Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions E3 ligase
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000133606 Gene ID 23608 Accession 7112
Symbol MKRN1 Alias RNF61 Full Name makorin ring finger protein 1
Status Confidence Length 26473 bases Strand Minus strand
Position 7 : 140453033 - 140479505 RNA binding domain zf-CCCH , zf-CCCH_2
Summary This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000255977 zf-CCCH PF00642 1.7e-18 1
ENSP00000255977 zf-CCCH PF00642 1.7e-18 2
ENSP00000255977 zf-CCCH PF00642 1.7e-18 3
ENSP00000255977 zf-CCCH_2 PF14608 1.6e-12 4
ENSP00000255977 zf-CCCH_2 PF14608 1.6e-12 5
ENSP00000255977 zf-CCCH_2 PF14608 1.6e-12 6
ENSP00000255977 zf-CCCH_2 PF14608 1.6e-12 7
ENSP00000416369 zf-CCCH PF00642 2.3e-17 1
ENSP00000416369 zf-CCCH PF00642 2.3e-17 2
ENSP00000416369 zf-CCCH PF00642 2.3e-17 3
ENSP00000416369 zf-CCCH_2 PF14608 1.1e-08 4
ENSP00000416369 zf-CCCH_2 PF14608 1.1e-08 5
ENSP00000416369 zf-CCCH_2 PF14608 1.1e-08 6
ENSP00000417863 zf-CCCH PF00642 2.5e-16 1
ENSP00000417863 zf-CCCH PF00642 2.5e-16 2
ENSP00000417863 zf-CCCH_2 PF14608 8.4e-11 3
ENSP00000417863 zf-CCCH_2 PF14608 8.4e-11 4
ENSP00000417863 zf-CCCH_2 PF14608 8.4e-11 5
ENSP00000417863 zf-CCCH_2 PF14608 8.4e-11 6
ENSP00000418864 zf-CCCH PF00642 1e-15 1
ENSP00000418864 zf-CCCH PF00642 1e-15 2
ENSP00000418864 zf-CCCH_2 PF14608 2.1e-07 3
ENSP00000418864 zf-CCCH_2 PF14608 2.1e-07 4
ENSP00000418864 zf-CCCH_2 PF14608 2.1e-07 5
ENSP00000418588 zf-CCCH PF00642 6.7e-13 1
ENSP00000417640 zf-CCCH PF00642 2.3e-11 1
ENSP00000417640 zf-CCCH PF00642 2.3e-11 2
ENSP00000418620 zf-CCCH PF00642 2.3e-10 1
ENSP00000419843 zf-CCCH PF00642 4.5e-10 1
ENSP00000419894 zf-CCCH PF00642 2.1e-09 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
26265008 Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. A Paul Cassar 2015-10-01 EMBO reports
31640799 The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation. Andrea Hildebrandt 2019-10-22 Genome biology
35463379 MRKNs: Gene, Functions, and Role in Disease and Infection. Tongtong Wang 2022-01-01 Frontiers in oncology
31972861 Evolutionary Conservation of MKRN3 and Other Makorins and Their Roles in Puberty Initiation and Endocrine Functions. Lydie Naulé 2019-07-01 Seminars in reproductive medicine
31978041 Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation. Annabelle Dold 2020-01-01 PLoS genetics
33217981 Role of CCCH-Type Zinc Finger Proteins in Human Adenovirus Infections. Zamaneh Hajikhezri 2020-11-18 Viruses

Transcripts

Name Transcript ID bp Protein Translation ID
MKRN1-201 ENST00000255977 3094 482aa ENSP00000255977
MKRN1-209 ENST00000475010 3467 No protein -
MKRN1-214 ENST00000495305 1390 175aa ENSP00000417640
MKRN1-208 ENST00000474576 1661 418aa ENSP00000417863
MKRN1-203 ENST00000463142 460 112aa ENSP00000417346
MKRN1-205 ENST00000468447 583 No protein -
MKRN1-211 ENST00000480552 906 111aa ENSP00000419894
MKRN1-215 ENST00000496169 1625 93aa ENSP00000417907
MKRN1-202 ENST00000443720 1601 329aa ENSP00000416369
MKRN1-206 ENST00000471104 1053 193aa ENSP00000418864
MKRN1-204 ENST00000467513 1133 165aa ENSP00000418588
MKRN1-213 ENST00000494939 784 136aa ENSP00000419843
MKRN1-216 ENST00000498535 607 108aa ENSP00000419695
MKRN1-207 ENST00000473444 720 102aa ENSP00000418620
MKRN1-210 ENST00000475180 560 39aa ENSP00000419259
MKRN1-212 ENST00000481705 636 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
20526Fibrinogen2.167e-005-
79989Age-Related Hearing Impairment 15E-924939585

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000133606homo_sapiensENSP0000031388160.749547.929homo_sapiensENSP0000025597763.900450.4149
ENSG00000133606homo_sapiensENSP0000017044761.057745.9135homo_sapiensENSP0000025597752.697139.6266

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000133606homo_sapiensENSP0000025597798.755298.7552nomascus_leucogenysENSNLEP0000000241398.755298.7552
ENSG00000133606homo_sapiensENSP0000025597795.850695.6432pan_paniscusENSPPAP0000003525999.78499.568
ENSG00000133606homo_sapiensENSP0000025597799.170198.9627pongo_abeliiENSPPYP0000002026199.170198.9627
ENSG00000133606homo_sapiensENSP0000025597799.792599.5851pan_troglodytesENSPTRP0000008414599.792599.5851
ENSG00000133606homo_sapiensENSP0000025597799.792599.5851pan_troglodytesENSPTRP0000003386199.792599.5851
ENSG00000133606homo_sapiensENSP0000025597780.497974.2739ornithorhynchus_anatinusENSOANP0000004132562.379457.5563
ENSG00000133606homo_sapiensENSP0000025597790.456486.3071sarcophilus_harrisiiENSSHAP0000003836591.213487.0293
ENSG00000133606homo_sapiensENSP0000025597791.078886.722notamacropus_eugeniiENSMEUP0000000675391.84187.4477
ENSG00000133606homo_sapiensENSP0000025597798.132896.2656choloepus_hoffmanniENSCHOP0000000975198.132896.2656
ENSG00000133606homo_sapiensENSP0000025597797.510494.8133dasypus_novemcinctusENSDNOP0000003516796.707894.0329
ENSG00000133606homo_sapiensENSP0000025597746.47342.9461echinops_telfairiENSETEP0000000595783.895177.5281
ENSG00000133606homo_sapiensENSP0000025597797.925397.0954callithrix_jacchusENSCJAP0000002477597.925397.0954
ENSG00000133606homo_sapiensENSP0000025597799.377699.1701cercocebus_atysENSCATP0000003359099.377699.1701
ENSG00000133606homo_sapiensENSP0000025597786.72286.5145macaca_fascicularisENSMFAP0000004607610099.7608
ENSG00000133606homo_sapiensENSP0000025597799.585199.3776macaca_mulattaENSMMUP0000007367799.585199.3776
ENSG00000133606homo_sapiensENSP0000025597798.755298.5477macaca_nemestrinaENSMNEP0000003410699.373799.1649
ENSG00000133606homo_sapiensENSP0000025597799.377699.1701papio_anubisENSPANP0000000497499.377699.1701
ENSG00000133606homo_sapiensENSP0000025597786.72286.3071mandrillus_leucophaeusENSMLEP0000001784099.523899.0476
ENSG00000133606homo_sapiensENSP0000025597789.419187.7593tursiops_truncatusENSTTRP0000000902797.732495.9184
ENSG00000133606homo_sapiensENSP0000025597784.647383.4025vulpes_vulpesENSVVUP0000000211885.355784.1004
ENSG00000133606homo_sapiensENSP0000025597795.020793.361mus_spretusMGP_SPRETEiJ_P007621195.218393.5551
ENSG00000133606homo_sapiensENSP0000025597798.132896.888equus_asinusENSEASP0000501420794.035892.8429
ENSG00000133606homo_sapiensENSP0000025597773.858968.4647capra_hircusENSCHIP0000001146383.177677.1028
ENSG00000133606homo_sapiensENSP0000025597794.398390.8714loxodonta_africanaENSLAFP0000001542594.398390.8714
ENSG00000133606homo_sapiensENSP0000025597796.47394.1909panthera_leoENSPLOP0000000865096.47394.1909
ENSG00000133606homo_sapiensENSP0000025597797.717896.0581ailuropoda_melanoleucaENSAMEP0000001884697.31495.6612
