Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerFlavivirusesSARS-COV-2Dengue
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucleP-body
BulkPerturb-seq DataSet_01_424 DataSet_01_476

Description

Ensembl ID ENSG00000141543 Gene ID 9775 Accession 18683
Symbol EIF4A3 Alias Fal1;RCPS;DDX48;MUK34;NUK34;NMP265;eIF4AIII;eIF4A-III;eIF-4A-III Full Name eukaryotic translation initiation factor 4A3
Status Confidence Length 12783 bases Strand Minus strand
Position 17 : 80134369 - 80147151 RNA binding domain DEAD
Summary This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000497641 DEAD PF00270 1.1e-41 1
ENSP00000497661 DEAD PF00270 1.1e-41 1
ENSP00000460439 DEAD PF00270 4.6e-30 1
ENSP00000460439 DEAD PF00270 4.6e-30 2

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34898474 YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1. Canghai Guan 2021-12-13 Aging
37137667 Mouse nuclear RNAi-defective 2 promotes splicing of weak 5' splice sites. Matyas Flemr 2023-08-01 RNA (New York, N.Y.)
33824281 Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression. Xiaoguang Gu 2021-04-06 Cell death & disease
32926734 EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1-2 signaling. Yutian Wei 2021-04-12 Neuro-oncology
33176280 Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression. Lei Wang 2020-11-07 Aging
26989025 Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3. Dong Han 2016-04-19 Oncotarget
31069274 Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation. Alborz Mazloomian 2019-01-01 Communications biology
25220460 The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex. Nele Hug 2014-09-25 Cell reports
32549918 Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes. Na Li 2020-06-01 The EPMA journal
37179359 Circ_0020256 induces fibroblast activation to drive cholangiocarcinoma development via recruitment of EIF4A3 protein to stabilize KLF4 mRNA. Zongyan Li 2023-05-13 Cell death discovery
35729321 Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty. Cedric Badowski 2022-06-21 NPJ precision oncology
37241009 Clinical Application of Circular RNAs as Biomarkers in Acute Ischemic Stroke. Chiara Siracusa 2023-05-16 Journal of personalized medicine
28093074 Insights into the design and interpretation of iCLIP experiments. Nejc Haberman 2017-01-16 Genome biology
35360855 Profile and Functional Prediction of Plasma Exosome-Derived CircRNAs From Acute Ischemic Stroke Patients. Jie Yang 2022-01-01 Frontiers in genetics
37626035 EIF4A3-mediated circ_0042881 activates the RAS pathway via miR-217/SOS1 axis to facilitate breast cancer progression. Chenxi Ju 2023-08-25 Cell death & disease
37011005 EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma. Wenhao Yu 2023-07-05 Molecular cancer research : MCR
34631278 LRRC4 mediates the formation of circular RNA CD44 to inhibitGBM cell proliferation. Jianbo Feng 2021-12-03 Molecular therapy. Nucleic acids
36597139 Exosome-derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase-3-dependent cleavage. Lifeng Ding 2023-01-01 Clinical and translational medicine
37627052 Pseudogenes in Cancer: State of the Art. Kenzuke Arturo Nakamura-García 2023-08-08 Cancers
31109436 [Cyclic RNA Molecule circ_0007766 Promotes the Proliferation of Lung Adenocarcinoma Cells by Up-regulating the Expression of Cyclin D1/CyclinE1/CDK4]. Shuai Zhang 2019-05-20 Zhongguo fei ai za zhi = Chinese journal of lung cancer
34869305 Expression and Functional Roles of Eukaryotic Initiation Factor 4A Family Proteins in Human Cancers. Chen Xue 2021-01-01 Frontiers in cell and developmental biology
35135542 circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling. Lin Zheng 2022-02-08 Molecular cancer
37243831 EIF4A3-Induced Exosomal circLRRC8A Alleviates Granulosa Cells Senescence Via the miR-125a-3p/NFE2L1 axis. Jie Xing 2023-08-01 Stem cell reviews and reports

Transcripts

Name Transcript ID bp Protein Translation ID
EIF4A3-209 ENST00000649764 2524 411aa ENSP00000497641
EIF4A3-205 ENST00000575978 3593 No protein -
EIF4A3-201 ENST00000570625 562 No protein -
EIF4A3-207 ENST00000576573 697 No protein -
EIF4A3-208 ENST00000647795 1579 411aa ENSP00000497661
EIF4A3-206 ENST00000576547 1492 390aa ENSP00000460439
EIF4A3-203 ENST00000575668 831 No protein -
EIF4A3-202 ENST00000570837 534 No protein -
EIF4A3-204 ENST00000575957 574 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000141543homo_sapiensENSP000003794755031.5421homo_sapiensENSP0000049764152.068132.8467
