Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions E3 ligase
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000135679 Gene ID 4193 Accession 6973
Symbol MDM2 Alias HDMX;LSKB;hdm2;ACTFS Full Name MDM2 proto-oncogene
Status Confidence Length 37368 bases Strand Plus strand
Position 12 : 68808177 - 68845544 RNA binding domain zf-RanBP
Summary This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000377062 zf-RanBP PF00641 8e-09 1
ENSP00000377064 zf-RanBP PF00641 8e-09 1
ENSP00000353611 zf-RanBP PF00641 1e-08 1
ENSP00000299252 zf-RanBP PF00641 1.1e-08 1
ENSP00000258148 zf-RanBP PF00641 1.7e-08 1
ENSP00000441841 zf-RanBP PF00641 1.8e-08 1
ENSP00000266624 zf-RanBP PF00641 1.8e-08 1
ENSP00000444430 zf-RanBP PF00641 1.9e-08 1
ENSP00000258149 zf-RanBP PF00641 2e-08 1
ENSP00000377068 zf-RanBP PF00641 2.1e-08 1
ENSP00000335096 zf-RanBP PF00641 2.1e-08 1
ENSP00000377065 zf-RanBP PF00641 6.2e-08 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
27748758 MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation. D-L Qi 2017-03-30 Oncogene
26687066 The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. G Christina Towers 2015-12-21 Nature communications
36182806 RNA binding protein IGF2BP1 meditates oxidative stress-induced granulosa cell dysfunction by regulating MDM2 mRNA stability in an m6A-dependent manner. Hongbei Mu 2022-09-24 Redox biology
22710720 MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability. E Xu 2013-04-25 Oncogene
33888565 The roles and regulation of MDM2 and MDMX: it is not just about p53. M Alyssa Klein 2021-05-01 Genes & development
25831048 Cisplatin fails to induce puma mediated apoptosis in mucosal melanomas. Kristin Marie Fritsche 2015-01-01 Oncotarget
26459564 Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the Multi-Ethnic Study of Atherosclerosis. B Erin Ware 2015-10-12 BMC genetics
21822304 MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells. L Gu 2012-03-15 Oncogene
35326742 Targeting an MDM2/MYC Axis to Overcome Drug Resistance in Multiple Myeloma. Omar Faruq 2022-03-21 Cancers
24147044 Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator. R Danielle Okoro 2013-01-01 PloS one
26397130 p53-mediated control of gene expression via mRNA translation during Endoplasmic Reticulum stress. Ignacio López 2015-01-01 Cell cycle (Georgetown, Tex.)
28274247 Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer. Jing Xiong 2017-03-09 Breast cancer research : BCR
27666947 Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Lubing Gu 2016-10-10 Cancer cell
19075680 Posttranscriptional regulation of p53 and its targets by RNA-binding proteins. Jin Zhang 2008-12-01 Current molecular medicine
25734904 Impact of TP53 codon 72 and MDM2 SNP 309 polymorphisms in pancreatic ductal adenocarcinoma. Yasuki Hori 2015-01-01 PloS one
26940078 A mix-and-read drop-based in vitro two-hybrid method for screening high-affinity peptide binders. Naiwen Cui 2016-03-04 Scientific reports

Transcripts

Name Transcript ID bp Protein Translation ID
MDM2-202 ENST00000258149 7490 497aa ENSP00000258149
MDM2-204 ENST00000311420 1583 84aa ENSP00000310742
MDM2-218 ENST00000493419 577 No protein -
MDM2-213 ENST00000393417 1683 76aa ENSP00000429021
MDM2-201 ENST00000258148 1361 442aa ENSP00000258148
MDM2-224 ENST00000539479 2523 491aa ENSP00000444430
MDM2-211 ENST00000393415 842 256aa ENSP00000377067
MDM2-221 ENST00000523991 505 143aa ENSP00000427828
MDM2-229 ENST00000543323 427 117aa ENSP00000439238
MDM2-212 ENST00000393416 1748 522aa ENSP00000377068
MDM2-217 ENST00000481186 1057 36aa ENSP00000431110
MDM2-208 ENST00000393410 732 243aa ENSP00000377062
MDM2-219 ENST00000496959 897 60aa ENSP00000429692
MDM2-203 ENST00000299252 966 321aa ENSP00000299252
MDM2-207 ENST00000360430 891 296aa ENSP00000353611
MDM2-220 ENST00000517852 393 130aa ENSP00000430257
MDM2-233 ENST00000546048 363 78aa ENSP00000445222
MDM2-225 ENST00000540352 1315 170aa ENSP00000445030
MDM2-227 ENST00000542502 1127 84aa ENSP00000444566
MDM2-223 ENST00000537182 1011 78aa ENSP00000443450
MDM2-222 ENST00000536089 1181 78aa ENSP00000444028
MDM2-210 ENST00000393413 657 218aa ENSP00000377065
MDM2-206 ENST00000350057 1401 466aa ENSP00000266624
MDM2-232 ENST00000545204 866 68aa ENSP00000444597
MDM2-231 ENST00000544561 1480 455aa ENSP00000441841
MDM2-234 ENST00000665020 1472 185aa ENSP00000499718
MDM2-235 ENST00000666617 1499 64aa ENSP00000499763
MDM2-236 ENST00000671567 1527 134aa ENSP00000499407
MDM2-205 ENST00000348801 799 266aa ENSP00000335096
MDM2-216 ENST00000478070 693 50aa ENSP00000430906
MDM2-215 ENST00000471946 251 No protein -
MDM2-228 ENST00000543046 432 No protein -
MDM2-226 ENST00000540709 502 No protein -
MDM2-230 ENST00000544125 649 No protein -
MDM2-214 ENST00000400501 406 No protein -
MDM2-209 ENST00000393412 1404 243aa ENSP00000377064

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000135679homo_sapiensENSP0000035615052.653132.2449homo_sapiensENSP0000025814951.911531.7907

