Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug Drug
Main interacting RNAs mRNA
Moonlighting functions Transmemebrane
Localizations N.A.
BulkPerturb-seq DataSet_01_186 DataSet_01_276

Description

Ensembl ID ENSG00000140718 Gene ID 79068 Accession 24678
Symbol FTO Alias GDFD;IFEX9;ALKBH9;BMIQ14 Full Name FTO alpha-ketoglutarate dependent dioxygenase
Status Confidence Length 456821 bases Strand Plus strand
Position 16 : 53701692 - 54158512 RNA binding domain FTO_NTD , FTO_CTD
Summary This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000490300 FTO_CTD PF12934 1.9e-58 1
ENSP00000418823 FTO_CTD PF12934 2.1e-57 1
ENSP00000418823 FTO_NTD PF12933 1.4e-126 2
ENSP00000489638 FTO_CTD PF12934 3.9e-57 1
ENSP00000489638 FTO_NTD PF12933 1.6e-126 2
ENSP00000490516 FTO_CTD PF12934 3.9e-57 1
ENSP00000490516 FTO_NTD PF12933 1.9e-126 2
ENSP00000489936 FTO_CTD PF12934 7.9e-43 1
ENSP00000489936 FTO_NTD PF12933 1e-126 2
ENSP00000489714 FTO_CTD PF12934 8e-42 1
ENSP00000489714 FTO_NTD PF12933 1.3e-62 2
ENSP00000489641 FTO_CTD PF12934 1.6e-41 1
ENSP00000489641 FTO_NTD PF12933 1.1e-126 2
ENSP00000490047 FTO_CTD PF12934 6.7e-41 1
ENSP00000490047 FTO_NTD PF12933 1.1e-126 2
ENSP00000490426 FTO_CTD PF12934 9e-41 1
ENSP00000490426 FTO_NTD PF12933 1.1e-126 2
ENSP00000489886 FTO_CTD PF12934 2e-30 1
ENSP00000489886 FTO_NTD PF12933 8.9e-127 2
ENSP00000415636 FTO_CTD PF12934 5e-26 1
ENSP00000417422 FTO_CTD PF12934 5e-26 1
ENSP00000417843 FTO_CTD PF12934 7.9e-21 1
ENSP00000489904 FTO_CTD PF12934 7.8e-14 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36814457 A computational map of the human-SARS-CoV-2 protein-RNA interactome predicted at single-nucleotide resolution. Marc Horlacher 2023-03-01 NAR genomics and bioinformatics
35605980 Enzymatic Characterization of In Vitro Activity of RNA Methyltransferase PCIF1 on DNA. Dan Yu 2022-05-23 Biochemistry

Transcripts

Name Transcript ID bp Protein Translation ID
FTO-215 ENST00000636491 1676 450aa ENSP00000490047
FTO-214 ENST00000636218 2227 457aa ENSP00000489641
FTO-217 ENST00000637001 1609 481aa ENSP00000489936
FTO-209 ENST00000570395 555 No protein -
FTO-216 ENST00000636992 1514 421aa ENSP00000489886
FTO-206 ENST00000471389 11573 505aa ENSP00000418823
FTO-222 ENST00000637969 2889 559aa ENSP00000490516
FTO-212 ENST00000636030 1636 No protein -
FTO-220 ENST00000637562 1524 455aa ENSP00000490426
FTO-221 ENST00000637845 2472 533aa ENSP00000489638
FTO-205 ENST00000464071 1065 70aa ENSP00000418424
FTO-208 ENST00000563011 2015 275aa ENSP00000489714
FTO-210 ENST00000612285 1852 173aa ENSP00000490300
FTO-202 ENST00000431610 707 106aa ENSP00000415636
FTO-203 ENST00000460382 1517 106aa ENSP00000417422
FTO-219 ENST00000637062 459 66aa ENSP00000489904
FTO-204 ENST00000463855 3056 127aa ENSP00000417843
FTO-211 ENST00000635892 1085 No protein -
FTO-201 ENST00000268349 2799 129aa ENSP00000268349
FTO-207 ENST00000472835 847 No protein -
FTO-213 ENST00000636091 5323 No protein -
FTO-218 ENST00000637049 2105 61aa ENSP00000489891

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
17828Body Mass Index2.237e-00517658951
17831Body Mass Index3.378e-00517658951
17838Body Mass Index1.802e-00517658951
17844Body Mass Index1.802e-00517658951
17847Body Mass Index3.954e-00517658951
17848Body Mass Index1.013e-00517658951
17849Body Mass Index1.802e-00517658951
17850Body Mass Index2.767e-00517658951
17851Body Mass Index2.604e-00517658951
17856Body Mass Index7.241e-00517658951
17860Body Weights and Measures9.547e-00617658951
17864Body Weights and Measures6.989e-00517658951
17865Body Weights and Measures2.954e-00517658951
17875Body Weights and Measures3.42e-00517658951
17880Body Weights and Measures3.42e-00517658951
17883Body Weights and Measures8.726e-00517658951
17884Body Weights and Measures1.466e-00517658951
17885Body Weights and Measures3.42e-00517658951
17886Body Weights and Measures1.052e-00517658951
17887Body Weights and Measures1.007e-00517658951
18070Waist Circumference3.141e-005-
18071Waist Circumference1.128e-005-
18116Body Weight1.503e-00517658951
18117Body Weight4.917e-00617658951
19049Acceleration7.888e-005-
19512Blood Pressure9.284e-005-
