Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000133703 Gene ID 3845 Accession 6407
Symbol KRAS Alias NS;NS3;OES;CFC2;RALD;K-Ras;KRAS1;KRAS2;RASK2;KI-RAS;C-K-RAS;K-RAS2A;K-RAS2B;K-RAS4A;K-RAS4B;K-Ras2;'C-K-RAS;c-Ki-ras;c-Ki-ras2 Full Name KRAS proto-oncogene, GTPase
Status Confidence Length 45691 bases Strand Minus strand
Position 12 : 25205246 - 25250936 RNA binding domain GTP_EFTU , MMR_HSR1
Summary This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000308495 GTP_EFTU PF00009 2.4e-06 1
ENSP00000308495 MMR_HSR1 PF01926 7.7e-05 2
ENSP00000508921 GTP_EFTU PF00009 2.4e-06 1
ENSP00000508921 MMR_HSR1 PF01926 7.7e-05 2
ENSP00000509238 GTP_EFTU PF00009 2.4e-06 1
ENSP00000509238 MMR_HSR1 PF01926 7.7e-05 2
ENSP00000256078 MMR_HSR1 PF01926 0.00011 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
26320939 Biogenesis, delivery, and function of extracellular RNA. G James Patton 2015-01-01 Journal of extracellular vesicles
34934837 Depletion of METTL3 alters cellular and extracellular levels of miRNAs containing m6A consensus sequences. J Jessica Abner 2021-12-01 Heliyon
27892494 Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Yongchao Dou 2016-11-28 Scientific reports
20617134 Clinical relevance of KRAS in human cancers. Sylwia Jancík 2010-01-01 Journal of biomedicine & biotechnology
31712554 KRAS regulation by small non-coding RNAs and SNARE proteins. Yonglu Che 2019-11-11 Nature communications
34661500 Mechanism of cargo sorting into small extracellular vesicles. Yiwen Chen 2021-12-01 Bioengineered
36522653 Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer. April Lo 2022-12-16 BMC cancer
26930719 Cis-acting elements in its 3' UTR mediate post-transcriptional regulation of KRAS. Minlee Kim 2016-03-15 Oncotarget
32369483 Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells. Almas Yaqoob 2020-01-01 PloS one
25772772 Circulating microRNAs as potential biomarkers for endometriosis. SiHyun Cho 2015-05-01 Fertility and sterility
35805073 Mutant KRAS-Associated Proteome Is Mainly Controlled by Exogenous Factors. Patrícia P Dias 2022-06-21 Cells
37627169 Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib. Aoife Nolan 2023-08-17 Cancers
28866730 EGFR-targeted therapies in the post-genomic era. Jue Mary Xu 2017-09-01 Cancer metastasis reviews
36977948 Roles and mechanisms of exosomal microRNAs in viral infections. Lingxiang Mao 2023-03-28 Archives of virology
34895045 Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells. Nadav Wallis 2022-01-01 RNA biology
27117408 KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes. J Andrew McKenzie 2016-05-03 Cell reports
31819612 A Molecular Epidemiological Analysis Of Programmed Cell Death Ligand-1 (PD-L1) Protein Expression, Mutations And Survival In Non-Small Cell Lung Cancer. B Matthew Schabath 2019-01-01 Cancer management and research
26573509 Role of KRAS-LCS6 polymorphism in advanced NSCLC patients treated with erlotinib or docetaxel in second line treatment (TAILOR). Monica Ganzinelli 2015-11-17 Scientific reports
22162691 Molecular targets for the treatment of juvenile myelomonocytic leukemia. Xiaoling Liu 2012-01-01 Advances in hematology
25853628 KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines. João Lavrado 2015-04-08 Scientific reports
22307873 A polymorphism in a let-7 microRNA binding site of KRAS in women with endometriosis. Olga Grechukhina 2012-03-01 EMBO molecular medicine

Transcripts

Name Transcript ID bp Protein Translation ID
KRAS-211 ENST00000690406 4919 54aa ENSP00000509798
KRAS-201 ENST00000256078 5430 189aa ENSP00000256078
KRAS-202 ENST00000311936 5306 188aa ENSP00000308495
KRAS-206 ENST00000686877 5420 55aa ENSP00000510431
KRAS-205 ENST00000685328 5287 188aa ENSP00000508921
KRAS-214 ENST00000693229 5187 163aa ENSP00000509223
KRAS-208 ENST00000687356 5101 40aa ENSP00000510511
KRAS-213 ENST00000692768 5075 122aa ENSP00000510254
KRAS-210 ENST00000688940 3630 188aa ENSP00000509238
