Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000134308 Gene ID 10971 Accession 12854
Symbol YWHAQ Alias 1C5;HS1;14-3-3 Full Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Status Confidence Length 47031 bases Strand Minus strand
Position 2 : 9583967 - 9630997 RNA binding domain N.A.
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
YWHAQ-201 ENST00000238081 2196 245aa ENSP00000238081
YWHAQ-202 ENST00000381844 2216 245aa ENSP00000371267
YWHAQ-205 ENST00000474715 709 No protein -
YWHAQ-203 ENST00000446619 665 149aa ENSP00000398990
YWHAQ-204 ENST00000460093 345 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
4457Cholesterol, LDL4.34076935891055E-817903299
8338Heart Rate6.8050755579474E-517903306
34554Platelet Function Tests1.2486500E-005-
37195Platelet Function Tests1.2400000E-006-
41273Platelet Function Tests6.0141074E-006-
622523-hydroxy-1-methylpropylmercapturic acid2E-726053186
62253Smoking2E-726053186
64957Depressive Disorder7E-727622933
64958Serotonin Uptake Inhibitors7E-727622933
64959Mood Disorders7E-727622933
83819Cleft Lip6E-928232668
83820Cleft Palate6E-928232668
96237Diagnostic Self Evaluation4E-620707712

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000134308homo_sapiensENSP0000026433577.254963.1373homo_sapiensENSP0000023808180.408265.7143
ENSG00000134308homo_sapiensENSP0000024897581.300869.5122homo_sapiensENSP0000023808181.632769.7959
ENSG00000134308homo_sapiensENSP0000030633080.971768.8259homo_sapiensENSP0000023808181.632769.3878
ENSG00000134308homo_sapiensENSP0000034098984.274269.3548homo_sapiensENSP0000023808185.306170.2041
ENSG00000134308homo_sapiensENSP0000030016190.650480.8943homo_sapiensENSP0000023808191.020481.2245
ENSG00000134308homo_sapiensENSP0000037928890.612279.5918homo_sapiensENSP0000023808190.612279.5918

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000134308homo_sapiensENSP00000238081100100nomascus_leucogenysENSNLEP0000001642896.837996.8379
ENSG00000134308homo_sapiensENSP000002380818076.3265pan_paniscusENSPPAP0000003983193.333389.0476
ENSG00000134308homo_sapiensENSP0000023808180.408275.5102pan_paniscusENSPPAP0000004322568.402864.2361
ENSG00000134308homo_sapiensENSP00000238081100100pongo_abeliiENSPPYP00000014137100100
ENSG00000134308homo_sapiensENSP00000238081100100pan_troglodytesENSPTRP0000002001996.837996.8379
ENSG00000134308homo_sapiensENSP00000238081100100gorilla_gorillaENSGGOP0000000154698.790398.7903
ENSG00000134308homo_sapiensENSP0000023808179.591876.3265gorilla_gorillaENSGGOP0000005053992.417188.6256
ENSG00000134308homo_sapiensENSP0000023808199.591897.551ornithorhynchus_anatinusENSOANP0000001240099.591897.551
ENSG00000134308homo_sapiensENSP0000023808199.183796.7347sarcophilus_harrisiiENSSHAP0000004458377.884675.9615
ENSG00000134308homo_sapiensENSP0000023808177.142974.6939notamacropus_eugeniiENSMEUP0000001317477.142974.6939
ENSG00000134308homo_sapiensENSP0000023808199.183798.7755dasypus_novemcinctusENSDNOP0000002634193.103492.7203
ENSG00000134308homo_sapiensENSP0000023808110099.5918dasypus_novemcinctusENSDNOP0000002153089.090988.7273
ENSG00000134308homo_sapiensENSP0000023808192.244992.2449echinops_telfairiENSETEP00000012447100100
ENSG00000134308homo_sapiensENSP0000023808193.469493.0612callithrix_jacchusENSCJAP0000008085290.157589.7638
