Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43FlavivirusesSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucleP-body
BulkPerturb-seq DataSet_01_193 DataSet_01_314 DataSet_02_33

Description

Ensembl ID ENSG00000134644 Gene ID 9698 Accession 14957
Symbol PUM1 Alias PUMH;HSPUM;PUMH1;PUML1;SCA47 Full Name pumilio RNA binding family member 1
Status Confidence Length 134486 bases Strand Minus strand
Position 1 : 30931506 - 31065991 RNA binding domain PUF
Summary This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000400141 PUF PF00806 7.8e-82 1
ENSP00000400141 PUF PF00806 7.8e-82 2
ENSP00000400141 PUF PF00806 7.8e-82 3
ENSP00000400141 PUF PF00806 7.8e-82 4
ENSP00000400141 PUF PF00806 7.8e-82 5
ENSP00000400141 PUF PF00806 7.8e-82 6
ENSP00000400141 PUF PF00806 7.8e-82 7
ENSP00000400141 PUF PF00806 7.8e-82 8
ENSP00000435825 PUF PF00806 3.7e-81 1
ENSP00000435825 PUF PF00806 3.7e-81 2
ENSP00000435825 PUF PF00806 3.7e-81 3
ENSP00000435825 PUF PF00806 3.7e-81 4
ENSP00000435825 PUF PF00806 3.7e-81 5
ENSP00000435825 PUF PF00806 3.7e-81 6
ENSP00000435825 PUF PF00806 3.7e-81 7
ENSP00000435825 PUF PF00806 3.7e-81 8
ENSP00000362847 PUF PF00806 3.8e-81 1
ENSP00000362847 PUF PF00806 3.8e-81 2
ENSP00000362847 PUF PF00806 3.8e-81 3
ENSP00000362847 PUF PF00806 3.8e-81 4
ENSP00000362847 PUF PF00806 3.8e-81 5
ENSP00000362847 PUF PF00806 3.8e-81 6
ENSP00000362847 PUF PF00806 3.8e-81 7
ENSP00000362847 PUF PF00806 3.8e-81 8
ENSP00000257075 PUF PF00806 5.9e-81 1
ENSP00000257075 PUF PF00806 5.9e-81 2
ENSP00000257075 PUF PF00806 5.9e-81 3
ENSP00000257075 PUF PF00806 5.9e-81 4
ENSP00000257075 PUF PF00806 5.9e-81 5
ENSP00000257075 PUF PF00806 5.9e-81 6
ENSP00000257075 PUF PF00806 5.9e-81 7
ENSP00000257075 PUF PF00806 5.9e-81 8
ENSP00000433850 PUF PF00806 8.6e-81 1
ENSP00000433850 PUF PF00806 8.6e-81 2
ENSP00000433850 PUF PF00806 8.6e-81 3
ENSP00000433850 PUF PF00806 8.6e-81 4
ENSP00000433850 PUF PF00806 8.6e-81 5
ENSP00000433850 PUF PF00806 8.6e-81 6
ENSP00000433850 PUF PF00806 8.6e-81 7
ENSP00000433850 PUF PF00806 8.6e-81 8
ENSP00000401777 PUF PF00806 8.6e-80 1
ENSP00000401777 PUF PF00806 8.6e-80 2
ENSP00000401777 PUF PF00806 8.6e-80 3
ENSP00000401777 PUF PF00806 8.6e-80 4
ENSP00000401777 PUF PF00806 8.6e-80 5
ENSP00000401777 PUF PF00806 8.6e-80 6
ENSP00000401777 PUF PF00806 8.6e-80 7
ENSP00000401777 PUF PF00806 8.6e-80 8
ENSP00000391723 PUF PF00806 1e-79 1
ENSP00000391723 PUF PF00806 1e-79 2
ENSP00000391723 PUF PF00806 1e-79 3
ENSP00000391723 PUF PF00806 1e-79 4
ENSP00000391723 PUF PF00806 1e-79 5
ENSP00000391723 PUF PF00806 1e-79 6
ENSP00000391723 PUF PF00806 1e-79 7
ENSP00000391723 PUF PF00806 1e-79 8
ENSP00000362852 PUF PF00806 1.1e-79 1
ENSP00000362852 PUF PF00806 1.1e-79 2
ENSP00000362852 PUF PF00806 1.1e-79 3
ENSP00000362852 PUF PF00806 1.1e-79 4
ENSP00000362852 PUF PF00806 1.1e-79 5
ENSP00000362852 PUF PF00806 1.1e-79 6
ENSP00000362852 PUF PF00806 1.1e-79 7
ENSP00000362852 PUF PF00806 1.1e-79 8
ENSP00000362846 PUF PF00806 1.4e-79 1
ENSP00000362846 PUF PF00806 1.4e-79 2
ENSP00000362846 PUF PF00806 1.4e-79 3
ENSP00000362846 PUF PF00806 1.4e-79 4
ENSP00000362846 PUF PF00806 1.4e-79 5
ENSP00000362846 PUF PF00806 1.4e-79 6
ENSP00000362846 PUF PF00806 1.4e-79 7
ENSP00000362846 PUF PF00806 1.4e-79 8
ENSP00000433373 PUF PF00806 3e-69 1
ENSP00000433373 PUF PF00806 3e-69 2
ENSP00000433373 PUF PF00806 3e-69 3
ENSP00000433373 PUF PF00806 3e-69 4
ENSP00000433373 PUF PF00806 3e-69 5
ENSP00000433373 PUF PF00806 3e-69 6
ENSP00000431213 PUF PF00806 5.9e-60 1
ENSP00000431213 PUF PF00806 5.9e-60 2
ENSP00000431213 PUF PF00806 5.9e-60 3
ENSP00000431213 PUF PF00806 5.9e-60 4
ENSP00000431213 PUF PF00806 5.9e-60 5
ENSP00000431213 PUF PF00806 5.9e-60 6
ENSP00000434096 PUF PF00806 5.6e-15 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
32503290 Challenges and Strategies in Ascribing Functions to Long Noncoding RNAs. Yang Zhao 2020-06-03 Cancers
29297114 Variation analysis of PUM1 gene in Chinese women with primary ovarian insufficiency. Wei Luo 2018-04-01 Journal of assisted reproduction and genetics
30728830 Long Non-coding RNA in Neuronal Development and Neurological Disorders. Ling Li 2018-01-01 Frontiers in genetics
28760986 PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2. Yonghong Liu 2017-08-15 Proceedings of the National Academy of Sciences of the United States of America
36566249 Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen. Pengjie Hu 2022-12-24 Nature communications
35386260 A de novo PUM1 Variant in a Girl With a Dravet-Like Syndrome: Case Report and Literature Review. Yuanzhen Ye 2022-01-01 Frontiers in pediatrics
37624174 Inducing Cytotoxicity in Colon Cancer Cells and Suppressing Cancer Stem Cells by Dolasetron and Ketoprofen through Inhibition of RNA Binding Protein PUM1. Ravi Gor 2023-08-03 Toxics
21748782 A majority of the cancer/testis antigens are intrinsically disordered proteins. Krithika Rajagopalan 2011-11-01 Journal of cellular biochemistry
36439123 Identification and validation of a signature based on macrophage cell marker genes to predict recurrent miscarriage by integrated analysis of single-cell and bulk RNA-sequencing. Peiru Wei 2022-01-01 Frontiers in immunology
23499436 The genetic code as expressed through relationships between mRNA structure and protein function. M David Mauger 2013-04-17 FEBS letters
19186050 Understanding and engineering RNA sequence specificity of PUF proteins. Gang Lu 2009-02-01 Current opinion in structural biology
27732849 MECP2 Is Post-transcriptionally Regulated during Human Neurodevelopment by Combinatorial Action of RNA-Binding Proteins and miRNAs. C Deivid Rodrigues 2016-10-11 Cell reports
25768905 Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. A Vincenzo Gennarino 2015-03-12 Cell
30197756 SPIN1 is a proto-oncogene and SPIN3 is a tumor suppressor in human seminoma. Mikolaj Damian Janecki 2018-08-21 Oncotarget
28604658 In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells. Dajung Jung 2017-06-12 Nature communications
33508364 RNA binding protein PUM1 promotes colon cancer cell proliferation and migration. Ravi Gor 2021-03-31 International journal of biological macromolecules
36294609 Alternative Transcription Start Site Usage and Functional Implications in Pathogenic Fungi. Vi Tuong Thi Dang 2022-10-03 Journal of fungi (Basel, Switzerland)
37456248 E2F3 accelerates the stemness of colon cancer cells by activating the STAT3 pathway. Qingkun Gao 2023-01-01 Frontiers in oncology
18411299 Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets. R Adam Morris 2008-06-01 Molecular and cellular biology
32316190 Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model. J Maciej Smialek 2020-04-16 Cells
30652968 Engineering a conserved RNA regulatory protein repurposes its biological function in vivo. D Vandita Bhat 2019-01-17 eLife
12459267 Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins. S Danislav Spassov 2002-10-16 Gene
31397673 A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity. Chen Qiu 2019-08-09 eLife
23742071 Engineering RNA-binding proteins for biology. Yu Chen 2013-08-01 The FEBS journal
31078383 A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins. Inga Jarmoskaite 2019-06-06 Molecular cell
30316580 Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins. C Aaron Goldstrohm 2018-12-01 Trends in genetics : TIG

Transcripts

Name Transcript ID bp Protein Translation ID
PUM1-205 ENST00000424085 4631 944aa ENSP00000400141
PUM1-201 ENST00000257075 5360 1186aa ENSP00000257075
PUM1-204 ENST00000373747 5375 1189aa ENSP00000362852
PUM1-214 ENST00000525843 4528 1125aa ENSP00000435825
PUM1-206 ENST00000426105 5385 1188aa ENSP00000391723
PUM1-211 ENST00000498419 3068 900aa ENSP00000433850
PUM1-207 ENST00000440538 3936 1162aa ENSP00000401777
PUM1-202 ENST00000373741 4242 1224aa ENSP00000362846
PUM1-203 ENST00000373742 3515 1127aa ENSP00000362847
PUM1-221 ENST00000530669 582 76aa ENSP00000434096
PUM1-220 ENST00000529846 683 227aa ENSP00000431213
PUM1-216 ENST00000525997 650 217aa ENSP00000433373
PUM1-219 ENST00000527498 652 90aa ENSP00000431779
PUM1-212 ENST00000498627 422 No protein -
PUM1-208 ENST00000471894 812 No protein -
PUM1-210 ENST00000490546 707 No protein -
PUM1-223 ENST00000532678 793 265aa ENSP00000435589
PUM1-217 ENST00000526128 579 No protein -
PUM1-218 ENST00000526215 586 94aa ENSP00000436921
PUM1-215 ENST00000525948 1103 94aa ENSP00000433099
PUM1-209 ENST00000480602 906 124aa ENSP00000437269
PUM1-213 ENST00000524516 561 No protein -
PUM1-222 ENST00000531867 549 96aa ENSP00000431470

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
13294Lupus Erythematosus, Systemic1.86E-518204446
13295Lupus Erythematosus, Systemic2.29E-518204446
13305Lupus Erythematosus, Systemic2.2E-518204446
13306Lupus Erythematosus, Systemic2.16E-518204446

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000134644homo_sapiensENSP0000035437085.902378.6654homo_sapiensENSP0000039172376.93670.4545

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000134644homo_sapiensENSP0000039172398.737498.569nomascus_leucogenysENSNLEP0000000150995.833395.6699
ENSG00000134644homo_sapiensENSP00000391723100100pan_paniscusENSPPAP0000004290897.697497.6974
ENSG00000134644homo_sapiensENSP00000391723100100pongo_abeliiENSPPYP0000000187199.915999.9159
ENSG00000134644homo_sapiensENSP00000391723100100pan_troglodytesENSPTRP0000007200597.697497.6974
ENSG00000134644homo_sapiensENSP00000391723100100gorilla_gorillaENSGGOP0000001170197.697497.6974
ENSG00000134644homo_sapiensENSP0000039172395.707193.266ornithorhynchus_anatinusENSOANP0000000776770.973869.1635
ENSG00000134644homo_sapiensENSP0000039172398.821597.9798sarcophilus_harrisiiENSSHAP0000001275798.655597.8151
ENSG00000134644homo_sapiensENSP0000039172376.515275.9259notamacropus_eugeniiENSMEUP0000000090674.083173.5126
ENSG00000134644homo_sapiensENSP0000039172381.481581.229choloepus_hoffmanniENSCHOP0000000907981.964481.7104
ENSG00000134644homo_sapiensENSP0000039172399.410899.2424dasypus_novemcinctusENSDNOP0000000849699.327299.159
ENSG00000134644homo_sapiensENSP0000039172376.262676.2626erinaceus_europaeusENSEEUP0000000355174.201574.2015
ENSG00000134644homo_sapiensENSP0000039172382.239181.734echinops_telfairiENSETEP0000000357082.937282.4278
ENSG00000134644homo_sapiensENSP0000039172399.915899.7475callithrix_jacchusENSCJAP0000001127599.497199.3294
ENSG00000134644homo_sapiensENSP0000039172397.727397.7273cercocebus_atysENSCATP00000006070100100
ENSG00000134644homo_sapiensENSP0000039172399.831699.8316macaca_fascicularisENSMFAP00000012012100100
ENSG00000134644homo_sapiensENSP00000391723100100macaca_mulattaENSMMUP00000078498100100
ENSG00000134644homo_sapiensENSP00000391723100100macaca_nemestrinaENSMNEP00000022503100100
ENSG00000134644homo_sapiensENSP00000391723100100papio_anubisENSPANP0000004277597.138297.1382
ENSG00000134644homo_sapiensENSP00000391723100100mandrillus_leucophaeusENSMLEP0000002980497.058897.0588
ENSG00000134644homo_sapiensENSP0000039172391.666791.4983tursiops_truncatusENSTTRP0000000703889.043388.8798
ENSG00000134644homo_sapiensENSP0000039172399.831699.4949vulpes_vulpesENSVVUP0000001976799.747799.4113
ENSG00000134644homo_sapiensENSP0000039172399.410898.9057mus_spretusMGP_SPRETEiJ_P006726999.327298.8225
ENSG00000134644homo_sapiensENSP0000039172399.663399.0741equus_asinusENSEASP0000501550299.663399.0741
ENSG00000134644homo_sapiensENSP0000039172399.579199.4108capra_hircusENSCHIP0000001046099.74799.5784
ENSG00000134644homo_sapiensENSP0000039172399.579198.9899loxodonta_africanaENSLAFP0000000263999.66399.0733
ENSG00000134644homo_sapiensENSP0000039172399.915899.6633panthera_leoENSPLOP0000001273299.831899.5795
ENSG00000134644homo_sapiensENSP0000039172399.831699.4949ailuropoda_melanoleucaENSAMEP0000001867296.895496.5686
ENSG00000134644homo_sapiensENSP0000039172399.747599.5791bos_indicus_hybridENSBIXP0000500603499.663699.4954
ENSG00000134644homo_sapiensENSP0000039172399.410898.8215oryctolagus_cuniculusENSOCUP0000000747297.68497.105
ENSG00000134644homo_sapiensENSP0000039172383.249279.7138equus_caballusENSECAP0000002821975.901872.6784
ENSG00000134644homo_sapiensENSP0000039172399.831699.4949canis_lupus_familiarisENSCAFP0084500925896.895496.5686
ENSG00000134644homo_sapiensENSP0000039172399.915899.6633panthera_pardusENSPPRP0000000535896.977196.732
ENSG00000134644homo_sapiensENSP0000039172397.895697.5589marmota_marmota_marmotaENSMMMP0000001312799.742799.3997
ENSG00000134644homo_sapiensENSP0000039172396.969796.8013balaenoptera_musculusENSBMSP0001000585599.826799.6534
ENSG00000134644homo_sapiensENSP0000039172399.494999.3266cavia_porcellusENSCPOP0000002353699.411399.2431
ENSG00000134644homo_sapiensENSP0000039172399.915899.6633felis_catusENSFCAP0000005101496.977196.732
ENSG00000134644homo_sapiensENSP0000039172390.740790.404ursus_americanusENSUAMP0000002329299.630399.2606
ENSG00000134644homo_sapiensENSP000003917235.555565.55556ursus_americanusENSUAMP0000002329498.507598.5075
ENSG00000134644homo_sapiensENSP0000039172398.905798.064monodelphis_domesticaENSMODP0000002129598.739597.8992
ENSG00000134644homo_sapiensENSP0000039172399.747599.5791bison_bison_bisonENSBBBP0000000450996.892996.7294
ENSG00000134644homo_sapiensENSP0000039172399.831699.6633monodon_monocerosENSMMNP0001501603299.747799.5795
ENSG00000134644homo_sapiensENSP0000039172399.915899.7475sus_scrofaENSSSCP0000004152099.831899.6636
ENSG00000134644homo_sapiensENSP0000039172398.232397.3064microcebus_murinusENSMICP0000003396697.902796.9799
ENSG00000134644homo_sapiensENSP0000039172399.831699.6633microcebus_murinusENSMICP0000003490199.413299.2456
ENSG00000134644homo_sapiensENSP0000039172399.326699.2424octodon_degusENSODEP0000000454499.410399.326
ENSG00000134644homo_sapiensENSP0000039172399.663399.1582jaculus_jaculusENSJJAP0000000063799.663399.1582
ENSG00000134644homo_sapiensENSP0000039172399.747599.5791ovis_aries_rambouilletENSOARP0002001622199.663699.4954
ENSG00000134644homo_sapiensENSP0000039172393.181892.8451ursus_maritimusENSUMAP0000001238199.819799.459
ENSG00000134644homo_sapiensENSP0000039172372.811472.5589ochotona_princepsENSOPRP0000000165072.689172.437
ENSG00000134644homo_sapiensENSP0000039172399.663399.4949delphinapterus_leucasENSDLEP0000003064999.747399.5788
ENSG00000134644homo_sapiensENSP0000039172399.831699.6633physeter_catodonENSPCTP0000500195299.747799.5795
ENSG00000134644homo_sapiensENSP0000039172399.410898.7374mus_caroliMGP_CAROLIEiJ_P006475199.327298.6543
ENSG00000134644homo_sapiensENSP0000039172399.410898.9899mus_musculusENSMUSP0000003031599.327298.9066
ENSG00000134644homo_sapiensENSP0000039172381.902481.6498dipodomys_ordiiENSDORP0000000175998.882198.5772
ENSG00000134644homo_sapiensENSP0000039172399.831699.3266mustela_putorius_furoENSMPUP0000001534499.831699.3266
ENSG00000134644homo_sapiensENSP0000039172399.747599.5791aotus_nancymaaeENSANAP0000002051599.831599.663
ENSG00000134644homo_sapiensENSP0000039172398.484898.1481saimiri_boliviensis_boliviensisENSSBOP0000003193396.534796.2046
ENSG00000134644homo_sapiensENSP0000039172392.003491.835vicugna_pacosENSVPAP0000000548191.771691.6037
ENSG00000134644homo_sapiensENSP00000391723100100chlorocebus_sabaeusENSCSAP000000169849999
ENSG00000134644homo_sapiensENSP0000039172383.333381.9024tupaia_belangeriENSTBEP0000001199584.978583.5193
ENSG00000134644homo_sapiensENSP0000039172399.410899.0741mesocricetus_auratusENSMAUP0000002561299.494599.1575
ENSG00000134644homo_sapiensENSP0000039172399.747599.5791phocoena_sinusENSPSNP0000001099396.972296.8085
ENSG00000134644homo_sapiensENSP0000039172399.831699.6633camelus_dromedariusENSCDRP0000502351099.747799.5795
ENSG00000134644homo_sapiensENSP0000039172399.831699.6633carlito_syrichtaENSTSYP0000002126999.747799.5795
ENSG00000134644homo_sapiensENSP0000039172399.831699.4949panthera_tigris_altaicaENSPTIP0000001012896.895496.5686
ENSG00000134644homo_sapiensENSP0000039172399.158298.8215rattus_norvegicusENSRNOP0000001583198.908598.5726
ENSG00000134644homo_sapiensENSP0000039172399.831699.6633prolemur_simusENSPSMP0000001282098.016597.8512
ENSG00000134644homo_sapiensENSP0000039172399.410898.9899microtus_ochrogasterENSMOCP0000001661499.410898.9899
ENSG00000134644homo_sapiensENSP0000039172392.845192.5926sorex_araneusENSSARP0000000279590.114489.8693
ENSG00000134644homo_sapiensENSP0000039172399.410899.1582peromyscus_maniculatus_bairdiiENSPEMP0000000831999.494599.2418
ENSG00000134644homo_sapiensENSP0000039172399.326699.1582bos_mutusENSBMUP0000001020896.484196.3205
ENSG00000134644homo_sapiensENSP0000039172399.410898.9057mus_spicilegusENSMSIP0000003828699.410898.9057
ENSG00000134644homo_sapiensENSP0000039172399.242498.8215cricetulus_griseus_chok1gshdENSCGRP0000102814599.493799.0717
ENSG00000134644homo_sapiensENSP0000039172397.643197.4747pteropus_vampyrusENSPVAP0000000492894.926494.7627
ENSG00000134644homo_sapiensENSP0000039172399.579199.2424myotis_lucifugusENSMLUP0000000593699.66399.326
ENSG00000134644homo_sapiensENSP0000039172398.737497.9798vombatus_ursinusENSVURP0001002520398.571497.8151
