Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs rRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000141101 Gene ID 28987 Accession 29540
Symbol NOB1 Alias ART-4;NOB1P;MST158;MSTP158;PSMD8BP1 Full Name NIN1 (RPN12) binding protein 1 homolog
Status Confidence Length 13056 bases Strand Minus strand
Position 16 : 69741871 - 69754926 RNA binding domain WRNPLPNID , NOB1_Zn_bind
Summary In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

GWAS

Protein-Protein Interaction (PPI)

Orthologs

Gene Ontology

Expression