ENSG00000134308homo_sapiensENSP0000023808173.877569.3878cercocebus_atysENSCATP0000001282087.019281.7308
ENSG00000134308homo_sapiensENSP00000238081100100cercocebus_atysENSCATP0000000794898.790398.7903
ENSG00000134308homo_sapiensENSP00000238081100100macaca_mulattaENSMMUP00000059482100100
ENSG00000134308homo_sapiensENSP00000238081100100macaca_nemestrinaENSMNEP0000002471998.790398.7903
ENSG00000134308homo_sapiensENSP00000238081100100papio_anubisENSPANP00000012919100100
ENSG00000134308homo_sapiensENSP00000238081100100mandrillus_leucophaeusENSMLEP0000001169498.790398.7903
ENSG00000134308homo_sapiensENSP0000023808198.775598.7755tursiops_truncatusENSTTRP00000000822100100
ENSG00000134308homo_sapiensENSP00000238081100100vulpes_vulpesENSVVUP00000002681100100
ENSG00000134308homo_sapiensENSP0000023808197.959297.551mus_spretusMGP_SPRETEiJ_P003345897.959297.551
ENSG00000134308homo_sapiensENSP00000238081100100equus_asinusENSEASP00005006473100100
ENSG00000134308homo_sapiensENSP00000238081100100capra_hircusENSCHIP00000009884100100
ENSG00000134308homo_sapiensENSP00000238081100100loxodonta_africanaENSLAFP0000000795197.609697.6096
ENSG00000134308homo_sapiensENSP00000238081100100panthera_leoENSPLOP00000003978100100
ENSG00000134308homo_sapiensENSP00000238081100100ailuropoda_melanoleucaENSAMEP00000009076100100
ENSG00000134308homo_sapiensENSP0000023808199.591899.5918bos_indicus_hybridENSBIXP0000501844657.957257.9572
ENSG00000134308homo_sapiensENSP0000023808110099.1837oryctolagus_cuniculusENSOCUP0000000903210099.1837
ENSG00000134308homo_sapiensENSP0000023808193.469493.0612equus_caballusENSECAP0000008871989.803989.4118
ENSG00000134308homo_sapiensENSP00000238081100100canis_lupus_familiarisENSCAFP00845035215100100
ENSG00000134308homo_sapiensENSP00000238081100100panthera_pardusENSPPRP00000026377100100
ENSG00000134308homo_sapiensENSP00000238081100100marmota_marmota_marmotaENSMMMP00000025839100100
ENSG00000134308homo_sapiensENSP00000238081100100balaenoptera_musculusENSBMSP00010025796100100
ENSG00000134308homo_sapiensENSP00000238081100100cavia_porcellusENSCPOP00000010178100100
ENSG00000134308homo_sapiensENSP0000023808195.510295.102felis_catusENSFCAP0000005948677.740977.4086
ENSG00000134308homo_sapiensENSP0000023808135.510234.2857monodelphis_domesticaENSMODP0000005073983.653880.7692
ENSG00000134308homo_sapiensENSP0000023808135.918433.0612monodelphis_domesticaENSMODP0000004897584.615477.8846
ENSG00000134308homo_sapiensENSP0000023808193.061293.0612bison_bison_bisonENSBBBP0000001887799.130499.1304
ENSG00000134308homo_sapiensENSP00000238081100100monodon_monocerosENSMMNP00015009692100100
ENSG00000134308homo_sapiensENSP0000023808192.653191.4286sus_scrofaENSSSCP0000006507087.984586.8217
ENSG00000134308homo_sapiensENSP00000238081100100microcebus_murinusENSMICP00000043142100100
ENSG00000134308homo_sapiensENSP0000023808199.591899.5918octodon_degusENSODEP0000000192299.591899.5918
ENSG00000134308homo_sapiensENSP0000023808110099.1837jaculus_jaculusENSJJAP0000000403210099.1837
ENSG00000134308homo_sapiensENSP00000238081100100ovis_aries_rambouilletENSOARP00020010975100100
ENSG00000134308homo_sapiensENSP00000238081100100ursus_maritimusENSUMAP00000004512100100
ENSG00000134308homo_sapiensENSP0000023808199.591899.5918delphinapterus_leucasENSDLEP0000000650299.591899.5918
ENSG00000134308homo_sapiensENSP00000238081100100physeter_catodonENSPCTP00005017839100100
ENSG00000134308homo_sapiensENSP0000023808110099.5918mus_caroliMGP_CAROLIEiJ_P003199210099.5918
ENSG00000134308homo_sapiensENSP0000023808110099.5918mus_musculusENSMUSP0000012360510099.5918
ENSG00000134308homo_sapiensENSP0000023808199.183798.7755dipodomys_ordiiENSDORP0000002777999.183798.7755
ENSG00000134308homo_sapiensENSP00000238081100100mustela_putorius_furoENSMPUP00000013154100100
ENSG00000134308homo_sapiensENSP0000023808193.469493.0612aotus_nancymaaeENSANAP0000001657488.41788.0309
ENSG00000134308homo_sapiensENSP0000023808174.693968.5714saimiri_boliviensis_boliviensisENSSBOP0000002806387.559880.3828
ENSG00000134308homo_sapiensENSP0000023808191.428688.9796saimiri_boliviensis_boliviensisENSSBOP0000002435995.319192.766
ENSG00000134308homo_sapiensENSP00000238081100100vicugna_pacosENSVPAP00000007488100100
ENSG00000134308homo_sapiensENSP0000023808161.224553.0612tupaia_belangeriENSTBEP0000000878878.53468.0628
ENSG00000134308homo_sapiensENSP0000023808187.346983.6735mesocricetus_auratusENSMAUP0000001858184.920681.3492
ENSG00000134308homo_sapiensENSP0000023808178.367373.0612mesocricetus_auratusENSMAUP0000000759789.302383.2558
ENSG00000134308homo_sapiensENSP00000238081100100phocoena_sinusENSPSNP00000031276100100
ENSG00000134308homo_sapiensENSP00000238081100100camelus_dromedariusENSCDRP00005031344100100
ENSG00000134308homo_sapiensENSP0000023808189.795989.7959carlito_syrichtaENSTSYP0000002454689.795989.7959
ENSG00000134308homo_sapiensENSP00000238081100100panthera_tigris_altaicaENSPTIP00000003405100100
ENSG00000134308homo_sapiensENSP0000023808110099.5918rattus_norvegicusENSRNOP0000007793210099.5918
ENSG00000134308homo_sapiensENSP00000238081100100prolemur_simusENSPSMP00000028851100100
ENSG00000134308homo_sapiensENSP00000238081100100microtus_ochrogasterENSMOCP00000023669100100
ENSG00000134308homo_sapiensENSP0000023808199.183798.7755sorex_araneusENSSARP0000001126699.183798.7755
ENSG00000134308homo_sapiensENSP0000023808110099.5918bos_mutusENSBMUP0000000423210099.5918
ENSG00000134308homo_sapiensENSP0000023808110099.5918mus_spicilegusENSMSIP0000002635910099.5918
ENSG00000134308homo_sapiensENSP00000238081100100cricetulus_griseus_chok1gshdENSCGRP00001027843100100
ENSG00000134308homo_sapiensENSP0000023808199.591899.1837myotis_lucifugusENSMLUP0000000491199.591899.1837
ENSG00000134308homo_sapiensENSP0000023808199.591897.9592vombatus_ursinusENSVURP0001002090299.591897.9592
ENSG00000134308homo_sapiensENSP00000238081100100rhinolophus_ferrumequinumENSRFEP00010013885100100
ENSG00000134308homo_sapiensENSP0000023808197.55197.1429neovison_visonENSNVIP0000001936499.583399.1667
ENSG00000134308homo_sapiensENSP00000238081100100heterocephalus_glaber_femaleENSHGLP00000000527100100
ENSG00000134308homo_sapiensENSP00000238081100100rhinopithecus_bietiENSRBIP0000000518296.837996.8379
ENSG00000134308homo_sapiensENSP00000238081100100canis_lupus_dingoENSCAFP00020034523100100
ENSG00000134308homo_sapiensENSP00000238081100100sciurus_vulgarisENSSVLP00005025113100100
ENSG00000134308homo_sapiensENSP0000023808199.591897.9592phascolarctos_cinereusENSPCIP0000003093899.591897.9592
ENSG00000134308homo_sapiensENSP00000238081100100nannospalax_galiliENSNGAP00000009797100100
ENSG00000134308homo_sapiensENSP00000238081100100bos_grunniensENSBGRP00000020338100100
