Ensembl ID ENSG00000137154 Gene ID 6194 Accession 10429
Gene Symbol RPS6 Alias S6;eS6 Full Name ribosomal protein S6
Position 9 : 19375715 - 19380236 Length 4522 bases Strand Minus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

ENSG00000137154 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000137154 RPS6 0.58 1.40e-12 KIRC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000137154 RPS6 tumours 15956968
ENSG00000137154 RPS6 tumor 16779802
ENSG00000137154 RPS6 tumor 17565818
ENSG00000137154 RPS6 tumors 18538015
ENSG00000137154 RPS6 tumours 19401700
ENSG00000137154 RPS6 DLBCL 21102526
ENSG00000137154 RPS6 cancer 21427355
ENSG00000137154 RPS6 pancreatic cancer 21565828
ENSG00000137154 RPS6 tumor 21890461
ENSG00000137154 RPS6 liver cancer 21931995
ENSG00000137154 RPS6 tumor 23015458
ENSG00000137154 RPS6 cancer 23227181
ENSG00000137154 RPS6 tumors 23598719
ENSG00000137154 RPS6 cancer 23759595
ENSG00000137154 RPS6 neuroendocrine tumors 23980085
ENSG00000137154 RPS6 bladder cancer 24072592
ENSG00000137154 RPS6 cancers 24427739
ENSG00000137154 RPS6 basal-like breast cancer 24658685
ENSG00000137154 RPS6 tumours 24811063
ENSG00000137154 RPS6 tumor 24886512
ENSG00000137154 RPS6 prostate cancer 25075204
ENSG00000137154 RPS6 tumor 25228590
ENSG00000137154 RPS6 colorectal cancer 25379021
ENSG00000137154 RPS6 breast cancer 25659153
ENSG00000137154 RPS6 cancers 25776026
ENSG00000137154 RPS6 tumors 25826091
ENSG00000137154 RPS6 cancer 25867072
ENSG00000137154 RPS6 cancer 25955731
ENSG00000137154 RPS6 tumor 25993328
ENSG00000137154 RPS6 cancers 26225263
ENSG00000137154 RPS6 cancer 26275051
ENSG00000137154 RPS6 pancreatic cancers 26436951
ENSG00000137154 RPS6 GBM 26857460
ENSG00000137154 RPS6 colon tumors 26863299
ENSG00000137154 RPS6 tumors 27618721
ENSG00000137154 RPS6 tumor 27663511
ENSG00000137154 RPS6 tumor 27713131
ENSG00000137154 RPS6 tumor 27799065
ENSG00000137154 RPS6 ovarian cancer 27926932
ENSG00000137154 RPS6 Tumor 28212559
ENSG00000137154 RPS6 tumor 28247844
ENSG00000137154 RPS6 tumor 28264936
ENSG00000137154 RPS6 breast cancer 28301598
ENSG00000137154 RPS6 GBM 28356518
ENSG00000137154 RPS6 tumor 28895411
ENSG00000137154 RPS6 GBM 28978054
ENSG00000137154 RPS6 tumor 29755689
ENSG00000137154 RPS6 tumours 30023006
ENSG00000137154 RPS6 tumor 30129426
ENSG00000137154 RPS6 Gastric Cancer 30504425
ENSG00000137154 RPS6 cancer 30806145
ENSG00000137154 RPS6 skin cancer 31040906
ENSG00000137154 RPS6 non-small cell lung cancer 31205542
ENSG00000137154 RPS6 Non-small cell lung cancer 31448672
ENSG00000137154 RPS6 tumor 6093101
ENSG00000137154 RPS6 tumor 8600571
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000137154 RPS6 MESO 0.023 low
ENSG00000137154 RPS6 SARC 0.048 high
ENSG00000137154 RPS6 UVM 0.039 low
ENSG00000137154 RPS6 UCEC 0.00018 low
ENSG00000137154 RPS6 THCA 0.01 low
ENSG00000137154 RPS6 ACC 0.0054 high
ENSG00000137154 RPS6 HNSC 0.011 high
ENSG00000137154 RPS6 KIRP 0.00044 high
ENSG00000137154 RPS6 LUAD 0.016 low
ENSG00000137154 RPS6 PCPG 0.0018 low
ENSG00000137154 RPS6 THYM 0.04 low
ENSG00000137154 RPS6 BRCA 0.0086 low
ENSG00000137154 RPS6 BLCA 0.0022 low
ENSG00000137154 RPS6 GBM 0.019 low
ENSG00000137154 RPS6 SKCM 0.0087 low
ENSG00000137154 RPS6 LIHC 0.029 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000137154 RPS6 LUSC Del 4.122708 0.105240 0.414599 0.678643
ENSG00000137154 RPS6 LUAD Del 2.493860 0.072177 0.369641 0.536822
ENSG00000137154 RPS6 LGG Del 13.522643 0.122616 0.552340 0.304094
ENSG00000137154 RPS6 SARC Del 1.398160 0.141966 0.521194 0.377432
ENSG00000137154 RPS6 GBM Del 61.688904 0.340369 0.678100 0.551127
ENSG00000137154 RPS6 PAAD Del 2.691157 0.081787 0.381548 0.489130
ENSG00000137154 RPS6 ESCA Del 0.677174 0.095909 0.432829 0.586957
ENSG00000137154 RPS6 SKCM Del 5.166031 0.123900 0.567479 0.673025
ENSG00000137154 RPS6 HNSC Amp 0.755963 0.117214 0.629964 0.216475
ENSG00000137154 RPS6 BLCA Del 6.001461 0.143823 0.514338 0.465686
ENSG00000137154 RPS6 STAD Del 2.033603 0.079051 0.424237 0.390023
ENSG00000137154 RPS6 MESO Del 1.510878 0.156798 0.540597 0.390805