Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq DataSet_01_167 DataSet_01_259

Description

Ensembl ID ENSG00000140694 Gene ID 5073 Accession 8609
Symbol PARN Alias DAN;DKCB6;PFBMFT4 Full Name poly(A)-specific ribonuclease
Status Confidence Length 197029 bases Strand Minus strand
Position 16 : 14435700 - 14632728 RNA binding domain RNA_bind , CAF1
Summary The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000444381 RNA_bind PF08675 2e-33 1
ENSP00000444381 CAF1 PF04857 1.7e-51 2
ENSP00000444381 CAF1 PF04857 1.7e-51 3
ENSP00000499078 RNA_bind PF08675 2.6e-33 1
ENSP00000499078 CAF1 PF04857 4.4e-88 2
ENSP00000498644 RNA_bind PF08675 2.6e-33 1
ENSP00000498644 CAF1 PF04857 4.6e-88 2
ENSP00000345456 RNA_bind PF08675 2.7e-33 1
ENSP00000345456 CAF1 PF04857 2.9e-69 2
ENSP00000499110 RNA_bind PF08675 2.7e-33 1
ENSP00000499110 CAF1 PF04857 4.7e-88 2
ENSP00000410525 RNA_bind PF08675 2.8e-33 1
ENSP00000410525 CAF1 PF04857 3.2e-67 2
ENSP00000410525 CAF1 PF04857 3.2e-67 3
ENSP00000498567 RNA_bind PF08675 3e-33 1
ENSP00000498567 CAF1 PF04857 1.2e-60 2
ENSP00000498567 CAF1 PF04857 1.2e-60 3
ENSP00000498567 CAF1 PF04857 1.2e-60 4
ENSP00000387911 RNA_bind PF08675 3e-33 1
ENSP00000387911 CAF1 PF04857 6e-88 2
ENSP00000513329 RNA_bind PF08675 3.1e-33 1
ENSP00000513329 CAF1 PF04857 6.5e-88 2
ENSP00000498741 RNA_bind PF08675 3.2e-33 1
ENSP00000498741 CAF1 PF04857 5.7e-81 2
ENSP00000498741 CAF1 PF04857 5.7e-81 3
ENSP00000498261 RNA_bind PF08675 9.1e-27 1
ENSP00000498261 CAF1 PF04857 2e-88 2
ENSP00000498640 RNA_bind PF08675 1.4e-26 1
ENSP00000498640 CAF1 PF04857 2.4e-88 2
ENSP00000498230 RNA_bind PF08675 1.6e-26 1
ENSP00000498230 CAF1 PF04857 2.2e-84 2
ENSP00000499051 RNA_bind PF08675 7.3e-26 1
ENSP00000499051 CAF1 PF04857 1e-52 2
ENSP00000499051 CAF1 PF04857 1e-52 3
ENSP00000498650 RNA_bind PF08675 8.5e-12 1
ENSP00000498650 CAF1 PF04857 1.8e-71 2
ENSP00000498898 CAF1 PF04857 1.5e-88 1
ENSP00000498315 CAF1 PF04857 7.8e-66 1
ENSP00000445659 CAF1 PF04857 7.8e-37 1
ENSP00000456279 CAF1 PF04857 3.5e-36 1
ENSP00000456982 CAF1 PF04857 6.4e-17 1
ENSP00000458103 CAF1 PF04857 5.5e-12 1
ENSP00000499206 CAF1 PF04857 5.5e-12 1
ENSP00000498294 CAF1 PF04857 6.5e-12 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25239613 Self-association of poly(A)-specific ribonuclease (PARN) triggered by the R3H domain. Guang-Jun He 2014-12-01 Biochimica et biophysica acta
19918970 Therapeutic RNA manipulation in liver disease. A Thomas Kerr 2010-03-01 Hepatology (Baltimore, Md.)
28964725 How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD. Julian Gomez-Cambronero 2018-05-01 Advances in biological regulation
29770436 All I's on the RADAR: role of ADAR in gene regulation. Galina Shevchenko 2018-09-01 FEBS letters
23388391 Distinct roles of the R3H and RRM domains in poly(A)-specific ribonuclease structural integrity and catalysis. Guang-Jun He 2013-06-01 Biochimica et biophysica acta
28053121 ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins. Aparna Anantharaman 2017-04-20 Nucleic acids research
26400160 PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells. Xiaokan Zhang 2015-12-15 Nucleic acids research
22392217 Regulation of cytoplasmic mRNA decay. R Daniel Schoenberg 2012-03-06 Nature reviews. Genetics
17785461 A multifunctional RNA recognition motif in poly(A)-specific ribonuclease with cap and poly(A) binding properties. Per Nilsson 2007-11-09 The Journal of biological chemistry
17624302 The R3H domain stabilizes poly(A)-specific ribonuclease by stabilizing the RRM domain. Wei-Feng Liu 2007-09-07 Biochemical and biophysical research communications
25851173 Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer. Tanya Todorova 2015-06-01 Trends in molecular medicine