ENSG00000134308homo_sapiensENSP0000023808179.591879.1837chinchilla_lanigeraENSCLAP0000000503776.771776.378
ENSG00000134308homo_sapiensENSP00000238081100100cervus_hanglu_yarkandensisENSCHYP00000017613100100
ENSG00000134308homo_sapiensENSP00000238081100100catagonus_wagneriENSCWAP00000014730100100
ENSG00000134308homo_sapiensENSP0000023808171.428666.5306ictidomys_tridecemlineatusENSSTOP0000002709484.134678.3654
ENSG00000134308homo_sapiensENSP00000238081100100otolemur_garnettiiENSOGAP00000000490100100
ENSG00000134308homo_sapiensENSP00000238081100100cebus_imitatorENSCCAP00000027792100100
ENSG00000134308homo_sapiensENSP0000023808193.061292.6531urocitellus_parryiiENSUPAP0001001435792.307791.9028
ENSG00000134308homo_sapiensENSP0000023808199.183799.1837moschus_moschiferusENSMMSP00000001006100100
ENSG00000134308homo_sapiensENSP00000238081100100rhinopithecus_roxellanaENSRROP0000004325598.790398.7903
ENSG00000134308homo_sapiensENSP0000023808193.469491.8367mus_pahariMGP_PahariEiJ_P008210953.504752.5701
ENSG00000134308homo_sapiensENSP00000238081100100propithecus_coquereliENSPCOP0000002900998.393698.3936
ENSG00000134308homo_sapiensENSP0000023808180.816370.2041caenorhabditis_elegansF52D10.3c.179.838769.3548
ENSG00000134308homo_sapiensENSP0000023808131.020422.0408caenorhabditis_elegansM117.3.160.843.2
ENSG00000134308homo_sapiensENSP0000023808182.040874.2857caenorhabditis_elegansM117.2a.381.048473.3871
ENSG00000134308homo_sapiensENSP0000023808186.938876.7347drosophila_melanogasterFBpp008750085.887175.8064
ENSG00000134308homo_sapiensENSP0000023808143.673533.8776ciona_intestinalisENSCINP0000002208470.860954.9669
ENSG00000134308homo_sapiensENSP0000023808184.89877.9592petromyzon_marinusENSPMAP0000000654784.552877.6423
ENSG00000134308homo_sapiensENSP0000023808189.387878.3673xenopus_tropicalisENSXETP0000001527989.024478.0488
ENSG00000134308homo_sapiensENSP0000023808199.591896.7347chrysemys_picta_belliiENSCPBP0000001945497.211294.4223
ENSG00000134308homo_sapiensENSP0000023808194.285792.6531sphenodon_punctatusENSSPUP0000002042599.141697.4249
ENSG00000134308homo_sapiensENSP0000023808151.020450.6122crocodylus_porosusENSCPRP0000500965010099.2
ENSG00000134308homo_sapiensENSP0000023808198.775596.7347laticauda_laticaudataENSLLTP0000000746871.176569.7059
ENSG00000134308homo_sapiensENSP0000023808198.775596.7347notechis_scutatusENSNSUP0000002871398.775596.7347
ENSG00000134308homo_sapiensENSP0000023808198.775596.7347pseudonaja_textilisENSPTXP0000001753998.775596.7347
ENSG00000134308homo_sapiensENSP0000023808193.877592.6531anas_platyrhynchos_platyrhynchosENSAPLP0000001735710098.6957
ENSG00000134308homo_sapiensENSP0000023808196.734795.5102gallus_gallusENSGALP0001000473210098.7342
ENSG00000134308homo_sapiensENSP0000023808151.020450.6122meleagris_gallopavoENSMGAP0000001951310099.2
ENSG00000134308homo_sapiensENSP0000023808110098.7755serinus_canariaENSSCAP0000001692410098.7755
ENSG00000134308homo_sapiensENSP0000023808199.183797.9592parus_majorENSPMJP0000001643098.380697.166
ENSG00000134308homo_sapiensENSP0000023808198.775596.3265anolis_carolinensisENSACAP0000000123798.775596.3265
ENSG00000134308homo_sapiensENSP0000023808198.775596.7347naja_najaENSNNAP0000001795698.775596.7347
