Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000139546 Gene ID 6895 Accession 11569
Symbol TARBP2 Alias LOQS;TRBP;TRBP1;TRBP2 Full Name TARBP2 subunit of RISC loading complex
Status Confidence Length 5511 bases Strand Plus strand
Position 12 : 53500921 - 53506431 RNA binding domain DND1_DSRM , dsrm
Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000377885 dsrm PF00035 2.3e-33 1
ENSP00000377885 dsrm PF00035 2.3e-33 2
ENSP00000416077 dsrm PF00035 2.3e-33 1
ENSP00000416077 dsrm PF00035 2.3e-33 2
ENSP00000266987 dsrm PF00035 3e-33 1
ENSP00000266987 dsrm PF00035 3e-33 2
ENSP00000447767 dsrm PF00035 1.5e-23 1
ENSP00000447767 dsrm PF00035 1.5e-23 2
ENSP00000458011 dsrm PF00035 1.1e-15 1
ENSP00000458011 DND1_DSRM PF14709 1.2e-05 2
ENSP00000448199 dsrm PF00035 1.9e-15 1
ENSP00000448199 DND1_DSRM PF14709 2e-05 2
ENSP00000448943 dsrm PF00035 1.2e-14 1
ENSP00000447262 dsrm PF00035 1.3e-14 1
ENSP00000450320 dsrm PF00035 2.1e-14 1
ENSP00000448948 dsrm PF00035 6.3e-14 1
ENSP00000447993 dsrm PF00035 1.3e-13 1
ENSP00000449537 dsrm PF00035 1.4e-06 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
27980417 Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer. Ryoko Oi 2016-01-01 Breast cancer : basic and clinical research
32305960 Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway. Guangnan Chen 2020-04-17 Aging
30759864 TARBP2-Enhanced Resistance during Tamoxifen Treatment in Breast Cancer. Ming-Yang Wang 2019-02-12 Cancers
35328439 New Insights on Metabolic and Genetic Basis of Migraine: Novel Impact on Management and Therapeutical Approach. Irene Simonetta 2022-03-11 International journal of molecular sciences
26660531 Gene-based pleiotropy across migraine with aura and migraine without aura patient groups. Huiying Zhao 2016-06-01 Cephalalgia : an international journal of headache
35008634 TARBP2 Suppresses Ubiquitin-Proteasomal Degradation of HIF-1α in Breast Cancer. Jie-Ning Li 2021-12-24 International journal of molecular sciences
23728460 Control of metastatic progression by microRNA regulatory networks. Nora Pencheva 2013-06-01 Nature cell biology
34174402 Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation. Benedicth Ukhueduan 2021-08-01 The international journal of biochemistry & cell biology
28174252 TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway. Sung-Hyun Byun 2017-03-01 Development (Cambridge, England)
31300274 Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay. Lisa Fish 2019-09-05 Molecular cell
32038627 Role of Host and Pathogen-Derived MicroRNAs in Immune Regulation During Infectious and Inflammatory Diseases. Kumari Chandan 2019-01-01 Frontiers in immunology
26229239 The Transcription Factor ZNF395 Is Required for the Maximal Hypoxic Induction of Proinflammatory Cytokines in U87-MG Cells. Christine Herwartz 2015-01-01 Mediators of inflammation
36555797 Challenging Cellular Homeostasis: Spatial and Temporal Regulation of miRNAs. Naomi N van 2022-12-18 International journal of molecular sciences
35813828 Non-Coding RNAs: New Dawn for Diabetes Mellitus Induced Erectile Dysfunction. Wenchao Xu 2022-01-01 Frontiers in molecular biosciences
32318100 ZNF143 in Chromatin Looping and Gene Regulation. Bingyu Ye 2020-01-01 Frontiers in genetics
35745855 A Historical Review of Brain Drug Delivery. M William Pardridge 2022-06-16 Pharmaceutics
35093087 Dynamic regulation and functions of mRNA m6A modification. Shanshan Wang 2022-01-29 Cancer cell international
37310138 Dicer structure and function: conserved and evolving features. David Zapletal 2023-07-05 EMBO reports
34249676 Loss of TARBP2 Drives the Progression of Hepatocellular Carcinoma via miR-145-SERPINE1 Axis. Li-Man Li 2021-01-01 Frontiers in oncology
26948382 A designed recombinant fusion protein for targeted delivery of siRNA to the mouse brain. Mohamed Mohamed Haroon 2016-04-28 Journal of controlled release : official journal of the Controlled Release Society
35562351 TARBP2-stablized SNHG7 regulates blood-brain barrier permeability by acting as a competing endogenous RNA to miR-17-5p/NFATC3 in Aβ-microenvironment. Hao Ning 2022-05-13 Cell death & disease
25043050 Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins. Hani Goodarzi 2014-09-11 Nature
34795295 GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain. Hassan Ghulam Dar 2021-11-18 Nature communications
33484209 TARBP2 promotes tumor angiogenesis and metastasis by destabilizing antiangiogenic factor mRNAs. Meicen Zhou 2021-03-01 Cancer science
28369725 RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma. C Hans Lee 2017-04-01 British journal of haematology

Transcripts

Name Transcript ID bp Protein Translation ID
TARBP2-214 ENST00000550147 1855 113aa ENSP00000450320
TARBP2-203 ENST00000456234 1368 345aa ENSP00000416077
TARBP2-220 ENST00000552857 916 165aa ENSP00000449537
TARBP2-201 ENST00000266987 1510 366aa ENSP00000266987
TARBP2-221 ENST00000710362 1510 376aa ENSP00000518233
TARBP2-212 ENST00000549610 1116 No protein -
TARBP2-205 ENST00000546889 1063 No protein -
TARBP2-209 ENST00000548971 1493 94aa ENSP00000447993
TARBP2-207 ENST00000547388 576 No protein -
TARBP2-218 ENST00000552650 954 No protein -
TARBP2-206 ENST00000547064 759 196aa ENSP00000448199
TARBP2-217 ENST00000551741 992 92aa ENSP00000447262
TARBP2-219 ENST00000552817 668 160aa ENSP00000458011
TARBP2-210 ENST00000549028 557 No protein -
TARBP2-211 ENST00000549572 1514 187aa ENSP00000448948
TARBP2-213 ENST00000549679 1466 88aa ENSP00000448943
TARBP2-202 ENST00000394357 1402 345aa ENSP00000377885
TARBP2-215 ENST00000550407 1132 227aa ENSP00000447767
TARBP2-216 ENST00000551157 1008 No protein -
TARBP2-208 ENST00000547541 430 No protein -
TARBP2-204 ENST00000546763 846 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000139546homo_sapiensENSP000004681818.240535.23385homo_sapiensENSP0000026698720.218612.8415
ENSG00000139546homo_sapiensENSP0000045750116.53397.56972homo_sapiensENSP0000026698722.677610.3825
ENSG00000139546homo_sapiensENSP000002650699.217885.02793homo_sapiensENSP0000026698727.049214.7541
ENSG00000139546homo_sapiensENSP0000032134711.30956.84524homo_sapiensENSP0000026698720.76512.5683
ENSG00000139546homo_sapiensENSP0000035501121.538512.5641homo_sapiensENSP0000026698722.950813.388
ENSG00000139546homo_sapiensENSP0000001587717.11849.55777homo_sapiensENSP0000026698732.786918.306
ENSG00000139546homo_sapiensENSP000002629619.478175.53781homo_sapiensENSP0000026698724.316914.2077
ENSG00000139546homo_sapiensENSP0000032515314.75138.57633homo_sapiensENSP0000026698723.497313.6612
ENSG00000139546homo_sapiensENSP0000029651317.70838.85417homo_sapiensENSP0000026698727.868913.9344
ENSG00000139546homo_sapiensENSP0000036092215.59798.83882homo_sapiensENSP0000026698724.590213.9344
ENSG00000139546homo_sapiensENSP0000037071316.10289.33694homo_sapiensENSP0000026698732.513718.8525
ENSG00000139546homo_sapiensENSP0000031817660.063946.3259homo_sapiensENSP0000026698751.366139.6175
ENSG00000139546homo_sapiensENSP0000042875617.543910.1754homo_sapiensENSP0000026698727.322415.847
ENSG00000139546homo_sapiensENSP0000035745910.03265.79119homo_sapiensENSP0000026698733.606619.3989

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000139546homo_sapiensENSP00000266987100100nomascus_leucogenysENSNLEP00000021465100100
ENSG00000139546homo_sapiensENSP00000266987100100pan_paniscusENSPPAP00000014549100100
ENSG00000139546homo_sapiensENSP0000026698799.726899.7268pongo_abeliiENSPPYP0000000522799.726899.7268
ENSG00000139546homo_sapiensENSP00000266987100100pan_troglodytesENSPTRP00000050292100100
ENSG00000139546homo_sapiensENSP0000026698799.726899.7268gorilla_gorillaENSGGOP0000001232999.726899.7268
ENSG00000139546homo_sapiensENSP0000026698781.69474.8634ornithorhynchus_anatinusENSOANP0000003699290.606183.0303