KRAS-212 ENST00000690804 2721 51aa ENSP00000508568
KRAS-204 ENST00000557334 1042 75aa ENSP00000452512
KRAS-209 ENST00000688228 1163 No protein -
KRAS-207 ENST00000686969 2957 43aa ENSP00000510479
KRAS-203 ENST00000556131 2937 43aa ENSP00000451856

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
8221Heart Diseases1.9539376742651E-517903304
8227Heart Diseases1.34228670028596E-517903304
16972Neuroblastoma1.43e-00523222812
36553Platelet Function Tests6.6400000E-006-
46604Liver Cirrhosis, Biliary4.1100000E-00620639880
68051Dysmenorrhea6E-727454463
76418Alzheimer Disease8E-727770636
103915Glucose6E-623400010
103916Hydrochlorothiazide6E-623400010

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000133703homo_sapiensENSP0000038968262.980850homo_sapiensENSP0000030849569.680955.3191
ENSG00000133703homo_sapiensENSP0000021612740.225625.188homo_sapiensENSP0000030849556.914935.6383
ENSG00000133703homo_sapiensENSP0000024530468.30647.541homo_sapiensENSP0000030849566.489446.2766
ENSG00000133703homo_sapiensENSP0000031909667.213146.9945homo_sapiensENSP0000030849565.425545.7447
ENSG00000133703homo_sapiensENSP0000022006235.338319.9248homo_sapiensENSP000003084955028.1915
ENSG00000133703homo_sapiensENSP0000035730659.817443.379homo_sapiensENSP0000030849569.680950.5319
ENSG00000133703homo_sapiensENSP0000027251965.53446.6019homo_sapiensENSP0000030849571.808551.0638
ENSG00000133703homo_sapiensENSP0000043781444.117624.5098homo_sapiensENSP0000030849547.872326.5957
ENSG00000133703homo_sapiensENSP0000029759633.108119.5946homo_sapiensENSP0000030849552.127730.8511
ENSG00000133703homo_sapiensENSP0000037746348.167525.6544homo_sapiensENSP0000030849548.936226.0638
ENSG00000133703homo_sapiensENSP0000047423037.93124.1379homo_sapiensENSP0000030849540.957426.0638
ENSG00000133703homo_sapiensENSP0000035872375.543557.0652homo_sapiensENSP0000030849573.936255.8511
ENSG00000133703homo_sapiensENSP0000020197932.214817.1141homo_sapiensENSP0000030849551.063827.1277
ENSG00000133703homo_sapiensENSP0000029975930.194816.8831homo_sapiensENSP0000030849549.468127.6596
ENSG00000133703homo_sapiensENSP0000049079351.07336.0515homo_sapiensENSP0000030849563.297944.6809
ENSG00000133703homo_sapiensENSP0000030984591.534485.1852homo_sapiensENSP0000030849592.021385.6383
ENSG00000133703homo_sapiensENSP0000035991171.038347.541homo_sapiensENSP0000030849569.148946.2766
ENSG00000133703homo_sapiensENSP0000026739628.529415.5882homo_sapiensENSP0000030849551.595728.1915
ENSG00000133703homo_sapiensENSP0000025695347.236230.1508homo_sapiensENSP000003084955031.9149
ENSG00000133703homo_sapiensENSP0000024870637.096823.3871homo_sapiensENSP0000030849548.936230.8511
ENSG00000133703homo_sapiensENSP0000032180558.525342.3963homo_sapiensENSP0000030849567.553248.9362
ENSG00000133703homo_sapiensENSP0000024679258.256946.789homo_sapiensENSP0000030849567.553254.2553
ENSG00000133703homo_sapiensENSP0000021610138.423621.6749homo_sapiensENSP0000030849541.489423.4043
ENSG00000133703homo_sapiensENSP0000000525765.048546.6019homo_sapiensENSP0000030849571.276651.0638
ENSG00000133703homo_sapiensENSP0000036491951.758835.1759homo_sapiensENSP0000030849554.787237.234
ENSG00000133703homo_sapiensENSP0000026218758.152234.7826homo_sapiensENSP0000030849556.914934.0426
ENSG00000133703homo_sapiensENSP0000025619665.686352.451homo_sapiensENSP0000030849571.276656.9149
ENSG00000133703homo_sapiensENSP0000032583651.010132.8283homo_sapiensENSP0000030849553.723434.5745
ENSG00000133703homo_sapiensENSP0000024146339.256223.9669homo_sapiensENSP0000030849550.531930.8511
ENSG00000133703homo_sapiensENSP0000022568837.722424.1993homo_sapiensENSP0000030849556.38336.1702
ENSG00000133703homo_sapiensENSP0000035854891.534483.5979homo_sapiensENSP0000030849592.021384.0426
ENSG00000133703homo_sapiensENSP0000040038549.479227.6042homo_sapiensENSP0000030849550.531928.1915
ENSG00000133703homo_sapiensENSP0000030106855.191332.7869homo_sapiensENSP0000030849553.723431.9149
ENSG00000133703homo_sapiensENSP0000049573637.117924.8908homo_sapiensENSP0000030849545.212830.3191