ENSG00000133606homo_sapiensENSP0000025597796.058194.3983bos_indicus_hybridENSBIXP0000502727192.047790.4573
ENSG00000133606homo_sapiensENSP0000025597784.024980.7054oryctolagus_cuniculusENSOCUP0000000877284.551181.2109
ENSG00000133606homo_sapiensENSP0000025597798.132896.888equus_caballusENSECAP0000001564994.035892.8429
ENSG00000133606homo_sapiensENSP0000025597796.88895.8506canis_lupus_familiarisENSCAFP0084504343896.288795.2577
ENSG00000133606homo_sapiensENSP0000025597796.265693.9834panthera_pardusENSPPRP0000000049596.265693.9834
ENSG00000133606homo_sapiensENSP0000025597785.269784.4398marmota_marmota_marmotaENSMMMP0000001291798.325497.3684
ENSG00000133606homo_sapiensENSP0000025597797.717896.0581balaenoptera_musculusENSBMSP0001002100297.717896.0581
ENSG00000133606homo_sapiensENSP0000025597789.83487.1369cavia_porcellusENSCPOP0000000085293.520590.7127
ENSG00000133606homo_sapiensENSP0000025597796.47394.3983felis_catusENSFCAP0000001853096.47394.3983
ENSG00000133606homo_sapiensENSP0000025597797.302995.4357ursus_americanusENSUAMP0000001758396.900895.0413
ENSG00000133606homo_sapiensENSP0000025597732.365123.8589monodelphis_domesticaENSMODP0000002731744.827633.046
ENSG00000133606homo_sapiensENSP0000025597745.435742.3237bison_bison_bisonENSBBBP0000002189283.587877.8626
ENSG00000133606homo_sapiensENSP0000025597796.47394.6058monodon_monocerosENSMMNP0001501360097.077295.1983
ENSG00000133606homo_sapiensENSP0000025597796.680594.1909sus_scrofaENSSSCP0000004733496.680594.1909
ENSG00000133606homo_sapiensENSP0000025597791.493889.834microcebus_murinusENSMICP0000000193486.470684.902
ENSG00000133606homo_sapiensENSP0000025597781.120379.0456octodon_degusENSODEP0000001852895.133892.7007
ENSG00000133606homo_sapiensENSP0000025597763.900457.6763octodon_degusENSODEP0000000835488.505779.8851
ENSG00000133606homo_sapiensENSP0000025597766.80561.6183octodon_degusENSODEP0000000917289.196782.2715
ENSG00000133606homo_sapiensENSP0000025597773.44467.6349octodon_degusENSODEP0000000019090.076382.9517
ENSG00000133606homo_sapiensENSP0000025597778.423275.5187jaculus_jaculusENSJJAP0000000005486.896683.6782
ENSG00000133606homo_sapiensENSP0000025597782.157780.2905jaculus_jaculusENSJJAP0000000597491.034588.9655
ENSG00000133606homo_sapiensENSP0000025597742.323738.1743ovis_aries_rambouilletENSOARP0002001558582.591174.4939
ENSG00000133606homo_sapiensENSP0000025597787.551985.6846ursus_maritimusENSUMAP0000002054894.407292.3937
ENSG00000133606homo_sapiensENSP0000025597791.908789.6266ochotona_princepsENSOPRP0000000945491.340289.0722
ENSG00000133606homo_sapiensENSP0000025597796.680594.8133delphinapterus_leucasENSDLEP0000002950797.28695.4071
ENSG00000133606homo_sapiensENSP0000025597784.854883.4025physeter_catodonENSPCTP0000500264597.846996.1722
ENSG00000133606homo_sapiensENSP0000025597795.435793.9834mus_caroliMGP_CAROLIEiJ_P007336395.634194.1788
ENSG00000133606homo_sapiensENSP0000025597795.228293.5685mus_musculusENSMUSP0000003198595.426293.763
ENSG00000133606homo_sapiensENSP0000025597783.19580.9129dipodomys_ordiiENSDORP0000000325792.396389.8617
ENSG00000133606homo_sapiensENSP0000025597784.439882.5726mustela_putorius_furoENSMPUP0000000342297.601995.4436
ENSG00000133606homo_sapiensENSP0000025597786.514586.3071aotus_nancymaaeENSANAP0000003910886.514586.3071
ENSG00000133606homo_sapiensENSP0000025597772.199270.7469vicugna_pacosENSVPAP0000000384892.553290.6915
ENSG00000133606homo_sapiensENSP0000025597786.514586.5145chlorocebus_sabaeusENSCSAP0000000450399.760899.7608
ENSG00000133606homo_sapiensENSP0000025597760.16658.9212tupaia_belangeriENSTBEP0000000392496.026594.0397
ENSG00000133606homo_sapiensENSP0000025597797.302995.0207phocoena_sinusENSPSNP0000002274697.302995.0207
ENSG00000133606homo_sapiensENSP0000025597785.684684.0249camelus_dromedariusENSCDRP0000500530898.803896.89
ENSG00000133606homo_sapiensENSP0000025597785.269784.8548carlito_syrichtaENSTSYP0000002279098.090797.6134
ENSG00000133606homo_sapiensENSP0000025597784.854882.7801panthera_tigris_altaicaENSPTIP0000000980784.854882.7801
ENSG00000133606homo_sapiensENSP0000025597795.020793.5685rattus_norvegicusENSRNOP0000001312495.218393.763
ENSG00000133606homo_sapiensENSP0000025597786.307181.1203prolemur_simusENSPSMP0000002816186.307181.1203
ENSG00000133606homo_sapiensENSP0000025597794.398392.7386prolemur_simusENSPSMP0000000837997.222295.5128
ENSG00000133606homo_sapiensENSP0000025597782.365181.1203microtus_ochrogasterENSMOCP0000000649995.203893.765
ENSG00000133606homo_sapiensENSP0000025597784.024980.7054sorex_araneusENSSARP0000001236584.37581.0417
ENSG00000133606homo_sapiensENSP0000025597794.605893.1535peromyscus_maniculatus_bairdiiENSPEMP000000279959593.5417
ENSG00000133606homo_sapiensENSP0000025597747.095443.9834bos_mutusENSBMUP0000001769480.496575.1773
ENSG00000133606homo_sapiensENSP0000025597795.643293.9834mus_spicilegusENSMSIP0000000390295.84294.1788
ENSG00000133606homo_sapiensENSP0000025597794.398392.7386cricetulus_griseus_chok1gshdENSCGRP0000101623094.594692.9314
ENSG00000133606homo_sapiensENSP0000025597786.929584.6473pteropus_vampyrusENSPVAP0000001054287.656985.3557
ENSG00000133606homo_sapiensENSP0000025597763.900457.8838myotis_lucifugusENSMLUP0000001905382.795775
ENSG00000133606homo_sapiensENSP0000025597785.062283.4025myotis_lucifugusENSMLUP0000000552897.387295.4869
ENSG00000133606homo_sapiensENSP0000025597790.663986.3071vombatus_ursinusENSVURP0001001877391.422687.0293
ENSG00000133606homo_sapiensENSP0000025597723.858920.9544rhinolophus_ferrumequinumENSRFEP0001000548170.552161.9632
ENSG00000133606homo_sapiensENSP0000025597796.88894.8133neovison_visonENSNVIP0000002781497.089495.0104
ENSG00000133606homo_sapiensENSP0000025597796.058194.3983bos_taurusENSBTAP0000001093293.914892.2921
ENSG00000133606homo_sapiensENSP0000025597761.618354.3568heterocephalus_glaber_femaleENSHGLP0000002257567.653859.6811
ENSG00000133606homo_sapiensENSP0000025597787.136987.1369rhinopithecus_bietiENSRBIP00000007512100100
ENSG00000133606homo_sapiensENSP0000025597793.153592.5311sciurus_vulgarisENSSVLP0000502176597.608796.9565
ENSG00000133606homo_sapiensENSP0000025597797.302996.6805sciurus_vulgarisENSSVLP0000501523097.302996.6805
ENSG00000133606homo_sapiensENSP0000025597779.875574.2739procavia_capensisENSPCAP0000001369791.666785.2381
ENSG00000133606homo_sapiensENSP0000025597793.983492.1162nannospalax_galiliENSNGAP0000001917194.57292.6931
ENSG00000133606homo_sapiensENSP0000025597745.228241.7012bos_grunniensENSBGRP0000000139682.889776.4259
ENSG00000133606homo_sapiensENSP0000025597782.572679.4606chinchilla_lanigeraENSCLAP0000000246295.215391.6268
