Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000140575 Gene ID 8826 Accession 6110
Symbol IQGAP1 Alias SAR1;p195;HUMORFA01 Full Name IQ motif containing GTPase activating protein 1
Status Confidence Length 113998 bases Strand Plus strand
Position 15 : 90388242 - 90502239 RNA binding domain N.A.
Summary This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25618329 IQGAPs choreograph cellular signaling from the membrane to the nucleus. M Jessica Smith 2015-03-01 Trends in cell biology
32209469 IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production. Yosef Sabo 2020-03-24 Cell reports
30948266 Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation. Shih-Han Lee 2019-05-16 Molecular cell
22973521 Watch the GAP: Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma. A Valentina Schmidt 2012-01-01 International journal of hepatology

Transcripts

Name Transcript ID bp Protein Translation ID
IQGAP1-201 ENST00000268182 7205 1657aa ENSP00000268182
IQGAP1-218 ENST00000633485 5863 1191aa ENSP00000488618
IQGAP1-214 ENST00000560738 3602 1085aa ENSP00000453181
IQGAP1-212 ENST00000560418 559 43aa ENSP00000452723
IQGAP1-208 ENST00000559809 1201 48aa ENSP00000484647
IQGAP1-207 ENST00000559682 376 No protein -
IQGAP1-211 ENST00000560373 350 107aa ENSP00000480393
IQGAP1-202 ENST00000558003 596 No protein -
IQGAP1-213 ENST00000560733 565 No protein -
IQGAP1-209 ENST00000560020 440 No protein -
IQGAP1-210 ENST00000560218 544 No protein -
IQGAP1-203 ENST00000558491 637 No protein -
IQGAP1-216 ENST00000561132 601 No protein -
IQGAP1-217 ENST00000561461 720 No protein -
IQGAP1-205 ENST00000559031 583 No protein -
IQGAP1-206 ENST00000559674 550 No protein -
IQGAP1-204 ENST00000558957 2313 No protein -
IQGAP1-215 ENST00000561086 2871 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000140575homo_sapiensENSP0000035445176.578859.2888homo_sapiensENSP0000026818275.377258.3585
ENSG00000140575homo_sapiensENSP0000027436478.095261.8413homo_sapiensENSP0000026818274.230558.7809

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000140575homo_sapiensENSP0000026818299.818999.7586nomascus_leucogenysENSNLEP0000001466499.818999.7586
ENSG00000140575homo_sapiensENSP0000026818299.336299.2154pan_paniscusENSPPAP0000003409299.336299.2154
ENSG00000140575homo_sapiensENSP0000026818299.758699.5172pongo_abeliiENSPPYP0000000769299.758699.5172
ENSG00000140575homo_sapiensENSP0000026818299.939799.9397pan_troglodytesENSPTRP0000001274399.939799.9397
ENSG00000140575homo_sapiensENSP0000026818299.939799.9397gorilla_gorillaENSGGOP0000004932399.939799.9397
ENSG00000140575homo_sapiensENSP0000026818295.715191.551ornithorhynchus_anatinusENSOANP0000000105095.715191.551
ENSG00000140575homo_sapiensENSP0000026818295.594491.551sarcophilus_harrisiiENSSHAP0000000990896.467792.3873
ENSG00000140575homo_sapiensENSP0000026818280.024176.5238notamacropus_eugeniiENSMEUP0000000844480.120876.6163
ENSG00000140575homo_sapiensENSP0000026818284.007282.4985choloepus_hoffmanniENSCHOP0000000481885.033683.5064
ENSG00000140575homo_sapiensENSP0000026818296.318694.5685dasypus_novemcinctusENSDNOP0000000314398.701396.9079
ENSG00000140575homo_sapiensENSP0000026818275.196173.627erinaceus_europaeusENSEEUP0000000599476.068474.4811
ENSG00000140575homo_sapiensENSP0000026818291.128588.9559echinops_telfairiENSETEP0000000533892.185689.9878
ENSG00000140575homo_sapiensENSP0000026818299.396598.6723callithrix_jacchusENSCJAP0000009138699.396598.6723
ENSG00000140575homo_sapiensENSP0000026818299.879399.5172cercocebus_atysENSCATP0000004173197.582697.2288
ENSG00000140575homo_sapiensENSP0000026818299.879399.4568macaca_fascicularisENSMFAP0000002566698.629398.2122
ENSG00000140575homo_sapiensENSP0000026818298.79398.4912macaca_mulattaENSMMUP0000001559898.200497.9004
ENSG00000140575homo_sapiensENSP0000026818298.068897.7671macaca_nemestrinaENSMNEP0000001425799.877199.5698
ENSG00000140575homo_sapiensENSP0000026818280.808780.0845papio_anubisENSPANP0000001446596.400395.5364
ENSG00000140575homo_sapiensENSP0000026818216.596316.5359papio_anubisENSPANP0000002634998.920998.5611
ENSG00000140575homo_sapiensENSP0000026818298.79398.3706mandrillus_leucophaeusENSMLEP0000003633499.87899.4509
ENSG00000140575homo_sapiensENSP0000026818296.318694.5081tursiops_truncatusENSTTRP0000000475296.260694.4511
ENSG00000140575homo_sapiensENSP0000026818296.741195.2323vulpes_vulpesENSVVUP0000000832598.524996.9883
ENSG00000140575homo_sapiensENSP0000026818297.948195.8358mus_spretusMGP_SPRETEiJ_P008375897.948195.8358
ENSG00000140575homo_sapiensENSP0000026818298.732797.4049equus_asinusENSEASP0000500967898.732797.4049
ENSG00000140575homo_sapiensENSP0000026818298.310296.379capra_hircusENSCHIP0000000618198.310296.379
ENSG00000140575homo_sapiensENSP0000026818295.534193.4822loxodonta_africanaENSLAFP0000001405295.823293.7651
ENSG00000140575homo_sapiensENSP0000026818297.344694.9909panthera_leoENSPLOP0000002490694.217391.9393
ENSG00000140575homo_sapiensENSP0000026818297.887795.8962ailuropoda_melanoleucaENSAMEP0000004126698.124696.1283
ENSG00000140575homo_sapiensENSP0000026818297.646395.4134bos_indicus_hybridENSBIXP0000503677394.619992.4561
ENSG00000140575homo_sapiensENSP0000026818298.491296.7411oryctolagus_cuniculusENSOCUP0000002634094.499192.8199
ENSG00000140575homo_sapiensENSP0000026818298.310296.7411equus_caballusENSECAP0000003984288.101786.6955
ENSG00000140575homo_sapiensENSP0000026818270.368169.2818canis_lupus_familiarisENSCAFP0084500368297.900996.3896
ENSG00000140575homo_sapiensENSP0000026818298.672396.5601panthera_pardusENSPPRP0000000173498.672396.5601
ENSG00000140575homo_sapiensENSP0000026818299.034497.7671marmota_marmota_marmotaENSMMMP0000002185399.034497.7671
ENSG00000140575homo_sapiensENSP0000026818298.611997.0428balaenoptera_musculusENSBMSP0001000283398.731197.1601
ENSG00000140575homo_sapiensENSP0000026818294.749592.939cavia_porcellusENSCPOP0000001259997.941496.0699
ENSG00000140575homo_sapiensENSP0000026818298.672396.6204felis_catusENSFCAP0000003483498.672396.6204
ENSG00000140575homo_sapiensENSP0000026818298.008496.1376ursus_americanusENSUAMP0000002990195.924494.0933
ENSG00000140575homo_sapiensENSP0000026818296.680792.6976monodelphis_domesticaENSMODP0000004087396.680792.6976
ENSG00000140575homo_sapiensENSP0000026818296.982595.1116bison_bison_bisonENSBBBP0000001575596.982595.1116
ENSG00000140575homo_sapiensENSP0000026818298.611996.9221monodon_monocerosENSMMNP0001500965698.611996.9221
ENSG00000140575homo_sapiensENSP0000026818298.068896.1376sus_scrofaENSSSCP0000000198495.084893.2124
ENSG00000140575homo_sapiensENSP0000026818298.913797.2842microcebus_murinusENSMICP0000001866498.913797.2842
ENSG00000140575homo_sapiensENSP0000026818298.068895.7755octodon_degusENSODEP0000002186798.12895.8333
ENSG00000140575homo_sapiensENSP0000026818298.672396.6204jaculus_jaculusENSJJAP0000002406098.672396.6204
ENSG00000140575homo_sapiensENSP0000026818297.58695.2927ovis_aries_rambouilletENSOARP0002002282994.561492.3392
ENSG00000140575homo_sapiensENSP0000026818297.58695.7755ursus_maritimusENSUMAP0000001299596.422294.6333
ENSG00000140575homo_sapiensENSP0000026818273.325372.0579ochotona_princepsENSOPRP0000000410974.175872.8938
ENSG00000140575homo_sapiensENSP0000026818298.611996.9221delphinapterus_leucasENSDLEP0000001054998.611996.9221
ENSG00000140575homo_sapiensENSP0000026818297.344695.5944physeter_catodonENSPCTP0000503142698.896497.1183
ENSG00000140575homo_sapiensENSP0000026818298.008495.9566mus_caroliMGP_CAROLIEiJ_P008040898.008495.9566
ENSG00000140575homo_sapiensENSP0000026818298.008495.9566mus_musculusENSMUSP0000012827898.008495.9566
ENSG00000140575homo_sapiensENSP0000026818298.310295.7755dipodomys_ordiiENSDORP0000000826798.310295.7755
ENSG00000140575homo_sapiensENSP0000026818296.922195.172mustela_putorius_furoENSMPUP0000001552098.709396.9269
ENSG00000140575homo_sapiensENSP0000026818299.396598.6723aotus_nancymaaeENSANAP0000001531199.396598.6723
ENSG00000140575homo_sapiensENSP0000026818298.672397.7671saimiri_boliviensis_boliviensisENSSBOP0000001413097.728696.832
ENSG00000140575homo_sapiensENSP0000026818288.292186.4816vicugna_pacosENSVPAP0000000007690.532288.6757
ENSG00000140575homo_sapiensENSP0000026818299.879399.5172chlorocebus_sabaeusENSCSAP0000001306899.879399.5172
ENSG00000140575homo_sapiensENSP0000026818291.309689.9819tupaia_belangeriENSTBEP0000000323994.326792.9551
ENSG00000140575homo_sapiensENSP0000026818298.672396.4997mesocricetus_auratusENSMAUP0000000614598.672396.4997
ENSG00000140575homo_sapiensENSP0000026818298.491296.8014phocoena_sinusENSPSNP0000000138098.491296.8014
ENSG00000140575homo_sapiensENSP0000026818298.853397.1636camelus_dromedariusENSCDRP0000501848998.853397.1636
ENSG00000140575homo_sapiensENSP0000026818298.249896.9825carlito_syrichtaENSTSYP0000002962798.249896.9825
ENSG00000140575homo_sapiensENSP0000026818298.068895.7755panthera_tigris_altaicaENSPTIP0000001501397.363795.0869
ENSG00000140575homo_sapiensENSP0000026818298.008495.9566rattus_norvegicusENSRNOP0000001802198.008495.9566
ENSG00000140575homo_sapiensENSP0000026818298.79397.586prolemur_simusENSPSMP0000001746098.79397.586
ENSG00000140575homo_sapiensENSP0000026818298.79396.4997microtus_ochrogasterENSMOCP0000000892898.673996.3834
ENSG00000140575homo_sapiensENSP0000026818297.948195.0513sorex_araneusENSSARP0000001300497.948195.0513
ENSG00000140575homo_sapiensENSP0000026818262.401960.5311peromyscus_maniculatus_bairdiiENSPEMP0000003468196.998194.0901
ENSG00000140575homo_sapiensENSP0000026818298.672396.379peromyscus_maniculatus_bairdiiENSPEMP0000002002898.672396.379
ENSG00000140575homo_sapiensENSP0000026818296.620494.7495bos_mutusENSBMUP0000000945398.40296.4966
ENSG00000140575homo_sapiensENSP0000026818297.344695.0513mus_spicilegusENSMSIP0000000279895.500393.2504
ENSG00000140575homo_sapiensENSP0000026818298.672396.3186cricetulus_griseus_chok1gshdENSCGRP0000101860298.672396.3186
ENSG00000140575homo_sapiensENSP0000026818283.584882.5588pteropus_vampyrusENSPVAP0000001127391.298690.178
ENSG00000140575homo_sapiensENSP0000026818270.00668.5576myotis_lucifugusENSMLUP0000002219895.788693.8068
ENSG00000140575homo_sapiensENSP0000026818282.015780.3259myotis_lucifugusENSMLUP0000000651498.335796.3097
ENSG00000140575homo_sapiensENSP0000026818296.801492.939vombatus_ursinusENSVURP0001002043796.801492.939
ENSG00000140575homo_sapiensENSP0000026818298.310296.0772rhinolophus_ferrumequinumENSRFEP0001003093198.250996.0193
ENSG00000140575homo_sapiensENSP0000026818291.249289.4387neovison_visonENSNVIP0000002087898.501696.5472
ENSG00000140575homo_sapiensENSP0000026818294.749592.758bos_taurusENSBTAP0000001736698.12596.0625
ENSG00000140575homo_sapiensENSP0000026818293.361591.4303heterocephalus_glaber_femaleENSHGLP0000001203897.973495.9468
ENSG00000140575homo_sapiensENSP0000026818296.258395.172rhinopithecus_bietiENSRBIP0000000127197.852896.7485
ENSG00000140575homo_sapiensENSP0000026818298.551697.0428canis_lupus_dingoENSCAFP0002002029398.551697.0428
ENSG00000140575homo_sapiensENSP0000026818299.155198.3102sciurus_vulgarisENSSVLP0000500965799.155198.3102
ENSG00000140575homo_sapiensENSP0000026818296.620492.6373phascolarctos_cinereusENSPCIP0000003047096.620492.6373
ENSG00000140575homo_sapiensENSP0000026818281.955380.2655procavia_capensisENSPCAP0000001142882.054480.3625
ENSG00000140575homo_sapiensENSP0000026818298.672397.1032nannospalax_galiliENSNGAP0000001099398.672397.1032
ENSG00000140575homo_sapiensENSP0000026818298.370696.4393bos_grunniensENSBGRP0000001614198.370696.4393
ENSG00000140575homo_sapiensENSP0000026818298.068896.1979chinchilla_lanigeraENSCLAP0000001917598.009796.1399
ENSG00000140575homo_sapiensENSP0000026818298.430996.3186cervus_hanglu_yarkandensisENSCHYP0000002960198.430996.3186
ENSG00000140575homo_sapiensENSP0000026818295.835894.2667catagonus_wagneriENSCWAP0000001655396.476394.8967
ENSG00000140575homo_sapiensENSP0000026818299.034497.8877ictidomys_tridecemlineatusENSSTOP0000002748199.034497.8877
ENSG00000140575homo_sapiensENSP0000026818298.732797.3446otolemur_garnettiiENSOGAP0000000563697.32395.9548
ENSG00000140575homo_sapiensENSP0000026818298.913797.8877cebus_imitatorENSCCAP0000003092999.514398.4821
ENSG00000140575homo_sapiensENSP0000026818298.430997.0428urocitellus_parryiiENSUPAP0001001876497.840496.4607
ENSG00000140575homo_sapiensENSP0000026818298.189596.3186moschus_moschiferusENSMMSP0000003136698.189596.3186
ENSG00000140575homo_sapiensENSP0000026818299.818999.3362rhinopithecus_roxellanaENSRROP0000002497197.523697.0519
ENSG00000140575homo_sapiensENSP0000026818298.068895.8962mus_pahariMGP_PahariEiJ_P001725798.068895.8962
ENSG00000140575homo_sapiensENSP0000026818283.464182.1364propithecus_coquereliENSPCOP0000000197098.785797.2143
ENSG00000140575homo_sapiensENSP0000026818241.279423.7779caenorhabditis_elegansF09C3.1.149.173328.3249
ENSG00000140575homo_sapiensENSP0000026818215.208211.8286ciona_intestinalisENSCINP0000003532273.469457.1429
ENSG00000140575homo_sapiensENSP0000026818223.777917.6826ciona_intestinalisENSCINP0000000141871.766853.3698
ENSG00000140575homo_sapiensENSP0000026818278.636162.4019petromyzon_marinusENSPMAP0000001024478.352462.1768
ENSG00000140575homo_sapiensENSP0000026818267.954153.2891eptatretus_burgeriENSEBUP0000000809875.67259.3414
ENSG00000140575homo_sapiensENSP0000026818289.438778.8171callorhinchus_miliiENSCMIP0000002256388.266877.7844
ENSG00000140575homo_sapiensENSP0000026818291.007882.4381latimeria_chalumnaeENSLACP0000000326890.95382.3884
ENSG00000140575homo_sapiensENSP0000026818288.774979.7224lepisosteus_oculatusENSLOCP0000001746288.828579.7705
ENSG00000140575homo_sapiensENSP0000026818285.274674.3512clupea_harengusENSCHAP0000004228782.776872.1734
ENSG00000140575homo_sapiensENSP0000026818287.386877.0066danio_rerioENSDARP0000009870487.492477.0997
ENSG00000140575homo_sapiensENSP0000026818286.300576.4635carassius_auratusENSCARP0000002205486.248576.4174
ENSG00000140575homo_sapiensENSP0000026818286.360976.2824carassius_auratusENSCARP0000007422584.976275.0594
ENSG00000140575homo_sapiensENSP0000026818278.575770.3078astyanax_mexicanusENSAMXP0000000787988.331179.0366
ENSG00000140575homo_sapiensENSP0000026818286.360976.3428ictalurus_punctatusENSIPUP0000003402384.875475.0297
ENSG00000140575homo_sapiensENSP0000026818286.662676.5842esox_luciusENSELUP0000004588586.50676.4458
ENSG00000140575homo_sapiensENSP0000026818238.382632.6494electrophorus_electricusENSEEEP0000003727379.301767.4564
ENSG00000140575homo_sapiensENSP0000026818254.677148.1593electrophorus_electricusENSEEEP0000004222867.160959.1549
ENSG00000140575homo_sapiensENSP0000026818286.90477.067oncorhynchus_kisutchENSOKIP0000511241186.330976.5588
ENSG00000140575homo_sapiensENSP0000026818265.781557.6343oncorhynchus_kisutchENSOKIP0000510017783.910773.5181
ENSG00000140575homo_sapiensENSP0000026818287.145477.3084oncorhynchus_mykissENSOMYP0000012979287.198177.3551
ENSG00000140575homo_sapiensENSP0000026818287.085177.248oncorhynchus_mykissENSOMYP0000011088487.137777.2947