ENSG00000141543homo_sapiensENSP0000038553626.337418.2442homo_sapiensENSP0000049764146.715332.3601
ENSG00000141543homo_sapiensENSP0000026323928.955216.5672homo_sapiensENSP0000049764147.201927.0073
ENSG00000141543homo_sapiensENSP0000048268025.882414.5098homo_sapiensENSP0000049764148.175227.0073
ENSG00000141543homo_sapiensENSP0000029383181.280866.5025homo_sapiensENSP0000049764180.29265.6934
ENSG00000141543homo_sapiensENSP0000030611753.556532.4268homo_sapiensENSP0000049764162.287137.7129
ENSG00000141543homo_sapiensENSP0000028807153.444732.3591homo_sapiensENSP0000049764162.287137.7129
ENSG00000141543homo_sapiensENSP0000048149522.700812.4563homo_sapiensENSP0000049764147.445326.0341
ENSG00000141543homo_sapiensENSP0000041653419.864312.1124homo_sapiensENSP0000049764149.878330.4136
ENSG00000141543homo_sapiensENSP0000036123225.469214.8794homo_sapiensENSP0000049764146.228727.0073
ENSG00000141543homo_sapiensENSP0000049264313.53387.5188homo_sapiensENSP0000049764143.795624.3309
ENSG00000141543homo_sapiensENSP0000023814631.166717.5homo_sapiensENSP0000049764145.498825.5474
ENSG00000141543homo_sapiensENSP0000022579231.75921.0098homo_sapiensENSP0000049764147.445331.3869
ENSG00000141543homo_sapiensENSP0000036866730.427918.3835homo_sapiensENSP0000049764146.715328.2238
ENSG00000141543homo_sapiensENSP0000033046033.44119.063homo_sapiensENSP0000049764150.36528.7105
ENSG00000141543homo_sapiensENSP0000026357650.931731.47homo_sapiensENSP0000049764159.85436.983
ENSG00000141543homo_sapiensENSP0000038049525.525515.1652homo_sapiensENSP0000049764141.362524.5742
ENSG00000141543homo_sapiensENSP0000031434820.228611.5429homo_sapiensENSP0000049764143.065724.5742
ENSG00000141543homo_sapiensENSP0000034612025.798216.092homo_sapiensENSP0000049764149.148430.6569
ENSG00000141543homo_sapiensENSP0000037457419.93611.8337homo_sapiensENSP0000049764145.498827.0073
ENSG00000141543homo_sapiensENSP0000035871624.635916.0194homo_sapiensENSP0000049764149.391732.1168
ENSG00000141543homo_sapiensENSP0000044226642.650124.6377homo_sapiensENSP0000049764150.121728.9538
ENSG00000141543homo_sapiensENSP0000036268727.679816.6893homo_sapiensENSP0000049764149.63529.927
ENSG00000141543homo_sapiensENSP0000047950432.387318.0301homo_sapiensENSP0000049764147.201926.2774
ENSG00000141543homo_sapiensENSP0000035936131.018519.4444homo_sapiensENSP0000049764148.905130.6569
ENSG00000141543homo_sapiensENSP0000032638181.326867.8133homo_sapiensENSP0000049764180.535367.1533
ENSG00000141543homo_sapiensENSP0000025877235.283420.4753homo_sapiensENSP0000049764146.958627.2506
ENSG00000141543homo_sapiensENSP0000049404030.815719.3353homo_sapiensENSP0000049764149.63531.1436
ENSG00000141543homo_sapiensENSP0000033672530.606119.3939homo_sapiensENSP0000049764149.148431.1436
ENSG00000141543homo_sapiensENSP0000024700338.923424.4306homo_sapiensENSP0000049764145.742128.7105
ENSG00000141543homo_sapiensENSP0000033034929.260518.4887homo_sapiensENSP0000049764144.282227.9805
ENSG00000141543homo_sapiensENSP0000024277649.882930.6792homo_sapiensENSP0000049764151.824831.8735
ENSG00000141543homo_sapiensENSP0000023308428.513517.4324homo_sapiensENSP0000049764151.338231.3869
ENSG00000141543homo_sapiensENSP0000030407222.36113.6209homo_sapiensENSP0000049764147.931929.1971
ENSG00000141543homo_sapiensENSP0000035069843.076925.7143homo_sapiensENSP0000049764147.688628.4672
ENSG00000141543homo_sapiensENSP0000031072323.170713.6585homo_sapiensENSP0000049764146.228727.2506
ENSG00000141543homo_sapiensENSP0000033234031.481519.0741homo_sapiensENSP0000049764141.362525.0608
ENSG00000141543homo_sapiensENSP0000042483827.209916.4365homo_sapiensENSP0000049764147.931928.9538
ENSG00000141543homo_sapiensENSP00000516984100100homo_sapiensENSP00000497641100100

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000141543homo_sapiensENSP00000497641100100nomascus_leucogenysENSNLEP00000018918100100
ENSG00000141543homo_sapiensENSP0000049764181.265278.5888pan_paniscusENSPPAP0000000506090.02787.062
ENSG00000141543homo_sapiensENSP00000497641100100pongo_abeliiENSPPYP00000009779100100
ENSG00000141543homo_sapiensENSP0000049764197.080396.5937pan_troglodytesENSPTRP0000006364496.610296.1259
ENSG00000141543homo_sapiensENSP0000049764199.270199.2701gorilla_gorillaENSGGOP0000004872397.142997.1429
ENSG00000141543homo_sapiensENSP0000049764198.783598.5401ornithorhynchus_anatinusENSOANP0000000055991.23691.0112
ENSG00000141543homo_sapiensENSP0000049764199.026899.0268sarcophilus_harrisiiENSSHAP0000003302999.026899.0268
ENSG00000141543homo_sapiensENSP0000049764199.270199.0268sarcophilus_harrisiiENSSHAP0000000530690.868690.6459
ENSG00000141543homo_sapiensENSP0000049764188.564588.5645notamacropus_eugeniiENSMEUP0000000778488.780588.7805
ENSG00000141543homo_sapiensENSP0000049764186.861386.618dasypus_novemcinctusENSDNOP0000000699396.486596.2162
ENSG00000141543homo_sapiensENSP0000049764193.430793.4307erinaceus_europaeusENSEEUP0000000547993.430793.4307
ENSG00000141543homo_sapiensENSP0000049764136.009735.7664echinops_telfairiENSETEP0000001039461.15760.7438
ENSG00000141543homo_sapiensENSP0000049764196.350494.1606callithrix_jacchusENSCJAP0000008586497.058894.8529
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567callithrix_jacchusENSCJAP0000006499799.756799.7567
ENSG00000141543homo_sapiensENSP0000049764193.430792.2141cercocebus_atysENSCATP0000003324597.709996.4377
ENSG00000141543homo_sapiensENSP00000497641100100cercocebus_atysENSCATP00000032403100100
ENSG00000141543homo_sapiensENSP0000049764198.053598.0535macaca_fascicularisENSMFAP00000024520100100
ENSG00000141543homo_sapiensENSP00000497641100100macaca_mulattaENSMMUP00000012539100100
ENSG00000141543homo_sapiensENSP0000049764190.024388.5645macaca_nemestrinaENSMNEP0000002998695.607294.0568
ENSG00000141543homo_sapiensENSP0000049764198.783598.7835macaca_nemestrinaENSMNEP0000003189194.859894.8598
ENSG00000141543homo_sapiensENSP00000497641100100papio_anubisENSPANP00000016283100100
ENSG00000141543homo_sapiensENSP0000049764186.131486.1314mandrillus_leucophaeusENSMLEP00000017474100100
ENSG00000141543homo_sapiensENSP0000049764176.642376.6423tursiops_truncatusENSTTRP0000000048188.98388.983
ENSG00000141543homo_sapiensENSP0000049764199.513499.5134vulpes_vulpesENSVVUP0000002454399.513499.5134
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567mus_spretusMGP_SPRETEiJ_P003284499.756799.7567
ENSG00000141543homo_sapiensENSP0000049764196.83796.837equus_asinusENSEASP0000505179599.749499.7494
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567capra_hircusENSCHIP0000002901799.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567loxodonta_africanaENSLAFP0000001310099.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567panthera_leoENSPLOP0000003071099.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567ailuropoda_melanoleucaENSAMEP0000001601199.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567bos_indicus_hybridENSBIXP0000502946799.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567equus_caballusENSECAP0000006539285.416785.4167
ENSG00000141543homo_sapiensENSP0000049764199.513499.5134canis_lupus_familiarisENSCAFP0084501865699.513499.5134
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567panthera_pardusENSPPRP0000002930799.756799.7567
ENSG00000141543homo_sapiensENSP0000049764188.807887.5912marmota_marmota_marmotaENSMMMP0000000815193.830392.545
ENSG00000141543homo_sapiensENSP0000049764198.783598.5401marmota_marmota_marmotaENSMMMP0000001528998.783598.5401
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567balaenoptera_musculusENSBMSP0001002965799.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567cavia_porcellusENSCPOP0000003015699.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567felis_catusENSFCAP0000000764399.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567ursus_americanusENSUAMP0000003621999.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567monodelphis_domesticaENSMODP0000000266299.756799.7567
ENSG00000141543homo_sapiensENSP0000049764196.350492.4574monodelphis_domesticaENSMODP0000001366796.585492.6829
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567bison_bison_bisonENSBBBP0000001001199.756799.7567
ENSG00000141543homo_sapiensENSP0000049764198.783598.5401monodon_monocerosENSMMNP0001503008398.067697.8261
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567sus_scrofaENSSSCP0000001817899.756799.7567
ENSG00000141543homo_sapiensENSP0000049764195.133890.9976microcebus_murinusENSMICP0000004174496.543292.3457
ENSG00000141543homo_sapiensENSP0000049764194.890594.6472microcebus_murinusENSMICP0000000832196.534796.2871
ENSG00000141543homo_sapiensENSP0000049764196.107192.7007microcebus_murinusENSMICP0000004482595.641692.2518
ENSG00000141543homo_sapiensENSP0000049764197.323696.1071microcebus_murinusENSMICP0000003328098.765497.5309
ENSG00000141543homo_sapiensENSP0000049764192.457489.5377microcebus_murinusENSMICP0000001086895.477492.4623