ENSG00000134644homo_sapiensENSP0000039172399.915899.7475rhinolophus_ferrumequinumENSRFEP0001001341199.831899.6636
ENSG00000134644homo_sapiensENSP0000039172399.747599.1582neovison_visonENSNVIP0000003139396.813796.2418
ENSG00000134644homo_sapiensENSP0000039172399.579199.4108bos_taurusENSBTAP0000002526299.74799.5784
ENSG00000134644homo_sapiensENSP0000039172399.326699.1582heterocephalus_glaber_femaleENSHGLP0000001927199.243199.0749
ENSG00000134644homo_sapiensENSP00000391723100100rhinopithecus_bietiENSRBIP0000003806397.138297.1382
ENSG00000134644homo_sapiensENSP0000039172392.424290.8249canis_lupus_dingoENSCAFP0002003178293.606191.9864
ENSG00000134644homo_sapiensENSP0000039172396.885596.633sciurus_vulgarisENSSVLP0000502209399.7499.4801
ENSG00000134644homo_sapiensENSP0000039172398.821598.1481phascolarctos_cinereusENSPCIP0000001849198.655597.9832
ENSG00000134644homo_sapiensENSP0000039172376.346875.7576procavia_capensisENSPCAP0000000189074.161973.5895
ENSG00000134644homo_sapiensENSP0000039172399.494999.3266nannospalax_galiliENSNGAP0000000267799.411399.2431
ENSG00000134644homo_sapiensENSP0000039172399.747599.5791bos_grunniensENSBGRP0000003628696.892996.7294
ENSG00000134644homo_sapiensENSP0000039172399.494999.4108chinchilla_lanigeraENSCLAP0000001109599.411399.3272
ENSG00000134644homo_sapiensENSP0000039172399.747599.4949cervus_hanglu_yarkandensisENSCHYP0000001163698.7598.5
ENSG00000134644homo_sapiensENSP0000039172399.915899.7475catagonus_wagneriENSCWAP0000002162699.831899.6636
ENSG00000134644homo_sapiensENSP0000039172399.831699.5791ictidomys_tridecemlineatusENSSTOP0000002413499.831699.5791
ENSG00000134644homo_sapiensENSP0000039172397.895697.138otolemur_garnettiiENSOGAP0000000991097.978197.2199
ENSG00000134644homo_sapiensENSP0000039172340.993340.5724cebus_imitatorENSCCAP0000002424697.205696.2076
ENSG00000134644homo_sapiensENSP0000039172399.831699.5791urocitellus_parryiiENSUPAP0001002492699.831699.5791
ENSG00000134644homo_sapiensENSP0000039172399.747599.4949moschus_moschiferusENSMMSP0000001152799.663699.4113
ENSG00000134644homo_sapiensENSP00000391723100100rhinopithecus_roxellanaENSRROP0000000501497.777897.7778
ENSG00000134644homo_sapiensENSP0000039172399.410898.8215mus_pahariMGP_PahariEiJ_P007983599.327298.7384
ENSG00000134644homo_sapiensENSP0000039172399.831699.6633propithecus_coquereliENSPCOP0000000152299.747799.5795
ENSG00000134644homo_sapiensENSP0000039172320.622911.532caenorhabditis_elegansF21H12.5.138.765821.6772
ENSG00000134644homo_sapiensENSP0000039172318.434311.1111caenorhabditis_elegansY45F10A.2.143.625526.2948
ENSG00000134644homo_sapiensENSP0000039172318.518511.1111caenorhabditis_elegansY73B6BL.38.143.564426.1386
ENSG00000134644homo_sapiensENSP0000039172320.538711.3636caenorhabditis_elegansH12I13.4.139.739421.987
ENSG00000134644homo_sapiensENSP0000039172317.08758.41751caenorhabditis_elegansF18A11.1.141.855720.6186
ENSG00000134644homo_sapiensENSP0000039172316.91928.33333caenorhabditis_elegansB0273.2.141.443320.4124
ENSG00000134644homo_sapiensENSP0000039172318.85529.76431caenorhabditis_elegansF54C9.8.140.506320.9765
ENSG00000134644homo_sapiensENSP0000039172333.417525.6734caenorhabditis_elegansW06B11.2.156.472343.3855
ENSG00000134644homo_sapiensENSP0000039172354.377142.3401drosophila_melanogasterFBpp030582342.139632.8115
ENSG00000134644homo_sapiensENSP0000039172342.760934.6801ciona_intestinalisENSCINP0000000803364.961652.6854
ENSG00000134644homo_sapiensENSP0000039172335.269429.8822petromyzon_marinusENSPMAP0000000668561.982352.5148
ENSG00000134644homo_sapiensENSP0000039172389.393983.7542callorhinchus_miliiENSCMIP0000004211186.764781.2908
ENSG00000134644homo_sapiensENSP0000039172391.161687.3737latimeria_chalumnaeENSLACP0000001954590.855787.0805
ENSG00000134644homo_sapiensENSP0000039172392.508489.1414lepisosteus_oculatusENSLOCP0000000627792.352988.9916
ENSG00000134644homo_sapiensENSP0000039172381.565775.8418clupea_harengusENSCHAP0000006001582.679276.8771
ENSG00000134644homo_sapiensENSP0000039172386.279580.1347danio_rerioENSDARP0000014079388.975782.6389
ENSG00000134644homo_sapiensENSP0000039172385.774479.7138carassius_auratusENSCARP0000006574788.378182.1336
ENSG00000134644homo_sapiensENSP0000039172385.521979.4613carassius_auratusENSCARP0000012519385.4579.3944
ENSG00000134644homo_sapiensENSP0000039172384.006777.2727astyanax_mexicanusENSAMXP0000004003981.736375.1843
ENSG00000134644homo_sapiensENSP0000039172385.185279.2929ictalurus_punctatusENSIPUP0000003023787.316781.277
ENSG00000134644homo_sapiensENSP0000039172384.090977.5253esox_luciusENSELUP0000002649785.311778.6507
ENSG00000134644homo_sapiensENSP0000039172385.858679.6296electrophorus_electricusENSEEEP0000003910288.695782.2609
ENSG00000134644homo_sapiensENSP0000039172365.319960.0168oncorhynchus_kisutchENSOKIP0000506515483.710976.9148
ENSG00000134644homo_sapiensENSP0000039172384.090977.2727oncorhynchus_kisutchENSOKIP0000504265385.898578.9338
ENSG00000134644homo_sapiensENSP0000039172384.259377.3569oncorhynchus_mykissENSOMYP0000008871782.183975.4516
ENSG00000134644homo_sapiensENSP0000039172381.565774.2424oncorhynchus_mykissENSOMYP000001412848577.3684
ENSG00000134644homo_sapiensENSP0000039172380.050572.5589salmo_salarENSSSAP0000016300883.862476.0141
ENSG00000134644homo_sapiensENSP0000039172382.323275.4209salmo_salarENSSSAP0000011696783.804676.7781
ENSG00000134644homo_sapiensENSP0000039172382.323275.5892salmo_truttaENSSTUP0000006822683.804676.9494
ENSG00000134644homo_sapiensENSP0000039172371.380562.963salmo_truttaENSSTUP0000010388763.615956.114
ENSG00000134644homo_sapiensENSP0000039172384.090978.7879gadus_morhuaENSGMOP0000006733784.232778.9207
ENSG00000134644homo_sapiensENSP000003917235.723915.63973fundulus_heteroclitusENSFHEP0000003509595.774794.3662
ENSG00000134644homo_sapiensENSP0000039172331.649829.1246fundulus_heteroclitusENSFHEP0000000667575.959669.899
ENSG00000134644homo_sapiensENSP0000039172384.343478.7879poecilia_reticulataENSPREP0000000761786.156580.4815
ENSG00000134644homo_sapiensENSP0000039172384.006778.5354xiphophorus_maculatusENSXMAP0000000296885.812680.2236
ENSG00000134644homo_sapiensENSP0000039172384.764379.2088oryzias_latipesENSORLP0000001438582.880777.4486
ENSG00000134644homo_sapiensENSP0000039172384.343478.7037cyclopterus_lumpusENSCLMP0000504272784.915379.2373
ENSG00000134644homo_sapiensENSP0000039172384.59679.4613oreochromis_niloticusENSONIP0000000286086.414481.1694
ENSG00000134644homo_sapiensENSP0000039172384.511879.1246haplochromis_burtoniENSHBUP0000001670486.328580.8255
ENSG00000134644homo_sapiensENSP0000039172378.282873.2323astatotilapia_callipteraENSACLP0000002856387.40681.7669
ENSG00000134644homo_sapiensENSP0000039172384.259378.9562sparus_aurataENSSAUP0001001057084.68779.357
ENSG00000134644homo_sapiensENSP0000039172336.868733.5017lates_calcariferENSLCAP0001001707778.918971.7117
ENSG00000134644homo_sapiensENSP000003917235.808085.55556lates_calcariferENSLCAP0001001704697.183192.9577
ENSG00000134644homo_sapiensENSP0000039172393.518590.6566xenopus_tropicalisENSXETP0000008028193.361390.5042
ENSG00000134644homo_sapiensENSP0000039172398.737497.7273chrysemys_picta_belliiENSCPBP0000002107797.587496.589
ENSG00000134644homo_sapiensENSP0000039172398.484897.3064sphenodon_punctatusENSSPUP0000000809598.484897.3064
ENSG00000134644homo_sapiensENSP0000039172398.232397.3064crocodylus_porosusENSCPRP0000500606098.48197.5527
ENSG00000134644homo_sapiensENSP0000039172386.279583.7542laticauda_laticaudataENSLLTP0000002136992.760290.0452
ENSG00000134644homo_sapiensENSP0000039172397.895696.4646notechis_scutatusENSNSUP0000001767695.720294.321
ENSG00000134644homo_sapiensENSP0000039172397.895696.4646pseudonaja_textilisENSPTXP0000001435898.143596.7089
ENSG00000134644homo_sapiensENSP0000039172398.737497.7273anas_platyrhynchos_platyrhynchosENSAPLP0000000911298.737497.7273
ENSG00000134644homo_sapiensENSP0000039172398.737497.7273gallus_gallusENSGALP0001001915998.820697.8096
ENSG00000134644homo_sapiensENSP000003917235.808085.80808meleagris_gallopavoENSMGAP0000001794697.183197.1831
ENSG00000134644homo_sapiensENSP0000039172330.387229.7138meleagris_gallopavoENSMGAP0000000012795.502693.3862
ENSG00000134644homo_sapiensENSP0000039172396.127994.1919serinus_canariaENSSCAP0000002031092.320190.4608
ENSG00000134644homo_sapiensENSP0000039172397.558995.8754anolis_carolinensisENSACAP0000003845695.15693.514
ENSG00000134644homo_sapiensENSP0000039172369.781165.8249neolamprologus_brichardiENSNBRP0000001387289.621684.5405
ENSG00000134644homo_sapiensENSP0000039172397.811496.2121naja_najaENSNNAP0000000847598.059196.4557
ENSG00000134644homo_sapiensENSP0000039172397.474796.0438podarcis_muralisENSPMRP0000002456184.340983.1027