32496897 The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery. B L Katherine Borden 2020-09-01 RNA biology
18641416 The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition. Takashi Nagata 2008-08-01 Nucleic acids research
31387300 The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage. Tian-Li Duan 2019-08-05 Cells
16601207 CUG-BP binds to RNA substrates and recruits PARN deadenylase. M C Karen Moraes 2006-06-01 RNA (New York, N.Y.)
33671234 Human Ccr4 and Caf1 Deadenylases Regulate Proliferation and Tumorigenicity of Human Gastric Cancer Cells via Modulating Cell Cycle Progression. Xiao-Hui Song 2021-02-17 Cancers
21741754 Global architecture of human poly(A)-specific ribonuclease by atomic force microscopy in liquid and dynamic light scattering. Anna Niedzwiecka 2011-10-01 Biophysical chemistry
22834816 Modulation of poly(A)-specific ribonuclease (PARN): current knowledge and perspectives. A A N Balatsos 2012-01-01 Current medicinal chemistry
23236441 An integrated in silico approach to design specific inhibitors targeting human poly(a)-specific ribonuclease. Dimitrios Vlachakis 2012-01-01 PloS one
34553588 Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. E Luam Araya 2021-11-19 ACS chemical biology
35217638 A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis. J Diego Páez-Moscoso 2022-02-25 Nature communications
30949591 Contributions of the C-terminal domain to poly(A)-specific ribonuclease (PARN) stability and self-association. Guang-Jun He 2019-07-01 Biochemistry and biophysics reports
32242127 Regulation of human telomerase in homeostasis and disease. M Caitlin Roake 2020-07-01 Nature reviews. Molecular cell biology
22936947 Posttranscriptional regulation of gene expression-adding another layer of complexity to the DNA damage response. Jorge Boucas 2012-01-01 Frontiers in genetics
26382858 mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. Anna Gebhardt 2015-09-18 Nature communications
16281054 Structural insight into poly(A) binding and catalytic mechanism of human PARN. Mousheng Wu 2005-12-07 The EMBO journal

Transcripts

Name Transcript ID bp Protein Translation ID
PARN-225 ENST00000651865 2997 614aa ENSP00000498567
PARN-203 ENST00000437198 3071 639aa ENSP00000387911
PARN-233 ENST00000697471 3365 No protein -
PARN-234 ENST00000697472 2955 No protein -
PARN-235 ENST00000697473 4352 No protein -
PARN-222 ENST00000651348 2983 349aa ENSP00000498315
PARN-217 ENST00000650990 2884 664aa ENSP00000498741
PARN-224 ENST00000651760 3912 49aa ENSP00000498642
PARN-232 ENST00000652727 2630 581aa ENSP00000498650
PARN-231 ENST00000652541 2870 65aa ENSP00000499206
PARN-228 ENST00000652066 2565 458aa ENSP00000499051
PARN-221 ENST00000651300 2706 65aa ENSP00000498294
PARN-202 ENST00000420015 2360 593aa ENSP00000410525
PARN-227 ENST00000652051 2552 446aa ENSP00000498898
PARN-201 ENST00000341484 2100 578aa ENSP00000345456
PARN-205 ENST00000539279 1557 464aa ENSP00000444381
PARN-236 ENST00000697474 3863 659aa ENSP00000513329
PARN-212 ENST00000564882 452 No protein -
PARN-219 ENST00000651049 2879 585aa ENSP00000498644
PARN-216 ENST00000650960 3075 590aa ENSP00000499110
PARN-223 ENST00000651634 2319 577aa ENSP00000499078
PARN-211 ENST00000564113 2114 No protein -
PARN-213 ENST00000564904 468 No protein -
PARN-237 ENST00000697475 2012 No protein -
PARN-238 ENST00000697476 1790 No protein -
PARN-229 ENST00000652411 2233 No protein -
PARN-230 ENST00000652501 1768 499aa ENSP00000498261
PARN-218 ENST00000651027 1740 524aa ENSP00000498640
PARN-226 ENST00000651913 1463 488aa ENSP00000498230
PARN-209 ENST00000563641 1446 65aa ENSP00000458103
PARN-215 ENST00000569444 783 261aa ENSP00000456279
PARN-210 ENST00000563697 508 No protein -
PARN-206 ENST00000562715 505 No protein -
PARN-220 ENST00000651241 1988 No protein -
PARN-239 ENST00000697477 1136 No protein -
PARN-204 ENST00000538472 808 207aa ENSP00000445659
PARN-208 ENST00000563155 335 No protein -
PARN-214 ENST00000566021 598 No protein -
PARN-207 ENST00000562896 577 109aa ENSP00000456982

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
54019Cholesterol, HDL1.0390000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000140694homo_sapiensENSP0000037600747.457627.6836homo_sapiensENSP0000038791139.436623.0047
ENSG00000140694homo_sapiensENSP0000036116227.254915.8824homo_sapiensENSP0000038791121.752712.6761
ENSG00000140694homo_sapiensENSP00000478668100100homo_sapiensENSP00000387911100100

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000140694homo_sapiensENSP0000038791199.37499.061nomascus_leucogenysENSNLEP0000001250499.37499.061
ENSG00000140694homo_sapiensENSP0000038791199.843599.687pan_paniscusENSPPAP0000001675999.843599.687
ENSG00000140694homo_sapiensENSP0000038791193.896793.2707pongo_abeliiENSPPYP0000002613894.488293.8583
ENSG00000140694homo_sapiensENSP0000038791110099.687pan_troglodytesENSPTRP0000001329310099.687
ENSG00000140694homo_sapiensENSP0000038791197.183196.8701gorilla_gorillaENSGGOP0000002010110099.6779
ENSG00000140694homo_sapiensENSP0000038791191.392885.6025ornithorhynchus_anatinusENSOANP0000002559584.760579.3904
ENSG00000140694homo_sapiensENSP0000038791194.366289.2019sarcophilus_harrisiiENSSHAP0000000981294.514189.3417
ENSG00000140694homo_sapiensENSP0000038791164.006360.4069notamacropus_eugeniiENSMEUP0000000748964.817761.1727
ENSG00000140694homo_sapiensENSP0000038791178.247376.0563choloepus_hoffmanniENSCHOP0000000623081.833179.5417
ENSG00000140694homo_sapiensENSP0000038791195.774793.1142dasypus_novemcinctusENSDNOP0000001795581.491379.2277
ENSG00000140694homo_sapiensENSP0000038791167.762164.6322erinaceus_europaeusENSEEUP0000000950768.18965.0394
ENSG00000140694homo_sapiensENSP0000038791166.353764.4757echinops_telfairiENSETEP0000001202169.508267.541
ENSG00000140694homo_sapiensENSP0000038791198.904597.4961callithrix_jacchusENSCJAP0000002930386.456985.2257
ENSG00000140694homo_sapiensENSP0000038791189.514989.2019cercocebus_atysENSCATP0000003728599.478399.1304
ENSG00000140694homo_sapiensENSP0000038791196.400695.9311macaca_fascicularisENSMFAP0000002719699.354898.871
ENSG00000140694homo_sapiensENSP0000038791199.217598.9045macaca_mulattaENSMMUP0000006009593.372693.0781
ENSG00000140694homo_sapiensENSP0000038791199.37499.061macaca_nemestrinaENSMNEP0000004516099.37499.061
ENSG00000140694homo_sapiensENSP0000038791199.37499.061papio_anubisENSPANP0000001394099.37499.061
ENSG00000140694homo_sapiensENSP0000038791199.37498.9045mandrillus_leucophaeusENSMLEP0000001515399.37498.9045
ENSG00000140694homo_sapiensENSP0000038791189.671488.1064tursiops_truncatusENSTTRP0000000266691.387689.7927
ENSG00000140694homo_sapiensENSP0000038791196.557193.4272vulpes_vulpesENSVVUP0000002656096.708593.5737
ENSG00000140694homo_sapiensENSP0000038791192.175386.385mus_spretusMGP_SPRETEiJ_P004227794.39188.4615
ENSG00000140694homo_sapiensENSP0000038791195.618292.9577equus_asinusENSEASP0000501645695.918493.2496
ENSG00000140694homo_sapiensENSP0000038791196.713694.3662capra_hircusENSCHIP0000001889296.865294.5141
ENSG00000140694homo_sapiensENSP0000038791195.774793.1142loxodonta_africanaENSLAFP0000001259096.988994.2948
ENSG00000140694homo_sapiensENSP0000038791196.087693.7402panthera_leoENSPLOP0000002269296.238293.8871
ENSG00000140694homo_sapiensENSP0000038791196.087692.9577ailuropoda_melanoleucaENSAMEP0000004248892.749289.7281
ENSG00000140694homo_sapiensENSP0000038791196.713694.3662bos_indicus_hybridENSBIXP0000500821093.353591.0876
ENSG00000140694homo_sapiensENSP0000038791194.835792.3318oryctolagus_cuniculusENSOCUP0000000028791.402788.9894
ENSG00000140694homo_sapiensENSP0000038791195.461792.6448equus_caballusENSECAP0000007096291.180988.4903
ENSG00000140694homo_sapiensENSP0000038791196.244192.8013canis_lupus_familiarisENSCAFP0084501509293.040889.7126
ENSG00000140694homo_sapiensENSP0000038791195.931193.5837panthera_pardusENSPPRP0000002712696.081593.7304