ENSG00000140575homo_sapiensENSP0000026818286.481676.5842salmo_salarENSSSAP0000001343785.654575.8518
ENSG00000140575homo_sapiensENSP0000026818286.421276.6445salmo_salarENSSSAP0000004509185.594775.9115
ENSG00000140575homo_sapiensENSP0000026818286.360976.3428salmo_truttaENSSTUP0000004131385.127975.2528
ENSG00000140575homo_sapiensENSP0000026818286.240276.4031salmo_truttaENSSTUP0000010991486.188276.3571
ENSG00000140575homo_sapiensENSP0000026818284.429773.9891gadus_morhuaENSGMOP0000002283484.531774.0786
ENSG00000140575homo_sapiensENSP0000026818278.575767.9541fundulus_heteroclitusENSFHEP0000003162182.877271.6741
ENSG00000140575homo_sapiensENSP0000026818284.610773.8684poecilia_reticulataENSPREP0000002554685.592274.7253
ENSG00000140575homo_sapiensENSP0000026818286.662675.7393xiphophorus_maculatusENSXMAP0000001826686.872475.9226
ENSG00000140575homo_sapiensENSP0000026818285.455674.4719oryzias_latipesENSORLP0000003112785.249874.2926
ENSG00000140575homo_sapiensENSP0000026818287.205875.6789cyclopterus_lumpusENSCLMP0000502352187.416875.8621
ENSG00000140575homo_sapiensENSP0000026818283.524473.1442oreochromis_niloticusENSONIP0000004443785.169274.5846
ENSG00000140575homo_sapiensENSP0000026818282.679573.3253haplochromis_burtoniENSHBUP0000002251389.30979.2047
ENSG00000140575homo_sapiensENSP0000026818287.567977.1877astatotilapia_callipteraENSACLP0000001173687.779877.3745
ENSG00000140575homo_sapiensENSP0000026818286.421276.041sparus_aurataENSSAUP0001003227782.583672.6644
ENSG00000140575homo_sapiensENSP0000026818286.72376.5842lates_calcariferENSLCAP0001000783386.985576.816
ENSG00000140575homo_sapiensENSP0000026818291.490682.8606xenopus_tropicalisENSXETP0000000278891.490682.8606
ENSG00000140575homo_sapiensENSP0000026818295.775591.2492chrysemys_picta_belliiENSCPBP0000003457895.6691.1392
ENSG00000140575homo_sapiensENSP0000026818292.275287.5679sphenodon_punctatusENSSPUP0000001791893.803789.0184
ENSG00000140575homo_sapiensENSP0000026818231.019928.0024crocodylus_porosusENSCPRP0000500607188.773880.1382
ENSG00000140575homo_sapiensENSP0000026818260.591457.2722crocodylus_porosusENSCPRP0000500572195.710290.4671
ENSG00000140575homo_sapiensENSP0000026818286.240279.2396laticauda_laticaudataENSLLTP0000001294092.973385.4262
ENSG00000140575homo_sapiensENSP0000026818291.55184.49notechis_scutatusENSNSUP0000002844090.947283.9329
ENSG00000140575homo_sapiensENSP0000026818292.75885.3953pseudonaja_textilisENSPTXP0000002203490.358683.1864
ENSG00000140575homo_sapiensENSP0000026818294.628889.0766anas_platyrhynchos_platyrhynchosENSAPLP0000002423294.571889.0229
ENSG00000140575homo_sapiensENSP0000026818294.14688.2317gallus_gallusENSGALP0001000004292.362386.5601
ENSG00000140575homo_sapiensENSP0000026818286.602380.0845meleagris_gallopavoENSMGAP0000001128693.668486.6188
ENSG00000140575homo_sapiensENSP0000026818266.928261.2553serinus_canariaENSSCAP0000002062893.193385.2941
ENSG00000140575homo_sapiensENSP0000026818215.811715.4496serinus_canariaENSSCAP0000002063796.323594.1176
ENSG00000140575homo_sapiensENSP0000026818294.266788.111parus_majorENSPMJP0000001591294.323788.1643
ENSG00000140575homo_sapiensENSP0000026818293.482285.697anolis_carolinensisENSACAP0000000358980.593173.8814
ENSG00000140575homo_sapiensENSP0000026818287.386877.0066neolamprologus_brichardiENSNBRP0000001394387.757677.3333
ENSG00000140575homo_sapiensENSP0000026818293.361585.9384naja_najaENSNNAP0000002619590.309483.129
ENSG00000140575homo_sapiensENSP0000026818290.52583.9469podarcis_muralisENSPMRP0000003608990.090183.5435
ENSG00000140575homo_sapiensENSP0000026818291.973485.7574geospiza_fortisENSGFOP0000000166492.307786.069
ENSG00000140575homo_sapiensENSP0000026818294.327188.2317taeniopygia_guttataENSTGUP0000001075194.441188.3384