ENSG00000134644homo_sapiensENSP0000039172388.804786.7845geospiza_fortisENSGFOP0000001614791.979189.8867
ENSG00000134644homo_sapiensENSP0000039172392.255990.1515taeniopygia_guttataENSTGUP0000003271789.178287.144
ENSG00000134644homo_sapiensENSP0000039172392.592688.6364erpetoichthys_calabaricusENSECRP0000002628692.281988.3389
ENSG00000134644homo_sapiensENSP0000039172384.343478.7037kryptolebias_marmoratusENSKMAP0000000465686.156580.3955
ENSG00000134644homo_sapiensENSP0000039172397.474795.8754salvator_merianaeENSSMRP0000000397997.721596.1181
ENSG00000134644homo_sapiensENSP0000039172384.343479.1246oryzias_javanicusENSOJAP0000000991984.915379.661
ENSG00000134644homo_sapiensENSP0000039172384.427679.2088amphilophus_citrinellusENSACIP0000002715486.990581.6132
ENSG00000134644homo_sapiensENSP0000039172384.175178.8721dicentrarchus_labraxENSDLAP0000505725384.175178.8721
ENSG00000134644homo_sapiensENSP0000039172384.680179.5455amphiprion_perculaENSAPEP0000002044386.500481.2554
ENSG00000134644homo_sapiensENSP0000039172384.175178.6195oryzias_sinensisENSOSIP0000002951484.602479.0186
ENSG00000134644homo_sapiensENSP0000039172398.821597.9798pelodiscus_sinensisENSPSIP0000001598298.821597.9798
ENSG00000134644homo_sapiensENSP0000039172398.56997.4747gopherus_evgoodeiENSGEVP0000501505798.56997.4747
ENSG00000134644homo_sapiensENSP0000039172398.653297.6431chelonoidis_abingdoniiENSCABP0000000480797.829796.828
ENSG00000134644homo_sapiensENSP0000039172384.680179.4613seriola_dumeriliENSSDUP0000001242286.500481.1694
ENSG00000134644homo_sapiensENSP0000039172384.680178.4512cottoperca_gobioENSCGOP0000003681284.113777.9264
ENSG00000134644homo_sapiensENSP0000039172398.821597.9798struthio_camelus_australisENSSCUP0000000318298.821597.9798
ENSG00000134644homo_sapiensENSP0000039172398.737497.8956anser_brachyrhynchusENSABRP0000001027398.737497.8956
ENSG00000134644homo_sapiensENSP0000039172384.932779.0404gasterosteus_aculeatusENSGACP0000000755885.508579.5763
ENSG00000134644homo_sapiensENSP0000039172377.693672.3064cynoglossus_semilaevisENSCSEP0000002504286.993480.9614
ENSG00000134644homo_sapiensENSP0000039172349.915846.9697poecilia_formosaENSPFOP0000000756191.230885.8462
ENSG00000134644homo_sapiensENSP0000039172384.59679.2088myripristis_murdjanENSMMDP0000505385185.241779.8134
ENSG00000134644homo_sapiensENSP0000039172384.59679.0404sander_luciopercaENSSLUP0000005698684.524878.9739
ENSG00000134644homo_sapiensENSP0000039172398.905797.9798strigops_habroptilaENSSHBP0000500640998.905797.9798
ENSG00000134644homo_sapiensENSP0000039172384.680179.5455amphiprion_ocellarisENSAOCP0000002008086.500481.2554
ENSG00000134644homo_sapiensENSP0000039172398.653297.6431terrapene_carolina_triunguisENSTMTP0000000630298.653297.6431
ENSG00000134644homo_sapiensENSP0000039172384.259377.4411hucho_huchoENSHHUP0000008310086.070579.1058
ENSG00000134644homo_sapiensENSP0000039172370.959664.3939hucho_huchoENSHHUP0000006150181.370773.8417
ENSG00000134644homo_sapiensENSP0000039172383.922678.7037betta_splendensENSBSLP0000004050584.13578.903
ENSG00000134644homo_sapiensENSP0000039172385.690279.9663pygocentrus_nattereriENSPNAP0000003609288.368182.4653
ENSG00000134644homo_sapiensENSP0000039172384.59679.2929anabas_testudineusENSATEP0000007153083.471878.2392
ENSG00000134644homo_sapiensENSP0000039172321.043817.9293ciona_savignyiENSCSAVP0000000780380.906268.932
ENSG00000134644homo_sapiensENSP0000039172337.03723.7374saccharomyces_cerevisiaeYLL013C50.056932.0819
ENSG00000134644homo_sapiensENSP0000039172328.36715.2357saccharomyces_cerevisiaeYPR042C31.348816.8372
ENSG00000134644homo_sapiensENSP0000039172329.79815.2357saccharomyces_cerevisiaeYJR091C32.447316.5903
ENSG00000134644homo_sapiensENSP0000039172377.525372.3906seriola_lalandi_dorsalisENSSLDP0000001221386.641680.9031
ENSG00000134644homo_sapiensENSP0000039172383.838478.5354labrus_bergyltaENSLBEP0000000329185.936180.5004
ENSG00000134644homo_sapiensENSP0000039172384.511879.2088pundamilia_nyerereiENSPNYP0000001257286.328580.9114
ENSG00000134644homo_sapiensENSP0000039172384.427679.1246mastacembelus_armatusENSMAMP0000001721286.242580.8255
ENSG00000134644homo_sapiensENSP0000039172384.680179.5455stegastes_partitusENSSPAP0000002207286.500481.2554