19519Blood Pressure7.618e-005-
27739Coronary Disease8.6460000E-005-
30340Potassium2.7840000E-005-
32679Body Mass Index3.3947667E-005-
32805Body Mass Index9.5155245E-005-
32895Body Mass Index9.9574260E-005-
35508Platelet Function Tests2.5876800E-005-
38988Platelet Function Tests1.5066100E-005-
41344Platelet Function Tests2.2874400E-005-
44578Platelet Function Tests8.3500973E-006-
47709Intelligence Tests1.6674600E-005-
47715Intelligence Tests2.1792800E-005-
48487Child Development Disorders, Pervasive2.1737300E-005-
48489Child Development Disorders, Pervasive2.8861500E-005-
49308Child Development Disorders, Pervasive3.3854000E-005-
50031Child Development Disorders, Pervasive1.3875000E-006-
50035Child Development Disorders, Pervasive4.0257000E-006-
54279Adiponectin7.0640000E-006-
54285Adiponectin7.4040000E-005-
5566225-Hydroxyvitamin D 23.6780000E-005-
60765Obesity1E-2819151714
61016Obesity7E-1819151714
61038Obesity5E-1319151714
61466Breast Neoplasms6E-723535733
62114Body Fat Distribution1E-1326833246
62208Obesity1E-721544081
63142Body Mass Index3E-3517434869
63430Body Mass Index5E-12020935630
63436Diabetes Mellitus, Type 23E-820581827
63628Obesity6E-1219553259
64654Obesity5E-11023563607
65208Obesity6E-3923563607
65257Hair3E-626926045
65985Body Mass Index8E-15325673413
66380Hip3E-5225673412
66566Waist-Hip Ratio1E-1725673412
67152Body Mass Index2E-719396169
67365Rhinitis, Allergic6E-725085501
68066Breast4E-727182965
68081Subcutaneous Fat6E-822589738
68181Body Mass Index4E-8425673413
68837Diabetes Mellitus, Type 27E-1417463249
69335Diabetes Mellitus, Type 21E-1217463248
69370Body Mass Index2E-1022982992
69663Breast Neoplasms3E-727117709
69683Osteoarthritis4E-622763110
70456Body Mass Index1E-724348519
70983Waist Circumference4E-10125673412
71377Body Weight6E-1419079260
71456Body Mass Index1E-4719079260
71848Diabetes Mellitus, Type 22E-1719056611
72021Menarche2E-1725231870
72464Body Mass Index2E-1625953783
72556Obesity3E-2621706003
73592Body Mass Index1E-9325673413
74017Body Mass Index1E-1023583978
74039Melanoma4E-1228212542
75161Melanoma4E-1223455637
75334Body Mass Index4E-1426604143
75534Waist Circumference8E-5925673412
76027Menarche3E-821102462
76766Subcutaneous Fat3E-622589738
76999Obesity1E-718159244
77171Obesity2E-1221552555
78199Breast Neoplasms2E-627117709
78270Body Mass Index2E-5123563607
78830Menarche1E-1227182965
79236Body Mass Index4E-1319079260
79731Body Weight5E-3619079260
79822Waist Circumference5E-1919557197
80088Body Fat Distribution1E-2526833246
80542Obesity1E-7923563607
81093Metabolic Syndrome X2E-922399527
81873Leptin1E-926833098
82635Cholesterol, HDL7E-924097068
82753Hip4E-4325673412
82800Atrial Fibrillation1E-1427790247
82801Blood Pressure1E-1427790247
82802Cholesterol1E-1427790247
82803Coronary Disease1E-1427790247
82804Diabetes Mellitus1E-1427790247
82805Electrocardiography1E-1427790247
82806Glucose1E-1427790247
82807Heart Failure1E-1427790247
82808Hematocrit1E-1427790247
82809Cholesterol, HDL1E-1427790247
82810Mortality1E-1427790247
82811Neoplasms1E-1427790247
82812Triglycerides1E-1427790247
82813Body Mass Index1E-1427790247
82814Stroke1E-1427790247
83609Body Mass Index7E-2724861553
83867Breast Neoplasms3E-827117709
85566Body Fat Distribution4E-2726833246
85683Body Mass Index4E-5119079261
87592Diabetes Mellitus, Type 22E-717554300
87745Diabetes Mellitus, Type 21E-2022693455
87932Waist-Hip Ratio1E-3825673412
87974Breast Neoplasms4E-823535733
89025Diabetes Mellitus, Type 27E-618372903
89132Body Fat Distribution7E-1426833246
89879Body Mass Index5E-2222344221
90064Body Fat Distribution2E-1326833246
90339Body Mass Index1E-2625953783
91444Diabetes Mellitus, Type 21E-1224509480
91658Sex Hormone-Binding Globulin9E-622675492
92459Body Mass Index5E-1626604143
93969Obesity3E-2823563609
96067Diabetes Mellitus, Type 26E-623209189
96360Body Mass Index1E-2625953783
96622Body Mass Index9E-1025044758
98784Diabetes Mellitus, Type 24E-1526818947
98796Body Mass Index2E-1424064335
99389Leukopenia1E-827558924
99390Purines1E-827558924
99391Inflammatory Bowel Diseases1E-827558924
99609Obesity5E-1920421936
99631Obesity2E-8123563607
100591Waist-Hip Ratio1E-2325673412
100651C-Reactive Protein5E-927286809