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000135679homo_sapiensENSP0000025814995.774793.9638nomascus_leucogenysENSNLEP0000003784295.0193.2136
ENSG00000135679homo_sapiensENSP0000025814995.774794.3662pan_paniscusENSPPAP0000001934395.390893.988
ENSG00000135679homo_sapiensENSP0000025814999.798899.1952pongo_abeliiENSPPYP0000004312999.798899.1952
ENSG00000135679homo_sapiensENSP0000025814995.774794.3662pan_troglodytesENSPTRP0000006286895.390893.988
ENSG00000135679homo_sapiensENSP0000025814995.573494.165gorilla_gorillaENSGGOP0000003943094.810493.4132
ENSG00000135679homo_sapiensENSP0000025814929.778725.3521ornithorhynchus_anatinusENSOANP0000003888973.631862.6866
ENSG00000135679homo_sapiensENSP0000025814984.305874.4467sarcophilus_harrisiiENSSHAP0000002707386.749576.6046
ENSG00000135679homo_sapiensENSP0000025814979.678168.6117sarcophilus_harrisiiENSSHAP0000003828563.258854.4728
ENSG00000135679homo_sapiensENSP0000025814942.857141.8511choloepus_hoffmanniENSCHOP0000000804776.344174.552
ENSG00000135679homo_sapiensENSP0000025814996.579592.3541dasypus_novemcinctusENSDNOP0000002958093.7589.6484
ENSG00000135679homo_sapiensENSP0000025814970.221363.3803dasypus_novemcinctusENSDNOP0000002450080.78772.9167
ENSG00000135679homo_sapiensENSP0000025814984.50780.2817erinaceus_europaeusENSEEUP0000001262287.136982.7801
ENSG00000135679homo_sapiensENSP0000025814975.452771.0262echinops_telfairiENSETEP0000000907276.064971.6024
ENSG00000135679homo_sapiensENSP0000025814987.122785.3119callithrix_jacchusENSCJAP0000006054397.522595.4955
ENSG00000135679homo_sapiensENSP0000025814991.750590.1408callithrix_jacchusENSCJAP0000001399897.854196.1373
ENSG00000135679homo_sapiensENSP0000025814999.798899.3964cercocebus_atysENSCATP0000004584299.798899.3964
ENSG00000135679homo_sapiensENSP0000025814946.277746.0765cercocebus_atysENSCATP0000000009098.712498.2833
ENSG00000135679homo_sapiensENSP0000025814998.591698.1891macaca_fascicularisENSMFAP0000005711899.796399.389
ENSG00000135679homo_sapiensENSP0000025814999.798899.3964macaca_mulattaENSMMUP0000001864599.798899.3964
ENSG00000135679homo_sapiensENSP0000025814999.798899.3964macaca_nemestrinaENSMNEP0000003653199.798899.3964
ENSG00000135679homo_sapiensENSP0000025814999.798899.3964papio_anubisENSPANP0000004658399.798899.3964
ENSG00000135679homo_sapiensENSP0000025814999.798899.3964mandrillus_leucophaeusENSMLEP0000003623799.798899.3964
ENSG00000135679homo_sapiensENSP0000025814980.482978.2696tursiops_truncatusENSTTRP0000001489180.808178.5859
ENSG00000135679homo_sapiensENSP0000025814923.742522.9376vulpes_vulpesENSVVUP0000001388892.187589.0625
ENSG00000135679homo_sapiensENSP0000025814933.199232.5956vulpes_vulpesENSVVUP0000001388393.220391.5254
ENSG00000135679homo_sapiensENSP0000025814986.317980.8853mus_spretusMGP_SPRETEiJ_P002608688.090382.5462
ENSG00000135679homo_sapiensENSP0000025814987.726483.0986equus_asinusENSEASP0000501144885.996181.4596
ENSG00000135679homo_sapiensENSP0000025814996.177192.7565capra_hircusENSCHIP0000002169697.352393.89
ENSG00000135679homo_sapiensENSP0000025814990.543386.1167loxodonta_africanaENSLAFP0000000493591.463486.9919
ENSG00000135679homo_sapiensENSP0000025814995.573493.5614panthera_leoENSPLOP0000002258696.741394.7047
ENSG00000135679homo_sapiensENSP0000025814995.17193.7626ailuropoda_melanoleucaENSAMEP0000002769997.125395.6879
ENSG00000135679homo_sapiensENSP0000025814994.768690.5433bos_indicus_hybridENSBIXP0000502861968.359965.312
ENSG00000135679homo_sapiensENSP0000025814917.303816.0966oryctolagus_cuniculusENSOCUP0000002465486.868780.8081
ENSG00000135679homo_sapiensENSP0000025814987.927683.2998equus_caballusENSECAP0000002795485.854681.336
ENSG00000135679homo_sapiensENSP0000025814991.951788.9336canis_lupus_familiarisENSCAFP0084502288366.812964.6199
ENSG00000135679homo_sapiensENSP0000025814996.177194.165panthera_pardusENSPPRP0000000359496.37194.3548
ENSG00000135679homo_sapiensENSP0000025814915.49315.0905marmota_marmota_marmotaENSMMMP0000002574893.902491.4634
ENSG00000135679homo_sapiensENSP0000025814948.490945.2716marmota_marmota_marmotaENSMMMP0000002032193.050286.8726
ENSG00000135679homo_sapiensENSP0000025814944.466840.4427marmota_marmota_marmotaENSMMMP0000000624890.204182.0408
ENSG00000135679homo_sapiensENSP0000025814996.579594.3662balaenoptera_musculusENSBMSP0001002300997.759795.5193
ENSG00000135679homo_sapiensENSP0000025814993.762688.5312cavia_porcellusENSCPOP0000002152394.908389.613
ENSG00000135679homo_sapiensENSP0000025814996.579594.165felis_catusENSFCAP0000002506767.415765.7303
ENSG00000135679homo_sapiensENSP0000025814995.372293.7626ursus_americanusENSUAMP0000002376395.757694.1414
ENSG00000135679homo_sapiensENSP0000025814926.156924.7485ursus_americanusENSUAMP0000002742978.787974.5455
ENSG00000135679homo_sapiensENSP0000025814984.708374.0443monodelphis_domesticaENSMODP0000000894786.983576.0331
ENSG00000135679homo_sapiensENSP0000025814997.183193.7626bison_bison_bisonENSBBBP0000001966197.183193.7626
ENSG00000135679homo_sapiensENSP0000025814997.384394.7686monodon_monocerosENSMMNP0001502871597.384394.7686
ENSG00000135679homo_sapiensENSP0000025814995.17192.3541sus_scrofaENSSSCP0000003469496.33493.4827
ENSG00000135679homo_sapiensENSP0000025814978.873274.6479microcebus_murinusENSMICP0000004464490.114985.2874
ENSG00000135679homo_sapiensENSP0000025814975.452772.2334microcebus_murinusENSMICP0000004365987.616883.8785
ENSG00000135679homo_sapiensENSP0000025814988.531285.5131microcebus_murinusENSMICP0000001802694.420691.2017
ENSG00000135679homo_sapiensENSP0000025814988.3383.501octodon_degusENSODEP0000000532891.84186.8201
ENSG00000135679homo_sapiensENSP0000025814977.66671.6298octodon_degusENSODEP0000000888986.741680
ENSG00000135679homo_sapiensENSP0000025814937.82734.8089octodon_degusENSODEP0000001153686.635979.7235
ENSG00000135679homo_sapiensENSP0000025814978.67273.2394octodon_degusENSODEP000000004839285.6471
ENSG00000135679homo_sapiensENSP0000025814936.820932.998jaculus_jaculusENSJJAP0000001313290.147880.7882
ENSG00000135679homo_sapiensENSP0000025814954.527251.5091jaculus_jaculusENSJJAP0000001864591.554186.4865
ENSG00000135679homo_sapiensENSP0000025814938.83335.6137jaculus_jaculusENSJJAP0000002208286.936979.7297
ENSG00000135679homo_sapiensENSP0000025814986.720382.8974ovis_aries_rambouilletENSOARP0002002595097.072192.7928
ENSG00000135679homo_sapiensENSP0000025814996.981993.3602ovis_aries_rambouilletENSOARP0002000532296.981993.3602
ENSG00000135679homo_sapiensENSP0000025814995.17193.5614ursus_maritimusENSUMAP0000002857097.125395.4825
ENSG00000135679homo_sapiensENSP0000025814991.348185.1107ochotona_princepsENSOPRP0000000886491.902885.6275
ENSG00000135679homo_sapiensENSP0000025814996.378393.7626delphinapterus_leucasENSDLEP0000000263597.55694.9083
ENSG00000135679homo_sapiensENSP0000025814997.384394.3662physeter_catodonENSPCTP0000500492997.384394.3662
ENSG00000135679homo_sapiensENSP0000025814985.513179.6781mus_caroliMGP_CAROLIEiJ_P002483386.032480.1619
ENSG00000135679homo_sapiensENSP0000025814986.720380.4829mus_musculusENSMUSP0000002040888.139181.7996
ENSG00000135679homo_sapiensENSP0000025814980.281774.0443dipodomys_ordiiENSDORP0000000677089.461982.5112
ENSG00000135679homo_sapiensENSP0000025814994.567491.9517mustela_putorius_furoENSMPUP0000001739496.509293.8398
ENSG00000135679homo_sapiensENSP0000025814982.092681.2877aotus_nancymaaeENSANAP0000001872597.607796.6507
ENSG00000135679homo_sapiensENSP0000025814996.981995.5734saimiri_boliviensis_boliviensisENSSBOP0000000326198.16796.7413
ENSG00000135679homo_sapiensENSP0000025814990.543387.9276vicugna_pacosENSVPAP0000000693895.541492.7813
ENSG00000135679homo_sapiensENSP0000025814998.390397.9879chlorocebus_sabaeusENSCSAP0000000059899.592799.1853
ENSG00000135679homo_sapiensENSP0000025814969.014165.3924tupaia_belangeriENSTBEP0000001191575.717471.7439
ENSG00000135679homo_sapiensENSP0000025814949.295845.8753mesocricetus_auratusENSMAUP0000002577790.740784.4444
ENSG00000135679homo_sapiensENSP0000025814997.384394.7686phocoena_sinusENSPSNP0000000611697.384394.7686
ENSG00000135679homo_sapiensENSP0000025814995.975992.9577camelus_dromedariusENSCDRP0000502176495.975992.9577
ENSG00000135679homo_sapiensENSP0000025814976.257570.2213carlito_syrichtaENSTSYP0000002300688.967181.9249
ENSG00000135679homo_sapiensENSP0000025814995.774793.7626panthera_tigris_altaicaENSPTIP0000001908596.94594.9083
ENSG00000135679homo_sapiensENSP0000025814985.311978.0684rattus_norvegicusENSRNOP0000007988588.888981.3417
ENSG00000135679homo_sapiensENSP0000025814997.183195.3722prolemur_simusENSPSMP0000000494597.575895.7576
ENSG00000135679homo_sapiensENSP0000025814990.34286.1167microtus_ochrogasterENSMOCP0000000811892.577388.2474
ENSG00000135679homo_sapiensENSP0000025814989.738484.7083sorex_araneusENSSARP0000000525491.020485.9184
ENSG00000135679homo_sapiensENSP0000025814920.120717.3038peromyscus_maniculatus_bairdiiENSPEMP0000003111381.300869.9187
ENSG00000135679homo_sapiensENSP0000025814936.820933.8028peromyscus_maniculatus_bairdiiENSPEMP0000000795691.044883.5821
ENSG00000135679homo_sapiensENSP0000025814996.378393.3602bos_mutusENSBMUP0000001469697.357794.3089
ENSG00000135679homo_sapiensENSP0000025814987.122781.2877mus_spicilegusENSMSIP0000002649483.752478.1431
ENSG00000135679homo_sapiensENSP0000025814987.726482.8974cricetulus_griseus_chok1gshdENSCGRP0000102429891.213486.1925
ENSG00000135679homo_sapiensENSP0000025814991.750587.9276pteropus_vampyrusENSPVAP0000000586791.566387.751
ENSG00000135679homo_sapiensENSP0000025814993.963889.9396myotis_lucifugusENSMLUP0000000910993.587289.5792
ENSG00000135679homo_sapiensENSP0000025814984.305875.4527vombatus_ursinusENSVURP0001003156478.464470.2247
ENSG00000135679homo_sapiensENSP0000025814924.748519.9195vombatus_ursinusENSVURP0001001772271.098357.2254
ENSG00000135679homo_sapiensENSP0000025814950.100647.0825rhinolophus_ferrumequinumENSRFEP0001001451389.891784.4765
ENSG00000135679homo_sapiensENSP0000025814936.418535.4125rhinolophus_ferrumequinumENSRFEP0001002094493.29990.7216
ENSG00000135679homo_sapiensENSP0000025814993.762689.9396rhinolophus_ferrumequinumENSRFEP0001000426793.762689.9396
ENSG00000135679homo_sapiensENSP0000025814961.569459.3561neovison_visonENSNVIP0000001334996.5393.0599
ENSG00000135679homo_sapiensENSP0000025814996.378392.9577bos_taurusENSBTAP0000007277897.357793.9024
ENSG00000135679homo_sapiensENSP0000025814919.517116.499heterocephalus_glaber_femaleENSHGLP0000005430384.347871.3043
ENSG00000135679homo_sapiensENSP0000025814980.885375.4527heterocephalus_glaber_femaleENSHGLP0000002592987.581781.6993
ENSG00000135679homo_sapiensENSP0000025814936.016134.004heterocephalus_glaber_femaleENSHGLP0000000869589.054784.0796
ENSG00000135679homo_sapiensENSP0000025814930.181128.3702heterocephalus_glaber_femaleENSHGLP0000000869390.909185.4545
ENSG00000135679homo_sapiensENSP0000025814991.348186.5191heterocephalus_glaber_femaleENSHGLP0000005470991.902887.0445
ENSG00000135679homo_sapiensENSP0000025814992.354187.3239heterocephalus_glaber_femaleENSHGLP0000002252890.711585.7708
ENSG00000135679homo_sapiensENSP0000025814995.774794.3662rhinopithecus_bietiENSRBIP0000000942792.787591.423
ENSG00000135679homo_sapiensENSP0000025814993.762691.7505canis_lupus_dingoENSCAFP0002002150195.687993.6345
ENSG00000135679homo_sapiensENSP0000025814943.259640.0402sciurus_vulgarisENSSVLP0000501368087.755181.2245
ENSG00000135679homo_sapiensENSP0000025814994.16591.1469sciurus_vulgarisENSSVLP0000501929194.545591.5152
ENSG00000135679homo_sapiensENSP0000025814929.979926.9618phascolarctos_cinereusENSPCIP0000000635886.127277.4566
ENSG00000135679homo_sapiensENSP0000025814922.132819.3159phascolarctos_cinereusENSPCIP0000002661590.909179.3388
ENSG00000135679homo_sapiensENSP0000025814952.112745.8753phascolarctos_cinereusENSPCIP0000000636186.333376
ENSG00000135679homo_sapiensENSP0000025814990.744585.1107procavia_capensisENSPCAP0000000835590.562284.9398
ENSG00000135679homo_sapiensENSP0000025814992.152987.5252nannospalax_galiliENSNGAP0000000948094.238789.5062
ENSG00000135679homo_sapiensENSP0000025814994.768690.7445bos_grunniensENSBGRP0000003601868.359965.4572
ENSG00000135679homo_sapiensENSP0000025814994.366289.7384chinchilla_lanigeraENSCLAP0000001433293.612889.022
ENSG00000135679homo_sapiensENSP0000025814994.16589.5372cervus_hanglu_yarkandensisENSCHYP0000000340068.321264.9635
ENSG00000135679homo_sapiensENSP0000025814993.360290.5433catagonus_wagneriENSCWAP0000002387595.867892.9752
ENSG00000135679homo_sapiensENSP0000025814943.66239.4366ictidomys_tridecemlineatusENSSTOP0000001585090.79582.0084
ENSG00000135679homo_sapiensENSP0000025814994.366291.7505ictidomys_tridecemlineatusENSSTOP0000001317195.9193.2515
ENSG00000135679homo_sapiensENSP0000025814939.83938.0282ictidomys_tridecemlineatusENSSTOP0000002446394.736890.4306
ENSG00000135679homo_sapiensENSP0000025814988.3384.1046otolemur_garnettiiENSOGAP0000002101489.046784.787
ENSG00000135679homo_sapiensENSP0000025814991.348184.1046otolemur_garnettiiENSOGAP0000001059993.223885.8316
ENSG00000135679homo_sapiensENSP0000025814997.585596.1771cebus_imitatorENSCCAP0000000109597.194495.7916
ENSG00000135679homo_sapiensENSP0000025814960.362257.1429cebus_imitatorENSCCAP0000003470481.521777.1739
ENSG00000135679homo_sapiensENSP0000025814994.16591.5493urocitellus_parryiiENSUPAP0001002974694.16591.5493
ENSG00000135679homo_sapiensENSP0000025814962.977955.7344urocitellus_parryiiENSUPAP0001000396090.462480.0578
ENSG00000135679homo_sapiensENSP0000025814996.579593.5614moschus_moschiferusENSMMSP0000002673396.579593.5614
ENSG00000135679homo_sapiensENSP0000025814995.573494.165rhinopithecus_roxellanaENSRROP0000004541092.592691.2281
ENSG00000135679homo_sapiensENSP0000025814988.3387.7264rhinopithecus_roxellanaENSRROP0000003381898.430597.7579
ENSG00000135679homo_sapiensENSP0000025814988.128881.8913mus_pahariMGP_PahariEiJ_P008782588.484882.2222
ENSG00000135679homo_sapiensENSP0000025814985.110782.6962propithecus_coquereliENSPCOP0000001375597.018394.2661
ENSG00000135679homo_sapiensENSP0000025814939.034222.9376ciona_intestinalisENSCINP0000000226741.364624.307
ENSG00000135679homo_sapiensENSP0000025814923.742516.0966petromyzon_marinusENSPMAP000000080975940
ENSG00000135679homo_sapiensENSP0000025814939.83925.7545eptatretus_burgeriENSEBUP0000000173146.698130.1887
ENSG00000135679homo_sapiensENSP0000025814964.185149.497callorhinchus_miliiENSCMIP0000004758670.575254.4248
ENSG00000135679homo_sapiensENSP0000025814973.641960.5634latimeria_chalumnaeENSLACP0000001159975.463962.0619
ENSG00000135679homo_sapiensENSP0000025814962.776748.8934lepisosteus_oculatusENSLOCP0000001995063.803749.6933
ENSG00000135679homo_sapiensENSP0000025814961.971844.8692clupea_harengusENSCHAP0000001085160.510843.8114
ENSG00000135679homo_sapiensENSP0000025814958.752544.8692danio_rerioENSDARP0000007232061.473746.9474
ENSG00000135679homo_sapiensENSP0000025814958.148945.674carassius_auratusENSCARP0000002965760.33447.3904
ENSG00000135679homo_sapiensENSP0000025814958.953744.8692carassius_auratusENSCARP0000003045361.297146.6527
ENSG00000135679homo_sapiensENSP0000025814960.764646.8813astyanax_mexicanusENSAMXP0000004887255.616942.9098
