Ensembl ID
ENSG00000133606
Gene ID
23608
Accession
7112
Gene Symbol
MKRN1
Alias
RNF61
Full Name
makorin ring finger protein 1
Position
7 : 140453033 - 140479505
Length
26473 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs mRNA RBP type
Canonical_RBPs
Summary
This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
ENSG00000133606 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000133606
MKRN1
0.30
4.02e-15
BRCA
ENSG00000133606
MKRN1
-0.5
2.65e-17
COAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000133606
MKRN1
tumors
19604354
ENSG00000133606
MKRN1
cancer
20473778
ENSG00000133606
MKRN1
tumour
22864571
ENSG00000133606
MKRN1
gastric cancer
23104211
ENSG00000133606
MKRN1
tumour
26183061
ENSG00000133606
MKRN1
cervical cancer
26817873
ENSG00000133606
MKRN1
gastric cancer
27470213
ENSG00000133606
MKRN1
gastric cancer
29665672
ENSG00000133606
MKRN1
cancer
29713058
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000133606
MKRN1
MESO
0.0041
low
show
ENSG00000133606
MKRN1
SARC
0.00052
low
show
ENSG00000133606
MKRN1
STAD
0.045
low
show
ENSG00000133606
MKRN1
UCEC
0.0085
low
show
ENSG00000133606
MKRN1
LGG
0.012
high
show
ENSG00000133606
MKRN1
LUSC
0.028
low
show
ENSG00000133606
MKRN1
HNSC
0.048
low
show
ENSG00000133606
MKRN1
KICH
0.002
high
show
ENSG00000133606
MKRN1
PCPG
0.017
high
show
ENSG00000133606
MKRN1
BRCA
0.047
low
show
ENSG00000133606
MKRN1
UCS
0.024
high
show
ENSG00000133606
MKRN1
OV
0.016
low
show
ENSG00000133606
MKRN1
DLBC
0.041
low
show
ENSG00000133606
MKRN1
KIRC
0.0022
low
show
ENSG00000133606
MKRN1
BLCA
0.0081
low
show
ENSG00000133606
MKRN1
LAML
0.041
low
show
ENSG00000133606
MKRN1
GBM
0.033
high
show
ENSG00000133606
MKRN1
LIHC
0.013
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000133606
MKRN1
LAML
Del
2.199738
0.051015
0.737472
0.120419
ENSG00000133606
MKRN1
LGG
Amp
6.512395
0.116803
0.683158
0.345029
ENSG00000133606
MKRN1
CESC
Del
1.214852
0.077437
0.494353
0.189831
ENSG00000133606
MKRN1
KIRP
Amp
0.681666
0.052082
0.919638
0.604167
ENSG00000133606
MKRN1
PAAD
Del
0.892302
0.049425
0.355670
0.086957
ENSG00000133606
MKRN1
ESCA
Del
4.264921
0.184168
0.386327
0.320652
ENSG00000133606
MKRN1
SKCM
Amp
5.875178
0.263734
0.728876
0.610354
ENSG00000133606
MKRN1
HNSC
Del
13.930776
0.142072
0.407292
0.224138
ENSG00000133606
MKRN1
STAD
Del
2.004932
0.078560
0.343156
0.174603
ENSG00000133606
MKRN1
UCEC
Del
0.841189
0.049613
0.483542
0.105751
ENSG00000133606
MKRN1
OV
Amp
8.557779
0.521170
0.728226
0.540587
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