8571 ENSG00000141759 homo_sapiens ENSP00000269601 49.2958 49.2958 dipodomys_ordii ENSDORP00000014116 98.5916 98.5916 ENSG00000141759 homo_sapiens ENSP00000269601 50 50 dipodomys_ordii ENSDORP00000023118 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 mustela_putorius_furo ENSMPUP00000016558 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 aotus_nancymaae ENSANAP00000014933 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 50 50 saimiri_boliviensis_boliviensis ENSSBOP00000001735 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 80.2817 76.0563 vicugna_pacos ENSVPAP00000005830 95 90 ENSG00000141759 homo_sapiens ENSP00000269601 68.3099 64.7887 chlorocebus_sabaeus ENSCSAP00000014269 94.1748 89.3204 ENSG00000141759 homo_sapiens ENSP00000269601 40.8451 40.8451 tupaia_belangeri ENSTBEP00000011350 65.1685 65.1685 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 mesocricetus_auratus ENSMAUP00000025252 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 phocoena_sinus ENSPSNP00000016867 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 camelus_dromedarius ENSCDRP00005012655 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 73.9437 63.3803 camelus_dromedarius ENSCDRP00005004311 71.9178 61.6438 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 carlito_syrichta ENSTSYP00000017527 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 99.2958 98.5916 panthera_tigris_altaica ENSPTIP00000010580 99.2958 98.5916 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 prolemur_simus ENSPSMP00000034757 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 microtus_ochrogaster ENSMOCP00000012977 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 64.0845 63.3803 sorex_araneus ENSSARP00000005188 100 98.9011 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 peromyscus_maniculatus_bairdii ENSPEMP00000025302 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 bos_mutus ENSBMUP00000024404 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 99.2958 99.2958 mus_spicilegus ENSMSIP00000002986 99.2958 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 mus_spicilegus ENSMSIP00000002885 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 98.5916 97.8873 cricetulus_griseus_chok1gshd ENSCGRP00001009293 98.5916 97.8873 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 cricetulus_griseus_chok1gshd ENSCGRP00001013714 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 pteropus_vampyrus ENSPVAP00000004544 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 myotis_lucifugus ENSMLUP00000008363 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 rhinolophus_ferrumequinum ENSRFEP00010029900 61.4719 61.039 ENSG00000141759 homo_sapiens ENSP00000269601 50 49.2958 neovison_vison ENSNVIP00000013930 100 98.5916 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 bos_taurus ENSBTAP00000018067 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 50 50 heterocephalus_glaber_female ENSHGLP00000057406 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 63.3803 60.5634 heterocephalus_glaber_female ENSHGLP00000036633 92.7835 88.6598 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 rhinopithecus_bieti ENSRBIP00000019362 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 canis_lupus_dingo ENSCAFP00020018328 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 sciurus_vulgaris ENSSVLP00005015967 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 97.8873 97.1831 procavia_capensis ENSPCAP00000003176 100 99.2806 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 nannospalax_galili ENSNGAP00000012521 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 bos_grunniens ENSBGRP00000039115 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 chinchilla_lanigera ENSCLAP00000020728 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 42.9577 39.4366 chinchilla_lanigera ENSCLAP00000015285 87.1429 80 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 cervus_hanglu_yarkandensis ENSCHYP00000039121 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 catagonus_wagneri ENSCWAP00000000913 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 ictidomys_tridecemlineatus ENSSTOP00000022461 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 otolemur_garnettii ENSOGAP00000020624 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 urocitellus_parryii ENSUPAP00010001216 74.7368 74.7368 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 moschus_moschiferus ENSMMSP00000009189 47.651 47.3154 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 rhinopithecus_roxellana ENSRROP00000021633 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 100 100 mus_pahari MGP_PahariEiJ_P0039783 100 100 ENSG00000141759 homo_sapiens ENSP00000269601 95.0704 86.6197 caenorhabditis_elegans Y54G2A.75.1 95.0704 86.6197 ENSG00000141759 homo_sapiens ENSP00000269601 98.5916 95.7747 drosophila_melanogaster FBpp0077125 98.5916 95.7747 ENSG00000141759 homo_sapiens ENSP00000269601 100 99.2958 meleagris_gallopavo ENSMGAP00000001686 100 99.2958 ENSG00000141759 homo_sapiens ENSP00000269601 94.3662 88.7324 ciona_savignyi ENSCSAVP00000004082 94.3662 88.7324 ENSG00000141759 homo_sapiens ENSP00000269601 79.5775 64.0845 saccharomyces_cerevisiae YPR082C 79.021 63.6364
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000245 involved_in spliceosomal complex assembly 1 TAS Homo_sapiens(9606) Process GO:0000375 involved_in RNA splicing, via transesterification reactions 1 TAS Homo_sapiens(9606) Process GO:0000398 involved_in mRNA splicing, via spliceosome 2 IDA,NAS Homo_sapiens(9606) Process GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 located_in nucleus 2 IDA,NAS Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 2 IDA,TAS Homo_sapiens(9606) Component GO:0005681 part_of spliceosomal complex 2 IBA,TAS Homo_sapiens(9606) Component GO:0005682 part_of U5 snRNP 1 IBA Homo_sapiens(9606) Component GO:0005829 located_in cytosol 1 IDA Homo_sapiens(9606) Component GO:0007049 involved_in cell cycle 1 IEA Homo_sapiens(9606) Process GO:0031965 located_in nuclear membrane 1 IDA Homo_sapiens(9606) Component GO:0046540 part_of U4/U6 x U5 tri-snRNP complex 3 IBA,IDA,IPI Homo_sapiens(9606) Component GO:0051301 involved_in cell division 1 IEA Homo_sapiens(9606) Process GO:0071005 part_of U2-type precatalytic spliceosome 1 IDA Homo_sapiens(9606) Component
Copyright © 2023, Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.
