RBP Type
Canonical_RBPs
Diseases
CHIKV SARS-COV-OC43 Flaviviruses HIV RV SARS-COV-2 Dengue Zika
Drug
Main interacting RNAs
rRNA
Moonlighting functions
Metabolic enzyme
Localizations
Stress granucle
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000137154 Gene ID
6194 Accession
10429
Symbol
RPS6
Alias
S6;eS6
Full Name
ribosomal protein S6
Status
Confidence
Length
4522 bases
Strand
Minus strand
Position
9 : 19375715 - 19380236
RNA binding domain
Ribosomal_S6e
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000369757
Ribosomal_S6e
PF01092 4.6e-58
1
ENSP00000369743
Ribosomal_S6e
PF01092 9.4e-44
1
ENSP00000369745
Ribosomal_S6e
PF01092 9.4e-44
1
ENSP00000369741
Ribosomal_S6e
PF01092 7.5e-14
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
Name
Transcript ID
bp
Protein
Translation ID
RPS6-204
ENST00000380394
1369
249aa
ENSP00000369757
RPS6-205
ENST00000498815
480
No protein
-
RPS6-203
ENST00000380384
1355
218aa
ENSP00000369745
RPS6-201
ENST00000315377
863
218aa
ENSP00000369743
RPS6-202
ENST00000380381
892
91aa
ENSP00000369741
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000137154
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000137154 homo_sapiens ENSP00000369757 99.1968 99.1968 pan_paniscus ENSPPAP00000029363 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 pan_troglodytes ENSPTRP00000060553 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 95.1807 94.3775 gorilla_gorilla ENSGGOP00000041090 97.5309 96.7078 ENSG00000137154 homo_sapiens ENSP00000369757 98.7952 98.7952 choloepus_hoffmanni ENSCHOP00000004087 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 99.1968 callithrix_jacchus ENSCJAP00000054854 100 99.1968 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 cercocebus_atys ENSCATP00000022796 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 macaca_fascicularis ENSMFAP00000025915 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 97.992 97.5904 macaca_nemestrina ENSMNEP00000039054 100 99.5902 ENSG00000137154 homo_sapiens ENSP00000369757 99.5984 99.1968 tursiops_truncatus ENSTTRP00000001686 100 99.5968 ENSG00000137154 homo_sapiens ENSP00000369757 98.3936 98.3936 mus_spretus MGP_SPRETEiJ_P0065358 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 equus_asinus ENSEASP00005028269 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 99.5984 capra_hircus ENSCHIP00000006669 97.6471 97.2549 ENSG00000137154 homo_sapiens ENSP00000369757 77.1084 67.8715 loxodonta_africana ENSLAFP00000028147 82.4034 72.5322 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 panthera_leo ENSPLOP00000010945 79.0476 79.0476 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 ailuropoda_melanoleuca ENSAMEP00000040457 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 99.5984 bos_indicus_hybrid ENSBIXP00005021735 100 99.5984 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 oryctolagus_cuniculus ENSOCUP00000002892 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 98.7952 98.7952 oryctolagus_cuniculus ENSOCUP00000020279 98.7952 98.7952 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 equus_caballus ENSECAP00000013727 99.2032 99.2032 ENSG00000137154 homo_sapiens ENSP00000369757 99.1968 98.7952 canis_lupus_familiaris ENSCAFP00845032118 99.1968 98.7952 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 panthera_pardus ENSPPRP00000002246 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 balaenoptera_musculus ENSBMSP00010000728 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 97.992 96.3855 