100652Cholesterol, HDL5E-927286809
100756Body Mass Index4E-2323669352
101039Body Mass Index1E-15625673413
101162Energy Intake1E-923636237
101312Body Mass Index4E-821037115
101313Pulmonary Disease, Chronic Obstructive4E-821037115
102681Body Fat Distribution4E-1526833246
102864Breast Neoplasms5E-827117709
102984Waist Circumference1E-5725673412
103167Leptin9E-826833098
103468Breast Neoplasms6E-1423535729
104257Body Mass Index4E-818454148
104610sam so eum1E-725888059
104611Medicine, Korean Traditional1E-725888059
104669Hip2E-8625673412
104820Body Weight9E-717658951
104821Waist-Hip Ratio3E-817658951
104822Body Mass Index9E-717658951
105695Blood Pressure2E-1727790247
105696Cholesterol2E-1727790247
105697Electrocardiography2E-1727790247
105698Glucose2E-1727790247
105699Hematocrit2E-1727790247
105700Cholesterol, HDL2E-1727790247
105701Triglycerides2E-1727790247
105702Body Mass Index2E-1727790247
106785Subcutaneous Fat1E-927918534
106864Triglycerides3E-824097068

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000140718

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000140718homo_sapiensENSP0000041882398.613998.2178nomascus_leucogenysENSNLEP0000004170089.087788.7299
ENSG00000140718homo_sapiensENSP0000041882399.009998.8119pan_paniscusENSPPAP0000000962889.445489.2665
ENSG00000140718homo_sapiensENSP0000041882398.217897.6238pongo_abeliiENSPPYP0000002864088.729988.1932
ENSG00000140718homo_sapiensENSP0000041882398.811998.6139pan_troglodytesENSPTRP0000009380089.266589.0877
ENSG00000140718homo_sapiensENSP0000041882399.009999.0099gorilla_gorillaENSGGOP0000003455789.445489.4454
ENSG00000140718homo_sapiensENSP0000041882353.267344.1584ornithorhynchus_anatinusENSOANP0000002116468.79857.0332
ENSG00000140718homo_sapiensENSP0000041882324.356421.1881ornithorhynchus_anatinusENSOANP0000003826576.397566.4596
ENSG00000140718homo_sapiensENSP0000041882382.376269.3069sarcophilus_harrisiiENSSHAP0000002247782.868569.7211
ENSG00000140718homo_sapiensENSP0000041882373.861462.9703notamacropus_eugeniiENSMEUP0000001030674.302863.3466
ENSG00000140718homo_sapiensENSP0000041882355.841653.8614choloepus_hoffmanniENSCHOP0000000110855.841653.8614
ENSG00000140718homo_sapiensENSP0000041882339.009937.6238dasypus_novemcinctusENSDNOP0000002927794.258490.9091
ENSG00000140718homo_sapiensENSP0000041882385.940678.0198echinops_telfairiENSETEP0000001014885.940678.0198
ENSG00000140718homo_sapiensENSP0000041882398.217897.0297callithrix_jacchusENSCJAP0000006541688.729987.6565
ENSG00000140718homo_sapiensENSP0000041882399.009998.4158cercocebus_atysENSCATP0000001321099.009998.4158
ENSG00000140718homo_sapiensENSP0000041882398.019897.4257macaca_fascicularisENSMFAP0000002008989.350288.8087
ENSG00000140718homo_sapiensENSP0000041882397.821897.0297macaca_mulattaENSMMUP0000007940183.16582.4916
ENSG00000140718homo_sapiensENSP0000041882397.623896.6337macaca_nemestrinaENSMNEP0000004497086.948986.067
ENSG00000140718homo_sapiensENSP0000041882397.425796.8317papio_anubisENSPANP0000004094685.268684.7487
ENSG00000140718homo_sapiensENSP0000041882398.415897.8218mandrillus_leucophaeusENSMLEP0000000403999.00498.4064
ENSG00000140718homo_sapiensENSP0000041882386.534782.1782tursiops_truncatusENSTTRP0000001206186.534782.1782
ENSG00000140718homo_sapiensENSP0000041882387.128782.9703vulpes_vulpesENSVVUP0000002659376.923173.2517
ENSG00000140718homo_sapiensENSP0000041882392.871386.9307mus_spretusMGP_SPRETEiJ_P008901293.426387.4502
ENSG00000140718homo_sapiensENSP0000041882394.851591.0891equus_asinusENSEASP0000505408486.775483.3333
ENSG00000140718homo_sapiensENSP0000041882394.455487.5247capra_hircusENSCHIP0000000498594.455487.5247
ENSG00000140718homo_sapiensENSP0000041882393.267388.1188loxodonta_africanaENSLAFP0000001311793.267388.1188
ENSG00000140718homo_sapiensENSP0000041882394.653590.8911panthera_leoENSPLOP0000000940478.489375.3695
ENSG00000140718homo_sapiensENSP0000041882319.207918.8119ailuropoda_melanoleucaENSAMEP0000003508091.509489.6226
ENSG00000140718homo_sapiensENSP0000041882393.069385.1485bos_indicus_hybridENSBIXP0000503407490.211182.5336
ENSG00000140718homo_sapiensENSP0000041882395.643691.8812oryctolagus_cuniculusENSOCUP0000003180095.833392.0635
ENSG00000140718homo_sapiensENSP0000041882394.653590.6931equus_caballusENSECAP0000003816889.849686.0902
ENSG00000140718homo_sapiensENSP0000041882394.257490.495canis_lupus_familiarisENSCAFP0084500335176.774273.7097
ENSG00000140718homo_sapiensENSP0000041882394.851591.0891panthera_pardusENSPPRP0000001670195.039791.2698
ENSG00000140718homo_sapiensENSP0000041882396.237691.8812marmota_marmota_marmotaENSMMMP0000001313596.428692.0635
ENSG00000140718homo_sapiensENSP0000041882395.049590.495balaenoptera_musculusENSBMSP0001002250192.485588.0539
ENSG00000140718homo_sapiensENSP0000041882392.079287.5247cavia_porcellusENSCPOP0000001164593.186488.5772
ENSG00000140718homo_sapiensENSP0000041882393.861490.099felis_catusENSFCAP0000000488290.978987.3321
ENSG00000140718homo_sapiensENSP0000041882391.485184.7525ursus_americanusENSUAMP0000001568685.239978.9668
ENSG00000140718homo_sapiensENSP0000041882380.594166.9307monodelphis_domesticaENSMODP0000004819877.969364.751
ENSG00000140718homo_sapiensENSP0000041882394.653587.7228bison_bison_bisonENSBBBP0000001708194.653587.7228
ENSG00000140718homo_sapiensENSP0000041882395.247590.495monodon_monocerosENSMMNP0001501275895.247590.495
ENSG00000140718homo_sapiensENSP0000041882391.881287.1287sus_scrofaENSSSCP0000004711091.159186.444
ENSG00000140718homo_sapiensENSP0000041882395.643693.2673microcebus_murinusENSMICP0000004702292.528790.2299
ENSG00000140718homo_sapiensENSP0000041882391.881287.3267octodon_degusENSODEP0000000589292.430387.8486
ENSG00000140718homo_sapiensENSP0000041882392.277286.1386jaculus_jaculusENSJJAP0000000928192.828786.6534
ENSG00000140718homo_sapiensENSP0000041882394.455487.3267ovis_aries_rambouilletENSOARP0002001081194.455487.3267
ENSG00000140718homo_sapiensENSP0000041882393.861488.3168ursus_maritimusENSUMAP0000000295183.450778.5211
ENSG00000140718homo_sapiensENSP0000041882394.059487.9208ochotona_princepsENSOPRP0000001577694.24688.0952
ENSG00000140718homo_sapiensENSP0000041882395.049590.297delphinapterus_leucasENSDLEP0000000994595.049590.297
ENSG00000140718homo_sapiensENSP0000041882395.049590.297physeter_catodonENSPCTP0000501752991.081686.5275
ENSG00000140718homo_sapiensENSP0000041882392.871386.5347mus_caroliMGP_CAROLIEiJ_P008550693.426387.0518
ENSG00000140718homo_sapiensENSP0000041882392.673386.7327mus_musculusENSMUSP0000006838093.227187.251
ENSG00000140718homo_sapiensENSP0000041882395.247591.6832dipodomys_ordiiENSDORP0000000876395.816792.2311
ENSG00000140718homo_sapiensENSP0000041882392.871388.9109mustela_putorius_furoENSMPUP0000000332282.862279.3286
ENSG00000140718homo_sapiensENSP0000041882398.217897.0297aotus_nancymaaeENSANAP0000003820498.217897.0297
ENSG00000140718homo_sapiensENSP0000041882397.623896.2376saimiri_boliviensis_boliviensisENSSBOP0000002941394.990493.6416
ENSG00000140718homo_sapiensENSP0000041882354.851553.4653vicugna_pacosENSVPAP0000000299454.851553.4653
ENSG00000140718homo_sapiensENSP0000041882389.50588.9109chlorocebus_sabaeusENSCSAP0000000161198.474997.8214
ENSG00000140718homo_sapiensENSP0000041882394.257491.8812tupaia_belangeriENSTBEP0000000841296.94594.501
ENSG00000140718homo_sapiensENSP0000041882393.465388.9109mesocricetus_auratusENSMAUP0000000054194.023989.4422
ENSG00000140718homo_sapiensENSP0000041882395.445590.6931phocoena_sinusENSPSNP0000002242795.445590.6931
ENSG00000140718homo_sapiensENSP0000041882395.247590.6931camelus_dromedariusENSCDRP0000500204895.247590.6931
ENSG00000140718homo_sapiensENSP0000041882386.534783.5644carlito_syrichtaENSTSYP0000002828194.588791.342
ENSG00000140718homo_sapiensENSP0000041882394.455490.6931panthera_tigris_altaicaENSPTIP0000001532494.642990.873
ENSG00000140718homo_sapiensENSP0000041882390.693184.7525rattus_norvegicusENSRNOP0000007370489.453183.5938
ENSG00000140718homo_sapiensENSP0000041882390.693188.1188prolemur_simusENSPSMP0000000944981.93279.6064
ENSG00000140718homo_sapiensENSP0000041882392.475386.7327microtus_ochrogasterENSMOCP0000001218193.027987.251
ENSG00000140718homo_sapiensENSP0000041882386.534778.6139sorex_araneusENSSARP0000000207886.706478.7698
ENSG00000140718homo_sapiensENSP0000041882392.475387.3267peromyscus_maniculatus_bairdiiENSPEMP0000002436993.027987.8486
ENSG00000140718homo_sapiensENSP0000041882394.653587.7228bos_mutusENSBMUP0000001351694.653587.7228
ENSG00000140718homo_sapiensENSP0000041882392.871387.1287mus_spicilegusENSMSIP0000002632193.426387.6494
ENSG00000140718homo_sapiensENSP0000041882392.871388.5149cricetulus_griseus_chok1gshdENSCGRP0000101203993.426389.0438
ENSG00000140718homo_sapiensENSP0000041882360.990158.0198pteropus_vampyrusENSPVAP0000001046461.658.6
ENSG00000140718homo_sapiensENSP0000041882372.277265.9406myotis_lucifugusENSMLUP0000000351488.807881.0219
ENSG00000140718homo_sapiensENSP0000041882380.594168.3168vombatus_ursinusENSVURP0001002600781.075768.7251
ENSG00000140718homo_sapiensENSP0000041882393.267387.7228rhinolophus_ferrumequinumENSRFEP0001002632093.452487.8968
ENSG00000140718homo_sapiensENSP0000041882392.277287.7228neovison_visonENSNVIP0000002199391.732387.2047
ENSG00000140718homo_sapiensENSP0000041882392.673385.1485bos_taurusENSBTAP0000006556490.173482.8516
ENSG00000140718homo_sapiensENSP0000041882393.069388.9109heterocephalus_glaber_femaleENSHGLP0000005399593.25489.0873
ENSG00000140718homo_sapiensENSP0000041882386.732784.7525rhinopithecus_bietiENSRBIP0000002921695.010892.8417
ENSG00000140718homo_sapiensENSP0000041882322.178220.198rhinopithecus_bietiENSRBIP0000002730088.18980.315
ENSG00000140718homo_sapiensENSP0000041882394.653591.2871canis_lupus_dingoENSCAFP0002000447087.067483.9709
ENSG00000140718homo_sapiensENSP0000041882395.643691.0891sciurus_vulgarisENSSVLP0000503273995.833391.2698
ENSG00000140718homo_sapiensENSP0000041882380.990169.3069phascolarctos_cinereusENSPCIP0000004584881.474169.7211
ENSG00000140718homo_sapiensENSP0000041882375.445569.505procavia_capensisENSPCAP0000000916582.289475.8099
ENSG00000140718homo_sapiensENSP0000041882393.861489.901nannospalax_galiliENSNGAP0000000062994.422390.4382
ENSG00000140718homo_sapiensENSP0000041882394.653587.7228bos_grunniensENSBGRP0000003895494.653587.7228
ENSG00000140718homo_sapiensENSP0000041882393.465389.3069chinchilla_lanigeraENSCLAP0000002036993.096688.9546
ENSG00000140718homo_sapiensENSP0000041882393.861486.5347cervus_hanglu_yarkandensisENSCHYP0000000980493.861486.5347
ENSG00000140718homo_sapiensENSP0000041882394.455490.6931catagonus_wagneriENSCWAP0000000420894.455490.6931
ENSG00000140718homo_sapiensENSP0000041882395.841691.2871ictidomys_tridecemlineatusENSSTOP0000002229896.031791.4683
ENSG00000140718homo_sapiensENSP0000041882376.237672.8713otolemur_garnettiiENSOGAP0000000459396.0191.7706
ENSG00000140718homo_sapiensENSP0000041882398.019895.6436cebus_imitatorENSCCAP0000001643698.019895.6436
ENSG00000140718homo_sapiensENSP0000041882395.841691.4851urocitellus_parryiiENSUPAP0001001798096.031791.6667
ENSG00000140718homo_sapiensENSP0000041882394.059486.9307moschus_moschiferusENSMMSP0000001394294.059486.9307
ENSG00000140718homo_sapiensENSP0000041882399.009998.6139rhinopithecus_roxellanaENSRROP0000003091999.009998.6139
ENSG00000140718homo_sapiensENSP0000041882392.673387.3267mus_pahariMGP_PahariEiJ_P005375793.227187.8486
ENSG00000140718homo_sapiensENSP0000041882395.247592.6733propithecus_coquereliENSPCOP0000001923992.145689.6552
ENSG00000140718homo_sapiensENSP0000041882367.722853.0693callorhinchus_miliiENSCMIP0000004260566.796952.3438
ENSG00000140718homo_sapiensENSP0000041882360.792148.5149latimeria_chalumnaeENSLACP0000000884072.576857.9196
ENSG00000140718homo_sapiensENSP0000041882328.712923.1683lepisosteus_oculatusENSLOCP0000000864271.078457.3529
ENSG00000140718homo_sapiensENSP0000041882360.792147.1287clupea_harengusENSCHAP0000004413248.119137.3041
ENSG00000140718homo_sapiensENSP0000041882363.366347.9208danio_rerioENSDARP0000010765656.437442.6808
ENSG00000140718homo_sapiensENSP0000041882362.772347.1287carassius_auratusENSCARP0000006847851.544738.6992
ENSG00000140718homo_sapiensENSP0000041882356.633742.1782carassius_auratusENSCARP0000002518248.229335.9191
ENSG00000140718homo_sapiensENSP0000041882357.227742.5743astyanax_mexicanusENSAMXP0000004724151.699538.4615
ENSG00000140718homo_sapiensENSP0000041882361.782246.7327ictalurus_punctatusENSIPUP0000002487955.221241.7699
ENSG00000140718homo_sapiensENSP0000041882362.574348.3168esox_luciusENSELUP0000007831345.402335.0575