ENSG00000140694homo_sapiensENSP0000038791188.575985.133marmota_marmota_marmotaENSMMMP0000002245992.032588.4553
ENSG00000140694homo_sapiensENSP0000038791196.244194.5227balaenoptera_musculusENSBMSP0001003053396.39594.6708
ENSG00000140694homo_sapiensENSP0000038791195.305291.0798cavia_porcellusENSCPOP0000002228295.604491.3658
ENSG00000140694homo_sapiensENSP0000038791196.087693.7402felis_catusENSFCAP0000004575596.238293.8871
ENSG00000140694homo_sapiensENSP0000038791161.971858.9984ursus_americanusENSUAMP0000001004386.274582.1351
ENSG00000140694homo_sapiensENSP0000038791191.549385.759monodelphis_domesticaENSMODP0000000605088.636483.0303
ENSG00000140694homo_sapiensENSP0000038791134.428833.3333bison_bison_bisonENSBBBP0000002239294.420691.4163
ENSG00000140694homo_sapiensENSP0000038791195.774794.2097monodon_monocerosENSMMNP0001500886195.924894.3574
ENSG00000140694homo_sapiensENSP0000038791195.305292.8013sus_scrofaENSSSCP0000007393795.454592.9467
ENSG00000140694homo_sapiensENSP0000038791198.278696.4006microcebus_murinusENSMICP0000001465798.432696.5517
ENSG00000140694homo_sapiensENSP0000038791186.854582.4726octodon_degusENSODEP0000000206492.809488.1271
ENSG00000140694homo_sapiensENSP0000038791193.427288.2629jaculus_jaculusENSJJAP0000002323695.367490.0958
ENSG00000140694homo_sapiensENSP0000038791196.713694.3662ovis_aries_rambouilletENSOARP0002002535196.865294.5141
ENSG00000140694homo_sapiensENSP0000038791196.244193.2707ursus_maritimusENSUMAP0000000573996.39593.4169
ENSG00000140694homo_sapiensENSP0000038791189.358485.446ochotona_princepsENSOPRP0000001113490.634986.6667
ENSG00000140694homo_sapiensENSP0000038791195.774794.2097delphinapterus_leucasENSDLEP0000000752995.924894.3574
ENSG00000140694homo_sapiensENSP0000038791196.087694.6792physeter_catodonENSPCTP0000501659096.238294.8276
ENSG00000140694homo_sapiensENSP0000038791192.175386.5415mus_caroliMGP_CAROLIEiJ_P004042494.39188.6218
ENSG00000140694homo_sapiensENSP0000038791192.331886.385mus_musculusENSMUSP0000005596994.551388.4615
ENSG00000140694homo_sapiensENSP0000038791131.298930.2034dipodomys_ordiiENSDORP0000002027798.522295.0739
ENSG00000140694homo_sapiensENSP0000038791195.774792.9577mustela_putorius_furoENSMPUP0000001435495.924893.1034
ENSG00000140694homo_sapiensENSP0000038791198.435196.8701aotus_nancymaaeENSANAP0000002743398.435196.8701
ENSG00000140694homo_sapiensENSP0000038791197.183196.2441saimiri_boliviensis_boliviensisENSSBOP0000003739799.201398.2428
ENSG00000140694homo_sapiensENSP0000038791189.045486.385vicugna_pacosENSVPAP0000000834292.67189.9023
ENSG00000140694homo_sapiensENSP0000038791199.217598.9045chlorocebus_sabaeusENSCSAP0000000440199.217598.9045
ENSG00000140694homo_sapiensENSP0000038791176.212872.457tupaia_belangeriENSTBEP0000000902285.28981.0858
ENSG00000140694homo_sapiensENSP0000038791187.323982.0031mesocricetus_auratusENSMAUP0000000597891.176585.6209
ENSG00000140694homo_sapiensENSP0000038791195.931194.2097phocoena_sinusENSPSNP0000000696596.081594.3574
ENSG00000140694homo_sapiensENSP0000038791195.305292.4883camelus_dromedariusENSCDRP0000501857395.454592.6332
ENSG00000140694homo_sapiensENSP0000038791196.087693.7402panthera_tigris_altaicaENSPTIP0000001192596.238293.8871
ENSG00000140694homo_sapiensENSP0000038791181.377277.1518rattus_norvegicusENSRNOP0000007253980.620276.4341
ENSG00000140694homo_sapiensENSP0000038791197.809196.0876prolemur_simusENSPSMP0000000689997.962496.2382
ENSG00000140694homo_sapiensENSP0000038791174.334970.579microtus_ochrogasterENSMOCP0000002638297.535992.6078
ENSG00000140694homo_sapiensENSP0000038791176.525872.9264sorex_araneusENSSARP0000001297784.602180.6228
ENSG00000140694homo_sapiensENSP0000038791191.392885.9155peromyscus_maniculatus_bairdiiENSPEMP0000002051293.7488.122
ENSG00000140694homo_sapiensENSP0000038791196.713694.3662bos_mutusENSBMUP0000002894593.353591.0876
ENSG00000140694homo_sapiensENSP0000038791192.018885.9155mus_spicilegusENSMSIP0000002565568.611464.0607
ENSG00000140694homo_sapiensENSP0000038791191.549386.072cricetulus_griseus_chok1gshdENSCGRP0000101011993.688
