Ensembl ID ENSG00000140575 Gene ID 8826 Accession 6110
Gene Symbol IQGAP1 Alias SAR1;p195;HUMORFA01 Full Name IQ motif containing GTPase activating protein 1
Position 15 : 90388242 - 90502239 Length 113998 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]

ENSG00000140575 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000140575 IQGAP1 -0.6 1.25e-16 PRAD
ENSG00000140575 IQGAP1 -0.9 1.67e-17 UCEC
ENSG00000140575 IQGAP1 1.85 3.95e-11 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000140575 IQGAP1 tumor 10611248
ENSG00000140575 IQGAP1 endometrial cancers 11027430
ENSG00000140575 IQGAP1 gastric cancers 11275980
ENSG00000140575 IQGAP1 gastric cancer 11289714
ENSG00000140575 IQGAP1 gastric cancer 12739007
ENSG00000140575 IQGAP1 gastric cancers 15611933
ENSG00000140575 IQGAP1 ovarian cancer 15655247
ENSG00000140575 IQGAP1 lung cancer 15706411
ENSG00000140575 IQGAP1 tumors 16387427
ENSG00000140575 IQGAP1 breast cancer 16930554
ENSG00000140575 IQGAP1 cancer 16982749
ENSG00000140575 IQGAP1 cancer 17085436
ENSG00000140575 IQGAP1 cancer 17957782
ENSG00000140575 IQGAP1 tumors 18180285
ENSG00000140575 IQGAP1 gastric cancer 18246045
ENSG00000140575 IQGAP1 cancer 18492260
ENSG00000140575 IQGAP1 tumor 18541705
ENSG00000140575 IQGAP1 tumors 19036171
ENSG00000140575 IQGAP1 cancer 19269319
ENSG00000140575 IQGAP1 cancer 19433088
ENSG00000140575 IQGAP1 cancers 19454477
ENSG00000140575 IQGAP1 colorectal cancer 19856315
ENSG00000140575 IQGAP1 tumor 20127691
ENSG00000140575 IQGAP1 cancer 20530982
ENSG00000140575 IQGAP1 cancer 20875083
ENSG00000140575 IQGAP1 thyroid cancer 20959410
ENSG00000140575 IQGAP1 oligodendroglial tumors 20966545
ENSG00000140575 IQGAP1 cancer 20976168
ENSG00000140575 IQGAP1 tumor 20977743
ENSG00000140575 IQGAP1 breast cancer 21318219
ENSG00000140575 IQGAP1 gastric cancer 21537845
ENSG00000140575 IQGAP1 colon cancer 21621326
ENSG00000140575 IQGAP1 oligodendroglial tumors 21625997
ENSG00000140575 IQGAP1 breast cancer 21724847
ENSG00000140575 IQGAP1 breast cancer 22315597
ENSG00000140575 IQGAP1 cancer 22451851
ENSG00000140575 IQGAP1 cancer 22483753
ENSG00000140575 IQGAP1 cancer 22505937
ENSG00000140575 IQGAP1 cancer 22964981
ENSG00000140575 IQGAP1 tumor 22973521
ENSG00000140575 IQGAP1 breast cancer 22992742
ENSG00000140575 IQGAP1 Gastric Cancer 23145020
ENSG00000140575 IQGAP1 breast cancer 23405264
ENSG00000140575 IQGAP1 cancers 23408967
ENSG00000140575 IQGAP1 tumor 23454766
ENSG00000140575 IQGAP1 GBM 23510696
ENSG00000140575 IQGAP1 breast cancer 23525242
ENSG00000140575 IQGAP1 tumors 23603816
ENSG00000140575 IQGAP1 tumor 23629919
ENSG00000140575 IQGAP1 cancer 23639840
ENSG00000140575 IQGAP1 cancer 23763998
ENSG00000140575 IQGAP1 tumors 23974104
ENSG00000140575 IQGAP1 cancer 24019536
ENSG00000140575 IQGAP1 pancreatic cancer 24103286
ENSG00000140575 IQGAP1 breast cancer 24155777
ENSG00000140575 IQGAP1 tumors 24252689
ENSG00000140575 IQGAP1 breast cancer 24550401
ENSG00000140575 IQGAP1 tumors 24649059
ENSG00000140575 IQGAP1 cancer 24763314
ENSG00000140575 IQGAP1 tumor 24800852
ENSG00000140575 IQGAP1 tumor 24849319
ENSG00000140575 IQGAP1 tumor 24998570
ENSG00000140575 IQGAP1 colorectal cancer 25044025
ENSG00000140575 IQGAP1 cancer 25070212
ENSG00000140575 IQGAP1 cancers 25305455
ENSG00000140575 IQGAP1 gastric cancer 25398317
ENSG00000140575 IQGAP1 non-small cell lung cancer 25436461
ENSG00000140575 IQGAP1 tumor 25531322
ENSG00000140575 IQGAP1 tumors 25563226
ENSG00000140575 IQGAP1 Epithelial Ovarian Cancer 25675045
ENSG00000140575 IQGAP1 tumor 25848980
ENSG00000140575 IQGAP1 prostate cancer 25924234
ENSG00000140575 IQGAP1 cancer 26033452