ENSG00000140718homo_sapiensENSP0000041882357.227743.3663electrophorus_electricusENSEEEP0000000376658.979644.6939
ENSG00000140718homo_sapiensENSP0000041882361.980247.9208oncorhynchus_kisutchENSOKIP0000500375848.22837.2881
ENSG00000140718homo_sapiensENSP0000041882361.980247.7228oncorhynchus_kisutchENSOKIP0000506027547.786336.7939
ENSG00000140718homo_sapiensENSP0000041882361.980248.3168oncorhynchus_mykissENSOMYP0000013575846.577436.3095
ENSG00000140718homo_sapiensENSP0000041882361.386147.1287oncorhynchus_mykissENSOMYP0000004412530.845823.6816
ENSG00000140718homo_sapiensENSP0000041882362.178248.3168salmo_salarENSSSAP0000015325949.293638.3046
ENSG00000140718homo_sapiensENSP0000041882361.782246.9307salmo_salarENSSSAP0000014361246.153835.0592
ENSG00000140718homo_sapiensENSP0000041882329.70322.1782salmo_truttaENSSTUP0000000677436.319627.1186
ENSG00000140718homo_sapiensENSP0000041882362.376248.3168salmo_truttaENSSTUP0000009151248.387137.4808
ENSG00000140718homo_sapiensENSP0000041882350.49538.8119gadus_morhuaENSGMOP0000005869550.49538.8119
ENSG00000140718homo_sapiensENSP0000041882360.990146.9307fundulus_heteroclitusENSFHEP0000002451747.311836.4055
ENSG00000140718homo_sapiensENSP0000041882357.821843.7624poecilia_reticulataENSPREP0000000939441.95431.7529
ENSG00000140718homo_sapiensENSP0000041882361.386147.3267xiphophorus_maculatusENSXMAP0000003828848.589337.4608
ENSG00000140718homo_sapiensENSP0000041882360.594146.7327oryzias_latipesENSORLP0000001721947.441936.5891
ENSG00000140718homo_sapiensENSP0000041882358.019845.9406cyclopterus_lumpusENSCLMP0000501705450.171239.726
ENSG00000140718homo_sapiensENSP0000041882361.386147.5248oreochromis_niloticusENSONIP0000005389647.112536.4742
ENSG00000140718homo_sapiensENSP0000041882361.188147.7228haplochromis_burtoniENSHBUP0000003537846.960536.6261
ENSG00000140718homo_sapiensENSP0000041882361.188147.7228astatotilapia_callipteraENSACLP0000002469646.960536.6261
ENSG00000140718homo_sapiensENSP0000041882359.80246.1386sparus_aurataENSSAUP0001003400745.688435.2496
ENSG00000140718homo_sapiensENSP0000041882357.425744.1584lates_calcariferENSLCAP0001003575342.0932.3657
ENSG00000140718homo_sapiensENSP0000041882366.336652.4752xenopus_tropicalisENSXETP0000010430965.302151.6569
ENSG00000140718homo_sapiensENSP0000041882375.049561.9802chrysemys_picta_belliiENSCPBP0000001653774.459761.4931
ENSG00000140718homo_sapiensENSP0000041882367.722855.4455sphenodon_punctatusENSSPUP0000002430367.992155.666
ENSG00000140718homo_sapiensENSP0000041882369.70356.0396crocodylus_porosusENSCPRP0000500470061.646249.5622
ENSG00000140718homo_sapiensENSP0000041882346.336633.2673laticauda_laticaudataENSLLTP0000002212956.658640.678
ENSG00000140718homo_sapiensENSP0000041882362.772349.703notechis_scutatusENSNSUP0000002318566.596652.7311
ENSG00000140718homo_sapiensENSP0000041882367.128753.6634pseudonaja_textilisENSPTXP0000001372173.695758.913
ENSG00000140718homo_sapiensENSP0000041882371.089158.0198anas_platyrhynchos_platyrhynchosENSAPLP0000002366262.872251.3135
ENSG00000140718homo_sapiensENSP0000041882374.059459.802gallus_gallusENSGALP0001003062060.322648.7097
ENSG00000140718homo_sapiensENSP0000041882341.980233.8614meleagris_gallopavoENSMGAP0000000428169.508256.0656
ENSG00000140718homo_sapiensENSP0000041882373.267357.6238serinus_canariaENSSCAP0000000622370.881255.7471
ENSG00000140718homo_sapiensENSP0000041882373.267358.2178parus_majorENSPMJP0000000220270.476256
ENSG00000140718homo_sapiensENSP0000041882358.613946.7327anolis_carolinensisENSACAP0000001620566.968353.3937
ENSG00000140718homo_sapiensENSP0000041882358.415845.7426neolamprologus_brichardiENSNBRP0000001250748.281537.8069
ENSG00000140718homo_sapiensENSP0000041882337.227729.1089naja_najaENSNNAP0000002870571.755756.1069
ENSG00000140718homo_sapiensENSP0000041882375.049559.604podarcis_muralisENSPMRP0000001720774.023458.7891
ENSG00000140718homo_sapiensENSP0000041882373.267358.6139geospiza_fortisENSGFOP0000000389972.54958.0392
ENSG00000140718homo_sapiensENSP0000041882373.663458.6139taeniopygia_guttataENSTGUP0000003248671.814757.1429
ENSG00000140718homo_sapiensENSP0000041882363.366348.5149erpetoichthys_calabaricusENSECRP0000002101662.256847.6654