ENSG00000133703homo_sapiensENSP0000025055973.91354.8913homo_sapiensENSP0000030849572.340453.7234

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617nomascus_leucogenysENSNLEP0000000637193.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617pan_paniscusENSPPAP0000003094693.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617pongo_abeliiENSPPYP0000003403793.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617pan_troglodytesENSPTRP0000008458893.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617gorilla_gorillaENSGGOP0000000786493.121788.8889
ENSG00000133703homo_sapiensENSP0000030849581.914973.4043ornithorhynchus_anatinusENSOANP0000003347160.629954.3307
ENSG00000133703homo_sapiensENSP0000030849510099.4681sarcophilus_harrisiiENSSHAP0000003630094.472493.9698
ENSG00000133703homo_sapiensENSP0000030849555.319152.6596notamacropus_eugeniiENSMEUP0000001138161.538558.5799
ENSG00000133703homo_sapiensENSP0000030849582.446881.383dasypus_novemcinctusENSDNOP0000002197081.151880.1047
ENSG00000133703homo_sapiensENSP0000030849593.085187.766erinaceus_europaeusENSEEUP0000000279893.085187.766
ENSG00000133703homo_sapiensENSP0000030849593.085188.2979echinops_telfairiENSETEP0000000190893.085188.2979
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617callithrix_jacchusENSCJAP0000005410293.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617cercocebus_atysENSCATP0000001162293.121788.8889
ENSG00000133703homo_sapiensENSP0000030849510099.4681macaca_fascicularisENSMFAP0000003463989.099588.6256
ENSG00000133703homo_sapiensENSP0000030849586.702183.5106macaca_mulattaENSMMUP0000000263539.563138.1068
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617macaca_nemestrinaENSMNEP0000004530093.121788.8889
ENSG00000133703homo_sapiensENSP0000030849586.702184.0426papio_anubisENSPANP0000000503841.902340.617
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617mandrillus_leucophaeusENSMLEP0000000843693.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298tursiops_truncatusENSTTRP0000001195493.121788.3598
ENSG00000133703homo_sapiensENSP0000030849510099.4681vulpes_vulpesENSVVUP0000004270044.976144.7368
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617mus_spretusMGP_SPRETEiJ_P008008593.121788.8889
ENSG00000133703homo_sapiensENSP0000030849581.914979.2553equus_asinusENSEASP0000500133693.333390.303
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298capra_hircusENSCHIP0000003273393.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.2979loxodonta_africanaENSLAFP0000001966993.121787.8307
ENSG00000133703homo_sapiensENSP0000030849585.638383.5106panthera_leoENSPLOP0000001825059.851358.3643
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298ailuropoda_melanoleucaENSAMEP0000000794944.89842.602
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298bos_indicus_hybridENSBIXP0000500106693.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298oryctolagus_cuniculusENSOCUP0000001041192.592688.3598
ENSG00000133703homo_sapiensENSP0000030849585.106483.5106equus_caballusENSECAP0000005415651.446950.4823
ENSG00000133703homo_sapiensENSP0000030849591.489484.5745equus_caballusENSECAP0000006658391.978685.0267
ENSG00000133703homo_sapiensENSP0000030849591.489485.1064equus_caballusENSECAP0000003902991.005384.6561
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298canis_lupus_familiarisENSCAFP0084503706993.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298panthera_pardusENSPPRP0000001450593.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298marmota_marmota_marmotaENSMMMP0000002062593.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298balaenoptera_musculusENSBMSP0001001566093.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617cavia_porcellusENSCPOP0000000961493.121788.8889
ENSG00000133703homo_sapiensENSP0000030849585.638383.5106felis_catusENSFCAP0000001600542.368441.3158
ENSG00000133703homo_sapiensENSP0000030849510099.4681ursus_americanusENSUAMP0000002081210099.4681