ENSG00000139546homo_sapiensENSP0000026698785.519183.0601sarcophilus_harrisiiENSSHAP0000000815285.054382.6087
ENSG00000139546homo_sapiensENSP0000026698784.972782.7869notamacropus_eugeniiENSMEUP0000000175293.957791.5408
ENSG00000139546homo_sapiensENSP0000026698753.278752.7322choloepus_hoffmanniENSCHOP0000000907867.708367.0139
ENSG00000139546homo_sapiensENSP0000026698796.994596.1749dasypus_novemcinctusENSDNOP0000000166696.994596.1749
ENSG00000139546homo_sapiensENSP0000026698737.704937.7049erinaceus_europaeusENSEEUP0000000157347.422747.4227
ENSG00000139546homo_sapiensENSP0000026698774.043772.9508erinaceus_europaeusENSEEUP0000000101086.581585.3035
ENSG00000139546homo_sapiensENSP0000026698781.967280.3279echinops_telfairiENSETEP0000000199981.967280.3279
ENSG00000139546homo_sapiensENSP0000026698796.721395.3552callithrix_jacchusENSCJAP0000003471391.948190.6494
ENSG00000139546homo_sapiensENSP0000026698799.726899.4536cercocebus_atysENSCATP0000000873399.726899.4536
ENSG00000139546homo_sapiensENSP0000026698799.726899.4536macaca_fascicularisENSMFAP0000001124099.726899.4536
ENSG00000139546homo_sapiensENSP0000026698799.726899.4536macaca_mulattaENSMMUP0000002433889.242188.9976
ENSG00000139546homo_sapiensENSP0000026698799.726899.4536macaca_nemestrinaENSMNEP0000002602999.726899.4536
ENSG00000139546homo_sapiensENSP0000026698799.726899.4536papio_anubisENSPANP0000001207299.726899.4536
ENSG00000139546homo_sapiensENSP0000026698799.726899.4536mandrillus_leucophaeusENSMLEP0000001080599.726899.4536
ENSG00000139546homo_sapiensENSP0000026698797.54195.9016tursiops_truncatusENSTTRP0000001628097.54195.9016
ENSG00000139546homo_sapiensENSP0000026698798.360798.0874vulpes_vulpesENSVVUP0000003951398.360798.0874
ENSG00000139546homo_sapiensENSP0000026698795.628493.9891mus_spretusMGP_SPRETEiJ_P004185795.890494.2466
ENSG00000139546homo_sapiensENSP0000026698798.360798.0874equus_asinusENSEASP0000501441698.360798.0874
ENSG00000139546homo_sapiensENSP0000026698796.994595.3552capra_hircusENSCHIP0000003181395.945994.3243
ENSG00000139546homo_sapiensENSP0000026698768.032865.3005loxodonta_africanaENSLAFP0000002193788.297984.7518
ENSG00000139546homo_sapiensENSP0000026698797.814296.9945panthera_leoENSPLOP0000000634697.814296.9945
ENSG00000139546homo_sapiensENSP0000026698792.349790.7104ailuropoda_melanoleucaENSAMEP0000001327597.97196.2319
ENSG00000139546homo_sapiensENSP0000026698798.360797.541bos_indicus_hybridENSBIXP0000503335098.360797.541
ENSG00000139546homo_sapiensENSP0000026698795.08293.1694oryctolagus_cuniculusENSOCUP0000000493695.08293.1694
ENSG00000139546homo_sapiensENSP0000026698794.535593.7158equus_caballusENSECAP0000000974179.176278.4897
ENSG00000139546homo_sapiensENSP0000026698798.360798.0874canis_lupus_familiarisENSCAFP0084502635798.360798.0874
ENSG00000139546homo_sapiensENSP0000026698798.087497.2678panthera_pardusENSPPRP0000000389698.087497.2678
ENSG00000139546homo_sapiensENSP0000026698797.267896.1749marmota_marmota_marmotaENSMMMP0000000364797.267896.1749
ENSG00000139546homo_sapiensENSP0000026698798.360797.2678balaenoptera_musculusENSBMSP0001001200998.360797.2678
ENSG00000139546homo_sapiensENSP0000026698794.262393.4426cavia_porcellusENSCPOP0000003098294.262393.4426
ENSG00000139546homo_sapiensENSP0000026698798.087497.2678felis_catusENSFCAP0000000718298.087497.2678
ENSG00000139546homo_sapiensENSP0000026698797.814296.9945ursus_americanusENSUAMP0000001102997.814296.9945
ENSG00000139546homo_sapiensENSP0000026698798.360797.541bison_bison_bisonENSBBBP0000001099698.360797.541
ENSG00000139546homo_sapiensENSP0000026698797.814296.1749monodon_monocerosENSMMNP0001502353097.814296.1749
ENSG00000139546homo_sapiensENSP0000026698798.360797.2678sus_scrofaENSSSCP0000005958698.360797.2678
ENSG00000139546homo_sapiensENSP0000026698793.169492.3497microcebus_murinusENSMICP0000004823498.840697.971
ENSG00000139546homo_sapiensENSP0000026698759.289658.7432octodon_degusENSODEP0000001820196.017795.1327
ENSG00000139546homo_sapiensENSP0000026698734.15332.7869jaculus_jaculusENSJJAP0000001089782.781579.4702
ENSG00000139546homo_sapiensENSP0000026698729.508229.235jaculus_jaculusENSJJAP0000000362099.082698.1651
ENSG00000139546homo_sapiensENSP0000026698797.814296.7213ovis_aries_rambouilletENSOARP0002002402795.212894.1489
ENSG00000139546homo_sapiensENSP0000026698797.267896.4481ursus_maritimusENSUMAP0000001421097.267896.4481
ENSG00000139546homo_sapiensENSP0000026698759.562857.6503ochotona_princepsENSOPRP0000001039496.888993.7778
ENSG00000139546homo_sapiensENSP0000026698795.355293.1694delphinapterus_leucasENSDLEP0000000483594.070191.9137
ENSG00000139546homo_sapiensENSP0000026698766.393463.6612physeter_catodonENSPCTP0000501258191.698187.9245
ENSG00000139546homo_sapiensENSP0000026698795.628493.9891mus_caroliMGP_CAROLIEiJ_P004001795.890494.2466
ENSG00000139546homo_sapiensENSP0000026698795.628493.9891mus_musculusENSMUSP0000015980593.582991.9786
ENSG00000139546homo_sapiensENSP0000026698769.398965.847dipodomys_ordiiENSDORP0000002237884.666780.3333
ENSG00000139546homo_sapiensENSP0000026698798.087496.9945mustela_putorius_furoENSMPUP0000000589398.356297.2603
ENSG00000139546homo_sapiensENSP0000026698710099.1803aotus_nancymaaeENSANAP0000003364810099.1803
ENSG00000139546homo_sapiensENSP0000026698710098.9071saimiri_boliviensis_boliviensisENSSBOP0000002157310098.9071
ENSG00000139546homo_sapiensENSP0000026698799.453699.1803chlorocebus_sabaeusENSCSAP0000000178999.453699.1803
ENSG00000139546homo_sapiensENSP0000026698746.721345.9016tupaia_belangeriENSTBEP0000001104754.458653.5032
ENSG00000139546homo_sapiensENSP0000026698795.628494.5355mesocricetus_auratusENSMAUP0000002234295.890494.7945
ENSG00000139546homo_sapiensENSP0000026698797.814296.1749phocoena_sinusENSPSNP0000000585697.814296.1749
ENSG00000139546homo_sapiensENSP0000026698798.907198.3607camelus_dromedariusENSCDRP0000500661798.907198.3607
ENSG00000139546homo_sapiensENSP0000026698798.360796.4481carlito_syrichtaENSTSYP0000002546198.360796.4481
ENSG00000139546homo_sapiensENSP0000026698791.803389.8907panthera_tigris_altaicaENSPTIP0000000573894.117692.1569
ENSG00000139546homo_sapiensENSP0000026698795.628492.3497rattus_norvegicusENSRNOP0000006132995.890492.6027
ENSG00000139546homo_sapiensENSP0000026698799.180398.3607prolemur_simusENSPSMP0000002713299.180398.3607
ENSG00000139546homo_sapiensENSP0000026698794.808792.3497microtus_ochrogasterENSMOCP0000000445095.068592.6027
ENSG00000139546homo_sapiensENSP0000026698751.639349.1803sorex_araneusENSSARP0000000092252.550
ENSG00000139546homo_sapiensENSP0000026698794.535592.6229peromyscus_maniculatus_bairdiiENSPEMP0000001450394.794592.8767
ENSG00000139546homo_sapiensENSP0000026698793.989192.8962bos_mutusENSBMUP0000002852598.285797.1429
ENSG00000139546homo_sapiensENSP0000026698774.863470.2186mus_spicilegusENSMSIP0000003007874.659470.0272
ENSG00000139546homo_sapiensENSP0000026698795.628494.2623cricetulus_griseus_chok1gshdENSCGRP0000100984095.890494.5205
ENSG00000139546homo_sapiensENSP0000026698792.076591.5301pteropus_vampyrusENSPVAP0000001158092.076591.5301
ENSG00000139546homo_sapiensENSP0000026698798.087497.2678myotis_lucifugusENSMLUP0000000913998.087497.2678
ENSG00000139546homo_sapiensENSP0000026698785.245983.0601vombatus_ursinusENSVURP0001001413787.150884.9162
ENSG00000139546homo_sapiensENSP0000026698798.087497.541rhinolophus_ferrumequinumENSRFEP0001000375798.087497.541
ENSG00000139546homo_sapiensENSP0000026698798.633997.8142neovison_visonENSNVIP0000000235598.633997.8142
ENSG00000139546homo_sapiensENSP0000026698798.360797.541bos_taurusENSBTAP0000000055898.360797.541
ENSG00000139546homo_sapiensENSP0000026698730.601130.3279heterocephalus_glaber_femaleENSHGLP0000004309799.11598.2301
ENSG00000139546homo_sapiensENSP0000026698724.863422.6776heterocephalus_glaber_femaleENSHGLP0000000168457.232752.2013
ENSG00000139546homo_sapiensENSP0000026698799.726899.4536rhinopithecus_bietiENSRBIP0000000688599.726899.4536
ENSG00000139546homo_sapiensENSP0000026698798.360798.0874canis_lupus_dingoENSCAFP0002002637398.360798.0874
ENSG00000139546homo_sapiensENSP0000026698797.267896.7213sciurus_vulgarisENSSVLP0000503139097.267896.7213
ENSG00000139546homo_sapiensENSP0000026698785.245983.0601phascolarctos_cinereusENSPCIP0000000800687.150884.9162
ENSG00000139546homo_sapiensENSP0000026698780.601180.0546procavia_capensisENSPCAP0000000499180.601180.0546
ENSG00000139546homo_sapiensENSP0000026698729.508229.235nannospalax_galiliENSNGAP0000001729799.082698.1651
ENSG00000139546homo_sapiensENSP0000026698798.360797.541bos_grunniensENSBGRP0000000578398.360797.541
ENSG00000139546homo_sapiensENSP0000026698795.355294.2623chinchilla_lanigeraENSCLAP0000001328295.355294.2623
ENSG00000139546homo_sapiensENSP0000026698798.087496.9945cervus_hanglu_yarkandensisENSCHYP0000000450598.087496.9945
ENSG00000139546homo_sapiensENSP0000026698798.087496.1749catagonus_wagneriENSCWAP0000001985798.087496.1749
ENSG00000139546homo_sapiensENSP0000026698796.994596.1749ictidomys_tridecemlineatusENSSTOP0000003180896.994596.1749
ENSG00000139546homo_sapiensENSP0000026698798.360797.2678otolemur_garnettiiENSOGAP0000000155298.360797.2678
ENSG00000139546homo_sapiensENSP0000026698799.453698.6339cebus_imitatorENSCCAP0000002997599.453698.6339
ENSG00000139546homo_sapiensENSP0000026698796.994596.1749urocitellus_parryiiENSUPAP0001002614396.994596.1749
ENSG00000139546homo_sapiensENSP0000026698798.360797.541moschus_moschiferusENSMMSP0000000875398.360797.541
ENSG00000139546homo_sapiensENSP0000026698799.726899.4536rhinopithecus_roxellanaENSRROP0000004347599.726899.4536
ENSG00000139546homo_sapiensENSP0000026698795.355293.4426mus_pahariMGP_PahariEiJ_P004336895.616493.6986
ENSG00000139546homo_sapiensENSP0000026698798.907198.0874propithecus_coquereliENSPCOP0000000471398.907198.0874
ENSG00000139546homo_sapiensENSP0000026698726.502714.2077caenorhabditis_elegansY95B8A.8.112.69636.80628
ENSG00000139546homo_sapiensENSP0000026698720.218611.4754drosophila_melanogasterFBpp008007615.9149.03226
ENSG00000139546homo_sapiensENSP0000026698717.21318.19672drosophila_melanogasterFBpp007685619.44449.25926
ENSG00000139546homo_sapiensENSP0000026698716.93998.46994drosophila_melanogasterFBpp007321920.945910.473
ENSG00000139546homo_sapiensENSP0000026698726.502713.9344drosophila_melanogasterFBpp030548910.97295.76923
ENSG00000139546homo_sapiensENSP0000026698723.22416.6667ciona_intestinalisENSCINP0000001280528.333320.3333
ENSG00000139546homo_sapiensENSP0000026698714.20777.37705ciona_intestinalisENSCINP0000003451813.9417.23861
ENSG00000139546homo_sapiensENSP0000026698722.404410.3825ciona_intestinalisENSCINP000000100468.658924.01267
ENSG00000139546homo_sapiensENSP0000026698723.770512.2951ciona_intestinalisENSCINP0000002604210.43175.39568
ENSG00000139546homo_sapiensENSP0000026698759.289652.7322petromyzon_marinusENSPMAP0000000012175.086566.782
ENSG00000139546homo_sapiensENSP0000026698754.644845.3552eptatretus_burgeriENSEBUP0000000323361.728451.2346
ENSG00000139546homo_sapiensENSP0000026698773.497366.3934callorhinchus_miliiENSCMIP0000002610881.762973.8602
ENSG00000139546homo_sapiensENSP0000026698766.393457.6503latimeria_chalumnaeENSLACP0000000800772.321462.7976
ENSG00000139546homo_sapiensENSP0000026698774.590266.6667lepisosteus_oculatusENSLOCP0000000691379.130470.7246
ENSG00000139546homo_sapiensENSP0000026698771.584762.8415clupea_harengusENSCHAP0000004594877.058867.6471
ENSG00000139546homo_sapiensENSP0000026698773.497364.7541danio_rerioENSDARP0000009423177.745768.4971
ENSG00000139546homo_sapiensENSP0000026698773.22465.5738carassius_auratusENSCARP0000008568178.134169.9708
ENSG00000139546homo_sapiensENSP0000026698772.404464.4809carassius_auratusENSCARP0000000633977.259568.8047
ENSG00000139546homo_sapiensENSP0000026698772.950864.4809astyanax_mexicanusENSAMXP0000001716377.616368.6047