ENSG00000141543homo_sapiensENSP0000049764194.647291.2409microcebus_murinusENSMICP0000004995296.049492.5926
ENSG00000141543homo_sapiensENSP0000049764199.026898.7835octodon_degusENSODEP0000001393692.290392.0635
ENSG00000141543homo_sapiensENSP0000049764199.513499.5134jaculus_jaculusENSJJAP0000001297299.513499.5134
ENSG00000141543homo_sapiensENSP0000049764199.026899.0268jaculus_jaculusENSJJAP0000001390499.026899.0268
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567ovis_aries_rambouilletENSOARP0002001862799.756799.7567
ENSG00000141543homo_sapiensENSP0000049764189.78189.2944ursus_maritimusENSUMAP0000002039486.619786.1502
ENSG00000141543homo_sapiensENSP0000049764198.540198.2968delphinapterus_leucasENSDLEP0000000815797.826197.5845
ENSG00000141543homo_sapiensENSP0000049764162.043862.0438physeter_catodonENSPCTP0000503125798.837298.8372
ENSG00000141543homo_sapiensENSP0000049764199.513499.5134mus_caroliMGP_CAROLIEiJ_P003140299.513499.5134
ENSG00000141543homo_sapiensENSP0000049764198.296896.837mus_musculusENSMUSP0000014480998.296896.837
ENSG00000141543homo_sapiensENSP0000049764198.053597.8102mus_musculusENSMUSP0000014519498.053597.8102
ENSG00000141543homo_sapiensENSP0000049764199.513499.2701mus_musculusENSMUSP0000002666799.513499.2701
ENSG00000141543homo_sapiensENSP0000049764195.377194.8905dipodomys_ordiiENSDORP0000001224693.556193.0788
ENSG00000141543homo_sapiensENSP0000049764189.78188.5645mustela_putorius_furoENSMPUP0000001211987.440886.2559
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567aotus_nancymaaeENSANAP0000000089899.756799.7567
ENSG00000141543homo_sapiensENSP0000049764198.783598.5401saimiri_boliviensis_boliviensisENSSBOP0000001597894.859894.6262
ENSG00000141543homo_sapiensENSP0000049764199.513499.5134mesocricetus_auratusENSMAUP0000001273899.513499.5134
ENSG00000141543homo_sapiensENSP0000049764199.513499.5134phocoena_sinusENSPSNP0000002813599.756199.7561
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567camelus_dromedariusENSCDRP0000502607499.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567carlito_syrichtaENSTSYP0000002810199.756799.7567
ENSG00000141543homo_sapiensENSP0000049764186.861386.3747panthera_tigris_altaicaENSPTIP0000000823698.076997.5275
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567rattus_norvegicusENSRNOP0000006630299.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567prolemur_simusENSPSMP0000000735399.756799.7567
ENSG00000141543homo_sapiensENSP0000049764184.428284.4282microtus_ochrogasterENSMOCP0000001925099.712699.7126
ENSG00000141543homo_sapiensENSP0000049764154.501254.5012sorex_araneusENSSARP00000008153100100
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567peromyscus_maniculatus_bairdiiENSPEMP0000000752599.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567bos_mutusENSBMUP0000002973699.756799.7567
ENSG00000141543homo_sapiensENSP0000049764189.537788.8078mus_spicilegusENSMSIP0000002204798.133397.3333
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567mus_spicilegusENSMSIP0000001952299.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.513499.5134cricetulus_griseus_chok1gshdENSCGRP0000102526299.513499.5134
ENSG00000141543homo_sapiensENSP0000049764182.725181.0219cricetulus_griseus_chok1gshdENSCGRP0000101823591.152889.2761
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567pteropus_vampyrusENSPVAP0000000342999.756799.7567
ENSG00000141543homo_sapiensENSP0000049764178.588873.4793myotis_lucifugusENSMLUP0000002232192.550186.533
ENSG00000141543homo_sapiensENSP0000049764182.481881.2652myotis_lucifugusENSMLUP0000000874398.260996.8116
ENSG00000141543homo_sapiensENSP0000049764197.566992.4574myotis_lucifugusENSMLUP0000002082697.566992.4574
ENSG00000141543homo_sapiensENSP0000049764199.513499.5134vombatus_ursinusENSVURP0001001284699.513499.5134
ENSG00000141543homo_sapiensENSP0000049764198.783598.2968rhinolophus_ferrumequinumENSRFEP0001003044192.906292.4485
ENSG00000141543homo_sapiensENSP0000049764199.756799.5134neovison_visonENSNVIP0000001879399.756799.5134
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567bos_taurusENSBTAP0000002132799.756799.7567
ENSG00000141543homo_sapiensENSP0000049764198.540198.5401heterocephalus_glaber_femaleENSHGLP0000000633785.44385.443
ENSG00000141543homo_sapiensENSP0000049764195.377194.6472rhinopithecus_bietiENSRBIP0000001165695.145694.4175
ENSG00000141543homo_sapiensENSP0000049764199.513499.5134canis_lupus_dingoENSCAFP0002001016699.513499.5134