cavia_porcellus ENSCPOP00000019059 97.992 96.3855 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 felis_catus ENSFCAP00000002340 79.0476 79.0476 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 ursus_americanus ENSUAMP00000017030 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 85.9438 84.3373 bison_bison_bison ENSBBBP00000027403 94.6903 92.9204 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 sus_scrofa ENSSSCP00000005557 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 99.1968 98.7952 microcebus_murinus ENSMICP00000044690 99.1968 98.7952 ENSG00000137154 homo_sapiens ENSP00000369757 98.7952 97.992 microcebus_murinus ENSMICP00000023543 98.7952 97.992 ENSG00000137154 homo_sapiens ENSP00000369757 35.743 33.7349 octodon_degus ENSODEP00000000700 87.2549 82.3529 ENSG00000137154 homo_sapiens ENSP00000369757 100 99.5984 ovis_aries_rambouillet ENSOARP00020028488 100 99.5984 ENSG00000137154 homo_sapiens ENSP00000369757 88.755 88.3534 ochotona_princeps ENSOPRP00000000679 91.3223 90.9091 ENSG00000137154 homo_sapiens ENSP00000369757 56.6265 56.6265 ochotona_princeps ENSOPRP00000011207 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 99.5984 99.5984 physeter_catodon ENSPCTP00005021230 99.5984 99.5984 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 mus_musculus ENSMUSP00000099878 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 96.7871 95.1807 aotus_nancymaae ENSANAP00000000975 96.7871 95.1807 ENSG00000137154 homo_sapiens ENSP00000369757 97.1888 96.7871 aotus_nancymaae ENSANAP00000026225 100 99.5868 ENSG00000137154 homo_sapiens ENSP00000369757 87.9518 85.9438 saimiri_boliviensis_boliviensis ENSSBOP00000002019 96.0526 93.8596 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 vicugna_pacos ENSVPAP00000005593 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 80.7229 77.51 mesocricetus_auratus ENSMAUP00000014559 89.7321 86.1607 ENSG00000137154 homo_sapiens ENSP00000369757 99.1968 99.1968 phocoena_sinus ENSPSNP00000000929 92.5094 92.5094 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 camelus_dromedarius ENSCDRP00005001338 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 79.1165 75.502 carlito_syrichta ENSTSYP00000016731 90.367 86.2385 ENSG00000137154 homo_sapiens ENSP00000369757 98.3936 98.3936 panthera_tigris_altaica ENSPTIP00000008583 98.3936 98.3936 ENSG00000137154 homo_sapiens ENSP00000369757 34.5382 34.1365 rattus_norvegicus ENSRNOP00000080926 93.4783 92.3913 ENSG00000137154 homo_sapiens ENSP00000369757 22.49 20.4819 rattus_norvegicus ENSRNOP00000065173 80 72.8571 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 microtus_ochrogaster ENSMOCP00000005155 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 99.5984 bos_mutus ENSBMUP00000020343 100 99.5984 ENSG00000137154 homo_sapiens ENSP00000369757 89.1566 85.9438 cricetulus_griseus_chok1gshd ENSCGRP00001016993 94.0678 90.678 ENSG00000137154 homo_sapiens ENSP00000369757 84.3373 81.9277 cricetulus_griseus_chok1gshd ENSCGRP00001027535 93.75 91.0714 ENSG00000137154 homo_sapiens ENSP00000369757 56.6265 55.8233 pteropus_vampyrus ENSPVAP00000013379 57.551 56.7347 ENSG00000137154 homo_sapiens ENSP00000369757 100 99.5984 myotis_lucifugus ENSMLUP00000006917 100 99.5984 ENSG00000137154 homo_sapiens ENSP00000369757 45.7831 44.5783 vombatus_ursinus ENSVURP00010023428 91.2 88.8 ENSG00000137154 homo_sapiens ENSP00000369757 90.7631 87.9518 vombatus_ursinus ENSVURP00010019441 90.7631 87.9518 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 