RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	CancerDengueZika
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granule or P-body
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000135930	Gene ID	9470	Accession	3293
Symbol	EIF4E2	Alias	4EHP;IF4e;4E-LP;h4EHP;EIF4EL3	Full Name	eukaryotic translation initiation factor 4E family member 2
Status	Confidence	Length	32986 bases	Strand	Plus strand
Position	2 : 232550659 - 232583644	RNA binding domain	IF4E
Summary	Enables ubiquitin protein ligase binding activity. Involved in positive regulation of miRNA mediated inhibition of translation. Acts upstream of or within negative regulation of translation. Located in P-body. Part of mRNA cap binding activity complex. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000258416	IF4E	PF01652	2.5e-59	1
ENSP00000386424	IF4E	PF01652	2.2e-48	1
ENSP00000386876	IF4E	PF01652	2.1e-59	1
ENSP00000386983	IF4E	PF01652	1.8e-48	1
ENSP00000386996	IF4E	PF01652	2.1e-59	1
ENSP00000387328	IF4E	PF01652	1.8e-48	1
ENSP00000387336	IF4E	PF01652	2.1e-59	1
ENSP00000390904	IF4E	PF01652	1.6e-59	1
ENSP00000508671	IF4E	PF01652	1.8e-48	1
ENSP00000509248	IF4E	PF01652	1.4e-41	1

Showing 1 to 10 of 10 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25843628	ChIRP.MS_PMID25843628_Hela_human	Hela	Ci Chu	2015 Apr 9	doi: 10.1016/j.cell.2015.03.025.?Epub 2015 Apr 2
30824702	PtexRIC_PMID30824702_293T_human	293T	Erika C Urdaneta	2019 Mar 1	doi: 10.1038/s41467-019-08942-3
31076284	R.Deep_PMID_31076284_Hs		Maiwen Caudron-Herger	2019 Jul 11	doi: 10.1016/j.molcel.2019.04.018.?Epub 2019 May 7
32313943	eRIC_PMID32313943_eRIC_human		Michael Backlund	2020 May 21	doi: 10.1093/nar/gkaa256
35427468	qRIC_PMID35427468_293T_human	293T	Carlos Henrique Vieira-Vieira	2022 Jun 2	doi: 10.1016/j.molcel.2022.03.024.?Epub 2022 Apr 14

Showing 1 to 6 of 6 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
34665823	Translational repression of NMD targets by GIGYF2 and EIF4E2.	Boris Zinshteyn	2021-10-01	PLoS genetics
35501376	Functional and pathologic association of aminoacyl-tRNA synthetases with cancer.	Yulseung Sung	2022-05-01	Experimental & molecular medicine
35568694	Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia.	Lei Sun	2022-05-14	Cell death & disease

Showing 1 to 3 of 3 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
EIF4E2-201	ENST00000258416	967	245aa	ENSP00000258416
EIF4E2-202	ENST00000409098	3448	234aa	ENSP00000386996
EIF4E2-203	ENST00000409167	2550	188aa	ENSP00000387328
EIF4E2-204	ENST00000409322	797	200aa	ENSP00000386424
EIF4E2-205	ENST00000409394	604	189aa	ENSP00000386983
EIF4E2-206	ENST00000409495	2693	233aa	ENSP00000386876
EIF4E2-207	ENST00000409514	3525	236aa	ENSP00000387336
EIF4E2-208	ENST00000444113	571	121aa	ENSP00000389578
EIF4E2-209	ENST00000454501	1048	213aa	ENSP00000390904
EIF4E2-210	ENST00000459714	4879	No protein	-

Showing 1 to 10 of 17 entries

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Gene Model

Click here to download ENSG00000135930's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
9761	Echocardiography	4.4172390052624E-6	17903301
34494	Platelet Function Tests	8.5600000E-006	-
81056	Carcinoma, Non-Small-Cell Lung	8E-8	21079520
98885	Body Height	1E-17	25282103

Showing 1 to 4 of 4 entries

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GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000135930	rs1656402	2	232561816	Non-small cell lung cancer (survival)	21079520	2.38	EFO_0003060
ENSG00000135930	rs13393800	2	232577381	Height	25282103	0.027	EFO_0004339
ENSG00000135930	rs74453786	2	232576992	Lung function (FVC)	30595370		EFO_0004312

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000135930's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000135930	homo_sapiens	ENSP00000393324	43.3036	26.7857	homo_sapiens	ENSP00000258416	39.5918	24.4898
ENSG00000135930	homo_sapiens	ENSP00000323714	46.281	29.3388	homo_sapiens	ENSP00000258416	45.7143	28.9796
ENSG00000135930	homo_sapiens	ENSP00000389624	54.8387	35.023	homo_sapiens	ENSP00000258416	48.5714	31.0204

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000135930	homo_sapiens	ENSP00000258416	100	99.5918	nomascus_leucogenys	ENSNLEP00000047364	100	99.5918
ENSG00000135930	homo_sapiens	ENSP00000258416	97.551	97.1429	pan_paniscus	ENSPPAP00000023189	95.9839	95.5823
ENSG00000135930	homo_sapiens	ENSP00000258416	100	100	pongo_abelii	ENSPPYP00000027445	100	100
ENSG00000135930	homo_sapiens	ENSP00000258416	97.551	97.1429	pan_troglodytes	ENSPTRP00000093015	95.9839	95.5823
ENSG00000135930	homo_sapiens	ENSP00000258416	79.1837	78.7755	gorilla_gorilla	ENSGGOP00000027864	95.098	94.6078
ENSG00000135930	homo_sapiens	ENSP00000258416	99.1837	98.3673	ornithorhynchus_anatinus	ENSOANP00000047930	99.1837	98.3673
ENSG00000135930	homo_sapiens	ENSP00000258416	53.0612	51.4286	sarcophilus_harrisii	ENSSHAP00000020636	90.2778	87.5
ENSG00000135930	homo_sapiens	ENSP00000258416	80.8163	76.3265	sarcophilus_harrisii	ENSSHAP00000030115	60.3659	57.0122
ENSG00000135930	homo_sapiens	ENSP00000258416	99.5918	97.9592	notamacropus_eugenii	ENSMEUP00000014166	99.5918	97.9592
ENSG00000135930	homo_sapiens	ENSP00000258416	58.3673	57.551	choloepus_hoffmanni	ENSCHOP00000011617	58.3673	57.551

Showing 1 to 10 of 248 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000340	enables RNA 7-methylguanosine cap binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0000339	enables RNA cap binding	1	TAS	Homo_sapiens(9606)	Function
GO:0000932	located_in P-body	1	IDA	Homo_sapiens(9606)	Component
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0003743	enables translation initiation factor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005845	part_of mRNA cap binding complex	1	IDA	Homo_sapiens(9606)	Component
GO:0006413	involved_in translational initiation	1	IEA	Homo_sapiens(9606)	Process

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression