RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	DUB
Localizations	P-body
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000135473	Gene ID	9924	Accession	20074
Symbol	PAN2	Alias	USP52	Full Name	poly(A) specific ribonuclease subunit PAN2
Status	Confidence	Length	17831 bases	Strand	Minus strand
Position	12 : 56316223 - 56334053	RNA binding domain	RNase_T
Summary	This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000257931	RNase_T	PF00929	8.6e-19	1
ENSP00000388231	RNase_T	PF00929	8.6e-19	1
ENSP00000401721	RNase_T	PF00929	8.6e-19	1
ENSP00000449861	RNase_T	PF00929	8.6e-19	1
ENSP00000481859	RNase_T	PF00929	8.6e-19	1

Showing 1 to 5 of 5 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
30824702	PtexRIC_PMID30824702_293T_human	293T	Erika C Urdaneta	2019 Mar 1	doi: 10.1038/s41467-019-08942-3
33332543	FAX.RIC_PMID33332543_Hela_human	Hela	Yongwoo Na	2021 Mar 18	doi: 10.1093/nar/gkaa1194
35427468	qRIC_PMID35427468_293T_human	293T	Carlos Henrique Vieira-Vieira	2022 Jun 2	doi: 10.1016/j.molcel.2022.03.024.?Epub 2022 Apr 14
37421941	RIC_PMID37421941_Hydra10_human		Wenhao Jin	2023 Jul 20	doi: 10.1016/j.molcel.2023.06.019.?Epub 2023 Jul 7

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
22817748	The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover.	Matthew Brook	2012-08-01	Biochemical Society transactions
27334371	Mutations in HECW2 are associated with intellectual disability and epilepsy.	Jonatan Halvardson	2016-10-01	Journal of medical genetics
27519690	Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets.	J John Shin	2016-09-01	Disease models & mechanisms
29860338	The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.	T Elizabeth Abshire	2018-07-06	Nucleic acids research

Showing 1 to 4 of 4 entries

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
PAN2-201	ENST00000257931	4537	1201aa	ENSP00000257931
PAN2-202	ENST00000425394	4592	1202aa	ENSP00000401721
PAN2-203	ENST00000440411	4523	1198aa	ENSP00000388231
PAN2-204	ENST00000547100	483	No protein	-
PAN2-205	ENST00000547226	2642	No protein	-
PAN2-206	ENST00000547518	540	No protein	-
PAN2-207	ENST00000547572	585	111aa	ENSP00000449092
PAN2-208	ENST00000547994	2605	No protein	-
PAN2-209	ENST00000548043	4641	1202aa	ENSP00000449861
PAN2-210	ENST00000548982	408	No protein	-

Showing 1 to 10 of 21 entries

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Gene Model

Click here to download ENSG00000135473's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
53273	Thyroxine	4.7300000E-005	-
60731	Waist Circumference	4E-9	26785701
65467	Body Height	7E-35	25429064

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000135473's PPI file

Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000135473	homo_sapiens	ENSP00000388231	95.1586	93.99	nomascus_leucogenys	ENSNLEP00000021252	97.6027	96.4041
ENSG00000135473	homo_sapiens	ENSP00000388231	100	99.9165	pan_paniscus	ENSPPAP00000000662	100	99.9165
ENSG00000135473	homo_sapiens	ENSP00000388231	99.7496	99.4992	pongo_abelii	ENSPPYP00000005305	99.0058	98.7572
ENSG00000135473	homo_sapiens	ENSP00000388231	100	99.9165	pan_troglodytes	ENSPTRP00000074921	100	99.9165
ENSG00000135473	homo_sapiens	ENSP00000388231	99.9165	99.8331	gorilla_gorilla	ENSGGOP00000051364	99.584	99.5008
ENSG00000135473	homo_sapiens	ENSP00000388231	91.5693	85.6427	ornithorhynchus_anatinus	ENSOANP00000008192	91.3406	85.4288
ENSG00000135473	homo_sapiens	ENSP00000388231	96.7446	92.8214	sarcophilus_harrisii	ENSSHAP00000000146	96.5029	92.5895
ENSG00000135473	homo_sapiens	ENSP00000388231	96.6611	92.6544	notamacropus_eugenii	ENSMEUP00000009251	96.4196	92.423
ENSG00000135473	homo_sapiens	ENSP00000388231	53.3389	52.5876	choloepus_hoffmanni	ENSCHOP00000011483	53.3389	52.5876
ENSG00000135473	homo_sapiens	ENSP00000388231	98.8314	97.3289	dasypus_novemcinctus	ENSDNOP00000008506	98.9967	97.4916

Showing 1 to 10 of 223 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000289	involved_in nuclear-transcribed mRNA poly(A) tail shortening	2	IBA,TAS	Homo_sapiens(9606)	Process
GO:0004535	enables poly(A)-specific ribonuclease activity	2	IDA,TAS	Homo_sapiens(9606)	Function
GO:0031251	part_of PAN complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0000175	enables 3-5-RNA exonuclease activity	1	IDA	Homo_sapiens(9606)	Function
GO:0000932	is_active_in P-body	1	IBA	Homo_sapiens(9606)	Component
GO:0003676	enables nucleic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0004843	NOT enables cysteine-type deubiquitinase activity	1	IKR	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IEA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression