Ensembl ID ENSG00000140718 Gene ID 79068 Accession 24678
Gene Symbol FTO Alias GDFD;IFEX9;ALKBH9;BMIQ14 Full Name FTO alpha-ketoglutarate dependent dioxygenase
Position 16 : 53701692 - 54158512 Length 456821 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

ENSG00000140718 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000140718 FTO 0.55 3.15e-16 KIRC
ENSG00000140718 FTO -0.8 2.94e-29 BRCA
ENSG00000140718 FTO -0.6 1.69e-17 LUSC
ENSG00000140718 FTO -0.5 1.88e-13 PRAD
ENSG00000140718 FTO -0.7 3.13e-17 UCEC
ENSG00000140718 FTO -0.6 3.54e-19 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000140718 FTO liver tumor 10200566
ENSG00000140718 FTO cancer 19542184
ENSG00000140718 FTO Cancer 19553294
ENSG00000140718 FTO Cancer 19726594
ENSG00000140718 FTO Tumor 20339516
ENSG00000140718 FTO endometrial cancer 20647405
ENSG00000140718 FTO prostate cancer 20976066
ENSG00000140718 FTO cancer 21179003
ENSG00000140718 FTO endometrial cancer 21347432
ENSG00000140718 FTO pancreatic cancer 21357378
ENSG00000140718 FTO breast cancer 21489227
ENSG00000140718 FTO breast cancer 21688152
ENSG00000140718 FTO endometrial cancer 22222214
ENSG00000140718 FTO Cancer 22384102
ENSG00000140718 FTO cancer 22396042
ENSG00000140718 FTO cancer 22503908
ENSG00000140718 FTO colorectal cancer 22511254
ENSG00000140718 FTO prostate cancer 22709667
ENSG00000140718 FTO breast cancer 23236435
ENSG00000140718 FTO cancer 23258813
ENSG00000140718 FTO breast cancer 23536562
ENSG00000140718 FTO cancer 23589710
ENSG00000140718 FTO cancers 23771786
ENSG00000140718 FTO pancreatic cancer 23835106
ENSG00000140718 FTO Cancer 23861046
ENSG00000140718 FTO breast cancer 23922112
ENSG00000140718 FTO breast cancer 24023349
ENSG00000140718 FTO breast cancer 24065098
ENSG00000140718 FTO breast cancer 24091943
ENSG00000140718 FTO cancer 24627050
ENSG00000140718 FTO pancreatic cancer 25177340
ENSG00000140718 FTO cancer 25279830
ENSG00000140718 FTO cancer 25387436
ENSG00000140718 FTO endometrial cancer 26134033
ENSG00000140718 FTO Breast Cancer 26146447
ENSG00000140718 FTO breast cancer 26322284
ENSG00000140718 FTO prostate cancer 26387087
ENSG00000140718 FTO breast cancer 26691922
ENSG00000140718 FTO breast cancer 26722548
ENSG00000140718 FTO pancreatic cancer 26821195
ENSG00000140718 FTO endometrial cancer 26884084
ENSG00000140718 FTO cancer 26931363
ENSG00000140718 FTO breast cancer 27117709
ENSG00000140718 FTO follicular thyroid cancer 27207655
ENSG00000140718 FTO Inflammatory Breast Cancer 27390851
ENSG00000140718 FTO colorectal cancer 27449576
ENSG00000140718 FTO breast cancer 27590511
ENSG00000140718 FTO Cancer 27600277
ENSG00000140718 FTO colon cancer 27990199
ENSG00000140718 FTO acute myeloid leukemia (AML) 28017614
ENSG00000140718 FTO lung cancer 28069048
ENSG00000140718 FTO cancer 28288181
ENSG00000140718 FTO tumor 28297667
ENSG00000140718 FTO breast cancer 28377418
ENSG00000140718 FTO Breast Cancer 28547937
ENSG00000140718 FTO breast cancer 28591216
ENSG00000140718 FTO breast cancer 28599470
ENSG00000140718 FTO cancers 28746203
ENSG00000140718 FTO gastric cancer 28849183
ENSG00000140718 FTO cancer 28881622
ENSG00000140718 FTO cancers 28933365
ENSG00000140718 FTO AML 29125541
ENSG00000140718 FTO Breast Cancer 29220587
ENSG00000140718 FTO cervical cancer 29228737
ENSG00000140718 FTO tumor 29249359
ENSG00000140718 FTO prostate cancers 29260910
ENSG00000140718 FTO Tumor 29269348
ENSG00000140718 FTO Prostate Cancer 29333375
ENSG00000140718 FTO AML acute myeloid leukemia 29374143
ENSG00000140718 FTO AML 29439529
ENSG00000140718 FTO Childhood Cancer 29675043
ENSG00000140718 FTO Wilms tumor 29680375
ENSG00000140718 FTO cancer 29686311
ENSG00000140718 FTO tumor 29842885
ENSG00000140718 FTO Wilms’ tumor 29900123
ENSG00000140718 FTO AML 30031372
ENSG00000140718 FTO cancers 30039919
ENSG00000140718 FTO cancers 30062093
ENSG00000140718 FTO AML 30096915
ENSG00000140718 FTO Cancer 30105001
ENSG00000140718 FTO AML 30149601
ENSG00000140718 FTO tumor 30297871
ENSG00000140718 FTO Cancer 30380400
ENSG00000140718 FTO breast cancer 30428628
ENSG00000140718 FTO cancer 30465076
ENSG00000140718 FTO cancer 30505654
ENSG00000140718 FTO colorectal cancer 30556861
ENSG00000140718 FTO tumor 30637548
ENSG00000140718 FTO breast cancer 30642840
ENSG00000140718 FTO tumour 30648791
ENSG00000140718 FTO wilms tumor 30701478
ENSG00000140718 FTO pancreatic cancer 30719115
ENSG00000140718 FTO cancer 30766746
ENSG00000140718 FTO GBM 30810537
ENSG00000140718 FTO tumor 30891567
ENSG00000140718 FTO cancer 30894375
ENSG00000140718 FTO lung cancer 30905413
ENSG00000140718 FTO breast tumor 30922314
ENSG00000140718 FTO Cancer 30953473
ENSG00000140718 FTO acute myeloid leukemia (AML) 30991023
ENSG00000140718 FTO acute myeloid leukemia (AML) 30991027
ENSG00000140718 FTO cancer 31007685
ENSG00000140718 FTO AML 31024852
ENSG00000140718 FTO breast cancer 31069256
ENSG00000140718 FTO AML 31142332
ENSG00000140718 FTO cancers 31143705
ENSG00000140718 FTO tumor 31159832
ENSG00000140718 FTO cancer 31176112
ENSG00000140718 FTO cancer 31187550
ENSG00000140718 FTO tumors 31239444
ENSG00000140718 FTO cancer 31243897
ENSG00000140718 FTO breast cancer 31426393
ENSG00000140718 FTO cancer 31447604
ENSG00000140718 FTO cancer 31519943
ENSG00000140718 FTO breast cancer 31555578
ENSG00000140718 FTO cancer 31616461
ENSG00000140718 FTO tumor 31632576
ENSG00000140718 FTO gastric cancer 31681576
ENSG00000140718 FTO cervical cancer 31711514
ENSG00000140718 FTO tumor 31720080
ENSG00000140718 FTO tumor 31722709
ENSG00000140718 FTO cervical cancer 31827395
ENSG00000140718 FTO tumor 31934180
ENSG00000140718 FTO cancer 31956264
ENSG00000140718 FTO tumour 31985880
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000140718 FTO MESO 0.026 low
ENSG00000140718 FTO STAD 0.0016 high
ENSG00000140718 FTO PAAD 0.034 low
ENSG00000140718 FTO UCEC 0.00028 high
ENSG00000140718 FTO ACC 0.015 low
ENSG00000140718 FTO HNSC 0.023 high
ENSG00000140718 FTO KIRP 0.049 low
ENSG00000140718 FTO KICH 0.0076 high
ENSG00000140718 FTO LUAD 0.012 low
ENSG00000140718 FTO THYM 0.021 low
ENSG00000140718 FTO BRCA 0.013 high
ENSG00000140718 FTO UCS 0.015 high
ENSG00000140718 FTO OV 0.04 high
ENSG00000140718 FTO BLCA 0.0046 high
ENSG00000140718 FTO LAML 0.017 low
ENSG00000140718 FTO LIHC 0.001 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000140718 FTO CESC Del 1.864280 0.088814 0.519861 0.200000
ENSG00000140718 FTO SARC Del 0.922670 0.128064 0.570788 0.525292
ENSG00000140718 FTO SKCM Del 0.740055 0.066965 0.490913 0.321526
ENSG00000140718 FTO UCEC Del 1.447427 0.057447 0.612147 0.261596