ENSG00000140575homo_sapiensENSP0000026818228.364525.8298erpetoichthys_calabaricusENSECRP0000002873593.439485.0895
ENSG00000140575homo_sapiensENSP0000026818226.916123.6572erpetoichthys_calabaricusENSECRP0000003177485.277274.9522
ENSG00000140575homo_sapiensENSP0000026818284.4973.6874kryptolebias_marmoratusENSKMAP0000001934087.390876.2172
ENSG00000140575homo_sapiensENSP0000026818293.059786.723salvator_merianaeENSSMRP0000002513392.891686.5663
ENSG00000140575homo_sapiensENSP0000026818286.179876.041oryzias_javanicusENSOJAP0000001268786.440776.2712
ENSG00000140575homo_sapiensENSP0000026818282.558873.1442amphilophus_citrinellusENSACIP0000001737788.658578.5483
ENSG00000140575homo_sapiensENSP0000026818286.300575.9203dicentrarchus_labraxENSDLAP0000504836186.404876.0121
ENSG00000140575homo_sapiensENSP0000026818287.748977.3687amphiprion_perculaENSAPEP0000000025387.961377.556
ENSG00000140575homo_sapiensENSP0000026818293.421888.3524pelodiscus_sinensisENSPSIP0000001368694.217989.1053
ENSG00000140575homo_sapiensENSP0000026818293.96589.0766gopherus_evgoodeiENSGEVP0000500990294.823489.8904
ENSG00000140575homo_sapiensENSP0000026818280.205275.3772chelonoidis_abingdoniiENSCABP0000000720393.263287.6491
ENSG00000140575homo_sapiensENSP0000026818287.326576.8859seriola_dumeriliENSSDUP0000002634787.750277.2589
ENSG00000140575homo_sapiensENSP0000026818285.817775.1358cottoperca_gobioENSCGOP0000004138985.200774.5956
ENSG00000140575homo_sapiensENSP0000026818293.602988.4128struthio_camelus_australisENSSCUP0000001453895.211889.9325
ENSG00000140575homo_sapiensENSP0000026818294.628888.9559anser_brachyrhynchusENSABRP0000000440994.571888.9023
ENSG00000140575homo_sapiensENSP0000026818286.179875.0151gasterosteus_aculeatusENSGACP0000002304886.336275.1511
ENSG00000140575homo_sapiensENSP0000026818286.783375.7996cynoglossus_semilaevisENSCSEP0000001514885.646274.8064
ENSG00000140575homo_sapiensENSP0000026818245.986741.0984poecilia_formosaENSPFOP0000002235592.363682.5455
ENSG00000140575homo_sapiensENSP0000026818280.989771.1527poecilia_formosaENSPFOP0000001225887.199576.6082
ENSG00000140575homo_sapiensENSP0000026818286.300576.5842myripristis_murdjanENSMMDP0000505154185.11975.5357
ENSG00000140575homo_sapiensENSP0000026818285.576374.2909sander_luciopercaENSSLUP0000004982585.62874.3357
ENSG00000140575homo_sapiensENSP0000026818285.757479.9638strigops_habroptilaENSSHBP0000500770393.795487.4587
ENSG00000140575homo_sapiensENSP0000026818287.869677.4291amphiprion_ocellarisENSAOCP0000002984788.082377.6165
ENSG00000140575homo_sapiensENSP0000026818291.188986.6626terrapene_carolina_triunguisENSTMTP0000000566792.984688.3692
ENSG00000140575homo_sapiensENSP0000026818246.469542.5468hucho_huchoENSHHUP0000003582090.588282.9412
ENSG00000140575homo_sapiensENSP0000026818287.024777.067hucho_huchoENSHHUP0000004685687.077377.1135
ENSG00000140575homo_sapiensENSP0000026818228.364523.7779hucho_huchoENSHHUP0000006539275.441463.2424
ENSG00000140575homo_sapiensENSP0000026818287.507576.2824betta_splendensENSBSLP0000003836787.719376.467
ENSG00000140575homo_sapiensENSP0000026818288.473178.5757pygocentrus_nattereriENSPNAP0000001587588.580178.6707
ENSG00000140575homo_sapiensENSP0000026818287.688677.6101anabas_testudineusENSATEP0000002550387.900877.7979
ENSG00000140575homo_sapiensENSP0000026818266.445449.7284ciona_savignyiENSCSAVP0000001338166.325349.6386
ENSG00000140575homo_sapiensENSP0000026818236.572119.312saccharomyces_cerevisiaeYPL242C40.535121.4047
ENSG00000140575homo_sapiensENSP0000026818287.688677.067seriola_lalandi_dorsalisENSSLDP0000003216587.900877.2535
ENSG00000140575homo_sapiensENSP0000026818284.550473.6874labrus_bergyltaENSLBEP0000002223085.950974.908
ENSG00000140575homo_sapiensENSP0000026818287.507577.1273pundamilia_nyerereiENSPNYP0000000427887.932177.5015
ENSG00000140575homo_sapiensENSP0000026818287.205876.6445stegastes_partitusENSSPAP0000001456386.891276.368
ENSG00000140575homo_sapiensENSP0000026818262.281254.4357acanthochromis_polyacanthusENSAPOP0000002522886.795675.8621
ENSG00000140575homo_sapiensENSP000002681823.74173.56065acanthochromis_polyacanthusENSAPOP0000000273689.855185.5072
ENSG00000140575homo_sapiensENSP0000026818227.640324.5625acanthochromis_polyacanthusENSAPOP0000000269493.089482.7236
ENSG00000140575homo_sapiensENSP0000026818294.930688.9559aquila_chrysaetos_chrysaetosENSACCP0002000542494.873388.9023
ENSG00000140575homo_sapiensENSP0000026818286.964476.3428nothobranchius_furzeriENSNFUP0001501559885.620975.1634
ENSG00000140575homo_sapiensENSP0000026818278.877569.3422cyprinodon_variegatusENSCVAP0000000282487.77777.1659
ENSG00000140575homo_sapiensENSP0000026818284.188374.4116denticeps_clupeoidesENSDCDP0000004466381.770272.2743
ENSG00000140575homo_sapiensENSP0000026818287.326576.4635larimichthys_croceaENSLCRP0000504886987.011476.1876
ENSG00000140575homo_sapiensENSP0000026818286.541975.2565takifugu_rubripesENSTRUP0000008623485.053473.962
ENSG00000140575homo_sapiensENSP0000026818294.568588.2317ficedula_albicollisENSFALP0000001192994.625688.285
ENSG00000140575homo_sapiensENSP0000026818286.90475.6789hippocampus_comesENSHCOP0000000518287.167175.908
ENSG00000140575homo_sapiensENSP0000026818287.326577.6101cyprinus_carpio_carpioENSCCRP0000017914285.824476.2752
ENSG00000140575homo_sapiensENSP0000026818287.386877.5498cyprinus_carpio_carpioENSCCRP0000012825787.492477.6435
ENSG00000140575homo_sapiensENSP0000026818294.568588.1714coturnix_japonicaENSCJPP0000500057994.511588.1182
ENSG00000140575homo_sapiensENSP0000026818227.700724.2607poecilia_latipinnaENSPLAP0000000962792.91581.3765
ENSG00000140575homo_sapiensENSP000002681823.74173.5003poecilia_latipinnaENSPLAP0000000964689.855184.058
ENSG00000140575homo_sapiensENSP0000026818280.929471.0923poecilia_latipinnaENSPLAP0000001357587.134576.5432
ENSG00000140575homo_sapiensENSP0000026818286.360975.9807sinocyclocheilus_grahamiENSSGRP0000010336386.885276.442
ENSG00000140575homo_sapiensENSP0000026818275.558266.5661sinocyclocheilus_grahamiENSSGRP0000002558287.065476.7038
ENSG00000140575homo_sapiensENSP0000026818287.447277.1273maylandia_zebraENSMZEP0000502117687.871477.5015
ENSG00000140575homo_sapiensENSP0000026818287.145476.5842tetraodon_nigroviridisENSTNIP0000001270287.356376.7695
ENSG00000140575homo_sapiensENSP0000026818287.145479.0585paramormyrops_kingsleyaeENSPKIP0000003875887.250879.1541
ENSG00000140575homo_sapiensENSP0000026818287.326577.8515scleropages_formosusENSSFOP0001502785487.537878.0399
ENSG00000140575homo_sapiensENSP0000026818291.973483.9469leptobrachium_leishanenseENSLLEP0000002835491.973483.9469
ENSG00000140575homo_sapiensENSP0000026818285.69774.8944scophthalmus_maximusENSSMAP0000004234578.976669.0211
ENSG00000140575homo_sapiensENSP0000026818219.070617.1394oryzias_melastigmaENSOMEP0000002296484.266775.7333
ENSG00000140575homo_sapiensENSP0000026818240.193136.3911oryzias_melastigmaENSOMEP0000000190592.243883.518

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001726located_in ruffle1IDAHomo_sapiens(9606)Component
GO:0001817involved_in regulation of cytokine production1IEAHomo_sapiens(9606)Process
GO:0005078enables MAP-kinase scaffold activity1IPIHomo_sapiens(9606)Function
GO:0005095enables GTPase inhibitor activity1TASHomo_sapiens(9606)Function
GO:0005096enables GTPase activator activity1IBAHomo_sapiens(9606)Function
GO:0005509enables calcium ion binding1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005516enables calmodulin binding2IBA,IDAHomo_sapiens(9606)Function