ENSG00000140694homo_sapiensENSP0000038791191.236388.7324pteropus_vampyrusENSPVAP0000000240992.539790
ENSG00000140694homo_sapiensENSP0000038791175.117473.2394myotis_lucifugusENSMLUP0000000494697.16694.7368
ENSG00000140694homo_sapiensENSP0000038791193.896788.4194vombatus_ursinusENSVURP0001001203894.043988.558
ENSG00000140694homo_sapiensENSP0000038791195.618292.6448rhinolophus_ferrumequinumENSRFEP0001002397195.76892.79
ENSG00000140694homo_sapiensENSP0000038791192.331887.6369neovison_visonENSNVIP0000002559992.621787.9121
ENSG00000140694homo_sapiensENSP0000038791196.713694.3662bos_taurusENSBTAP0000006480193.353591.0876
ENSG00000140694homo_sapiensENSP0000038791195.618290.7668heterocephalus_glaber_femaleENSHGLP0000001520994.290189.5062
ENSG00000140694homo_sapiensENSP0000038791151.486751.3302rhinopithecus_bietiENSRBIP0000000397898.798898.4985
ENSG00000140694homo_sapiensENSP0000038791196.400692.9577canis_lupus_dingoENSCAFP0002003091296.551793.1034
ENSG00000140694homo_sapiensENSP0000038791195.461792.4883sciurus_vulgarisENSSVLP0000503220895.611392.6332
ENSG00000140694homo_sapiensENSP0000038791193.896788.2629phascolarctos_cinereusENSPCIP0000000306471.258966.9834
ENSG00000140694homo_sapiensENSP0000038791181.377278.7167procavia_capensisENSPCAP0000000165285.950483.1405
ENSG00000140694homo_sapiensENSP0000038791130.985930.3599nannospalax_galiliENSNGAP0000002643698.019896.0396
ENSG00000140694homo_sapiensENSP0000038791189.514987.011bos_grunniensENSBGRP0000004190796.621693.9189
ENSG00000140694homo_sapiensENSP0000038791195.148790.9233chinchilla_lanigeraENSCLAP0000002245695.148790.9233
ENSG00000140694homo_sapiensENSP0000038791195.305292.3318catagonus_wagneriENSCWAP0000001686395.454592.4765
ENSG00000140694homo_sapiensENSP0000038791195.461791.5493ictidomys_tridecemlineatusENSSTOP0000000673096.214592.2713
ENSG00000140694homo_sapiensENSP0000038791175.117473.3959otolemur_garnettiiENSOGAP0000001311097.759795.5193
ENSG00000140694homo_sapiensENSP0000038791199.06197.8091cebus_imitatorENSCCAP0000002519799.06197.8091
ENSG00000140694homo_sapiensENSP0000038791195.461791.8623urocitellus_parryiiENSUPAP0001002873196.214592.5868
ENSG00000140694homo_sapiensENSP0000038791195.931193.1142moschus_moschiferusENSMMSP0000001994096.232393.4066
ENSG00000140694homo_sapiensENSP0000038791151.486751.3302rhinopithecus_roxellanaENSRROP0000000278198.798898.4985
ENSG00000140694homo_sapiensENSP0000038791191.236386.072mus_pahariMGP_PahariEiJ_P002782193.429588.141
ENSG00000140694homo_sapiensENSP0000038791195.461793.2707propithecus_coquereliENSPCOP0000001515297.913395.6661
ENSG00000140694homo_sapiensENSP0000038791138.341220.6573caenorhabditis_elegansK10C8.1.143.286223.3216
ENSG00000140694homo_sapiensENSP0000038791151.799736.6197ciona_intestinalisENSCINP0000002026262.808344.4023
ENSG00000140694homo_sapiensENSP0000038791167.449155.2426petromyzon_marinusENSPMAP0000000438682.409267.4952
ENSG00000140694homo_sapiensENSP0000038791134.741828.0125eptatretus_burgeriENSEBUP0000001097569.158955.7632
ENSG00000140694homo_sapiensENSP0000038791182.785670.892callorhinchus_miliiENSCMIP0000001751782.015570.2326
ENSG00000140694homo_sapiensENSP0000038791169.170662.1283latimeria_chalumnaeENSLACP0000000473483.553975.0473
ENSG00000140694homo_sapiensENSP0000038791182.003170.266lepisosteus_oculatusENSLOCP0000000080172.676862.2746
ENSG00000140694homo_sapiensENSP0000038791180.594767.9186clupea_harengusENSCHAP0000002723775.072963.2653
ENSG00000140694homo_sapiensENSP0000038791177.934365.1017danio_rerioENSDARP0000013913175.454563.0303
ENSG00000140694homo_sapiensENSP0000038791177.464865.1017carassius_auratusENSCARP0000010583376.153864
ENSG00000140694homo_sapiensENSP0000038791177.464865.1017carassius_auratusENSCARP0000010185176.153864
ENSG00000140694homo_sapiensENSP0000038791178.090867.6056astyanax_mexicanusENSAMXP0000001278477.60567.1851
ENSG00000140694homo_sapiensENSP0000038791169.170658.0595ictalurus_punctatusENSIPUP0000001831774.161162.2483
ENSG00000140694homo_sapiensENSP0000038791180.751267.7621esox_luciusENSELUP0000007562168.43557.4271
ENSG00000140694homo_sapiensENSP0000038791179.186267.6056electrophorus_electricusENSEEEP0000004282678.086466.6667
ENSG00000140694homo_sapiensENSP0000038791181.220767.6056oncorhynchus_kisutchENSOKIP0000507399374.46261.9799
ENSG00000140694homo_sapiensENSP0000038791181.220767.6056oncorhynchus_kisutchENSOKIP0000506311974.46261.9799
ENSG00000140694homo_sapiensENSP0000038791180.438266.8232oncorhynchus_mykissENSOMYP0000013840266.066854.8843
ENSG00000140694homo_sapiensENSP0000038791165.101753.5211oncorhynchus_mykissENSOMYP0000014189956.216246.2162
ENSG00000140694homo_sapiensENSP0000038791181.064266.8232salmo_salarENSSSAP0000016715374.318561.2626
ENSG00000140694homo_sapiensENSP0000038791181.220766.9797salmo_salarENSSSAP0000001052174.46261.406
ENSG00000140694homo_sapiensENSP0000038791181.064266.8232salmo_truttaENSSTUP000000055317461
ENSG00000140694homo_sapiensENSP0000038791172.613558.6854salmo_truttaENSSTUP0000008717866.762653.9568
ENSG00000140694homo_sapiensENSP0000038791180.907769.0141gadus_morhuaENSGMOP0000006286075.917864.7577
ENSG00000140694homo_sapiensENSP0000038791173.395962.1283fundulus_heteroclitusENSFHEP0000002898573.395962.1283
ENSG00000140694homo_sapiensENSP0000038791181.377269.0141poecilia_reticulataENSPREP0000000016576.134764.5681
ENSG00000140694homo_sapiensENSP0000038791181.220768.8576xiphophorus_maculatusENSXMAP0000001486576.099764.5161
ENSG00000140694homo_sapiensENSP0000038791127.2323.4742oryzias_latipesENSORLP0000002995686.138674.2574
ENSG00000140694homo_sapiensENSP0000038791180.594768.2316cyclopterus_lumpusENSCLMP0000500023475.292463.7427
ENSG00000140694homo_sapiensENSP0000038791182.003170.7355oreochromis_niloticusENSONIP0000000019377.172366.5685
ENSG00000140694homo_sapiensENSP0000038791182.003170.579haplochromis_burtoniENSHBUP0000001590177.172366.4212
ENSG00000140694homo_sapiensENSP0000038791181.846670.4225astatotilapia_callipteraENSACLP0000000701377.252666.4697
ENSG00000140694homo_sapiensENSP0000038791181.533669.7966sparus_aurataENSSAUP0001000433975.39864.5441
ENSG00000140694homo_sapiensENSP0000038791177.464867.2926lates_calcariferENSLCAP0001002601181.548670.8402
ENSG00000140694homo_sapiensENSP0000038791185.13374.1784xenopus_tropicalisENSXETP0000008827286.07675
ENSG00000140694homo_sapiensENSP0000038791182.159675.4304chrysemys_picta_belliiENSCPBP0000000848090.673683.247
ENSG00000140694homo_sapiensENSP0000038791192.018885.133sphenodon_punctatusENSSPUP0000000997492.16385.2665
ENSG00000140694homo_sapiensENSP0000038791191.392883.7246crocodylus_porosusENSCPRP0000500551085.131277.9883
ENSG00000140694homo_sapiensENSP0000038791186.541576.9953laticauda_laticaudataENSLLTP0000001283887.22477.6025
ENSG00000140694homo_sapiensENSP0000038791172.45764.1628notechis_scutatusENSNSUP0000000467081.370872.0562
ENSG00000140694homo_sapiensENSP0000038791184.037674.0219pseudonaja_textilisENSPTXP0000001878971.409662.8989
ENSG00000140694homo_sapiensENSP0000038791173.552465.8842anas_platyrhynchos_platyrhynchosENSAPLP0000002079587.03777.963
ENSG00000140694homo_sapiensENSP0000038791190.610382.3161gallus_gallusENSGALP0001002938390.468882.1875
ENSG00000140694homo_sapiensENSP0000038791180.281771.6745meleagris_gallopavoENSMGAP0000002370590.316980.6338
ENSG00000140694homo_sapiensENSP0000038791183.411675.5869serinus_canariaENSSCAP0000001586992.374483.7088
ENSG00000140694homo_sapiensENSP0000038791192.957784.82parus_majorENSPMJP0000001370593.103484.953
ENSG00000140694homo_sapiensENSP0000038791189.671480.9077anolis_carolinensisENSACAP0000000489388.153879.5385
ENSG00000140694homo_sapiensENSP0000038791175.586965.8842neolamprologus_brichardiENSNBRP0000000875083.132572.4613
ENSG00000140694homo_sapiensENSP0000038791185.44676.2128naja_najaENSNNAP0000000709984.389575.2705
ENSG00000140694homo_sapiensENSP0000038791190.766882.9421podarcis_muralisENSPMRP000000355708073.1034
ENSG00000140694homo_sapiensENSP0000038791183.098675.1174geospiza_fortisENSGFOP0000000599292.027783.1889
ENSG00000140694homo_sapiensENSP0000038791192.331883.7246taeniopygia_guttataENSTGUP0000000516492.476583.8558
ENSG00000140694homo_sapiensENSP0000038791179.812269.1706erpetoichthys_calabaricusENSECRP0000001641581.339770.4944
ENSG00000140694homo_sapiensENSP0000038791181.377269.4836kryptolebias_marmoratusENSKMAP0000001259576.583265.3903
ENSG00000140694homo_sapiensENSP0000038791183.411675.1174salvator_merianaeENSSMRP0000000429286.106677.5444
ENSG00000140694homo_sapiensENSP0000038791171.674561.0329oryzias_javanicusENSOJAP0000000257279.376167.591
ENSG00000140694homo_sapiensENSP0000038791174.804463.5368amphilophus_citrinellusENSACIP0000000097073.879462.7512
ENSG00000140694homo_sapiensENSP0000038791181.533670.1095dicentrarchus_labraxENSDLAP0000505366476.058465.4015
ENSG00000140694homo_sapiensENSP0000038791169.170659.6244amphiprion_perculaENSAPEP0000001505384.836973.1286
ENSG00000140694homo_sapiensENSP0000038791180.907768.7011oryzias_sinensisENSOSIP0000004425277.279565.6203
ENSG00000140694homo_sapiensENSP0000038791190.297383.2551pelodiscus_sinensisENSPSIP0000001697690.156283.125
ENSG00000140694homo_sapiensENSP0000038791191.862385.133gopherus_evgoodeiENSGEVP0000502114192.150785.4003
ENSG00000140694homo_sapiensENSP0000038791186.854578.7167chelonoidis_abingdoniiENSCABP0000002898287.677779.4629
ENSG00000140694homo_sapiensENSP0000038791181.690170.266seriola_dumeriliENSSDUP0000001999876.093365.4519
ENSG00000140694homo_sapiensENSP0000038791180.438268.2316cottoperca_gobioENSCGOP0000000949075.811264.3068
ENSG00000140694homo_sapiensENSP0000038791183.098675.4304struthio_camelus_australisENSSCUP0000002193991.868583.391
ENSG00000140694homo_sapiensENSP0000038791183.098675.1174anser_brachyrhynchusENSABRP0000001146280.211572.5076
ENSG00000140694homo_sapiensENSP0000038791177.621367.2926gasterosteus_aculeatusENSGACP0000002578079.614869.0209
ENSG00000140694homo_sapiensENSP0000038791176.525863.8498cynoglossus_semilaevisENSCSEP0000000316370.664758.9595
ENSG00000140694homo_sapiensENSP0000038791181.377269.0141poecilia_formosaENSPFOP0000001302276.134764.5681
ENSG00000140694homo_sapiensENSP0000038791182.003170.4225myripristis_murdjanENSMMDP0000500135276.496465.6934
ENSG00000140694homo_sapiensENSP0000038791181.220768.8576sander_luciopercaENSSLUP0000000209676.888965.1852
ENSG00000140694homo_sapiensENSP0000038791192.175383.8811strigops_habroptilaENSSHBP0000500528792.319784.0125
ENSG00000140694homo_sapiensENSP0000038791180.907769.6401amphiprion_ocellarisENSAOCP0000000060175.364464.8688
ENSG00000140694homo_sapiensENSP0000038791156.96451.6432terrapene_carolina_triunguisENSTMTP0000003045584.064776.2125
ENSG00000140694homo_sapiensENSP0000038791131.924929.2645terrapene_carolina_triunguisENSTMTP0000001585495.327187.3832
ENSG00000140694homo_sapiensENSP0000038791116.901413.302hucho_huchoENSHHUP0000002280083.076965.3846
ENSG00000140694homo_sapiensENSP0000038791124.256718.3099hucho_huchoENSHHUP0000006466474.879256.5217
ENSG00000140694homo_sapiensENSP0000038791153.990644.1315hucho_huchoENSHHUP0000000357568.588556.0636
ENSG00000140694homo_sapiensENSP0000038791181.220769.7966betta_splendensENSBSLP0000000232275.766465.1095
ENSG00000140694homo_sapiensENSP0000038791172.45761.8153pygocentrus_nattereriENSPNAP0000003152276.782865.5058
ENSG00000140694homo_sapiensENSP0000038791182.316171.205anabas_testudineusENSATEP0000000660876.900666.5205
ENSG00000140694homo_sapiensENSP0000038791125.039122.0657seriola_lalandi_dorsalisENSSLDP0000000957985.106475
ENSG00000140694homo_sapiensENSP0000038791178.716767.7621labrus_bergyltaENSLBEP0000001198078.963967.9749
ENSG00000140694homo_sapiensENSP0000038791181.846670.4225pundamilia_nyerereiENSPNYP0000000903477.366966.568
ENSG00000140694homo_sapiensENSP0000038791181.690169.6401mastacembelus_armatusENSMAMP0000001029175.982564.7744
ENSG00000140694homo_sapiensENSP0000038791182.003170.892stegastes_partitusENSSPAP0000000936476.832866.4223