ENSG00000134644homo_sapiensENSP0000039172353.282848.4007oncorhynchus_tshawytschaENSOTSP0000500557090.042781.7923
ENSG00000134644homo_sapiensENSP0000039172381.060674.8316oncorhynchus_tshawytschaENSOTSP0000505513783.088976.7041
ENSG00000134644homo_sapiensENSP0000039172384.680179.5455acanthochromis_polyacanthusENSAPOP0000003317486.500481.2554
ENSG00000134644homo_sapiensENSP0000039172398.821597.9798aquila_chrysaetos_chrysaetosENSACCP0002001355698.738497.8974
ENSG00000134644homo_sapiensENSP0000039172381.144875.1684nothobranchius_furzeriENSNFUP0001504711885.385379.0965
ENSG00000134644homo_sapiensENSP0000039172384.343478.5354cyprinodon_variegatusENSCVAP0000002358286.156580.2236
ENSG00000134644homo_sapiensENSP0000039172381.649875.8418denticeps_clupeoidesENSDCDP0000004273483.9177.9412
ENSG00000134644homo_sapiensENSP0000039172384.427679.0404larimichthys_croceaENSLCRP0000502197684.5779.1737
ENSG00000134644homo_sapiensENSP0000039172384.427679.3771takifugu_rubripesENSTRUP0000005881686.020680.8748
ENSG00000134644homo_sapiensENSP0000039172396.969795.4545ficedula_albicollisENSFALP0000000129997.297395.777
ENSG00000134644homo_sapiensENSP000003917237569.1919hippocampus_comesENSHCOP0000001964386.003979.3436
ENSG00000134644homo_sapiensENSP0000039172384.427678.367cyprinus_carpio_carpioENSCCRP0000009413384.285778.2353
ENSG00000134644homo_sapiensENSP0000039172385.774479.6296cyprinus_carpio_carpioENSCCRP0000009407087.467881.2017
ENSG00000134644homo_sapiensENSP0000039172398.56997.6431coturnix_japonicaENSCJPP0000501906098.320797.3971
ENSG00000134644homo_sapiensENSP0000039172384.090978.5354poecilia_latipinnaENSPLAP0000002255883.528478.01
ENSG00000134644homo_sapiensENSP0000039172385.774479.6296sinocyclocheilus_grahamiENSSGRP0000003240285.919179.7639
ENSG00000134644homo_sapiensENSP0000039172385.690279.798sinocyclocheilus_grahamiENSSGRP0000009482388.291482.2203
ENSG00000134644homo_sapiensENSP0000039172384.511879.1246maylandia_zebraENSMZEP0000500768186.328580.8255
ENSG00000134644homo_sapiensENSP0000039172384.59679.3771tetraodon_nigroviridisENSTNIP0000002010685.604880.3237
ENSG00000134644homo_sapiensENSP0000039172387.03781.4815paramormyrops_kingsleyaeENSPKIP0000002931587.404981.8259
ENSG00000134644homo_sapiensENSP0000039172387.121281.3131scleropages_formosusENSSFOP0001507649685.678879.9669
ENSG00000134644homo_sapiensENSP0000039172393.013589.9832leptobrachium_leishanenseENSLLEP0000000297992.237189.2321
ENSG00000134644homo_sapiensENSP0000039172384.175178.7037scophthalmus_maximusENSSMAP0000005714684.104378.6375
ENSG00000134644homo_sapiensENSP0000039172370.707166.4141oryzias_melastigmaENSOMEP0000002705787.774382.4451
ENSG00000134644homo_sapiensENSP000003917234.208753.53535oryzias_melastigmaENSOMEP0000001917087.719373.6842

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000932located_in P-body1IDAHomo_sapiens(9606)Component
GO:0003723enables RNA binding2HDA,IDAHomo_sapiens(9606)Function
GO:0003730enables mRNA 3-UTR binding2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0007283involved_in spermatogenesis1ISSHomo_sapiens(9606)Process
GO:0008344involved_in adult locomotory behavior1ISSHomo_sapiens(9606)Process
GO:0010494located_in cytoplasmic stress granule1IDAHomo_sapiens(9606)Component
GO:0010608acts_upstream_of_or_within post-transcriptional regulation of gene expression2IDA,IMPHomo_sapiens(9606)Process
GO:0016441involved_in post-transcriptional gene silencing1ISSHomo_sapiens(9606)Process
GO:0035196involved_in miRNA processing2IBA,IMPHomo_sapiens(9606)Process
GO:0035198enables miRNA binding1IDAHomo_sapiens(9606)Function
GO:0043488involved_in regulation of mRNA stability2IBA,IDAHomo_sapiens(9606)Process
GO:0048863involved_in stem cell differentiation1ISSHomo_sapiens(9606)Process
GO:0051726involved_in regulation of cell cycle1IDAHomo_sapiens(9606)Process
GO:0051983involved_in regulation of chromosome segregation1IDAHomo_sapiens(9606)Process
GO:0060964involved_in regulation of miRNA-mediated gene silencing1TASHomo_sapiens(9606)Process
GO:0061157involved_in mRNA destabilization1ISSHomo_sapiens(9606)Process
GO:1900246involved_in positive regulation of RIG-I signaling pathway1IDAHomo_sapiens(9606)Process
GO:2000637involved_in positive regulation of miRNA-mediated gene silencing1IDAHomo_sapiens(9606)Process

Expression