GO:0005547enables phosphatidylinositol-3,4,5-trisphosphate binding1IDAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005874located_in microtubule1IDAHomo_sapiens(9606)Component
GO:0005884located_in actin filament1TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane2IDA,TASHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0005938is_active_in cell cortex1IBAHomo_sapiens(9606)Component
GO:0007165involved_in signal transduction1TASHomo_sapiens(9606)Process
GO:0007173involved_in epidermal growth factor receptor signaling pathway2IBA,IMPHomo_sapiens(9606)Process
GO:0007346involved_in regulation of mitotic cell cycle1IMPHomo_sapiens(9606)Process
GO:0008543involved_in fibroblast growth factor receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0009898located_in cytoplasmic side of plasma membrane1IDAHomo_sapiens(9606)Component
GO:0010761involved_in fibroblast migration1IBAHomo_sapiens(9606)Process
GO:0015629colocalizes_with actin cytoskeleton1ISSHomo_sapiens(9606)Component
GO:0015630colocalizes_with microtubule cytoskeleton1ISSHomo_sapiens(9606)Component
GO:0016323located_in basolateral plasma membrane1IEAHomo_sapiens(9606)Component
GO:0016324located_in apical plasma membrane1IDAHomo_sapiens(9606)Component
GO:0016328located_in lateral plasma membrane1IEAHomo_sapiens(9606)Component
GO:0016477involved_in cell migration1IMPHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1IPIHomo_sapiens(9606)Function
GO:0019903enables protein phosphatase binding1IPIHomo_sapiens(9606)Function
GO:0019904enables protein domain specific binding1IPIHomo_sapiens(9606)Function
GO:0030424located_in axon1ISSHomo_sapiens(9606)Component
GO:0030426located_in growth cone1ISSHomo_sapiens(9606)Component
GO:0030496located_in midbody1IDAHomo_sapiens(9606)Component
GO:0030667located_in secretory granule membrane1TASHomo_sapiens(9606)Component
GO:0030864located_in cortical actin cytoskeleton1IEAHomo_sapiens(9606)Component
GO:0031267enables small GTPase binding1IPIHomo_sapiens(9606)Function
GO:0035305involved_in negative regulation of dephosphorylation1IEAHomo_sapiens(9606)Process
GO:0036057located_in slit diaphragm1ISSHomo_sapiens(9606)Component
GO:0036120involved_in cellular response to platelet-derived growth factor stimulus1IEAHomo_sapiens(9606)Process
GO:0036464located_in cytoplasmic ribonucleoprotein granule1IDAHomo_sapiens(9606)Component
GO:0043005located_in neuron projection1ISSHomo_sapiens(9606)Component
GO:0043087involved_in regulation of GTPase activity1IEAHomo_sapiens(9606)Process
GO:0043410involved_in positive regulation of MAPK cascade1IMPHomo_sapiens(9606)Process
GO:0043539enables protein serine/threonine kinase activator activity1IDAHomo_sapiens(9606)Function
GO:0044548enables S100 protein binding1IPIHomo_sapiens(9606)Function
GO:0045296enables cadherin binding1HDAHomo_sapiens(9606)Function
GO:0045860involved_in positive regulation of protein kinase activity2IBA,IMPHomo_sapiens(9606)Process
GO:0048008involved_in platelet-derived growth factor receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0051015enables actin filament binding1IBAHomo_sapiens(9606)Function
GO:0060090enables molecular adaptor activity1IDAHomo_sapiens(9606)Function
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0071277involved_in cellular response to calcium ion1IDAHomo_sapiens(9606)Process
GO:0071364involved_in cellular response to epidermal growth factor stimulus1IMPHomo_sapiens(9606)Process
GO:0072015involved_in podocyte development1ISSHomo_sapiens(9606)Process
GO:1903479involved_in mitotic actomyosin contractile ring assembly actin filament organization1IBAHomo_sapiens(9606)Process
GO:1990138involved_in neuron projection extension1IMPHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex1IEAHomo_sapiens(9606)Component

Expression