Ensembl ID ENSG00000133706 Gene ID 51520 Accession 6512
Gene Symbol LARS1 Alias LRS;LARS;LEUS;LFIS;ILFS1;LEURS;PIG44;RNTLS;HSPC192;hr025Cl Full Name leucyl-tRNA synthetase 1
Position 5 : 146110566 - 146182696 Length 72131 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]

ENSG00000133706 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000133706 LARS1 0.43 6.31e-12 COAD
ENSG00000133706 LARS1 0.67 2.82e-25 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000133706 LARS1 tumor 16936591
ENSG00000133706 LARS1 rectal cancer 22504191
ENSG00000133706 LARS1 Cancer 23939851
ENSG00000133706 LARS1 rectal cancer 24448844
ENSG00000133706 LARS1 cancer 24510587
ENSG00000133706 LARS1 tumor 26508878
ENSG00000133706 LARS1 bone tumors 27745757
ENSG00000133706 LARS1 Cancer 28044239
ENSG00000133706 LARS1 rectal cancer 29313107
ENSG00000133706 LARS1 tumors 30001383
ENSG00000133706 LARS1 Cancer 30083782
ENSG00000133706 LARS1 tumor 30562780
ENSG00000133706 LARS1 Cancer 30837792
ENSG00000133706 LARS1 rectal cancer 31082911
ENSG00000133706 LARS1 colonic cancer 31183455
ENSG00000133706 LARS1 breast cancer 31889940
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000133706 LARS1 SARC 0.0023 high
ENSG00000133706 LARS1 UVM 0.0047 high
ENSG00000133706 LARS1 THCA 0.00044 high
ENSG00000133706 LARS1 LGG 0.006 low
ENSG00000133706 LARS1 LUSC 0.021 low
ENSG00000133706 LARS1 READ 0.00016 low
ENSG00000133706 LARS1 KIRP 0.047 high
ENSG00000133706 LARS1 KICH 0.00027 high
ENSG00000133706 LARS1 PCPG 0.024 low
ENSG00000133706 LARS1 THYM 0.02 high
ENSG00000133706 LARS1 BRCA 0.042 high
ENSG00000133706 LARS1 COAD 0.0098 low
ENSG00000133706 LARS1 UCS 0.0054 high
ENSG00000133706 LARS1 ESCA 0.04 high
ENSG00000133706 LARS1 OV 0.037 high
ENSG00000133706 LARS1 KIRC 0.003 low
ENSG00000133706 LARS1 PRAD 0.041 low
ENSG00000133706 LARS1 BLCA 0.034 high
ENSG00000133706 LARS1 LAML 0.034 low
ENSG00000133706 LARS1 GBM 0.048 low
ENSG00000133706 LARS1 SKCM 0.00023 low
ENSG00000133706 LARS1 CESC 0.014 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000133706 LARS1 LAML Del 6.879801 0.096928 0.801561 0.089005
ENSG00000133706 LARS1 LGG Del 2.337882 0.055293 0.408471 0.101365
ENSG00000133706 LARS1 SKCM Del 6.041303 0.133340 0.498712 0.348774
ENSG00000133706 LARS1 KIRC Amp 52.984248 0.299704 0.545451 0.613636