rhinolophus_ferrumequinum ENSRFEP00010012639 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 99.5984 bos_taurus ENSBTAP00000049139 100 99.5984 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 heterocephalus_glaber_female ENSHGLP00000030166 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 rhinopithecus_bieti ENSRBIP00000028179 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 91.5663 90.3614 rhinopithecus_bieti ENSRBIP00000006604 99.5633 98.2533 ENSG00000137154 homo_sapiens ENSP00000369757 65.0602 65.0602 canis_lupus_dingo ENSCAFP00020016188 90.5028 90.5028 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 sciurus_vulgaris ENSSVLP00005028434 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 64.257 62.249 phascolarctos_cinereus ENSPCIP00000011218 81.6327 79.0816 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 nannospalax_galili ENSNGAP00000018868 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 99.5984 bos_grunniens ENSBGRP00000003221 100 99.5984 ENSG00000137154 homo_sapiens ENSP00000369757 61.4458 58.6345 chinchilla_lanigera ENSCLAP00000015065 85.4749 81.5642 ENSG00000137154 homo_sapiens ENSP00000369757 95.1807 93.5743 cervus_hanglu_yarkandensis ENSCHYP00000006407 81.7241 80.3448 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 catagonus_wagneri ENSCWAP00000015627 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 91.9679 90.3614 ictidomys_tridecemlineatus ENSSTOP00000028121 97.0339 95.339 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 otolemur_garnettii ENSOGAP00000014549 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 cebus_imitator ENSCCAP00000026763 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 urocitellus_parryii ENSUPAP00010023925 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 30.1205 28.5141 moschus_moschiferus ENSMMSP00000023084 90.3614 85.5422 ENSG00000137154 homo_sapiens ENSP00000369757 100 100 rhinopithecus_roxellana ENSRROP00000025541 100 100 ENSG00000137154 homo_sapiens ENSP00000369757 90.3614 89.5582 rhinopithecus_roxellana ENSRROP00000015237 98.2533 97.3799 ENSG00000137154 homo_sapiens ENSP00000369757 87.9518 87.9518 rhinopithecus_roxellana ENSRROP00000004157 98.2063 98.2063 ENSG00000137154 homo_sapiens ENSP00000369757 98.3936 96.7871 propithecus_coquereli ENSPCOP00000001014 99.5935 97.9675 ENSG00000137154 homo_sapiens ENSP00000369757 77.1084 61.4458 caenorhabditis_elegans Y71A12B.1a.1 78.0488 62.1951 ENSG00000137154 homo_sapiens ENSP00000369757 85.9438 75.1004 drosophila_melanogaster FBpp0071087 86.2903 75.4032 ENSG00000137154 homo_sapiens ENSP00000369757 88.3534 76.3052 ciona_intestinalis ENSCINP00000003510 88.7097 76.6129 ENSG00000137154 homo_sapiens ENSP00000369757 85.5422 77.9116 lepisosteus_oculatus ENSLOCP00000013648 77.7372 70.8029 ENSG00000137154 homo_sapiens ENSP00000369757 49.3976 47.7912 carassius_auratus ENSCARP00000116484 93.1818 90.1515 ENSG00000137154 homo_sapiens ENSP00000369757 20.8835 19.2771 laticauda_laticaudata ENSLLTP00000016285 60.4651 55.814 ENSG00000137154 homo_sapiens ENSP00000369757 37.751 35.3414 laticauda_laticaudata ENSLLTP00000016276 92.1569 86.2745 ENSG00000137154 homo_sapiens ENSP00000369757 62.6506 50.6024 anas_platyrhynchos_platyrhynchos ENSAPLP00000018457 31.7073 25.6098 ENSG00000137154 homo_sapiens ENSP00000369757 29.7189 24.8996 podarcis_muralis ENSPMRP00000005073 74 62 ENSG00000137154 homo_sapiens ENSP00000369757 17.6707 15.6627 taeniopygia_guttata ENSTGUP00000021366 61.9718 54.9296 ENSG00000137154 homo_sapiens ENSP00000369757 89.1566 75.9036 ciona_savignyi ENSCSAVP00000012874 89.5161 76.2097 ENSG00000137154 homo_sapiens ENSP00000369757 73.0924 59.4378 saccharomyces_cerevisiae YPL090C 77.1186 62.7119 ENSG00000137154 homo_sapiens ENSP00000369757 73.0924 59.4378 saccharomyces_cerevisiae YBR181C 77.1186 62.7119 ENSG00000137154 homo_sapiens ENSP00000369757 36.1446 33.3333 sinocyclocheilus_grahami ENSSGRP00000059789 73.7705 68.0328
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000082 involved_in G1/S transition of mitotic cell cycle 1 IEA Homo_sapiens(9606) Process GO:0001890 involved_in placenta development 1 IEA Homo_sapiens(9606) Process GO:0002181 involved_in cytoplasmic translation 3 IC,IDA,NAS Homo_sapiens(9606) Process GO:0002309 involved_in T cell proliferation involved in immune response 1 IEA Homo_sapiens(9606) Process GO:0003723 enables RNA binding 1 HDA Homo_sapiens(9606) Function GO:0003735 enables structural constituent of ribosome 3 HDA,IDA,IMP Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 located_in nucleus 2 HDA,IDA Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 1 TAS Homo_sapiens(9606) Component GO:0005730 located_in nucleolus 1 IDA Homo_sapiens(9606) Component GO:0005737 located_in cytoplasm 1 NAS Homo_sapiens(9606) Component GO:0005783 located_in endoplasmic reticulum 1 IDA Homo_sapiens(9606) Component GO:0005829 located_in cytosol 2 IDA,TAS Homo_sapiens(9606) Component GO:0005844 part_of polysome 1 IEA Homo_sapiens(9606) Component GO:0006364 involved_in rRNA processing 1 IMP Homo_sapiens(9606) Process GO:0006412 involved_in translation 1 IC Homo_sapiens(9606) Process GO:0006924 involved_in activation-induced cell death of T cells 1 IEA Homo_sapiens(9606) Process GO:0007369 involved_in gastrulation 1 IEA Homo_sapiens(9606) Process GO:0008284 involved_in positive regulation of cell population proliferation 1 IMP Homo_sapiens(9606) Process GO:0015935 part_of small ribosomal subunit 1 IDA Homo_sapiens(9606) Component GO:0016020 located_in membrane 1 HDA Homo_sapiens(9606) Component GO:0019901 enables protein kinase binding 1 IPI Homo_sapiens(9606) Function GO:0022605 involved_in mammalian oogenesis stage 1 IEA Homo_sapiens(9606) Process GO:0022626 located_in cytosolic ribosome 1 IDA Homo_sapiens(9606) Component GO:0022627 part_of cytosolic small ribosomal subunit 3 HDA,IDA,NAS Homo_sapiens(9606) Component GO:0030425 located_in dendrite 1 IDA Homo_sapiens(9606) Component GO:0031929 involved_in TOR signaling 1 IDA Homo_sapiens(9606) Process GO:0032040 part_of small-subunit processome 1 IDA Homo_sapiens(9606) Component GO:0033077 involved_in T cell differentiation in thymus 1 IEA Homo_sapiens(9606) Process GO:0036464 located_in cytoplasmic ribonucleoprotein granule 1 IDA Homo_sapiens(9606) Component GO:0042274 involved_in ribosomal small subunit biogenesis 2 IDA,IMP Homo_sapiens(9606) Process GO:0042593 involved_in glucose homeostasis 1 ISS Homo_sapiens(9606) Process GO:0043065 involved_in positive regulation of apoptotic process 1 IDA Homo_sapiens(9606) Process GO:0043066 involved_in negative regulation of apoptotic process 1 IEA Homo_sapiens(9606) Process GO:0044297 located_in cell body 1 IDA Homo_sapiens(9606) Component GO:0048471 located_in perinuclear region of cytoplasm 1 IEA Homo_sapiens(9606) Component GO:0048821 involved_in erythrocyte development 1 IEA Homo_sapiens(9606) Process GO:1990904 part_of ribonucleoprotein complex 1 IDA Homo_sapiens(9606) Component
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