ENSG00000133606homo_sapiensENSP0000025597790.24988.1743cervus_hanglu_yarkandensisENSCHYP0000001452696.452394.235
ENSG00000133606homo_sapiensENSP0000025597796.265694.1909cervus_hanglu_yarkandensisENSCHYP0000002984796.265694.1909
ENSG00000133606homo_sapiensENSP0000025597794.813393.1535catagonus_wagneriENSCWAP0000002157494.813393.1535
ENSG00000133606homo_sapiensENSP0000025597741.701239.834ictidomys_tridecemlineatusENSSTOP0000002876492.201888.0734
ENSG00000133606homo_sapiensENSP0000025597715.145212.8631ictidomys_tridecemlineatusENSSTOP0000002194765.178655.3571
ENSG00000133606homo_sapiensENSP0000025597797.302996.0581otolemur_garnettiiENSOGAP0000000883295.325294.1057
ENSG00000133606homo_sapiensENSP0000025597797.925397.3029cebus_imitatorENSCCAP0000003951897.925397.3029
ENSG00000133606homo_sapiensENSP0000025597797.510496.888urocitellus_parryiiENSUPAP0001001992197.510496.888
ENSG00000133606homo_sapiensENSP0000025597723.858921.5768moschus_moschiferusENSMMSP0000002945970.121963.4146
ENSG00000133606homo_sapiensENSP0000025597725.103722.1992moschus_moschiferusENSMMSP0000002608970.348862.2093
ENSG00000133606homo_sapiensENSP0000025597793.568593.5685rhinopithecus_roxellanaENSRROP0000002754499.120999.1209
ENSG00000133606homo_sapiensENSP0000025597794.605893.361mus_pahariMGP_PahariEiJ_P004948294.802593.5551
ENSG00000133606homo_sapiensENSP0000025597786.099681.1203propithecus_coquereliENSPCOP0000002892187.923782.839
ENSG00000133606homo_sapiensENSP0000025597795.435793.7759propithecus_coquereliENSPCOP0000000087496.033494.3633
ENSG00000133606homo_sapiensENSP0000025597774.481363.4855callorhinchus_miliiENSCMIP0000004828876.873765.5246
ENSG00000133606homo_sapiensENSP0000025597766.182658.0913latimeria_chalumnaeENSLACP0000001730877.995168.4597
ENSG00000133606homo_sapiensENSP0000025597775.518764.3154lepisosteus_oculatusENSLOCP0000001987782.539770.2948
ENSG00000133606homo_sapiensENSP0000025597773.236562.2407clupea_harengusENSCHAP0000005932978.794666.9643
ENSG00000133606homo_sapiensENSP0000025597773.651562.6556danio_rerioENSDARP0000006106980.865668.7927
ENSG00000133606homo_sapiensENSP0000025597773.02962.4481carassius_auratusENSCARP000000491788068.4091
ENSG00000133606homo_sapiensENSP0000025597772.821662.0332carassius_auratusENSCARP0000002223978.876467.191
ENSG00000133606homo_sapiensENSP0000025597773.236562.4481carassius_auratusENSCARP0000000356380.593668.7215
ENSG00000133606homo_sapiensENSP0000025597772.406662.4481astyanax_mexicanusENSAMXP0000002932678.251167.4888
ENSG00000133606homo_sapiensENSP0000025597773.02962.8631ictalurus_punctatusENSIPUP0000002508776.688566.0131
ENSG00000133606homo_sapiensENSP0000025597770.954460.7884esox_luciusENSELUP0000003335174.509863.8344
ENSG00000133606homo_sapiensENSP0000025597772.406660.9958electrophorus_electricusENSEEEP0000003735579.498966.9704
ENSG00000133606homo_sapiensENSP0000025597719.087115.5602oncorhynchus_kisutchENSOKIP0000511517362.162250.6757
ENSG00000133606homo_sapiensENSP0000025597742.116235.2697oncorhynchus_kisutchENSOKIP0000510222171.985860.2837
ENSG00000133606homo_sapiensENSP0000025597770.124559.3361oncorhynchus_mykissENSOMYP0000014340360.249650.9804
ENSG00000133606homo_sapiensENSP0000025597770.124559.5436oncorhynchus_mykissENSOMYP0000012227959.929150.8865
ENSG00000133606homo_sapiensENSP0000025597770.539459.5436salmo_salarENSSSAP0000002032173.91362.3913
ENSG00000133606homo_sapiensENSP0000025597762.240751.6598salmo_salarENSSSAP0000014747775.566762.7204
ENSG00000133606homo_sapiensENSP0000025597770.954459.751salmo_truttaENSSTUP0000007862576.169364.1425
ENSG00000133606homo_sapiensENSP0000025597771.784259.9585gadus_morhuaENSGMOP0000000176977.927965.0901
ENSG00000133606homo_sapiensENSP0000025597772.199258.2988fundulus_heteroclitusENSFHEP0000000986773.728859.5339
ENSG00000133606homo_sapiensENSP0000025597774.688861.4108poecilia_reticulataENSPREP0000002599282.379967.7346
ENSG00000133606homo_sapiensENSP0000025597770.331957.4689xiphophorus_maculatusENSXMAP0000000510682.682967.561
ENSG00000133606homo_sapiensENSP0000025597772.821660.166oryzias_latipesENSORLP0000001598875.646662.5
ENSG00000133606homo_sapiensENSP0000025597773.236561.2033cyclopterus_lumpusENSCLMP0000503645181.902568.4455
ENSG00000133606homo_sapiensENSP0000025597772.199259.5436oreochromis_niloticusENSONIP0000006732170.731758.3333
ENSG00000133606homo_sapiensENSP0000025597763.900452.4896haplochromis_burtoniENSHBUP0000003193879.177465.0386
ENSG00000133606homo_sapiensENSP0000025597773.02960.3734astatotilapia_callipteraENSACLP0000002044181.670567.5174
ENSG00000133606homo_sapiensENSP0000025597773.44460.7884sparus_aurataENSSAUP0001000344668.47256.6731
ENSG00000133606homo_sapiensENSP0000025597773.44461.2033lates_calcariferENSLCAP0001002819582.134668.4455
ENSG00000133606homo_sapiensENSP0000025597777.593469.0871xenopus_tropicalisENSXETP0000011417082.926873.8359
ENSG00000133606homo_sapiensENSP0000025597785.684680.083chrysemys_picta_belliiENSCPBP0000001613488.247982.4786
ENSG00000133606homo_sapiensENSP0000025597778.838271.9917sphenodon_punctatusENSSPUP0000000523485.585678.1532
ENSG00000133606homo_sapiensENSP0000025597781.120375.5187crocodylus_porosusENSCPRP0000502592583.725977.9443
ENSG00000133606homo_sapiensENSP0000025597778.008371.7842laticauda_laticaudataENSLLTP0000002022689.311282.1853
ENSG00000133606homo_sapiensENSP0000025597782.572676.1411notechis_scutatusENSNSUP0000001870581.89375.5144
ENSG00000133606homo_sapiensENSP0000025597782.365176.1411pseudonaja_textilisENSPTXP0000001040281.687275.5144
ENSG00000133606homo_sapiensENSP0000025597780.08374.8963anas_platyrhynchos_platyrhynchosENSAPLP0000003130576.892471.9124
ENSG00000133606homo_sapiensENSP0000025597779.668174.2739gallus_gallusENSGALP0001001892782.758677.1552
ENSG00000133606homo_sapiensENSP0000025597768.879763.4855meleagris_gallopavoENSMGAP0000002890878.859972.6841
ENSG00000133606homo_sapiensENSP0000025597776.141170.7469serinus_canariaENSSCAP0000001309084.174378.211
ENSG00000133606homo_sapiensENSP0000025597773.02965.3527parus_majorENSPMJP0000001219375.698967.7419
ENSG00000133606homo_sapiensENSP0000025597784.232478.0083anolis_carolinensisENSACAP0000001078583.539177.3663
ENSG00000133606homo_sapiensENSP0000025597782.572676.1411naja_najaENSNNAP0000002644181.89375.5144
ENSG00000133606homo_sapiensENSP0000025597784.439878.4232podarcis_muralisENSPMRP0000001987981.891376.0563
ENSG00000133606homo_sapiensENSP0000025597776.348570.9544geospiza_fortisENSGFOP0000000301787.203881.0427
ENSG00000133606homo_sapiensENSP0000025597781.120375.3112taeniopygia_guttataENSTGUP0000003151474.76169.4073