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567sciurus_vulgarisENSSVLP0000502114999.756799.7567
ENSG00000141543homo_sapiensENSP0000049764191.484288.5645phascolarctos_cinereusENSPCIP0000000848768.115965.942
ENSG00000141543homo_sapiensENSP0000049764184.184983.9416procavia_capensisENSPCAP0000000276988.94688.6889
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567nannospalax_galiliENSNGAP0000000308499.756799.7567
ENSG00000141543homo_sapiensENSP0000049764198.540198.5401bos_grunniensENSBGRP0000003502598.780598.7805
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567chinchilla_lanigeraENSCLAP0000002117499.756799.7567
ENSG00000141543homo_sapiensENSP0000049764198.783598.7835cervus_hanglu_yarkandensisENSCHYP0000001586280.876580.8765
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567catagonus_wagneriENSCWAP0000001961599.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567ictidomys_tridecemlineatusENSSTOP0000002526199.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.513499.2701otolemur_garnettiiENSOGAP0000002216999.513499.2701
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567otolemur_garnettiiENSOGAP0000000670599.756799.7567
ENSG00000141543homo_sapiensENSP0000049764198.540198.5401cebus_imitatorENSCCAP0000003646994.626294.6262
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567urocitellus_parryiiENSUPAP0001000531999.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567moschus_moschiferusENSMMSP0000003066299.756799.7567
ENSG00000141543homo_sapiensENSP00000497641100100rhinopithecus_roxellanaENSRROP00000037822100100
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567mus_pahariMGP_PahariEiJ_P003811999.756799.7567
ENSG00000141543homo_sapiensENSP0000049764199.756799.7567propithecus_coquereliENSPCOP0000001648399.756799.7567
ENSG00000141543homo_sapiensENSP0000049764191.727584.1849caenorhabditis_elegansY65B4A.6a.194.486286.7168
ENSG00000141543homo_sapiensENSP0000049764192.457484.1849caenorhabditis_elegansF33D11.10.195.238186.7168
ENSG00000141543homo_sapiensENSP0000049764191.970885.4015drosophila_melanogasterFBpp008132494.736887.9699
ENSG00000141543homo_sapiensENSP0000049764193.917387.8345ciona_intestinalisENSCINP0000001600594.146388.0488
ENSG00000141543homo_sapiensENSP0000049764195.863792.7007eptatretus_burgeriENSEBUP0000000546491.203788.1944
ENSG00000141543homo_sapiensENSP0000049764188.564586.618callorhinchus_miliiENSCMIP0000001107288.564586.618
ENSG00000141543homo_sapiensENSP0000049764196.593795.1338latimeria_chalumnaeENSLACP0000000012397.783296.3054
ENSG00000141543homo_sapiensENSP0000049764196.350496.1071lepisosteus_oculatusENSLOCP0000001945196.116595.8738
ENSG00000141543homo_sapiensENSP0000049764196.350495.8637clupea_harengusENSCHAP0000001115395.652295.1691
ENSG00000141543homo_sapiensENSP0000049764195.863795.1338danio_rerioENSDARP0000013597497.044396.3054
ENSG00000141543homo_sapiensENSP0000049764195.863795.1338carassius_auratusENSCARP0000000741595.169194.4444
ENSG00000141543homo_sapiensENSP0000049764191.727590.2676carassius_auratusENSCARP0000002050083.407182.0796
ENSG00000141543homo_sapiensENSP0000049764195.133894.4039carassius_auratusENSCARP0000012788582.83982.2034
ENSG00000141543homo_sapiensENSP0000049764196.107195.3771carassius_auratusENSCARP0000002017492.941292.2353
ENSG00000141543homo_sapiensENSP0000049764196.350495.8637astyanax_mexicanusENSAMXP0000004121397.536997.0443
ENSG00000141543homo_sapiensENSP0000049764196.593795.8637ictalurus_punctatusENSIPUP0000003245897.783297.0443
ENSG00000141543homo_sapiensENSP0000049764196.350495.3771esox_luciusENSELUP0000005918395.883894.9153
ENSG00000141543homo_sapiensENSP0000049764196.593795.6204electrophorus_electricusENSEEEP0000000254189.013588.1166
ENSG00000141543homo_sapiensENSP0000049764194.647293.4307oncorhynchus_kisutchENSOKIP0000504953195.1193.8875
ENSG00000141543homo_sapiensENSP0000049764196.593795.1338oncorhynchus_kisutchENSOKIP0000502837096.359294.9029
ENSG00000141543homo_sapiensENSP0000049764195.377193.674oncorhynchus_mykissENSOMYP0000009613087.305185.7461
ENSG00000141543homo_sapiensENSP0000049764196.83795.6204oncorhynchus_mykissENSOMYP0000004057896.36895.1574
ENSG00000141543homo_sapiensENSP0000049764195.620493.9173salmo_salarENSSSAP0000000072585.434883.913
ENSG00000141543homo_sapiensENSP0000049764185.888184.1849salmo_salarENSSSAP0000009528194.38592.5134
ENSG00000141543homo_sapiensENSP0000049764195.863794.6472salmo_truttaENSSTUP0000003549397.044395.8128
ENSG00000141543homo_sapiensENSP0000049764196.350494.8905salmo_truttaENSSTUP0000003951296.821595.3545
ENSG00000141543homo_sapiensENSP0000049764195.863794.4039gadus_morhuaENSGMOP0000006128796.097694.6341
ENSG00000141543homo_sapiensENSP0000049764138.199537.4696fundulus_heteroclitusENSFHEP0000000461191.279189.5349
ENSG00000141543homo_sapiensENSP0000049764196.593796.3504poecilia_reticulataENSPREP0000000880597.783297.5369
ENSG00000141543homo_sapiensENSP0000049764196.350496.1071xiphophorus_maculatusENSXMAP0000001414997.536997.2906
ENSG00000141543homo_sapiensENSP0000049764160.583957.9075oryzias_latipesENSORLP0000004010059.855857.2115
ENSG00000141543homo_sapiensENSP0000049764197.080396.1071cyclopterus_lumpusENSCLMP0000502409296.610295.6416
ENSG00000141543homo_sapiensENSP0000049764196.593795.6204oreochromis_niloticusENSONIP0000004825193.853492.9078
ENSG00000141543homo_sapiensENSP0000049764196.350495.8637haplochromis_burtoniENSHBUP0000001310897.536997.0443
ENSG00000141543homo_sapiensENSP0000049764196.107195.6204astatotilapia_callipteraENSACLP0000000622797.290696.798
ENSG00000141543homo_sapiensENSP0000049764189.78187.1046sparus_aurataENSSAUP0001000003386.01483.4499
ENSG00000141543homo_sapiensENSP0000049764195.620494.6472sparus_aurataENSSAUP0001000004489.115688.2086
ENSG00000141543homo_sapiensENSP0000049764196.350495.8637lates_calcariferENSLCAP0001002454797.536997.0443
ENSG00000141543homo_sapiensENSP0000049764197.323696.5937xenopus_tropicalisENSXETP0000006927596.385595.6627
ENSG00000141543homo_sapiensENSP0000049764181.751879.0754chrysemys_picta_belliiENSCPBP0000002567288.18985.3018
ENSG00000141543homo_sapiensENSP0000049764197.810297.5669sphenodon_punctatusENSSPUP0000001802398.048897.8049
ENSG00000141543homo_sapiensENSP0000049764197.810297.0803crocodylus_porosusENSCPRP0000501595788.741788.0795
ENSG00000141543homo_sapiensENSP0000049764197.080396.837laticauda_laticaudataENSLLTP0000002315396.844796.6019
ENSG00000141543homo_sapiensENSP0000049764198.053597.8102notechis_scutatusENSNSUP0000002229198.292798.0488
ENSG00000141543homo_sapiensENSP0000049764198.053597.8102pseudonaja_textilisENSPTXP0000000564298.292798.0488
ENSG00000141543homo_sapiensENSP0000049764198.296897.5669anas_platyrhynchos_platyrhynchosENSAPLP0000001460390.380389.7092
ENSG00000141543homo_sapiensENSP0000049764197.810296.5937gallus_gallusENSGALP0001002392295.486994.2993
ENSG00000141543homo_sapiensENSP0000049764187.591287.3479meleagris_gallopavoENSMGAP0000000738969.230869.0385
ENSG00000141543homo_sapiensENSP0000049764198.053597.3236serinus_canariaENSSCAP0000000046698.292797.561
ENSG00000141543homo_sapiensENSP0000049764197.080396.1071parus_majorENSPMJP0000000364991.095990.1826
ENSG00000141543homo_sapiensENSP0000049764197.566997.0803anolis_carolinensisENSACAP0000001421093.039492.5754
ENSG00000141543homo_sapiensENSP0000049764196.593796.1071neolamprologus_brichardiENSNBRP0000002846697.783297.2906
ENSG00000141543homo_sapiensENSP0000049764198.053597.8102naja_najaENSNNAP0000000085198.292798.0488
ENSG00000141543homo_sapiensENSP0000049764198.296897.8102podarcis_muralisENSPMRP0000000147498.536698.0488
ENSG00000141543homo_sapiensENSP0000049764181.995181.0219geospiza_fortisENSGFOP0000000805095.738694.6023
ENSG00000141543homo_sapiensENSP0000049764198.053597.3236taeniopygia_guttataENSTGUP0000000220498.292797.561
ENSG00000141543homo_sapiensENSP0000049764196.593795.3771erpetoichthys_calabaricusENSECRP0000003161696.829395.6098
ENSG00000141543homo_sapiensENSP0000049764193.917392.4574kryptolebias_marmoratusENSKMAP0000001350991.25389.8345
ENSG00000141543homo_sapiensENSP0000049764191.484288.0779salvator_merianaeENSSMRP0000001914586.238583.0275
ENSG00000141543homo_sapiensENSP0000049764196.350496.1071oryzias_javanicusENSOJAP0000000076597.536997.2906
ENSG00000141543homo_sapiensENSP0000049764196.350495.8637amphilophus_citrinellusENSACIP0000001248297.536997.0443
ENSG00000141543homo_sapiensENSP0000049764196.83795.6204dicentrarchus_labraxENSDLAP0000504770196.83795.6204
ENSG00000141543homo_sapiensENSP0000049764196.350495.8637amphiprion_perculaENSAPEP0000002629497.536997.0443
ENSG00000141543homo_sapiensENSP0000049764161.557257.6642oryzias_sinensisENSOSIP0000002549280.830775.7188
ENSG00000141543homo_sapiensENSP0000049764124.574222.6277oryzias_sinensisENSOSIP0000001813677.099270.9924
ENSG00000141543homo_sapiensENSP0000049764167.883267.8832pelodiscus_sinensisENSPSIP00000004283100100
ENSG00000141543homo_sapiensENSP0000049764197.810297.3236gopherus_evgoodeiENSGEVP0000500375498.288597.7995
ENSG00000141543homo_sapiensENSP0000049764197.810297.3236chelonoidis_abingdoniiENSCABP0000000166698.288597.7995
ENSG00000141543homo_sapiensENSP0000049764196.593796.3504seriola_dumeriliENSSDUP0000002983497.783297.5369
ENSG00000141543homo_sapiensENSP0000049764195.377194.1606cottoperca_gobioENSCGOP0000005163492.235391.0588
ENSG00000141543homo_sapiensENSP0000049764181.751880.0487struthio_camelus_australisENSSCUP0000002267782.151680.4401
ENSG00000141543homo_sapiensENSP0000049764198.296897.5669anser_brachyrhynchusENSABRP0000001872090.178689.5089
ENSG00000141543homo_sapiensENSP0000049764196.107194.6472gasterosteus_aculeatusENSGACP0000002642795.641694.1889
ENSG00000141543homo_sapiensENSP0000049764196.350495.8637cynoglossus_semilaevisENSCSEP0000003279497.536997.0443
ENSG00000141543homo_sapiensENSP0000049764196.593796.1071poecilia_formosaENSPFOP0000000949295.432794.9519
ENSG00000141543homo_sapiensENSP0000049764195.133894.6472myripristis_murdjanENSMMDP000050000719291.5294
ENSG00000141543homo_sapiensENSP0000049764196.593795.6204sander_luciopercaENSSLUP0000000812796.359295.3884
ENSG00000141543homo_sapiensENSP0000049764198.540197.5669strigops_habroptilaENSSHBP0000501632198.30197.3301
ENSG00000141543homo_sapiensENSP0000049764196.350495.8637amphiprion_ocellarisENSAOCP0000001666197.536997.0443
ENSG00000141543homo_sapiensENSP0000049764197.810297.3236terrapene_carolina_triunguisENSTMTP0000002672598.288597.7995
ENSG00000141543homo_sapiensENSP0000049764194.160692.944hucho_huchoENSHHUP0000003416392.362891.1694
ENSG00000141543homo_sapiensENSP0000049764196.350494.6472hucho_huchoENSHHUP0000003087795.883894.1889
ENSG00000141543homo_sapiensENSP0000049764190.997686.618betta_splendensENSBSLP0000001577588.416184.1608
ENSG00000141543homo_sapiensENSP0000049764196.350495.3771pygocentrus_nattereriENSPNAP0000002351097.536996.5517
ENSG00000141543homo_sapiensENSP0000049764196.593796.1071anabas_testudineusENSATEP0000002134796.359295.8738
ENSG00000141543homo_sapiensENSP0000049764187.591282.9684ciona_savignyiENSCSAVP0000001687297.56192.4119
ENSG00000141543homo_sapiensENSP0000049764179.318759.3674saccharomyces_cerevisiaeYDR021W81.704361.1529
ENSG00000141543homo_sapiensENSP0000049764178.588859.3674saccharomyces_cerevisiaeYJL138C81.772161.7722
ENSG00000141543homo_sapiensENSP0000049764178.588859.3674saccharomyces_cerevisiaeYKR059W81.772161.7722
ENSG00000141543homo_sapiensENSP0000049764188.321286.8613seriola_lalandi_dorsalisENSSLDP0000001272693.076991.5385
ENSG00000141543homo_sapiensENSP0000049764127.980527.9805seriola_lalandi_dorsalisENSSLDP00000018880100100
ENSG00000141543homo_sapiensENSP0000049764127.493926.764seriola_lalandi_dorsalisENSSLDP0000001309285.606183.3333
ENSG00000141543homo_sapiensENSP0000049764188.807886.618labrus_bergyltaENSLBEP0000002743990.346588.1188
ENSG00000141543homo_sapiensENSP0000049764196.350495.8637pundamilia_nyerereiENSPNYP0000002237497.536997.0443
ENSG00000141543homo_sapiensENSP0000049764197.323695.6204mastacembelus_armatusENSMAMP0000005749897.56195.8537
ENSG00000141543homo_sapiensENSP0000049764195.133894.8905stegastes_partitusENSSPAP0000002254295.365995.1219
ENSG00000141543homo_sapiensENSP0000049764195.863794.6472oncorhynchus_tshawytschaENSOTSP0000505867795.631194.4175
ENSG00000141543homo_sapiensENSP0000049764189.294485.4015oncorhynchus_tshawytschaENSOTSP0000509558490.17286.2408
ENSG00000141543homo_sapiensENSP0000049764196.350495.8637acanthochromis_polyacanthusENSAPOP0000003048097.536997.0443
ENSG00000141543homo_sapiensENSP0000049764198.540197.5669aquila_chrysaetos_chrysaetosENSACCP0002000788598.30197.3301
ENSG00000141543homo_sapiensENSP0000049764196.350496.1071nothobranchius_furzeriENSNFUP0001500617791.45591.224
ENSG00000141543homo_sapiensENSP0000049764196.350495.6204cyprinodon_variegatusENSCVAP0000002348097.536996.798
ENSG00000141543homo_sapiensENSP0000049764195.377194.4039denticeps_clupeoidesENSDCDP0000000210895.145694.1748
ENSG00000141543homo_sapiensENSP0000049764195.620494.8905larimichthys_croceaENSLCRP0000503618089.115688.4354
ENSG00000141543homo_sapiensENSP0000049764195.620494.4039takifugu_rubripesENSTRUP0000002916096.79895.5665
ENSG00000141543homo_sapiensENSP0000049764188.564587.5912ficedula_albicollisENSFALP0000000244585.849184.9057
ENSG00000141543homo_sapiensENSP0000049764185.401583.455hippocampus_comesENSHCOP0000000896875.809974.0821