ENSG00000133703homo_sapiensENSP0000030849595.212894.6809monodelphis_domesticaENSMODP0000003749192.26891.7526
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298bison_bison_bisonENSBBBP0000000148393.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298monodon_monocerosENSMMNP0001502274493.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617sus_scrofaENSSSCP0000002183693.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617octodon_degusENSODEP0000001408793.121788.8889
ENSG00000133703homo_sapiensENSP0000030849588.297985.1064jaculus_jaculusENSJJAP0000000857897.07693.5673
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298ovis_aries_rambouilletENSOARP0002000461993.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298ursus_maritimusENSUMAP0000000400793.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617ochotona_princepsENSOPRP0000001100693.121788.8889
ENSG00000133703homo_sapiensENSP0000030849579.787273.4043delphinapterus_leucasENSDLEP0000001268247.923344.0895
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298physeter_catodonENSPCTP0000502711193.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617mus_caroliMGP_CAROLIEiJ_P007681193.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617mus_musculusENSMUSP0000010733993.121788.8889
ENSG00000133703homo_sapiensENSP0000030849576.595770.7447dipodomys_ordiiENSDORP0000002111588.343681.5951
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617dipodomys_ordiiENSDORP0000001078093.121788.8889
ENSG00000133703homo_sapiensENSP0000030849586.702182.9787mustela_putorius_furoENSMPUP0000001021778.365475
ENSG00000133703homo_sapiensENSP0000030849510099.4681aotus_nancymaaeENSANAP0000002517989.099588.6256
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617saimiri_boliviensis_boliviensisENSSBOP0000001132393.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298vicugna_pacosENSVPAP0000000029693.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617chlorocebus_sabaeusENSCSAP0000000402593.121788.8889
ENSG00000133703homo_sapiensENSP0000030849577.659677.1277tupaia_belangeriENSTBEP0000000330997.333396.6667
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298mesocricetus_auratusENSMAUP0000001875993.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298phocoena_sinusENSPSNP0000001000393.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298camelus_dromedariusENSCDRP0000502935193.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617carlito_syrichtaENSTSYP0000000424393.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298panthera_tigris_altaicaENSPTIP0000001255793.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617prolemur_simusENSPSMP0000002644593.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298microtus_ochrogasterENSMOCP0000001106992.592688.3598
ENSG00000133703homo_sapiensENSP0000030849568.61763.8298sorex_araneusENSSARP0000000718990.209883.9161
ENSG00000133703homo_sapiensENSP0000030849593.61788.2979peromyscus_maniculatus_bairdiiENSPEMP0000003426293.121787.8307
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298bos_mutusENSBMUP0000002662893.121788.3598
ENSG00000133703homo_sapiensENSP0000030849589.361783.5106cricetulus_griseus_chok1gshdENSCGRP0000101156788.888983.0688
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298cricetulus_griseus_chok1gshdENSCGRP0000100503193.121788.3598
ENSG00000133703homo_sapiensENSP0000030849590.425583.5106cricetulus_griseus_chok1gshdENSCGRP0000101146489.947183.0688
ENSG00000133703homo_sapiensENSP0000030849589.893684.0426cricetulus_griseus_chok1gshdENSCGRP0000101124089.41883.5979
ENSG00000133703homo_sapiensENSP0000030849588.297980.8511cricetulus_griseus_chok1gshdENSCGRP0000101089587.830780.4233
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298pteropus_vampyrusENSPVAP0000001289192.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617myotis_lucifugusENSMLUP0000001452793.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61788.2979vombatus_ursinusENSVURP0001002022893.121787.8307
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298neovison_visonENSNVIP0000000145893.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298bos_taurusENSBTAP0000004075193.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617heterocephalus_glaber_femaleENSHGLP0000001227493.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617rhinopithecus_bietiENSRBIP0000002657593.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61788.2979canis_lupus_dingoENSCAFP0002001596489.795984.6939
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298sciurus_vulgarisENSSVLP0000501655793.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298phascolarctos_cinereusENSPCIP0000001862493.121788.3598
ENSG00000133703homo_sapiensENSP0000030849568.61763.8298procavia_capensisENSPCAP0000000282268.25463.4921
ENSG00000133703homo_sapiensENSP0000030849592.021387.766nannospalax_galiliENSNGAP0000000094591.534487.3016
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298bos_grunniensENSBGRP0000000249293.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617chinchilla_lanigeraENSCLAP0000002405793.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298cervus_hanglu_yarkandensisENSCHYP0000001867893.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298catagonus_wagneriENSCWAP0000002701093.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298ictidomys_tridecemlineatusENSSTOP0000000854593.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617otolemur_garnettiiENSOGAP0000001326872.42869.1358
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617cebus_imitatorENSCCAP0000002811693.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298urocitellus_parryiiENSUPAP0001002006893.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298moschus_moschiferusENSMMSP0000003215093.121788.3598
ENSG00000133703homo_sapiensENSP0000030849574.468169.1489rhinopithecus_roxellanaENSRROP0000000944278.212372.6257
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617mus_pahariMGP_PahariEiJ_P005316893.121788.8889
ENSG00000133703homo_sapiensENSP0000030849596.808590.9574eptatretus_burgeriENSEBUP0000002435296.808590.9574
ENSG00000133703homo_sapiensENSP0000030849598.404396.2766callorhinchus_miliiENSCMIP0000003469498.404396.2766
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617latimeria_chalumnaeENSLACP0000002297693.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298lepisosteus_oculatusENSLOCP0000001886692.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617clupea_harengusENSCHAP0000003334193.121788.8889
ENSG00000133703homo_sapiensENSP0000030849592.021387.234danio_rerioENSDARP0000014770391.534486.7725
ENSG00000133703homo_sapiensENSP0000030849593.61788.2979carassius_auratusENSCARP0000009421793.121787.8307
ENSG00000133703homo_sapiensENSP0000030849593.61788.2979carassius_auratusENSCARP0000002597493.121787.8307
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617astyanax_mexicanusENSAMXP0000001772793.121788.8889
ENSG00000133703homo_sapiensENSP0000030849594.148989.8936ictalurus_punctatusENSIPUP0000000616693.650889.418
ENSG00000133703homo_sapiensENSP0000030849593.085189.3617esox_luciusENSELUP0000002699192.592688.8889
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298electrophorus_electricusENSEEEP0000004637393.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298oncorhynchus_kisutchENSOKIP0000509907692.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298oncorhynchus_kisutchENSOKIP0000501282292.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298oncorhynchus_mykissENSOMYP0000001230792.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298oncorhynchus_mykissENSOMYP0000008849892.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298salmo_salarENSSSAP0000007095792.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298salmo_salarENSSSAP0000016993392.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298salmo_truttaENSSTUP0000010820792.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298salmo_truttaENSSTUP0000000826392.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.085189.8936gadus_morhuaENSGMOP0000001132692.592689.418
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298fundulus_heteroclitusENSFHEP0000000795592.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617poecilia_reticulataENSPREP0000002706093.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298xiphophorus_maculatusENSXMAP0000003336392.592688.3598
ENSG00000133703homo_sapiensENSP0000030849594.148988.8298oryzias_latipesENSORLP0000003197693.650888.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298cyclopterus_lumpusENSCLMP0000504990292.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617oreochromis_niloticusENSONIP0000001852893.121788.8889
ENSG00000133703homo_sapiensENSP0000030849599.468198.4043haplochromis_burtoniENSHBUP0000002903286.175185.2535
ENSG00000133703homo_sapiensENSP0000030849599.468198.4043astatotilapia_callipteraENSACLP0000004085986.175185.2535
ENSG00000133703homo_sapiensENSP0000030849599.468198.4043astatotilapia_callipteraENSACLP0000004109786.175185.2535
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617sparus_aurataENSSAUP0001000880693.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617lates_calcariferENSLCAP0001003572893.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298xenopus_tropicalisENSXETP0000011868892.592688.3598
ENSG00000133703homo_sapiensENSP0000030849510098.9362chrysemys_picta_belliiENSCPBP000000122748079.1489
ENSG00000133703homo_sapiensENSP0000030849510099.4681sphenodon_punctatusENSSPUP0000002452710099.4681
ENSG00000133703homo_sapiensENSP0000030849510098.4043crocodylus_porosusENSCPRP0000501646392.610891.133
ENSG00000133703homo_sapiensENSP0000030849574.468169.1489laticauda_laticaudataENSLLTP0000001069591.503384.9673
ENSG00000133703homo_sapiensENSP0000030849593.61788.2979notechis_scutatusENSNSUP0000000405093.121787.8307
ENSG00000133703homo_sapiensENSP0000030849593.61788.2979pseudonaja_textilisENSPTXP0000000000993.121787.8307
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298anas_platyrhynchos_platyrhynchosENSAPLP0000001583993.121788.3598
ENSG00000133703homo_sapiensENSP0000030849510098.9362gallus_gallusENSGALP000100201579493
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298meleagris_gallopavoENSMGAP0000001445193.121788.3598
ENSG00000133703homo_sapiensENSP0000030849510098.9362serinus_canariaENSSCAP0000001265595.431594.4162
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298parus_majorENSPMJP0000001196393.121788.3598
ENSG00000133703homo_sapiensENSP0000030849510098.9362anolis_carolinensisENSACAP0000001668510098.9362
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617neolamprologus_brichardiENSNBRP0000000557193.121788.8889
ENSG00000133703homo_sapiensENSP0000030849565.957460.1064naja_najaENSNNAP0000000899071.264464.9425
ENSG00000133703homo_sapiensENSP0000030849581.38379.7872naja_najaENSNNAP0000000896697.452295.5414
ENSG00000133703homo_sapiensENSP0000030849585.106481.9149podarcis_muralisENSPMRP0000003703118.079117.4011
ENSG00000133703homo_sapiensENSP0000030849510098.9362geospiza_fortisENSGFOP0000000469010098.9362
ENSG00000133703homo_sapiensENSP0000030849584.042681.383taeniopygia_guttataENSTGUP0000003787572.811170.5069
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298erpetoichthys_calabaricusENSECRP0000000817192.592688.3598
ENSG00000133703homo_sapiensENSP0000030849594.148989.3617kryptolebias_marmoratusENSKMAP0000000529693.650888.8889
ENSG00000133703homo_sapiensENSP0000030849599.468197.8723salvator_merianaeENSSMRP0000000873999.468197.8723
ENSG00000133703homo_sapiensENSP0000030849594.148988.8298oryzias_javanicusENSOJAP0000004825493.650888.3598
ENSG00000133703homo_sapiensENSP0000030849592.553288.2979amphilophus_citrinellusENSACIP0000000012957.049254.4262
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617dicentrarchus_labraxENSDLAP0000507986493.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617amphiprion_perculaENSAPEP0000001067493.121788.8889