ENSG00000135679homo_sapiensENSP0000025814958.350145.8753ictalurus_punctatusENSIPUP0000003651061.310848.203
ENSG00000135679homo_sapiensENSP0000025814958.350144.0644esox_luciusENSELUP0000001347759.917445.2479
ENSG00000135679homo_sapiensENSP0000025814959.356146.6801electrophorus_electricusENSEEEP0000005237657.617245.3125
ENSG00000135679homo_sapiensENSP0000025814959.154944.668oncorhynchus_kisutchENSOKIP0000505190960.493845.679
ENSG00000135679homo_sapiensENSP0000025814959.154944.668oncorhynchus_kisutchENSOKIP0000510076260.493845.679
ENSG00000135679homo_sapiensENSP0000025814959.356145.2716oncorhynchus_mykissENSOMYP0000008606760.699646.2963
ENSG00000135679homo_sapiensENSP0000025814959.356145.2716oncorhynchus_mykissENSOMYP0000011116960.699646.2963
ENSG00000135679homo_sapiensENSP0000025814960.16145.2716salmo_salarENSSSAP0000006566256.415142.4528
ENSG00000135679homo_sapiensENSP0000025814960.16145.2716salmo_salarENSSSAP0000017911857.279743.1034
ENSG00000135679homo_sapiensENSP0000025814959.557345.0704salmo_truttaENSSTUP0000005347960.285145.6212
ENSG00000135679homo_sapiensENSP0000025814954.124740.8451salmo_truttaENSSTUP0000006139358.605744.2266
ENSG00000135679homo_sapiensENSP0000025814957.344144.4668fundulus_heteroclitusENSFHEP0000002725950.983939.5349
ENSG00000135679homo_sapiensENSP0000025814952.112738.6318poecilia_reticulataENSPREP0000003234759.677444.2396
ENSG00000135679homo_sapiensENSP0000025814952.716339.0342xiphophorus_maculatusENSXMAP0000002871655.982941.453
ENSG00000135679homo_sapiensENSP0000025814957.947743.8632oryzias_latipesENSORLP0000003470657.831343.7751
ENSG00000135679homo_sapiensENSP0000025814958.551344.4668cyclopterus_lumpusENSCLMP0000502361155.961542.5
ENSG00000135679homo_sapiensENSP0000025814914.486910.4628oreochromis_niloticusENSONIP0000006943464.285746.4286
ENSG00000135679homo_sapiensENSP0000025814911.87129.65795oreochromis_niloticusENSONIP0000007554361.458350
ENSG00000135679homo_sapiensENSP0000025814957.344143.8632haplochromis_burtoniENSHBUP0000000288454.597741.7625
ENSG00000135679homo_sapiensENSP0000025814957.545343.8632astatotilapia_callipteraENSACLP0000001840754.684541.6826
ENSG00000135679homo_sapiensENSP0000025814958.551345.0704sparus_aurataENSSAUP0001005955454.392541.8692
ENSG00000135679homo_sapiensENSP0000025814958.350143.8632lates_calcariferENSLCAP0001001417456.751542.6614
ENSG00000135679homo_sapiensENSP0000025814944.66833.4004lates_calcariferENSLCAP0001001594652.983339.6181
ENSG00000135679homo_sapiensENSP0000025814958.350143.8632lates_calcariferENSLCAP0001000527156.751542.6614
ENSG00000135679homo_sapiensENSP0000025814974.245556.338xenopus_tropicalisENSXETP0000011376346.473635.2645
ENSG00000135679homo_sapiensENSP0000025814982.49569.0141chrysemys_picta_belliiENSCPBP0000001822884.016470.2869
ENSG00000135679homo_sapiensENSP0000025814979.678165.5936sphenodon_punctatusENSSPUP0000000121080.816366.5306
ENSG00000135679homo_sapiensENSP0000025814943.259635.4125crocodylus_porosusENSCPRP0000501000377.898663.7681
ENSG00000135679homo_sapiensENSP0000025814932.796827.7666crocodylus_porosusENSCPRP0000500999886.243473.0159
ENSG00000135679homo_sapiensENSP0000025814976.056360.161laticauda_laticaudataENSLLTP0000002399481.115964.1631
ENSG00000135679homo_sapiensENSP0000025814975.855159.7586notechis_scutatusENSNSUP0000000505280.901363.7339
ENSG00000135679homo_sapiensENSP0000025814916.700213.6821pseudonaja_textilisENSPTXP0000001157383.838468.6869
ENSG00000135679homo_sapiensENSP0000025814976.056359.7586pseudonaja_textilisENSPTXP0000001050381.115963.7339
ENSG00000135679homo_sapiensENSP0000025814912.877311.2676anas_platyrhynchos_platyrhynchosENSAPLP0000002654295.522483.5821
ENSG00000135679homo_sapiensENSP0000025814965.593653.9235anas_platyrhynchos_platyrhynchosENSAPLP0000001091477.068663.357
ENSG00000135679homo_sapiensENSP0000025814981.086566.3984gallus_gallusENSGALP0001001760483.436968.323
ENSG00000135679homo_sapiensENSP0000025814980.080564.9899meleagris_gallopavoENSMGAP0000001093883.613467.8571
ENSG00000135679homo_sapiensENSP0000025814980.281767.002serinus_canariaENSSCAP0000001235282.43868.8017
ENSG00000135679homo_sapiensENSP0000025814981.690169.0141parus_majorENSPMJP0000001671381.362768.7375
ENSG00000135679homo_sapiensENSP0000025814972.635858.7525anolis_carolinensisENSACAP0000000419269.289856.0461
ENSG00000135679homo_sapiensENSP0000025814946.076534.4064neolamprologus_brichardiENSNBRP0000001812451.8138.6878
ENSG00000135679homo_sapiensENSP0000025814964.788749.8994naja_najaENSNNAP0000000611875.586958.216
ENSG00000135679homo_sapiensENSP0000025814973.843157.7465podarcis_muralisENSPMRP0000002771978.924761.7204
ENSG00000135679homo_sapiensENSP0000025814979.678166.1972geospiza_fortisENSGFOP0000000992781.987668.1159
ENSG00000135679homo_sapiensENSP0000025814980.482967.2032taeniopygia_guttataENSTGUP0000002207082.644669.0083
ENSG00000135679homo_sapiensENSP0000025814961.971847.8873erpetoichthys_calabaricusENSECRP0000000234765.116350.3171
ENSG00000135679homo_sapiensENSP0000025814953.923540.4427kryptolebias_marmoratusENSKMAP0000000109259.821444.8661