ENSG00000141543homo_sapiensENSP0000049764195.620494.6472cyprinus_carpio_carpioENSCCRP0000012209391.395390.4651
ENSG00000141543homo_sapiensENSP0000049764183.698380.0487cyprinus_carpio_carpioENSCCRP0000008134144.617442.6719
ENSG00000141543homo_sapiensENSP0000049764198.053596.3504coturnix_japonicaENSCJPP0000500445692.219790.6179
ENSG00000141543homo_sapiensENSP0000049764196.350496.1071poecilia_latipinnaENSPLAP0000000546397.536997.2906
ENSG00000141543homo_sapiensENSP0000049764196.350495.1338sinocyclocheilus_grahamiENSSGRP0000005039797.058895.8333
ENSG00000141543homo_sapiensENSP0000049764195.377194.6472maylandia_zebraENSMZEP0000500025791.375390.676
ENSG00000141543homo_sapiensENSP0000049764189.294488.8078maylandia_zebraENSMZEP0000502050796.325595.8005
ENSG00000141543homo_sapiensENSP0000049764196.593795.6204tetraodon_nigroviridisENSTNIP0000000549196.125995.1574
ENSG00000141543homo_sapiensENSP0000049764195.863795.1338paramormyrops_kingsleyaeENSPKIP0000003964397.044396.3054
ENSG00000141543homo_sapiensENSP0000049764195.620494.4039scleropages_formosusENSSFOP0001506811686.373685.2747
ENSG00000141543homo_sapiensENSP0000049764196.350495.1338scleropages_formosusENSSFOP0001507216689.592888.4615
ENSG00000141543homo_sapiensENSP0000049764196.107194.1606leptobrachium_leishanenseENSLLEP0000001982094.724292.8058
ENSG00000141543homo_sapiensENSP0000049764196.83796.1071scophthalmus_maximusENSSMAP0000003778195.903695.1807
ENSG00000141543homo_sapiensENSP0000049764196.350496.1071oryzias_melastigmaENSOMEP0000002626897.536997.2906

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000184involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1IMPHomo_sapiens(9606)Process
GO:0000398involved_in mRNA splicing, via spliceosome2IC,IDAHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003724enables RNA helicase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0003729enables mRNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IDAHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005730is_active_in nucleolus1IBAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006364involved_in rRNA processing1IEAHomo_sapiens(9606)Process
GO:0006406involved_in mRNA export from nucleus1NASHomo_sapiens(9606)Process
GO:0008143enables poly(A) binding1IDAHomo_sapiens(9606)Function
GO:0008306involved_in associative learning1IEAHomo_sapiens(9606)Process
GO:0014070involved_in response to organic cyclic compound1IEAHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016607located_in nuclear speck1IEAHomo_sapiens(9606)Component
GO:0016887enables ATP hydrolysis activity1IEAHomo_sapiens(9606)Function
GO:0017148involved_in negative regulation of translation1IDAHomo_sapiens(9606)Process
GO:0030425located_in dendrite1IEAHomo_sapiens(9606)Component
GO:0035145part_of exon-exon junction complex3IDA,IPI,ISSHomo_sapiens(9606)Component
GO:0035368enables selenocysteine insertion sequence binding1IEAHomo_sapiens(9606)Function
GO:0035613enables RNA stem-loop binding1IEAHomo_sapiens(9606)Function
GO:0035640involved_in exploration behavior1IEAHomo_sapiens(9606)Process
GO:0043021enables ribonucleoprotein complex binding1IEAHomo_sapiens(9606)Function
GO:0043025located_in neuronal cell body1IEAHomo_sapiens(9606)Component
GO:0045727involved_in positive regulation of translation1IMPHomo_sapiens(9606)Process
GO:0048701involved_in embryonic cranial skeleton morphogenesis1IMPHomo_sapiens(9606)Process
GO:0071006part_of U2-type catalytic step 1 spliceosome1IDAHomo_sapiens(9606)Component
GO:0071013part_of catalytic step 2 spliceosome2IBA,IDAHomo_sapiens(9606)Component
GO:0072715involved_in cellular response to selenite ion1IEAHomo_sapiens(9606)Process
GO:0090394involved_in negative regulation of excitatory postsynaptic potential1IEAHomo_sapiens(9606)Process
GO:0098794located_in postsynapse1IEAHomo_sapiens(9606)Component
GO:0098978located_in glutamatergic synapse1IEAHomo_sapiens(9606)Component
GO:0099578involved_in regulation of translation at postsynapse, modulating synaptic transmission1IEAHomo_sapiens(9606)Process
GO:1904570involved_in negative regulation of selenocysteine incorporation1IEAHomo_sapiens(9606)Process
GO:1904574involved_in negative regulation of selenocysteine insertion sequence binding1IEAHomo_sapiens(9606)Process
GO:1990416involved_in cellular response to brain-derived neurotrophic factor stimulus1IEAHomo_sapiens(9606)Process
GO:2000622involved_in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay2IDA,ISSHomo_sapiens(9606)Process

Expression