ENSG00000139546homo_sapiensENSP0000026698772.950864.7541ictalurus_punctatusENSIPUP0000003534772.162264.0541
ENSG00000139546homo_sapiensENSP0000026698772.950865.3005esox_luciusENSELUP0000001012376.945268.8761
ENSG00000139546homo_sapiensENSP0000026698772.950865.0273electrophorus_electricusENSEEEP0000004460777.391368.9855
ENSG00000139546homo_sapiensENSP0000026698768.032858.1967oncorhynchus_kisutchENSOKIP0000505487966.223456.6489
ENSG00000139546homo_sapiensENSP0000026698772.131164.2076oncorhynchus_mykissENSOMYP0000006567275.862167.5287
ENSG00000139546homo_sapiensENSP0000026698768.852559.0164salmo_salarENSSSAP0000017003166.315856.8421
ENSG00000139546homo_sapiensENSP0000026698773.497365.5738salmo_truttaENSSTUP0000001191377.521669.1643
ENSG00000139546homo_sapiensENSP0000026698771.857963.1148gadus_morhuaENSGMOP0000000133676.231966.9565
ENSG00000139546homo_sapiensENSP0000026698769.398962.2951fundulus_heteroclitusENSFHEP0000003068178.395170.3704
ENSG00000139546homo_sapiensENSP0000026698772.131164.2076poecilia_reticulataENSPREP0000001147576.521768.1159
ENSG00000139546homo_sapiensENSP0000026698772.131164.7541xiphophorus_maculatusENSXMAP0000001787076.521768.6957
ENSG00000139546homo_sapiensENSP0000026698772.950864.4809oryzias_latipesENSORLP0000000656477.391368.4058
ENSG00000139546homo_sapiensENSP0000026698772.404463.1148cyclopterus_lumpusENSCLMP0000501653277.034967.1512
ENSG00000139546homo_sapiensENSP0000026698771.038363.9344oreochromis_niloticusENSONIP0000000643076.923169.2308
ENSG00000139546homo_sapiensENSP0000026698772.131164.2076haplochromis_burtoniENSHBUP0000001668576.521768.1159
ENSG00000139546homo_sapiensENSP0000026698770.76563.388astatotilapia_callipteraENSACLP0000002731775.072567.2464
ENSG00000139546homo_sapiensENSP0000026698772.677663.9344sparus_aurataENSSAUP0001005903877.101467.8261
ENSG00000139546homo_sapiensENSP0000026698772.404464.2076lates_calcariferENSLCAP0001003630776.811668.1159
ENSG00000139546homo_sapiensENSP0000026698774.863466.9399xenopus_tropicalisENSXETP0000011396168.671761.4035
ENSG00000139546homo_sapiensENSP0000026698781.69474.3169chrysemys_picta_belliiENSCPBP0000000080083.055675.5556
ENSG00000139546homo_sapiensENSP0000026698761.748652.1858sphenodon_punctatusENSSPUP0000000763769.113258.4098
ENSG00000139546homo_sapiensENSP0000026698778.688571.8579crocodylus_porosusENSCPRP0000500968183.23776.0116
ENSG00000139546homo_sapiensENSP0000026698781.967273.224laticauda_laticaudataENSLLTP0000000053871.770364.1148
ENSG00000139546homo_sapiensENSP0000026698781.69472.9508notechis_scutatusENSNSUP0000000374283.055674.1667
ENSG00000139546homo_sapiensENSP0000026698781.69472.9508pseudonaja_textilisENSPTXP0000001017171.190563.5714
ENSG00000139546homo_sapiensENSP0000026698779.23570.765gallus_gallusENSGALP0001003610379.889871.3499
ENSG00000139546homo_sapiensENSP0000026698713.934413.1148meleagris_gallopavoENSMGAP0000002673487.93182.7586
ENSG00000139546homo_sapiensENSP0000026698721.311516.9399serinus_canariaENSSCAP0000000553644.067835.0282
ENSG00000139546homo_sapiensENSP0000026698724.590219.1257parus_majorENSPMJP0000000098448.91338.0435
ENSG00000139546homo_sapiensENSP0000026698781.420872.9508anolis_carolinensisENSACAP0000004071772.506164.9635
ENSG00000139546homo_sapiensENSP0000026698723.22421.8579neolamprologus_brichardiENSNBRP0000001531469.105765.0406
ENSG00000139546homo_sapiensENSP0000026698732.240426.5027neolamprologus_brichardiENSNBRP0000000498764.130452.7174
ENSG00000139546homo_sapiensENSP0000026698781.967273.4973naja_najaENSNNAP0000001348171.770364.3541
ENSG00000139546homo_sapiensENSP0000026698778.961771.0383podarcis_muralisENSPMRP0000000184969.138862.201
ENSG00000139546homo_sapiensENSP0000026698720.76518.0328geospiza_fortisENSGFOP0000000456658.015350.3817
ENSG00000139546homo_sapiensENSP0000026698722.950819.9454taeniopygia_guttataENSTGUP0000002066790.322678.4946
ENSG00000139546homo_sapiensENSP0000026698722.950819.9454taeniopygia_guttataENSTGUP0000002483290.322678.4946
