Ensembl ID ENSG00000141543 Gene ID 9775 Accession 18683
Gene Symbol EIF4A3 Alias Fal1;RCPS;DDX48;MUK34;NUK34;NMP265;eIF4AIII;eIF4A-III;eIF-4A-III Full Name eukaryotic translation initiation factor 4A3
Position 17 : 80134369 - 80147151 Length 12783 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]

ENSG00000141543 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000141543 EIF4A3 0.85 1.46e-53 BRCA
ENSG00000141543 EIF4A3 0.56 2.65e-11 COAD
ENSG00000141543 EIF4A3 -0.8 3.18e-18 KICH
ENSG00000141543 EIF4A3 1.00 1.21e-33 LUSC
ENSG00000141543 EIF4A3 1.03 5.47e-12 GBM
ENSG00000141543 EIF4A3 0.65 1.26e-14 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000141543 EIF4A3 gastric cancer 12127692
ENSG00000141543 EIF4A3 pancreatic cancer 15796914
ENSG00000141543 EIF4A3 tumour 18427545
ENSG00000141543 EIF4A3 tumor 25625699
ENSG00000141543 EIF4A3 cancer 26840568
ENSG00000141543 EIF4A3 epithelial ovarian cancer 29571014
ENSG00000141543 EIF4A3 breast cancer 30588240
ENSG00000141543 EIF4A3 tumour 31069274
ENSG00000141543 EIF4A3 tumor 31898336
ENSG00000141543 EIF4A3 tumour 31924997
ENSG00000141543 EIF4A3 tumors 31975383
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000141543 EIF4A3 STAD 0.039 high
ENSG00000141543 EIF4A3 UVM 0.0017 high
ENSG00000141543 EIF4A3 UCEC 0.016 high
ENSG00000141543 EIF4A3 THCA 0.02 low
ENSG00000141543 EIF4A3 LUSC 0.013 high
ENSG00000141543 EIF4A3 HNSC 0.021 high
ENSG00000141543 EIF4A3 READ 0.0095 low
ENSG00000141543 EIF4A3 KICH 0.0018 high
ENSG00000141543 EIF4A3 LUAD 0.0042 high
ENSG00000141543 EIF4A3 COAD 0.0063 low
ENSG00000141543 EIF4A3 ESCA 0.0037 high
ENSG00000141543 EIF4A3 KIRC 0.0069 low
ENSG00000141543 EIF4A3 PRAD 0.0025 high
ENSG00000141543 EIF4A3 BLCA 0.0033 high
ENSG00000141543 EIF4A3 LAML 0.032 high
ENSG00000141543 EIF4A3 CESC 0.0039 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000141543 EIF4A3 LUSC Amp 1.017340 0.204805 0.442621 0.443114
ENSG00000141543 EIF4A3 LUAD Amp 3.234598 0.173676 0.403338 0.505814
ENSG00000141543 EIF4A3 LGG Amp 2.097083 0.064295 0.490918 0.089669
ENSG00000141543 EIF4A3 CESC Del 1.641278 0.085511 0.460950 0.145763
ENSG00000141543 EIF4A3 ACC Amp 0.765694 0.254482 0.752765 0.188889
ENSG00000141543 EIF4A3 UCS Amp 0.999789 0.543410 0.691465 0.571429
ENSG00000141543 EIF4A3 PAAD Del 2.995993 0.086494 0.345252 0.217391
ENSG00000141543 EIF4A3 SKCM Amp 5.611761 0.257424 0.568986 0.337875
ENSG00000141543 EIF4A3 LIHC Amp 10.292023 0.292723 0.691984 0.381081
ENSG00000141543 EIF4A3 BLCA Amp 1.749736 0.201579 0.454823 0.473039
ENSG00000141543 EIF4A3 BRCA Amp 19.423992 0.344987 0.619299 0.366667
ENSG00000141543 EIF4A3 UCEC Amp 3.904035 0.165797 0.563390 0.174397
ENSG00000141543 EIF4A3 UVM Amp 0.815688 0.175682 0.773563 0.175000
ENSG00000141543 EIF4A3 OV Amp 3.989075 0.427963 0.566014 0.373057