ENSG00000140694homo_sapiensENSP0000038791126.917123.4742acanthochromis_polyacanthusENSAPOP000000320398675
ENSG00000140694homo_sapiensENSP0000038791192.644884.9765aquila_chrysaetos_chrysaetosENSACCP0002001725192.7985.1097
ENSG00000140694homo_sapiensENSP0000038791180.907768.5446nothobranchius_furzeriENSNFUP0001500069875.917864.3172
ENSG00000140694homo_sapiensENSP0000038791180.281769.1706cyprinodon_variegatusENSCVAP0000002805075.552365.0957
ENSG00000140694homo_sapiensENSP0000038791181.220769.1706denticeps_clupeoidesENSDCDP0000004775277.117465.6761
ENSG00000140694homo_sapiensENSP0000038791179.655768.3881larimichthys_croceaENSLCRP0000500591573.875263.4253
ENSG00000140694homo_sapiensENSP0000038791181.220769.1706takifugu_rubripesENSTRUP0000003885472.79161.9916
ENSG00000140694homo_sapiensENSP0000038791192.331883.7246ficedula_albicollisENSFALP0000002541285.507277.5362
ENSG00000140694homo_sapiensENSP0000038791172.613562.2848hippocampus_comesENSHCOP0000002165580.836269.338
ENSG00000140694homo_sapiensENSP0000038791177.464865.1017cyprinus_carpio_carpioENSCCRP0000013184876.153864
ENSG00000140694homo_sapiensENSP0000038791190.923382.0031coturnix_japonicaENSCJPP0000501641291.496182.5197
ENSG00000140694homo_sapiensENSP0000038791181.377269.1706poecilia_latipinnaENSPLAP0000002211776.134764.7145
ENSG00000140694homo_sapiensENSP0000038791161.971849.7653sinocyclocheilus_grahamiENSSGRP0000002905059.281447.6048
ENSG00000140694homo_sapiensENSP0000038791181.846670.4225maylandia_zebraENSMZEP0000501812477.252666.4697
ENSG00000140694homo_sapiensENSP0000038791180.125268.8576tetraodon_nigroviridisENSTNIP0000001108281.528770.0637
ENSG00000140694homo_sapiensENSP0000038791183.098669.1706paramormyrops_kingsleyaeENSPKIP0000000662973.7561.3889
ENSG00000140694homo_sapiensENSP0000038791182.472670.266scleropages_formosusENSSFOP0001506299976.487765.1669
ENSG00000140694homo_sapiensENSP0000038791184.350572.9264leptobrachium_leishanenseENSLLEP0000002783384.881973.3858
ENSG00000140694homo_sapiensENSP0000038791181.846668.2316scophthalmus_maximusENSSMAP0000006384974.714362.2857
ENSG00000140694homo_sapiensENSP0000038791180.594768.5446oryzias_melastigmaENSOMEP0000003349976.636965.1786

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000184involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1IEAHomo_sapiens(9606)Process
GO:0000289involved_in nuclear-transcribed mRNA poly(A) tail shortening1IBAHomo_sapiens(9606)Process
GO:0000495involved_in box H/ACA RNA 3-end processing1IDAHomo_sapiens(9606)Process
GO:0003723enables RNA binding2HDA,IBAHomo_sapiens(9606)Function
GO:0003730enables mRNA 3-UTR binding1TASHomo_sapiens(9606)Function
GO:0004518enables nuclease activity1TASHomo_sapiens(9606)Function
GO:0004535enables poly(A)-specific ribonuclease activity3IBA,IDA,IMPHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0007292involved_in female gamete generation1TASHomo_sapiens(9606)Process
GO:0009451involved_in RNA modification1TASHomo_sapiens(9606)Process
GO:0010587involved_in miRNA catabolic process1IDAHomo_sapiens(9606)Process
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0019901enables protein kinase binding1IPIHomo_sapiens(9606)Function
GO:0032212involved_in positive regulation of telomere maintenance via telomerase1IMPHomo_sapiens(9606)Process
GO:0043169enables cation binding1IMPHomo_sapiens(9606)Function
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0051973involved_in positive regulation of telomerase activity1IMPHomo_sapiens(9606)Process
GO:0070034enables telomerase RNA binding1ICHomo_sapiens(9606)Function
GO:0071051involved_in polyadenylation-dependent snoRNA 3-end processing1IDAHomo_sapiens(9606)Process
GO:0090669involved_in telomerase RNA stabilization1IMPHomo_sapiens(9606)Process
GO:0110008involved_in ncRNA deadenylation1IMPHomo_sapiens(9606)Process
GO:1904872involved_in regulation of telomerase RNA localization to Cajal body1IMPHomo_sapiens(9606)Process

Expression