ENSG00000139546homo_sapiensENSP0000026698772.677665.0273erpetoichthys_calabaricusENSECRP0000000736280.606172.1212
ENSG00000139546homo_sapiensENSP0000026698772.677664.2076kryptolebias_marmoratusENSKMAP0000001626277.101468.1159
ENSG00000139546homo_sapiensENSP0000026698783.060173.7705salvator_merianaeENSSMRP0000000325183.746674.3802
ENSG00000139546homo_sapiensENSP0000026698772.404464.7541oryzias_javanicusENSOJAP0000000307576.811668.6957
ENSG00000139546homo_sapiensENSP0000026698772.131164.4809amphilophus_citrinellusENSACIP0000002168577.876169.6165
ENSG00000139546homo_sapiensENSP0000026698771.311564.2076dicentrarchus_labraxENSDLAP0000502814575.433567.9191
ENSG00000139546homo_sapiensENSP0000026698772.677665.0273amphiprion_perculaENSAPEP0000001171777.101468.9855
ENSG00000139546homo_sapiensENSP0000026698770.491862.8415oryzias_sinensisENSOSIP0000004954275.218767.0554
ENSG00000139546homo_sapiensENSP0000026698781.147574.0437gopherus_evgoodeiENSGEVP0000500573282.575.2778
ENSG00000139546homo_sapiensENSP0000026698781.967274.3169chelonoidis_abingdoniiENSCABP0000000629883.333375.5556
ENSG00000139546homo_sapiensENSP0000026698772.404464.2076seriola_dumeriliENSSDUP0000002593876.811668.1159
ENSG00000139546homo_sapiensENSP0000026698770.491862.8415cottoperca_gobioENSCGOP0000000680176.106267.8466
ENSG00000139546homo_sapiensENSP0000026698772.404463.1148gasterosteus_aculeatusENSGACP0000000880474.647965.0704
ENSG00000139546homo_sapiensENSP0000026698772.404465.0273cynoglossus_semilaevisENSCSEP0000001654776.811668.9855
ENSG00000139546homo_sapiensENSP0000026698771.857964.4809poecilia_formosaENSPFOP0000000749476.231968.4058
ENSG00000139546homo_sapiensENSP0000026698772.950864.2076myripristis_murdjanENSMMDP0000500872878.070268.7134
ENSG00000139546homo_sapiensENSP0000026698772.677664.4809sander_luciopercaENSSLUP0000004268377.101468.4058
ENSG00000139546homo_sapiensENSP0000026698778.688570.2186strigops_habroptilaENSSHBP0000502455080.222871.5877
ENSG00000139546homo_sapiensENSP0000026698772.677665.0273amphiprion_ocellarisENSAOCP0000002085177.101468.9855
ENSG00000139546homo_sapiensENSP0000026698781.69474.3169terrapene_carolina_triunguisENSTMTP0000000705983.055675.5556
ENSG00000139546homo_sapiensENSP0000026698773.497365.5738hucho_huchoENSHHUP0000000203077.521669.1643
ENSG00000139546homo_sapiensENSP0000026698772.677663.388betta_splendensENSBSLP0000005336177.101467.2464
ENSG00000139546homo_sapiensENSP0000026698773.22466.3934pygocentrus_nattereriENSPNAP0000000472177.681270.4348
ENSG00000139546homo_sapiensENSP0000026698772.404464.2076anabas_testudineusENSATEP0000003640276.811668.1159
ENSG00000139546homo_sapiensENSP000002669877.650272.73224ciona_savignyiENSCSAVP0000000326611.3364.04858
ENSG00000139546homo_sapiensENSP000002669874.371582.45902ciona_savignyiENSCSAVP000000115297.619054.28571
ENSG00000139546homo_sapiensENSP0000026698772.404464.2076seriola_lalandi_dorsalisENSSLDP0000000226776.811668.1159
ENSG00000139546homo_sapiensENSP0000026698772.950864.7541labrus_bergyltaENSLBEP0000001959675.423766.9492
ENSG00000139546homo_sapiensENSP0000026698772.131164.2076pundamilia_nyerereiENSPNYP0000001869476.521768.1159
ENSG00000139546homo_sapiensENSP0000026698771.857963.6612mastacembelus_armatusENSMAMP0000001516173.259164.9025
ENSG00000139546homo_sapiensENSP0000026698772.404464.4809stegastes_partitusENSSPAP0000003037676.811668.4058
ENSG00000139546homo_sapiensENSP0000026698767.486358.1967oncorhynchus_tshawytschaENSOTSP0000508608069.577560
ENSG00000139546homo_sapiensENSP0000026698772.677664.7541acanthochromis_polyacanthusENSAPOP0000001677077.101468.6957
ENSG00000139546homo_sapiensENSP0000026698721.857921.3115aquila_chrysaetos_chrysaetosENSACCP0002001433489.887687.6404
ENSG00000139546homo_sapiensENSP0000026698772.131164.4809nothobranchius_furzeriENSNFUP0001503342276.521768.4058
ENSG00000139546homo_sapiensENSP0000026698772.404463.9344cyprinodon_variegatusENSCVAP0000000807476.811667.8261