ENSG00000140718homo_sapiensENSP0000041882361.782246.7327kryptolebias_marmoratusENSKMAP0000002290447.416435.8663
ENSG00000140718homo_sapiensENSP0000041882372.673359.2079salvator_merianaeENSSMRP0000000751370.172157.1702
ENSG00000140718homo_sapiensENSP0000041882361.188146.9307oryzias_javanicusENSOJAP0000000300048.05636.8585
ENSG00000140718homo_sapiensENSP0000041882359.207945.9406amphilophus_citrinellusENSACIP0000000514455.576243.1227
ENSG00000140718homo_sapiensENSP0000041882360.792146.5347dicentrarchus_labraxENSDLAP0000508116148.499237.1248
ENSG00000140718homo_sapiensENSP0000041882361.188147.3267amphiprion_perculaENSAPEP0000001366848.892437.8165
ENSG00000140718homo_sapiensENSP0000041882360.39646.5347oryzias_sinensisENSOSIP0000005029246.636135.9327
ENSG00000140718homo_sapiensENSP0000041882375.049561.1881pelodiscus_sinensisENSPSIP0000000817574.459760.7073
ENSG00000140718homo_sapiensENSP0000041882358.613947.7228gopherus_evgoodeiENSGEVP0000501851371.844758.4951
ENSG00000140718homo_sapiensENSP0000041882366.930754.8515chelonoidis_abingdoniiENSCABP0000002881170.124557.4689
ENSG00000140718homo_sapiensENSP0000041882361.386147.7228seriola_dumeriliENSSDUP0000000826248.136637.4224
ENSG00000140718homo_sapiensENSP0000041882360.19846.9307cottoperca_gobioENSCGOP0000005169248.025337.4408
ENSG00000140718homo_sapiensENSP0000041882370.49558.0198struthio_camelus_australisENSSCUP0000001575574.321561.1691
ENSG00000140718homo_sapiensENSP0000041882374.455460.7921anser_brachyrhynchusENSABRP0000002638973.725560.1961
ENSG00000140718homo_sapiensENSP0000041882348.118838.8119gasterosteus_aculeatusENSGACP0000002202860.297848.6352
ENSG00000140718homo_sapiensENSP0000041882360.594146.1386cynoglossus_semilaevisENSCSEP0000001421447.663636.2928
ENSG00000140718homo_sapiensENSP0000041882342.772334.0594poecilia_formosaENSPFOP0000001605046.753237.2294
ENSG00000140718homo_sapiensENSP0000041882361.782248.1188myripristis_murdjanENSMMDP0000505239148.598137.8505
ENSG00000140718homo_sapiensENSP000004188236047.1287sander_luciopercaENSSLUP0000004971845.909136.0606
ENSG00000140718homo_sapiensENSP0000041882338.811930.297strigops_habroptilaENSSHBP0000500553167.820152.9412
ENSG00000140718homo_sapiensENSP0000041882361.386147.5248amphiprion_ocellarisENSAOCP0000000245849.050637.9747
ENSG00000140718homo_sapiensENSP0000041882375.049561.7822terrapene_carolina_triunguisENSTMTP0000000356774.459761.2967
ENSG00000140718homo_sapiensENSP0000041882335.247525.7426hucho_huchoENSHHUP0000007720637.632127.4841
ENSG00000140718homo_sapiensENSP0000041882318.811916.2376hucho_huchoENSHHUP0000007721364.625855.7823
ENSG00000140718homo_sapiensENSP0000041882347.326738.4158hucho_huchoENSHHUP0000000255450.851141.2766
ENSG00000140718homo_sapiensENSP0000041882359.80245.9406betta_splendensENSBSLP0000001050245.896735.2584
ENSG00000140718homo_sapiensENSP0000041882362.574346.7327pygocentrus_nattereriENSPNAP0000001796953.559340
ENSG00000140718homo_sapiensENSP0000041882360.990146.9307anabas_testudineusENSATEP0000005186645.765235.2155
ENSG00000140718homo_sapiensENSP0000041882355.049544.1584seriola_lalandi_dorsalisENSSLDP0000002325959.401747.6496
ENSG00000140718homo_sapiensENSP0000041882358.415844.7525labrus_bergyltaENSLBEP0000001537045.10734.5566
ENSG00000140718homo_sapiensENSP0000041882360.19846.7327pundamilia_nyerereiENSPNYP0000001471546.270935.9209
ENSG00000140718homo_sapiensENSP0000041882361.188147.3267mastacembelus_armatusENSMAMP0000006103647.981437.1118
ENSG00000140718homo_sapiensENSP0000041882361.386147.7228stegastes_partitusENSSPAP0000002014947.112536.6261
ENSG00000140718homo_sapiensENSP0000041882344.950534.4554oncorhynchus_tshawytschaENSOTSP0000503620853.537741.0377
ENSG00000140718homo_sapiensENSP0000041882330.891121.9802oncorhynchus_tshawytschaENSOTSP0000503673836.194925.7541
ENSG00000140718homo_sapiensENSP0000041882361.386147.5248acanthochromis_polyacanthusENSAPOP0000001966347.112536.4742
ENSG00000140718homo_sapiensENSP0000041882370.891156.6337aquila_chrysaetos_chrysaetosENSACCP0002000483473.814458.9691
ENSG00000140718homo_sapiensENSP0000041882353.663440.7921nothobranchius_furzeriENSNFUP0001504615240.690730.9309
ENSG00000140718homo_sapiensENSP0000041882358.811945.7426cyprinodon_variegatusENSCVAP0000001351554.898342.6987
ENSG00000140718homo_sapiensENSP0000041882361.584245.9406denticeps_clupeoidesENSDCDP0000005176148.06835.8578
ENSG00000140718homo_sapiensENSP0000041882361.188147.5248larimichthys_croceaENSLCRP0000506385448.892437.9747
ENSG00000140718homo_sapiensENSP0000041882361.782247.7228takifugu_rubripesENSTRUP0000004895049.133937.9528
ENSG00000140718homo_sapiensENSP0000041882373.465358.0198ficedula_albicollisENSFALP0000002614969.736855.0752
ENSG00000140718homo_sapiensENSP0000041882360.39646.5347hippocampus_comesENSHCOP0000000013848.644337.4801
ENSG00000140718homo_sapiensENSP0000041882362.772346.7327cyprinus_carpio_carpioENSCCRP0000017153950.158237.3418
ENSG00000140718homo_sapiensENSP0000041882359.009942.5743cyprinus_carpio_carpioENSCCRP0000017956749.58435.7737
ENSG00000140718homo_sapiensENSP0000041882332.475226.1386coturnix_japonicaENSCJPP0000501492862.595450.3817
ENSG00000140718homo_sapiensENSP0000041882361.386147.3267poecilia_latipinnaENSPLAP0000000837748.589337.4608
ENSG00000140718homo_sapiensENSP0000041882362.574346.7327sinocyclocheilus_grahamiENSSGRP0000007925554.109640.411
ENSG00000140718homo_sapiensENSP0000041882357.227742.1782sinocyclocheilus_grahamiENSSGRP0000003758351.699538.1038
ENSG00000140718homo_sapiensENSP0000041882361.386147.7228maylandia_zebraENSMZEP0000500890347.112536.6261
ENSG00000140718homo_sapiensENSP0000041882347.722836.6337tetraodon_nigroviridisENSTNIP0000001661160.552846.4824
ENSG00000140718homo_sapiensENSP0000041882362.376246.9307paramormyrops_kingsleyaeENSPKIP0000001080854.592741.0745
ENSG00000140718homo_sapiensENSP0000041882361.188146.7327scleropages_formosusENSSFOP0001500166855.776242.5993
ENSG00000140718homo_sapiensENSP0000041882360.19847.5248leptobrachium_leishanenseENSLLEP0000002412567.256653.0973
ENSG00000140718homo_sapiensENSP0000041882360.594146.7327scophthalmus_maximusENSSMAP0000001455549.038537.8205
ENSG00000140718homo_sapiensENSP0000041882361.188146.9307oryzias_melastigmaENSOMEP0000001433848.130836.9159

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001659involved_in temperature homeostasis1IEAHomo_sapiens(9606)Process
GO:0005634located_in nucleus2IDA,ISSHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0006307involved_in DNA dealkylation involved in DNA repair1IDAHomo_sapiens(9606)Process
GO:0008198enables ferrous iron binding2IBA,IDAHomo_sapiens(9606)Function
GO:0010883involved_in regulation of lipid storage1IMPHomo_sapiens(9606)Process
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0016740enables transferase activity1IEAHomo_sapiens(9606)Function
GO:0035515enables oxidative RNA demethylase activity1IDAHomo_sapiens(9606)Function
GO:0035516enables oxidative DNA demethylase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0035552involved_in oxidative single-stranded DNA demethylation2IBA,IDAHomo_sapiens(9606)Process
GO:0035553involved_in oxidative single-stranded RNA demethylation3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0040014involved_in regulation of multicellular organism growth1IEAHomo_sapiens(9606)Process
GO:0042245involved_in RNA repair1IDAHomo_sapiens(9606)Process
GO:0043231located_in intracellular membrane-bounded organelle1IDAHomo_sapiens(9606)Component
GO:0043734enables DNA-N1-methyladenine dioxygenase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0044065involved_in regulation of respiratory system process1IEAHomo_sapiens(9606)Process
GO:0060612involved_in adipose tissue development1IEAHomo_sapiens(9606)Process
GO:0061157involved_in mRNA destabilization1IDAHomo_sapiens(9606)Process
GO:0070350involved_in regulation of white fat cell proliferation1IEAHomo_sapiens(9606)Process
GO:0070989involved_in oxidative demethylation1IDAHomo_sapiens(9606)Process
GO:0080111involved_in DNA demethylation1IDAHomo_sapiens(9606)Process
GO:0090335involved_in regulation of brown fat cell differentiation1IMPHomo_sapiens(9606)Process
GO:1990931enables mRNA N6-methyladenosine dioxygenase activity3IBA,IDA,IMPHomo_sapiens(9606)Function
GO:1990984enables tRNA demethylase activity1IDAHomo_sapiens(9606)Function

Expression