Ensembl ID ENSG00000134644 Gene ID 9698 Accession 14957
Gene Symbol PUM1 Alias PUMH;HSPUM;PUMH1;PUML1;SCA47 Full Name pumilio RNA binding family member 1
Position 1 : 30931506 - 31065991 Length 134486 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ENSG00000134644 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000134644 PUM1 -0.3 5.39e-20 KIRC
ENSG00000134644 PUM1 -0.2 4.62e-11 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000134644 PUM1 breast tumors 15287981
ENSG00000134644 PUM1 tumour 18042273
ENSG00000134644 PUM1 cancer 18211679
ENSG00000134644 PUM1 cancer 18776931
ENSG00000134644 PUM1 breast tumors 19544972
ENSG00000134644 PUM1 breast cancer 23151593
ENSG00000134644 PUM1 tumor 23720140
ENSG00000134644 PUM1 tumor 25151966
ENSG00000134644 PUM1 tumor 26383775
ENSG00000134644 PUM1 ovarian cancer 29428722
ENSG00000134644 PUM1 cancers 29722104
ENSG00000134644 PUM1 tumor 30197756
ENSG00000134644 PUM1 non-small cell lung cancer 30229827
ENSG00000134644 PUM1 breast cancer 30792813
ENSG00000134644 PUM1 cancers 30881377
ENSG00000134644 PUM1 pancreatic cancer 31128486
ENSG00000134644 PUM1 tumor 31395860
ENSG00000134644 PUM1 ovarian cancer 31751911
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000134644 PUM1 MESO 0.011 low
ENSG00000134644 PUM1 PAAD 0.0027 high
ENSG00000134644 PUM1 LGG 0.027 high
ENSG00000134644 PUM1 HNSC 0.03 low
ENSG00000134644 PUM1 READ 0.015 low
ENSG00000134644 PUM1 KICH 0.02 high
ENSG00000134644 PUM1 LUAD 0.034 low
ENSG00000134644 PUM1 COAD 2e-04 low
ENSG00000134644 PUM1 ESCA 0.025 low
ENSG00000134644 PUM1 OV 0.01 high
ENSG00000134644 PUM1 DLBC 0.019 high
ENSG00000134644 PUM1 PRAD 0.028 high
ENSG00000134644 PUM1 LAML 0.019 low
ENSG00000134644 PUM1 GBM 0.0023 low
ENSG00000134644 PUM1 SKCM 0.025 high
ENSG00000134644 PUM1 LIHC 0.00045 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000134644 PUM1 CHOL Del 13.347089 0.811987 0.689078 0.638889
ENSG00000134644 PUM1 LUSC Del 1.657922 0.078876 0.376401 0.417166
ENSG00000134644 PUM1 KIRP Del 4.968518 0.064658 0.577129 0.173611
ENSG00000134644 PUM1 READ Del 8.025934 0.198814 0.444844 0.442424
ENSG00000134644 PUM1 COAD Del 13.329587 0.131790 0.443147 0.334812
ENSG00000134644 PUM1 PAAD Del 0.878891 0.048837 0.349936 0.293478
ENSG00000134644 PUM1 ESCA Del 0.943856 0.104146 0.337449 0.364130
ENSG00000134644 PUM1 HNSC Del 0.680730 0.053718 0.349033 0.162835
ENSG00000134644 PUM1 LIHC Del 14.115483 0.196047 0.531626 0.370270
ENSG00000134644 PUM1 PCPG Del 1.858225 0.082201 0.673292 0.623457
ENSG00000134644 PUM1 BRCA Del 12.187766 0.122901 0.396874 0.365741
ENSG00000134644 PUM1 STAD Del 4.975696 0.108265 0.356393 0.240363
ENSG00000134644 PUM1 UCEC Amp 1.221251 0.116293 0.583499 0.105751
ENSG00000134644 PUM1 UCEC Del 5.193434 0.089986 0.476056 0.107607
ENSG00000134644 PUM1 KIRC Del 3.622255 0.040599 0.415831 0.170455
ENSG00000134644 PUM1 UVM Del 1.063142 0.073079 0.762192 0.300000
ENSG00000134644 PUM1 OV Del 11.066971 0.309836 0.538552 0.319516