ENSG00000134308homo_sapiensENSP0000023808186.530680.8163podarcis_muralisENSPMRP0000001716279.400774.1573
ENSG00000134308homo_sapiensENSP0000023808182.857178.7755podarcis_muralisENSPMRP0000001717495.305290.6103
ENSG00000134308homo_sapiensENSP0000023808184.081680podarcis_muralisENSPMRP0000003020488.41284.1202
ENSG00000134308homo_sapiensENSP0000023808198.775596.3265podarcis_muralisENSPMRP0000001770498.775596.3265
ENSG00000134308homo_sapiensENSP0000023808184.081680podarcis_muralisENSPMRP0000001717888.41284.1202
ENSG00000134308homo_sapiensENSP0000023808184.081679.5918podarcis_muralisENSPMRP0000001717088.41283.691
ENSG00000134308homo_sapiensENSP0000023808110098.7755geospiza_fortisENSGFOP0000001150510098.7755
ENSG00000134308homo_sapiensENSP0000023808198.775597.551taeniopygia_guttataENSTGUP0000001933585.815684.7518
ENSG00000134308homo_sapiensENSP0000023808198.775596.3265salvator_merianaeENSSMRP0000000775998.775596.3265
ENSG00000134308homo_sapiensENSP0000023808199.591897.1429pelodiscus_sinensisENSPSIP0000001420399.591897.1429
ENSG00000134308homo_sapiensENSP0000023808199.591896.7347gopherus_evgoodeiENSGEVP0000501182599.591896.7347
ENSG00000134308homo_sapiensENSP0000023808199.591896.7347chelonoidis_abingdoniiENSCABP0000001104899.591896.7347
ENSG00000134308homo_sapiensENSP0000023808110098.7755struthio_camelus_australisENSSCUP0000001639710098.7755
ENSG00000134308homo_sapiensENSP0000023808110098.7755anser_brachyrhynchusENSABRP0000001191010098.7755
ENSG00000134308homo_sapiensENSP0000023808110098.7755strigops_habroptilaENSSHBP0000500781410098.7755
ENSG00000134308homo_sapiensENSP0000023808199.591896.7347terrapene_carolina_triunguisENSTMTP0000000280499.591896.7347
ENSG00000134308homo_sapiensENSP0000023808135.10224.898hucho_huchoENSHHUP0000006910071.074450.4132
ENSG00000134308homo_sapiensENSP0000023808176.734760.8163ciona_savignyiENSCSAVP0000001730372.307757.3077
ENSG00000134308homo_sapiensENSP0000023808138.367328.5714acanthochromis_polyacanthusENSAPOP0000003406075.806456.4516
ENSG00000134308homo_sapiensENSP0000023808110098.7755aquila_chrysaetos_chrysaetosENSACCP0002001825310098.7755
ENSG00000134308homo_sapiensENSP0000023808110098.7755ficedula_albicollisENSFALP0000002545010098.7755
ENSG00000134308homo_sapiensENSP0000023808110098.7755coturnix_japonicaENSCJPP0000501303210098.7755
ENSG00000134308homo_sapiensENSP0000023808188.979680leptobrachium_leishanenseENSLLEP0000002736787.903279.0323

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0006605involved_in protein targeting1IEAHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1IBAHomo_sapiens(9606)Process
GO:0007264involved_in small GTPase mediated signal transduction1IEAHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0019904enables protein domain specific binding1IEAHomo_sapiens(9606)Function
GO:0021762involved_in substantia nigra development1HEPHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0034766involved_in negative regulation of monoatomic ion transmembrane transport1IEAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0044325enables transmembrane transporter binding1IEAHomo_sapiens(9606)Function
GO:0045202located_in synapse1IEAHomo_sapiens(9606)Component
GO:0045892involved_in negative regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0071889enables 14-3-3 protein binding1IEAHomo_sapiens(9606)Function

Expression