ENSG00000135679homo_sapiensENSP0000025814974.245560.5634salvator_merianaeENSSMRP0000002203679.525964.8707
ENSG00000135679homo_sapiensENSP0000025814958.148943.662oryzias_javanicusENSOJAP0000003909058.739844.1057
ENSG00000135679homo_sapiensENSP0000025814943.058332.1932amphilophus_citrinellusENSACIP0000000042152.322739.1198
ENSG00000135679homo_sapiensENSP0000025814912.07249.85915amphilophus_citrinellusENSACIP0000002369863.157951.5789
ENSG00000135679homo_sapiensENSP0000025814913.480910.4628amphilophus_citrinellusENSACIP0000002372361.467947.7064
ENSG00000135679homo_sapiensENSP0000025814957.947744.668dicentrarchus_labraxENSDLAP0000501010656.360143.4442
ENSG00000135679homo_sapiensENSP0000025814914.084510.8652amphiprion_perculaENSAPEP0000001935561.946947.7876
ENSG00000135679homo_sapiensENSP0000025814912.877310.4628amphiprion_perculaENSAPEP0000001940764.646552.5253
ENSG00000135679homo_sapiensENSP0000025814958.752545.2716amphiprion_perculaENSAPEP0000002670358.283444.9102
ENSG00000135679homo_sapiensENSP0000025814958.148944.0644oryzias_sinensisENSOSIP0000003780557.455343.5388
ENSG00000135679homo_sapiensENSP0000025814976.6664.5875pelodiscus_sinensisENSPSIP0000001849281.935569.0323
ENSG00000135679homo_sapiensENSP0000025814919.517115.2918pelodiscus_sinensisENSPSIP0000000159674.615458.4615
ENSG00000135679homo_sapiensENSP0000025814972.83758.5513gopherus_evgoodeiENSGEVP0000500244575.89161.0063
ENSG00000135679homo_sapiensENSP0000025814928.571423.1388gopherus_evgoodeiENSGEVP0000502152179.329664.2458
ENSG00000135679homo_sapiensENSP0000025814912.877310.2616gopherus_evgoodeiENSGEVP0000502034575.294160
ENSG00000135679homo_sapiensENSP0000025814931.187125.5533gopherus_evgoodeiENSGEVP0000503015273.459760.1896
ENSG00000135679homo_sapiensENSP0000025814934.607628.3702gopherus_evgoodeiENSGEVP0000502144275.109261.5721
ENSG00000135679homo_sapiensENSP0000025814914.084510.8652gopherus_evgoodeiENSGEVP0000502023552.238840.2985
ENSG00000135679homo_sapiensENSP0000025814928.370224.9497chelonoidis_abingdoniiENSCABP0000002121388.12577.5
ENSG00000135679homo_sapiensENSP0000025814918.309915.2918chelonoidis_abingdoniiENSCABP000000224617058.4615
ENSG00000135679homo_sapiensENSP0000025814935.412528.169chelonoidis_abingdoniiENSCABP0000002245774.261659.0717
ENSG00000135679homo_sapiensENSP0000025814958.350144.8692seriola_dumeriliENSSDUP0000002404857.539744.246
ENSG00000135679homo_sapiensENSP0000025814979.879366.3984struthio_camelus_australisENSSCUP0000000638574.905762.2642
ENSG00000135679homo_sapiensENSP0000025814981.287768.008anser_brachyrhynchusENSABRP0000002650281.616268.2828
ENSG00000135679homo_sapiensENSP0000025814954.728441.2475gasterosteus_aculeatusENSGACP0000000141556.78542.7975
ENSG00000135679homo_sapiensENSP0000025814949.698237.0221cynoglossus_semilaevisENSCSEP0000000532359.37544.2308
ENSG00000135679homo_sapiensENSP0000025814956.136842.6559poecilia_formosaENSPFOP0000001739959.235745.0106
ENSG00000135679homo_sapiensENSP0000025814957.746544.4668myripristis_murdjanENSMMDP0000501485248.154437.0805
ENSG00000135679homo_sapiensENSP0000025814957.746544.668sander_luciopercaENSSLUP0000001758057.285444.3114
ENSG00000135679homo_sapiensENSP0000025814981.690168.2093strigops_habroptilaENSSHBP0000502293784.05870.1863
ENSG00000135679homo_sapiensENSP0000025814950.704239.4366amphiprion_ocellarisENSAOCP0000000415654.545542.4242
ENSG00000135679homo_sapiensENSP0000025814942.655931.1871amphiprion_ocellarisENSAOCP0000002317252.475238.3663
ENSG00000135679homo_sapiensENSP0000025814982.696269.4165terrapene_carolina_triunguisENSTMTP0000002292681.065168.0473
ENSG00000135679homo_sapiensENSP0000025814925.955720.5231hucho_huchoENSHHUP0000001014752.868941.8033
ENSG00000135679homo_sapiensENSP0000025814956.941743.662betta_splendensENSBSLP0000005008457.755144.2857
ENSG00000135679homo_sapiensENSP0000025814959.356145.2716pygocentrus_nattereriENSPNAP0000000297360.327246.0123
ENSG00000135679homo_sapiensENSP0000025814912.67619.65795anabas_testudineusENSATEP0000004747163.636448.4848
ENSG00000135679homo_sapiensENSP0000025814912.67619.65795anabas_testudineusENSATEP0000006493463.636448.4848
ENSG00000135679homo_sapiensENSP0000025814957.746544.0644anabas_testudineusENSATEP0000003155956.944443.4524
ENSG00000135679homo_sapiensENSP0000025814923.3412.6761ciona_savignyiENSCSAVP0000001966345.669324.8032
ENSG00000135679homo_sapiensENSP0000025814958.350144.8692seriola_lalandi_dorsalisENSSLDP0000002145257.539744.246
ENSG00000135679homo_sapiensENSP0000025814952.112739.839labrus_bergyltaENSLBEP0000002127356.550243.2314
ENSG00000135679homo_sapiensENSP0000025814949.49737.827pundamilia_nyerereiENSPNYP0000002299053.829341.1379
ENSG00000135679homo_sapiensENSP0000025814958.551344.0644mastacembelus_armatusENSMAMP0000002700058.083843.7126
ENSG00000135679homo_sapiensENSP0000025814957.947744.2656stegastes_partitusENSSPAP0000001912256.031142.8016
ENSG00000135679homo_sapiensENSP0000025814913.883311.67oncorhynchus_tshawytschaENSOTSP0000502947470.408259.1837
ENSG00000135679homo_sapiensENSP0000025814958.551344.668acanthochromis_polyacanthusENSAPOP0000001935456.835943.3594
ENSG00000135679homo_sapiensENSP0000025814981.287768.008aquila_chrysaetos_chrysaetosENSACCP0002002037383.471169.8347
ENSG00000135679homo_sapiensENSP0000025814954.32640.2414nothobranchius_furzeriENSNFUP0001505200057.446842.5532
ENSG00000135679homo_sapiensENSP0000025814957.947744.8692cyprinodon_variegatusENSCVAP0000002342659.75146.2656
ENSG00000135679homo_sapiensENSP0000025814960.16144.668denticeps_clupeoidesENSDCDP0000005738461.270545.4918
ENSG00000135679homo_sapiensENSP0000025814957.344143.662larimichthys_croceaENSLCRP0000505208555.339842.1359
ENSG00000135679homo_sapiensENSP0000025814920.120713.8833larimichthys_croceaENSLCRP0000505211755.555638.3333
ENSG00000135679homo_sapiensENSP0000025814957.947743.4608takifugu_rubripesENSTRUP0000002087658.181843.6364
ENSG00000135679homo_sapiensENSP0000025814981.086568.008ficedula_albicollisENSFALP0000001057483.264569.8347
ENSG00000135679homo_sapiensENSP0000025814956.136842.4547hippocampus_comesENSHCOP0000001904354.174840.9709
ENSG00000135679homo_sapiensENSP0000025814960.16146.0765cyprinus_carpio_carpioENSCCRP0000008042154.862442.0183
ENSG00000135679homo_sapiensENSP0000025814958.752546.0765cyprinus_carpio_carpioENSCCRP0000015439460.082347.1193
ENSG00000135679homo_sapiensENSP0000025814971.629857.7465coturnix_japonicaENSCJPP0000501967879.464364.0625
ENSG00000135679homo_sapiensENSP0000025814956.539242.8571poecilia_latipinnaENSPLAP0000000350759.660345.2229
ENSG00000135679homo_sapiensENSP0000025814959.154946.2777sinocyclocheilus_grahamiENSSGRP0000009106657.421944.9219
ENSG00000135679homo_sapiensENSP0000025814947.484936.0161sinocyclocheilus_grahamiENSSGRP0000007207458.852944.6384
ENSG00000135679homo_sapiensENSP0000025814957.545343.8632maylandia_zebraENSMZEP0000502889354.684541.6826
ENSG00000135679homo_sapiensENSP0000025814947.887337.827tetraodon_nigroviridisENSTNIP000000225815644.2353
ENSG00000135679homo_sapiensENSP0000025814923.138817.1026tetraodon_nigroviridisENSTNIP0000000826764.606747.7528
ENSG00000135679homo_sapiensENSP0000025814958.551345.4728paramormyrops_kingsleyaeENSPKIP0000000618563.537149.345
ENSG00000135679homo_sapiensENSP0000025814958.350145.674scleropages_formosusENSSFOP0001502647064.732150.6696
ENSG00000135679homo_sapiensENSP0000025814970.221355.7344leptobrachium_leishanenseENSLLEP0000004485571.079456.4155
ENSG00000135679homo_sapiensENSP0000025814956.941743.0583scophthalmus_maximusENSSMAP0000001300553.195540.2256
ENSG00000135679homo_sapiensENSP0000025814958.148944.2656oryzias_melastigmaENSOMEP0000002157458.148944.2656

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0000209involved_in protein polyubiquitination1TASHomo_sapiens(9606)Process
GO:0001568involved_in blood vessel development1IEAHomo_sapiens(9606)Process
GO:0001974involved_in blood vessel remodeling1IEAHomo_sapiens(9606)Process
GO:0002027involved_in regulation of heart rate1IEAHomo_sapiens(9606)Process
GO:0002039enables p53 binding2IBA,IPIHomo_sapiens(9606)Function
GO:0003181involved_in atrioventricular valve morphogenesis1IEAHomo_sapiens(9606)Process
GO:0003203involved_in endocardial cushion morphogenesis1IEAHomo_sapiens(9606)Process
GO:0003281involved_in ventricular septum development1IEAHomo_sapiens(9606)Process
GO:0003283involved_in atrial septum development1IEAHomo_sapiens(9606)Process
GO:0004842enables ubiquitin-protein transferase activity2IDA,IMPHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IDA,IMPHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus2IDA,IMPHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm2IDA,IMPHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1TASHomo_sapiens(9606)Component
GO:0006511involved_in ubiquitin-dependent protein catabolic process4IDA,IGI,IMPHomo_sapiens(9606)Process
GO:0006915involved_in apoptotic process1IDAHomo_sapiens(9606)Process
GO:0006977involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1IMPHomo_sapiens(9606)Process
GO:0007049involved_in cell cycle1IBAHomo_sapiens(9606)Process
GO:0007089involved_in traversing start control point of mitotic cell cycle1IEAHomo_sapiens(9606)Process
GO:0008097enables 5S rRNA binding1IDAHomo_sapiens(9606)Function
GO:0008270enables zinc ion binding1IDAHomo_sapiens(9606)Function
GO:0008284involved_in positive regulation of cell population proliferation1TASHomo_sapiens(9606)Process
GO:0009410involved_in response to xenobiotic stimulus1IEAHomo_sapiens(9606)Process
GO:0009636involved_in response to toxic substance1IEAHomo_sapiens(9606)Process
GO:0010039involved_in response to iron ion1IEAHomo_sapiens(9606)Process
GO:0010468involved_in regulation of gene expression1IBAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IEAHomo_sapiens(9606)Process
GO:0010955involved_in negative regulation of protein processing1IEAHomo_sapiens(9606)Process
GO:0010977involved_in negative regulation of neuron projection development1IEAHomo_sapiens(9606)Process
GO:0016567involved_in protein ubiquitination2IBA,IDAHomo_sapiens(9606)Process
GO:0016604colocalizes_with nuclear body1IDAHomo_sapiens(9606)Component
GO:0016874enables ligase activity1IDAHomo_sapiens(9606)Function
GO:0016925involved_in protein sumoylation1TASHomo_sapiens(9606)Process
GO:0017053part_of transcription repressor complex1IPIHomo_sapiens(9606)Component
GO:0019789enables SUMO transferase activity1EXPHomo_sapiens(9606)Function
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0019904enables protein domain specific binding1IPIHomo_sapiens(9606)Function
GO:0030666located_in endocytic vesicle membrane1TASHomo_sapiens(9606)Component
GO:0031625enables ubiquitin protein ligase binding1IPIHomo_sapiens(9606)Function
GO:0031648involved_in protein destabilization2IDA,IMPHomo_sapiens(9606)Process
GO:0032026involved_in response to magnesium ion1IEAHomo_sapiens(9606)Process
GO:0032436involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process1IDAHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex2IDA,IMPHomo_sapiens(9606)Component
GO:0033612enables receptor serine/threonine kinase binding1IEAHomo_sapiens(9606)Function
GO:0034504involved_in protein localization to nucleus1IDAHomo_sapiens(9606)Process
GO:0042176involved_in regulation of protein catabolic process1IDAHomo_sapiens(9606)Process
GO:0042220involved_in response to cocaine1IEAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042975enables peroxisome proliferator activated receptor binding1IEAHomo_sapiens(9606)Function
GO:0043021enables ribonucleoprotein complex binding1IDAHomo_sapiens(9606)Function
GO:0043066involved_in negative regulation of apoptotic process1IBAHomo_sapiens(9606)Process
GO:0043130enables ubiquitin binding1IDAHomo_sapiens(9606)Function
GO:0043154involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process1IEAHomo_sapiens(9606)Process
GO:0043161involved_in proteasome-mediated ubiquitin-dependent protein catabolic process1TASHomo_sapiens(9606)Process
GO:0043518involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator1IDAHomo_sapiens(9606)Process
GO:0045184involved_in establishment of protein localization1IDAHomo_sapiens(9606)Process
GO:0045472involved_in response to ether1IEAHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription2IDA,IMPHomo_sapiens(9606)Process
GO:0045931involved_in positive regulation of mitotic cell cycle1IMPHomo_sapiens(9606)Process
GO:0046677involved_in response to antibiotic1IEPHomo_sapiens(9606)Process
GO:0046827involved_in positive regulation of protein export from nucleus1IEAHomo_sapiens(9606)Process
GO:0048545involved_in response to steroid hormone1IEAHomo_sapiens(9606)Process
GO:0051149involved_in positive regulation of muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:0051603involved_in proteolysis involved in protein catabolic process1IMPHomo_sapiens(9606)Process
GO:0051726acts_upstream_of regulation of cell cycle1IDAHomo_sapiens(9606)Process
GO:0051865involved_in protein autoubiquitination1IMPHomo_sapiens(9606)Process
GO:0060411involved_in cardiac septum morphogenesis1IEAHomo_sapiens(9606)Process
GO:0061630enables ubiquitin protein ligase activity4IBA,IDA,IMP,TASHomo_sapiens(9606)Function
GO:0061663enables NEDD8 ligase activity1IMPHomo_sapiens(9606)Function
GO:0065003involved_in protein-containing complex assembly1IDAHomo_sapiens(9606)Process
GO:0070301involved_in cellular response to hydrogen peroxide1IEAHomo_sapiens(9606)Process
GO:0071301involved_in cellular response to vitamin B11IEAHomo_sapiens(9606)Process
GO:0071312involved_in cellular response to alkaloid1IEAHomo_sapiens(9606)Process
GO:0071363involved_in cellular response to growth factor stimulus1IEAHomo_sapiens(9606)Process
GO:0071375involved_in cellular response to peptide hormone stimulus1IEAHomo_sapiens(9606)Process
GO:0071391involved_in cellular response to estrogen stimulus1IEAHomo_sapiens(9606)Process
GO:0071456involved_in cellular response to hypoxia1IEPHomo_sapiens(9606)Process
GO:0071480involved_in cellular response to gamma radiation1IDAHomo_sapiens(9606)Process
GO:0071494involved_in cellular response to UV-C1IEAHomo_sapiens(9606)Process
GO:0072537involved_in fibroblast activation1IEAHomo_sapiens(9606)Process
GO:0072717involved_in cellular response to actinomycin D1IDAHomo_sapiens(9606)Process
GO:0097718enables disordered domain specific binding1IPIHomo_sapiens(9606)Function
GO:1901797involved_in negative regulation of signal transduction by p53 class mediator2IDA,TASHomo_sapiens(9606)Process
GO:1902254involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator1IMPHomo_sapiens(9606)Process
GO:1904404involved_in response to formaldehyde1IEAHomo_sapiens(9606)Process
GO:1904707involved_in positive regulation of vascular associated smooth muscle cell proliferation1IEAHomo_sapiens(9606)Process
GO:1904754involved_in positive regulation of vascular associated smooth muscle cell migration1IEAHomo_sapiens(9606)Process
GO:1990000involved_in amyloid fibril formation1IMPHomo_sapiens(9606)Process
GO:1990785involved_in response to water-immersion restraint stress1IEAHomo_sapiens(9606)Process

Expression