ENSG00000133606homo_sapiensENSP0000025597769.91759.751erpetoichthys_calabaricusENSECRP0000000495982.80170.7617
ENSG00000133606homo_sapiensENSP0000025597774.273961.8257kryptolebias_marmoratusENSKMAP0000001460683.062669.1415
ENSG00000133606homo_sapiensENSP0000025597783.402577.1784salvator_merianaeENSSMRP0000002056481.707375.6098
ENSG00000133606homo_sapiensENSP0000025597770.331956.639oryzias_javanicusENSOJAP0000003520178.472263.1944
ENSG00000133606homo_sapiensENSP0000025597769.502157.8838amphilophus_citrinellusENSACIP0000002735377.188964.2857
ENSG00000133606homo_sapiensENSP0000025597772.614160.3734dicentrarchus_labraxENSDLAP0000501527180.645267.0507
ENSG00000133606homo_sapiensENSP0000025597773.02961.4108amphiprion_perculaENSAPEP0000000186181.860568.8372
ENSG00000133606homo_sapiensENSP0000025597745.850637.9668oryzias_sinensisENSOSIP0000001033178.928665.3571
ENSG00000133606homo_sapiensENSP0000025597778.215873.029pelodiscus_sinensisENSPSIP0000000924990.407784.4125
ENSG00000133606homo_sapiensENSP0000025597785.684680.2905gopherus_evgoodeiENSGEVP0000501326988.059782.516
ENSG00000133606homo_sapiensENSP0000025597785.892180.4979chelonoidis_abingdoniiENSCABP0000003033488.461582.906
ENSG00000133606homo_sapiensENSP0000025597773.236560.5809seriola_dumeriliENSSDUP0000002555881.902567.7494
ENSG00000133606homo_sapiensENSP0000025597773.02961.6183cottoperca_gobioENSCGOP0000000571174.576362.9237
ENSG00000133606homo_sapiensENSP0000025597780.705475.1037struthio_camelus_australisENSSCUP0000002414074.095268.9524
ENSG00000133606homo_sapiensENSP0000025597780.08374.4813anser_brachyrhynchusENSABRP0000000559879.752174.1736
ENSG00000133606homo_sapiensENSP0000025597769.502157.6763gasterosteus_aculeatusENSGACP0000002541576.834963.7615
ENSG00000133606homo_sapiensENSP0000025597768.879758.0913cynoglossus_semilaevisENSCSEP0000002540978.301966.0377
ENSG00000133606homo_sapiensENSP0000025597774.688861.4108poecilia_formosaENSPFOP0000000665482.379967.7346
ENSG00000133606homo_sapiensENSP0000025597771.784260.166myripristis_murdjanENSMMDP0000502506276.04463.7363
ENSG00000133606homo_sapiensENSP0000025597773.44462.0332sander_luciopercaENSSLUP0000003566882.134669.3736
ENSG00000133606homo_sapiensENSP0000025597781.327875.3112strigops_habroptilaENSSHBP0000501472978.472.6
ENSG00000133606homo_sapiensENSP0000025597769.087158.0913amphiprion_ocellarisENSAOCP0000002353980.24167.4699
ENSG00000133606homo_sapiensENSP0000025597785.477279.8755terrapene_carolina_triunguisENSTMTP0000002921388.602182.7957
ENSG00000133606homo_sapiensENSP0000025597713.27811.8257hucho_huchoENSHHUP0000000095786.486577.027
ENSG00000133606homo_sapiensENSP0000025597710.78848.92116hucho_huchoENSHHUP0000000527276.470663.2353
ENSG00000133606homo_sapiensENSP0000025597772.821658.9212betta_splendensENSBSLP0000001575681.627966.0465
ENSG00000133606homo_sapiensENSP0000025597772.821662.8631pygocentrus_nattereriENSPNAP0000000228178.173767.4833
ENSG00000133606homo_sapiensENSP0000025597773.858960.3734anabas_testudineusENSATEP0000003364582.598667.5174
ENSG00000133606homo_sapiensENSP0000025597721.161813.0705saccharomyces_cerevisiaeYPL054W33.88720.9302
ENSG00000133606homo_sapiensENSP0000025597773.236560.5809seriola_lalandi_dorsalisENSSLDP0000001830481.902567.7494