ENSG00000133703homo_sapiensENSP0000030849594.148988.8298oryzias_sinensisENSOSIP0000002956293.650888.3598
ENSG00000133703homo_sapiensENSP0000030849510098.9362pelodiscus_sinensisENSPSIP0000001695682.819481.9383
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298gopherus_evgoodeiENSGEVP0000500490593.121788.3598
ENSG00000133703homo_sapiensENSP0000030849510098.9362chelonoidis_abingdoniiENSCABP0000000608310098.9362
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617seriola_dumeriliENSSDUP0000002447393.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617cottoperca_gobioENSCGOP0000004638093.121788.8889
ENSG00000133703homo_sapiensENSP0000030849510098.4043struthio_camelus_australisENSSCUP0000000698282.096180.786
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298anser_brachyrhynchusENSABRP0000002583093.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.085187.766gasterosteus_aculeatusENSGACP0000001544390.673685.4922
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298cynoglossus_semilaevisENSCSEP0000000895892.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617poecilia_formosaENSPFOP0000001555693.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617myripristis_murdjanENSMMDP0000505254893.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617sander_luciopercaENSSLUP0000005270493.121788.8889
ENSG00000133703homo_sapiensENSP0000030849510098.9362strigops_habroptilaENSSHBP0000501678810098.9362
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617amphiprion_ocellarisENSAOCP0000002805193.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298terrapene_carolina_triunguisENSTMTP0000001992293.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298hucho_huchoENSHHUP0000001529292.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298hucho_huchoENSHHUP0000009180092.592688.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617betta_splendensENSBSLP0000002325993.121788.8889
ENSG00000133703homo_sapiensENSP0000030849510098.4043pygocentrus_nattereriENSPNAP0000002153997.916796.3542
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617anabas_testudineusENSATEP0000003083393.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617seriola_lalandi_dorsalisENSSLDP0000002868193.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617labrus_bergyltaENSLBEP0000003817493.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617pundamilia_nyerereiENSPNYP0000001827193.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617mastacembelus_armatusENSMAMP0000005414693.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617stegastes_partitusENSSPAP0000001309793.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298oncorhynchus_tshawytschaENSOTSP0000503535192.592688.3598
ENSG00000133703homo_sapiensENSP0000030849594.148989.8936acanthochromis_polyacanthusENSAPOP0000002911093.650889.418
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298aquila_chrysaetos_chrysaetosENSACCP0002001165793.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.085187.234nothobranchius_furzeriENSNFUP0001505181692.592686.7725
ENSG00000133703homo_sapiensENSP0000030849593.085187.766cyprinodon_variegatusENSCVAP0000000473392.592687.3016
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298denticeps_clupeoidesENSDCDP0000005121792.631687.8947
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617larimichthys_croceaENSLCRP0000505416993.121788.8889
ENSG00000133703homo_sapiensENSP0000030849599.468197.8723takifugu_rubripesENSTRUP0000005281489.047687.619
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298ficedula_albicollisENSFALP0000000403193.121788.3598
ENSG00000133703homo_sapiensENSP0000030849594.148989.3617hippocampus_comesENSHCOP0000002295293.650888.8889
ENSG00000133703homo_sapiensENSP0000030849588.297985.6383cyprinus_carpio_carpioENSCCRP0000009130987.830785.1852
ENSG00000133703homo_sapiensENSP0000030849584.574581.383cyprinus_carpio_carpioENSCCRP0000004509881.958878.866