ENSG00000139546homo_sapiensENSP0000026698772.950865.847denticeps_clupeoidesENSDCDP0000005581177.616370.0581
ENSG00000139546homo_sapiensENSP0000026698772.404464.2076larimichthys_croceaENSLCRP0000504537876.811668.1159
ENSG00000139546homo_sapiensENSP0000026698771.857963.9344takifugu_rubripesENSTRUP0000003676676.231967.8261
ENSG00000139546homo_sapiensENSP0000026698718.032817.2131ficedula_albicollisENSFALP0000001594151.162848.8372
ENSG00000139546homo_sapiensENSP0000026698771.311563.1148hippocampus_comesENSHCOP0000001732375.652266.9565
ENSG00000139546homo_sapiensENSP0000026698722.677618.0328cyprinus_carpio_carpioENSCCRP0000007749763.846250.7692
ENSG00000139546homo_sapiensENSP0000026698724.316922.1311coturnix_japonicaENSCJPP0000500864478.761171.6814
ENSG00000139546homo_sapiensENSP0000026698772.131164.7541poecilia_latipinnaENSPLAP0000001406076.521768.6957
ENSG00000139546homo_sapiensENSP0000026698773.497365.847sinocyclocheilus_grahamiENSSGRP0000007671677.745769.6532
ENSG00000139546homo_sapiensENSP0000026698773.22464.7541sinocyclocheilus_grahamiENSSGRP0000008555177.456668.4971
ENSG00000139546homo_sapiensENSP0000026698771.857964.2076maylandia_zebraENSMZEP0000500908076.231968.1159
ENSG00000139546homo_sapiensENSP0000026698772.677663.6612tetraodon_nigroviridisENSTNIP0000000986677.101467.5362
ENSG00000139546homo_sapiensENSP0000026698773.22465.847paramormyrops_kingsleyaeENSPKIP0000001592875.49367.8873
ENSG00000139546homo_sapiensENSP0000026698772.950865.5738scleropages_formosusENSSFOP0001501673174.789967.2269
ENSG00000139546homo_sapiensENSP0000026698756.284246.1749leptobrachium_leishanenseENSLLEP0000000928550.243941.2195
ENSG00000139546homo_sapiensENSP0000026698772.677663.6612scophthalmus_maximusENSSMAP0000002084977.101467.5362
ENSG00000139546homo_sapiensENSP0000026698772.404464.2076oryzias_melastigmaENSOMEP0000001719076.811668.1159

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003725enables double-stranded RNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006417involved_in regulation of translation1IEAHomo_sapiens(9606)Process
GO:0006469involved_in negative regulation of protein kinase activity1TASHomo_sapiens(9606)Process
GO:0016442part_of RISC complex2IBA,IDAHomo_sapiens(9606)Component
GO:0016604located_in nuclear body1IDAHomo_sapiens(9606)Component
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0030422involved_in siRNA processing2IBA,IDAHomo_sapiens(9606)Process
GO:0031054involved_in pre-miRNA processing1IDAHomo_sapiens(9606)Process
GO:0035196involved_in miRNA processing1IDAHomo_sapiens(9606)Process
GO:0035197enables siRNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0035198enables miRNA binding1IEAHomo_sapiens(9606)Function
GO:0036002enables pre-mRNA binding1TASHomo_sapiens(9606)Function
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042803enables protein homodimerization activity1IPIHomo_sapiens(9606)Function
GO:0045070involved_in positive regulation of viral genome replication1IDAHomo_sapiens(9606)Process
GO:0046782involved_in regulation of viral transcription1IDAHomo_sapiens(9606)Process
GO:0048471located_in perinuclear region of cytoplasm1IEAHomo_sapiens(9606)Component
GO:0050689involved_in negative regulation of defense response to virus by host1IDAHomo_sapiens(9606)Process
GO:0070578part_of RISC-loading complex3IBA,IDA,IPIHomo_sapiens(9606)Component
GO:0070883contributes_to pre-miRNA binding2IDAHomo_sapiens(9606)Function
GO:0070920involved_in regulation of regulatory ncRNA processing1IBAHomo_sapiens(9606)Process
GO:0070921involved_in regulation of siRNA processing1IEAHomo_sapiens(9606)Process
GO:0070922involved_in RISC complex assembly1IDAHomo_sapiens(9606)Process
GO:0098795involved_in global gene silencing by mRNA cleavage1IMPHomo_sapiens(9606)Process
GO:1903798involved_in regulation of miRNA processing1IEAHomo_sapiens(9606)Process

Expression