ENSG00000133606homo_sapiensENSP0000025597773.651560.7884labrus_bergyltaENSLBEP0000003226782.366667.9814
ENSG00000133606homo_sapiensENSP0000025597773.02960.3734pundamilia_nyerereiENSPNYP0000001978481.670567.5174
ENSG00000133606homo_sapiensENSP0000025597773.651560.7884mastacembelus_armatusENSMAMP0000003464082.366667.9814
ENSG00000133606homo_sapiensENSP0000025597773.02961.2033stegastes_partitusENSSPAP0000001195281.670568.4455
ENSG00000133606homo_sapiensENSP0000025597773.02961.2033acanthochromis_polyacanthusENSAPOP0000002075981.670568.4455
ENSG00000133606homo_sapiensENSP0000025597782.157776.7635aquila_chrysaetos_chrysaetosENSACCP0002001081083.018977.5681
ENSG00000133606homo_sapiensENSP0000025597774.481362.2407nothobranchius_furzeriENSNFUP0001500562183.294769.6056
ENSG00000133606homo_sapiensENSP0000025597774.273960.5809cyprinodon_variegatusENSCVAP0000000584083.062667.7494
ENSG00000133606homo_sapiensENSP0000025597773.651562.0332denticeps_clupeoidesENSDCDP0000005387980.498967.8005
ENSG00000133606homo_sapiensENSP0000025597774.273962.0332larimichthys_croceaENSLCRP0000505008783.644969.8598
ENSG00000133606homo_sapiensENSP0000025597769.709558.9212takifugu_rubripesENSTRUP0000003050373.043561.7391
ENSG00000133606homo_sapiensENSP0000025597778.423271.9917ficedula_albicollisENSFALP0000000387680.769274.1453
ENSG00000133606homo_sapiensENSP0000025597765.352753.9419hippocampus_comesENSHCOP0000000720075.539662.3501
ENSG00000133606homo_sapiensENSP0000025597772.821662.0332cyprinus_carpio_carpioENSCCRP0000002984578.876467.191
ENSG00000133606homo_sapiensENSP0000025597772.199261.6183cyprinus_carpio_carpioENSCCRP0000002982873.885463.0573
ENSG00000133606homo_sapiensENSP0000025597780.290574.8963coturnix_japonicaENSCJPP0000502594983.047277.4678
ENSG00000133606homo_sapiensENSP0000025597774.481361.4108poecilia_latipinnaENSPLAP0000002626982.15167.7346
ENSG00000133606homo_sapiensENSP0000025597762.655653.112sinocyclocheilus_grahamiENSSGRP0000007410677.63565.8098
ENSG00000133606homo_sapiensENSP0000025597772.821661.8257sinocyclocheilus_grahamiENSSGRP0000000022579.772767.7273
ENSG00000133606homo_sapiensENSP0000025597773.02960.3734maylandia_zebraENSMZEP0000502561481.670567.5174
ENSG00000133606homo_sapiensENSP0000025597769.087158.0913tetraodon_nigroviridisENSTNIP0000000362377.803765.4206
ENSG00000133606homo_sapiensENSP0000025597772.199262.6556paramormyrops_kingsleyaeENSPKIP0000001269274.518264.6681
ENSG00000133606homo_sapiensENSP0000025597772.406662.0332scleropages_formosusENSSFOP0001502663578.251167.0404
ENSG00000133606homo_sapiensENSP0000025597753.319546.6805leptobrachium_leishanenseENSLLEP0000002556571.787762.8492
ENSG00000133606homo_sapiensENSP0000025597768.672259.1286scophthalmus_maximusENSSMAP0000001833173.230163.0531
ENSG00000133606homo_sapiensENSP0000025597773.44460.3734oryzias_melastigmaENSOMEP0000003337382.134667.5174

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000209involved_in protein polyubiquitination1IDAHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005575is_active_in cellular_component1NDHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0016567involved_in protein ubiquitination1IBAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0061630enables ubiquitin protein ligase activity3IBA,IDA,TASHomo_sapiens(9606)Function

Expression