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298coturnix_japonicaENSCJPP0000500302593.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617poecilia_latipinnaENSPLAP0000000708893.121788.8889
ENSG00000133703homo_sapiensENSP0000030849593.085188.2979sinocyclocheilus_grahamiENSSGRP0000007786092.592687.8307
ENSG00000133703homo_sapiensENSP0000030849593.61788.8298sinocyclocheilus_grahamiENSSGRP0000007716993.121788.3598
ENSG00000133703homo_sapiensENSP0000030849593.61789.3617maylandia_zebraENSMZEP0000502394093.121788.8889
ENSG00000133703homo_sapiensENSP0000030849594.148989.3617tetraodon_nigroviridisENSTNIP0000001511893.650888.8889
ENSG00000133703homo_sapiensENSP0000030849594.148988.2979paramormyrops_kingsleyaeENSPKIP0000000099993.650887.8307
ENSG00000133703homo_sapiensENSP0000030849594.148988.8298scleropages_formosusENSSFOP0001503755393.650888.3598
ENSG00000133703homo_sapiensENSP0000030849593.61788.2979leptobrachium_leishanenseENSLLEP0000003931693.121787.8307
ENSG00000133703homo_sapiensENSP0000030849593.085188.8298scophthalmus_maximusENSSMAP0000001200492.592688.3598
ENSG00000133703homo_sapiensENSP0000030849594.148988.8298oryzias_melastigmaENSOMEP0000001000293.650888.3598

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000139located_in Golgi membrane1TASHomo_sapiens(9606)Component
GO:0000165involved_in MAPK cascade1TASHomo_sapiens(9606)Process
GO:0001934involved_in positive regulation of protein phosphorylation1IMPHomo_sapiens(9606)Process
GO:0003924enables GTPase activity2IBA,TASHomo_sapiens(9606)Function
GO:0003925enables G protein activity1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005525enables GTP binding1IBAHomo_sapiens(9606)Function
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005741located_in mitochondrial outer membrane1TASHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane2IBA,TASHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0007265involved_in Ras protein signal transduction1IBAHomo_sapiens(9606)Process
GO:0008542involved_in visual learning1IEAHomo_sapiens(9606)Process
GO:0009898located_in cytoplasmic side of plasma membrane1IDAHomo_sapiens(9606)Component
GO:0010628involved_in positive regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0014009involved_in glial cell proliferation1IEAHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016601involved_in Rac protein signal transduction1IEAHomo_sapiens(9606)Process
GO:0019003enables GDP binding1IBAHomo_sapiens(9606)Function
GO:0021897involved_in forebrain astrocyte development1IEAHomo_sapiens(9606)Process
GO:0030036involved_in actin cytoskeleton organization1IEAHomo_sapiens(9606)Process
GO:0030857involved_in negative regulation of epithelial cell differentiation1IEAHomo_sapiens(9606)Process
GO:0032228involved_in regulation of synaptic transmission, GABAergic1IEAHomo_sapiens(9606)Process
GO:0035022involved_in positive regulation of Rac protein signal transduction1IEAHomo_sapiens(9606)Process
GO:0035914involved_in skeletal muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:0038002involved_in endocrine signaling1IEAHomo_sapiens(9606)Process
GO:0043495enables protein-membrane adaptor activity1IEAHomo_sapiens(9606)Function
GO:0043524involved_in negative regulation of neuron apoptotic process1IEAHomo_sapiens(9606)Process
GO:0044877enables protein-containing complex binding1IDAHomo_sapiens(9606)Function
GO:0048169involved_in regulation of long-term neuronal synaptic plasticity1IEAHomo_sapiens(9606)Process
GO:0048873involved_in homeostasis of number of cells within a tissue1IEAHomo_sapiens(9606)Process
GO:0051146involved_in striated muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:0051402involved_in neuron apoptotic process1IEAHomo_sapiens(9606)Process
GO:0060252involved_in positive regulation of glial cell proliferation1IEAHomo_sapiens(9606)Process
GO:0060441involved_in epithelial tube branching involved in lung morphogenesis1IEAHomo_sapiens(9606)Process
GO:0060509involved_in type I pneumocyte differentiation1IEAHomo_sapiens(9606)Process

Expression