ENSG00000140575 IQGAP1 thyroid cancer 26046126
ENSG00000140575 IQGAP1 Tumors 26078295
ENSG00000140575 IQGAP1 cancer 26195666
ENSG00000140575 IQGAP1 Tumor 26252773
ENSG00000140575 IQGAP1 breast cancer 26398880
ENSG00000140575 IQGAP1 cancer 26464624
ENSG00000140575 IQGAP1 breast cancer 26919099
ENSG00000140575 IQGAP1 endometrial cancer 26934121
ENSG00000140575 IQGAP1 pancreatic cancer 27100492
ENSG00000140575 IQGAP1 cancer 27264994
ENSG00000140575 IQGAP1 thyroid cancer 27470543
ENSG00000140575 IQGAP1 cancer 27486972
ENSG00000140575 IQGAP1 tumor 27488117
ENSG00000140575 IQGAP1 tumor 27573425
ENSG00000140575 IQGAP1 cancer 27729612
ENSG00000140575 IQGAP1 cancer 27870828
ENSG00000140575 IQGAP1 cancer 27880081
ENSG00000140575 IQGAP1 tumor 28035419
ENSG00000140575 IQGAP1 Tumor 28098764
ENSG00000140575 IQGAP1 gastric cancer 28223821
ENSG00000140575 IQGAP1 cancer 28259970
ENSG00000140575 IQGAP1 cancer 28282856
ENSG00000140575 IQGAP1 thyroid cancer 28352188
ENSG00000140575 IQGAP1 cancer 28396345
ENSG00000140575 IQGAP1 cancer 28441737
ENSG00000140575 IQGAP1 cancers 28445541
ENSG00000140575 IQGAP1 gastric cancer 28567184
ENSG00000140575 IQGAP1 Pancreatic Cancer 28720574
ENSG00000140575 IQGAP1 colon cancer 28739799
ENSG00000140575 IQGAP1 tumors 28928806
ENSG00000140575 IQGAP1 colorectal cancer 28987385
ENSG00000140575 IQGAP1 cancer 29065872
ENSG00000140575 IQGAP1 cancers 29073199
ENSG00000140575 IQGAP1 cancers 29097261
ENSG00000140575 IQGAP1 tumor 29125886
ENSG00000140575 IQGAP1 tumor 29240845
ENSG00000140575 IQGAP1 breast cancer 29262632
ENSG00000140575 IQGAP1 tumour 29679050
ENSG00000140575 IQGAP1 tumor 29731875
ENSG00000140575 IQGAP1 colon cancer 29745605
ENSG00000140575 IQGAP1 Breast Cancer 29779034
ENSG00000140575 IQGAP1 cancers 29846864
ENSG00000140575 IQGAP1 tumors 29892299
ENSG00000140575 IQGAP1 tumor 29900122
ENSG00000140575 IQGAP1 tumors 30001383
ENSG00000140575 IQGAP1 tumor 30015941
ENSG00000140575 IQGAP1 pancreatic cancer 30201002
ENSG00000140575 IQGAP1 colorectal cancer 30272357
ENSG00000140575 IQGAP1 ovarian cancer 30367951
ENSG00000140575 IQGAP1 tumor 30540680
ENSG00000140575 IQGAP1 tumors 30794467
ENSG00000140575 IQGAP1 tumor 30854040
ENSG00000140575 IQGAP1 gastric cancer 31090961
ENSG00000140575 IQGAP1 pancreatic cancer 31101875
ENSG00000140575 IQGAP1 cancer 31235839
ENSG00000140575 IQGAP1 tumors 31389160
ENSG00000140575 IQGAP1 Lung Cancer 31431460
ENSG00000140575 IQGAP1 cancer 31597661
ENSG00000140575 IQGAP1 cancer 31640697
ENSG00000140575 IQGAP1 oral cancer 31798960
ENSG00000140575 IQGAP1 cancers 31836492
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000140575 IQGAP1 SARC 0.047 low
ENSG00000140575 IQGAP1 STAD 0.021 high
ENSG00000140575 IQGAP1 UCEC 0.019 low
ENSG00000140575 IQGAP1 ACC 0.045 high
ENSG00000140575 IQGAP1 HNSC 0.049 high
ENSG00000140575 IQGAP1 KIRP 0.019 high
ENSG00000140575 IQGAP1 KICH 0.0024 high
ENSG00000140575 IQGAP1 THYM 0.044 low
ENSG00000140575 IQGAP1 TGCT 0.0086 high
ENSG00000140575 IQGAP1 SKCM 0.00018 low
ENSG00000140575 IQGAP1 CESC 0.036 low
ENSG00000140575 IQGAP1 LIHC 0.049 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000140575 IQGAP1 LUSC Amp 0.871041 0.199562 0.433690 0.333333
ENSG00000140575 IQGAP1 CESC Amp 1.777701 0.171260 0.544559 0.257627
ENSG00000140575 IQGAP1 ESCA Amp 0.718383 0.260744 0.527982 0.315217
ENSG00000140575 IQGAP1 SKCM Amp 3.667812 0.208229 0.537942 0.326975
ENSG00000140575 IQGAP1 BRCA Amp 2.927570 0.184281 0.618170 0.167593
ENSG00000140575 IQGAP1 STAD Amp 10.140870 0.330339 0.677116 0.242630
ENSG00000140575 IQGAP1 OV Amp 0.998452 0.339412 0.673122 0.243523