Ensembl ID ENSG00000133606 Gene ID 23608 Accession 7112
Gene Symbol MKRN1 Alias RNF61 Full Name makorin ring finger protein 1
Position 7 : 140453033 - 140479505 Length 26473 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

ENSG00000133606 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000133606 MKRN1 0.30 4.02e-15 BRCA
ENSG00000133606 MKRN1 -0.5 2.65e-17 COAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000133606 MKRN1 tumors 19604354
ENSG00000133606 MKRN1 cancer 20473778
ENSG00000133606 MKRN1 tumour 22864571
ENSG00000133606 MKRN1 gastric cancer 23104211
ENSG00000133606 MKRN1 tumour 26183061
ENSG00000133606 MKRN1 cervical cancer 26817873
ENSG00000133606 MKRN1 gastric cancer 27470213
ENSG00000133606 MKRN1 gastric cancer 29665672
ENSG00000133606 MKRN1 cancer 29713058
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000133606 MKRN1 MESO 0.0041 low
ENSG00000133606 MKRN1 SARC 0.00052 low
ENSG00000133606 MKRN1 STAD 0.045 low
ENSG00000133606 MKRN1 UCEC 0.0085 low
ENSG00000133606 MKRN1 LGG 0.012 high
ENSG00000133606 MKRN1 LUSC 0.028 low
ENSG00000133606 MKRN1 HNSC 0.048 low
ENSG00000133606 MKRN1 KICH 0.002 high
ENSG00000133606 MKRN1 PCPG 0.017 high
ENSG00000133606 MKRN1 BRCA 0.047 low
ENSG00000133606 MKRN1 UCS 0.024 high
ENSG00000133606 MKRN1 OV 0.016 low
ENSG00000133606 MKRN1 DLBC 0.041 low
ENSG00000133606 MKRN1 KIRC 0.0022 low
ENSG00000133606 MKRN1 BLCA 0.0081 low
ENSG00000133606 MKRN1 LAML 0.041 low
ENSG00000133606 MKRN1 GBM 0.033 high
ENSG00000133606 MKRN1 LIHC 0.013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000133606 MKRN1 LAML Del 2.199738 0.051015 0.737472 0.120419
ENSG00000133606 MKRN1 LGG Amp 6.512395 0.116803 0.683158 0.345029
ENSG00000133606 MKRN1 CESC Del 1.214852 0.077437 0.494353 0.189831
ENSG00000133606 MKRN1 KIRP Amp 0.681666 0.052082 0.919638 0.604167
ENSG00000133606 MKRN1 PAAD Del 0.892302 0.049425 0.355670 0.086957
ENSG00000133606 MKRN1 ESCA Del 4.264921 0.184168 0.386327 0.320652
ENSG00000133606 MKRN1 SKCM Amp 5.875178 0.263734 0.728876 0.610354
ENSG00000133606 MKRN1 HNSC Del 13.930776 0.142072 0.407292 0.224138
ENSG00000133606 MKRN1 STAD Del 2.004932 0.078560 0.343156 0.174603
ENSG00000133606 MKRN1 UCEC Del 0.841189 0.049613 0.483542 0.105751
ENSG00000133606 MKRN1 OV Amp 8.557779 0.521170 0.728226 0.540587