RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	N.A.
Main interacting RNAs	tRNA
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000133706	Gene ID	51520	Accession	6512
Symbol	LARS1	Alias	LRS;LARS;LEUS;LFIS;ILFS1;LEURS;PIG44;RNTLS;HSPC192;hr025Cl	Full Name	leucyl-tRNA synthetase 1
Status	Confidence	Length	72131 bases	Strand	Minus strand
Position	5 : 146110566 - 146182696	RNA binding domain	tRNA-synt_1g , tRNA-synt_1e , tRNA-synt_1 , Anticodon_1
Summary	This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]