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Drugs target to KRAS
| Drug name | Drug type | Disease/phenotype | Mechanism of action(MoA) | Phase | Status | Source |
|---|---|---|---|---|---|---|
| ADAGRASIB | Small molecule | metastatic colorectal cancer | GTPase KRas inhibitor | 3.0 | Recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | neoplasm | GTPase KRas inhibitor | 2.0 | Not yet recruiting | ClinicalTrials |
| ADAGRASIB | Small molecule | metastatic malignant neoplasm | GTPase KRas inhibitor | 1.0 | Recruiting | ClinicalTrials |
| ADAGRASIB | Small molecule | metastatic neoplasm | GTPase KRas inhibitor | 1.0 | Recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | colorectal adenocarcinoma | GTPase KRas inhibitor | 3.0 | Recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | non-small cell lung carcinoma | GTPase KRas inhibitor | 1.0 | Not yet recruiting | ClinicalTrials |
| ADAGRASIB | Small molecule | metastatic malignant neoplasm | GTPase KRas inhibitor | 1.0 | Active, not recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | non-small cell lung carcinoma | GTPase KRas inhibitor | 2.0 | Active, not recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | non-small cell lung carcinoma | GTPase KRas inhibitor | 1.0 | Recruiting | ClinicalTrials |
| ADAGRASIB | Small molecule | pancreatic carcinoma | GTPase KRas inhibitor | 1.0 | Not yet recruiting | ClinicalTrials |
| ADAGRASIB | Small molecule | neoplasm | GTPase KRas inhibitor | 1.0 | Active, not recruiting | ClinicalTrials |
| ADAGRASIB | Small molecule | non-small cell lung carcinoma | GTPase KRas inhibitor | 2.0 | Recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | non-small cell lung carcinoma | GTPase KRas inhibitor | 2.0 | Not yet recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | neoplasm | GTPase KRas inhibitor | 1.0 | Active, not recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | neoplasm | GTPase KRas inhibitor | 1.0 | Recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | liver disease | GTPase KRas inhibitor | 1.0 | Completed | ClinicalTrials |
| SOTORASIB | Small molecule | neoplasm | GTPase KRas inhibitor | 4.0 | - | ATC |
| SOTORASIB | Small molecule | non-small cell lung carcinoma | GTPase KRas inhibitor | 2.0 | Recruiting | ClinicalTrials |
| ADAGRASIB | Small molecule | non-small cell lung carcinoma | GTPase KRas inhibitor | 3.0 | Recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | lung adenocarcinoma | GTPase KRas inhibitor | 2.0 | Recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | pancreatic carcinoma | GTPase KRas inhibitor | 1.0 | Recruiting | ClinicalTrials |
| ADAGRASIB | Small molecule | non-small cell lung carcinoma | GTPase KRas inhibitor | 2.0 | Not yet recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | lung cancer | GTPase KRas inhibitor | 2.0 | Recruiting | ClinicalTrials |
| SOTORASIB | Small molecule | non-small cell lung carcinoma | GTPase KRas inhibitor | 4.0 | - | FDA |