Ensembl ID ENSG00000140694 Gene ID 5073 Accession 8609
Gene Symbol PARN Alias DAN;DKCB6;PFBMFT4 Full Name poly(A)-specific ribonuclease
Position 16 : 14435700 - 14632728 Length 197029 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

ENSG00000140694 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000140694 PARN 0.53 1.96e-21 HNSC
ENSG00000140694 PARN 0.72 2.04e-66 BRCA
ENSG00000140694 PARN 0.89 1.13e-38 KICH
ENSG00000140694 PARN 0.79 7.61e-28 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000140694 PARN tumour 20379136
ENSG00000140694 PARN tumour 22041582
ENSG00000140694 PARN cancer 22834816
ENSG00000140694 PARN cancer 23236441
ENSG00000140694 PARN cancer 25049417
ENSG00000140694 PARN gastric cancer 25499764
ENSG00000140694 PARN cancers 26400160
ENSG00000140694 PARN cancer 26541675
ENSG00000140694 PARN breast cancer 28011629
ENSG00000140694 PARN breast cancer 30091053
ENSG00000140694 PARN cancer 31273937
ENSG00000140694 PARN cancer 31749682
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000140694 PARN SARC 0.028 low
ENSG00000140694 PARN STAD 0.028 high
ENSG00000140694 PARN PAAD 0.0017 high
ENSG00000140694 PARN THCA 0.0045 high
ENSG00000140694 PARN LUSC 0.05 low
ENSG00000140694 PARN HNSC 0.00028 high
ENSG00000140694 PARN READ 0.014 low
ENSG00000140694 PARN KICH 0.031 low
ENSG00000140694 PARN PCPG 0.0038 low
ENSG00000140694 PARN COAD 0.02 high
ENSG00000140694 PARN UCS 0.018 high
ENSG00000140694 PARN BLCA 0.00021 high
ENSG00000140694 PARN CESC 0.021 low
ENSG00000140694 PARN LIHC 0.0041 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency