RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000132661	Gene ID	29107	Accession	15913
Symbol	NXT1	Alias	P15;MTR2	Full Name	nuclear transport factor 2 like export factor 1
Status	Confidence	Length	3981 bases	Strand	Plus strand
Position	20 : 23350791 - 23354771	RNA binding domain	NTF2
Summary	The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000254998	NTF2	PF02136	2.4e-29	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
25628361	The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNA.	Shintaro Aibara	2015-02-18	Nucleic acids research
36423112	Tough Way In, Tough Way Out: The Complex Interplay of Host and Viral Factors in Nucleocytoplasmic Trafficking during HIV-1 Infection.	Satarupa Sarkar	2022-11-12	Viruses
10848583	RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro.	B Ossareh-Nazari	2000-07-01	Molecular and cellular biology
27708137	An NXF1 mRNA with a retained intron is expressed in hippocampal and neocortical neurons and is translated into a protein that functions as an Nxf1 cofactor.	Ying Li	2016-12-01	Molecular biology of the cell
11149927	NXT1 is necessary for the terminal step of Crm1-mediated nuclear export.	E B Black	2001-01-08	The Journal of cell biology
31263181	Structural basis for influenza virus NS1 protein block of mRNA nuclear export.	Ke Zhang	2019-10-01	Nature microbiology
30819645	The mRNA Export Receptor NXF1 Coordinates Transcriptional Dynamics, Alternative Polyadenylation, and mRNA Export.	Suli Chen	2019-04-04	Molecular cell

Name	Transcript ID	bp	Protein	Translation ID
NXT1-201	ENST00000254998	1062	140aa	ENSP00000254998

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000132661	homo_sapiens	ENSP00000219169	44.0945	25.1968	homo_sapiens	ENSP00000254998	40	22.8571
ENSG00000132661	homo_sapiens	ENSP00000361178	88.7324	73.2394	homo_sapiens	ENSP00000254998	90	74.2857

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	pan_paniscus	ENSPPAP00000004909	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	pongo_abelii	ENSPPYP00000012029	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	pan_troglodytes	ENSPTRP00000022835	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	70	66.4286	gorilla_gorilla	ENSGGOP00000045749	84.4828	80.1724
ENSG00000132661	homo_sapiens	ENSP00000254998	97.1429	92.1429	choloepus_hoffmanni	ENSCHOP00000006322	97.1429	92.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	97.1429	92.1429	dasypus_novemcinctus	ENSDNOP00000011702	97.1429	92.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	96.4286	93.5714	erinaceus_europaeus	ENSEEUP00000012575	96.4286	93.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	99.2857	callithrix_jacchus	ENSCJAP00000062598	58.8235	58.4034
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	cercocebus_atys	ENSCATP00000006013	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	macaca_fascicularis	ENSMFAP00000057457	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	macaca_mulatta	ENSMMUP00000029459	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	macaca_nemestrina	ENSMNEP00000006650	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	mandrillus_leucophaeus	ENSMLEP00000006777	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.8571	tursiops_truncatus	ENSTTRP00000010758	99.2857	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	vulpes_vulpes	ENSVVUP00000016456	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	mus_spretus	MGP_SPRETEiJ_P0057211	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	96.4286	equus_asinus	ENSEASP00005045249	100	96.4286
ENSG00000132661	homo_sapiens	ENSP00000254998	98.5714	95	loxodonta_africana	ENSLAFP00000022277	98.5714	95
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	panthera_leo	ENSPLOP00000001148	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.8571	ailuropoda_melanoleuca	ENSAMEP00000019780	100	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.1429	bos_indicus_hybrid	ENSBIXP00005004877	99.2857	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.8571	oryctolagus_cuniculus	ENSOCUP00000023941	99.2857	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	100	96.4286	equus_caballus	ENSECAP00000034341	73.2984	70.6806
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	panthera_pardus	ENSPPRP00000029006	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.8571	marmota_marmota_marmota	ENSMMMP00000004813	100	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.8571	balaenoptera_musculus	ENSBMSP00010017335	99.2857	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.1429	cavia_porcellus	ENSCPOP00000007915	100	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	felis_catus	ENSFCAP00000006020	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.8571	ursus_americanus	ENSUAMP00000028272	100	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.8571	monodon_monoceros	ENSMMNP00015018877	99.2857	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	97.8571	95	sus_scrofa	ENSSSCP00000007582	97.8571	95
ENSG00000132661	homo_sapiens	ENSP00000254998	98.5714	96.4286	microcebus_murinus	ENSMICP00000046814	98.5714	96.4286
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.1429	octodon_degus	ENSODEP00000026467	100	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	jaculus_jaculus	ENSJJAP00000007666	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	85.7143	80.7143	jaculus_jaculus	ENSJJAP00000010286	89.5522	84.3284
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.1429	ovis_aries_rambouillet	ENSOARP00020005992	99.2857	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.8571	ursus_maritimus	ENSUMAP00000005093	100	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	96.4286	ochotona_princeps	ENSOPRP00000005647	99.2857	96.4286
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.8571	delphinapterus_leucas	ENSDLEP00000006845	99.2857	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.8571	physeter_catodon	ENSPCTP00005031491	99.2857	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	mus_caroli	MGP_CAROLIEiJ_P0055077	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	mus_musculus	ENSMUSP00000105587	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	dipodomys_ordii	ENSDORP00000020072	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	mustela_putorius_furo	ENSMPUP00000019136	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	99.2857	aotus_nancymaae	ENSANAP00000001142	100	99.2857
ENSG00000132661	homo_sapiens	ENSP00000254998	100	99.2857	saimiri_boliviensis_boliviensis	ENSSBOP00000040673	100	99.2857
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	chlorocebus_sabaeus	ENSCSAP00000018200	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	100	99.2857	tupaia_belangeri	ENSTBEP00000010595	100	99.2857
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.8571	mesocricetus_auratus	ENSMAUP00000003651	100	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.8571	phocoena_sinus	ENSPSNP00000015406	99.2857	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	59.2857	53.5714	camelus_dromedarius	ENSCDRP00005015103	56.0811	50.6757
ENSG00000132661	homo_sapiens	ENSP00000254998	98.5714	95.7143	camelus_dromedarius	ENSCDRP00005028690	98.5714	95.7143
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	96.4286	carlito_syrichta	ENSTSYP00000006895	99.2857	96.4286
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	panthera_tigris_altaica	ENSPTIP00000001466	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.8571	rattus_norvegicus	ENSRNOP00000006205	99.2857	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.1429	prolemur_simus	ENSPSMP00000012013	99.2857	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	98.5714	95.7143	microtus_ochrogaster	ENSMOCP00000021313	98.5714	95.7143
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.1429	sorex_araneus	ENSSARP00000007091	99.2857	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.8571	peromyscus_maniculatus_bairdii	ENSPEMP00000008927	99.2857	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.1429	bos_mutus	ENSBMUP00000003875	99.2857	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	mus_spicilegus	ENSMSIP00000003294	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.8571	cricetulus_griseus_chok1gshd	ENSCGRP00001005372	100	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	85.7143	80	cricetulus_griseus_chok1gshd	ENSCGRP00001013205	92.3077	86.1538
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.8571	pteropus_vampyrus	ENSPVAP00000013254	100	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.8571	myotis_lucifugus	ENSMLUP00000022331	100	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.1429	rhinolophus_ferrumequinum	ENSRFEP00010015594	99.2857	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.1429	bos_taurus	ENSBTAP00000006568	99.2857	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	rhinopithecus_bieti	ENSRBIP00000004687	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	canis_lupus_dingo	ENSCAFP00020035478	45.3074	44.6602
ENSG00000132661	homo_sapiens	ENSP00000254998	91.4286	90	sciurus_vulgaris	ENSSVLP00005000321	98.4615	96.9231
ENSG00000132661	homo_sapiens	ENSP00000254998	100	99.2857	sciurus_vulgaris	ENSSVLP00005000307	100	99.2857
ENSG00000132661	homo_sapiens	ENSP00000254998	98.5714	95.7143	procavia_capensis	ENSPCAP00000008698	98.5714	95.7143
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	nannospalax_galili	ENSNGAP00000001076	100	98.5714
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.1429	bos_grunniens	ENSBGRP00000011308	99.2857	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.8571	chinchilla_lanigera	ENSCLAP00000018213	99.2857	97.8571
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.1429	cervus_hanglu_yarkandensis	ENSCHYP00000035253	99.2857	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	97.8571	94.2857	catagonus_wagneri	ENSCWAP00000023561	97.8571	94.2857
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	96.4286	ictidomys_tridecemlineatus	ENSSTOP00000018678	99.2857	96.4286
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.1429	otolemur_garnettii	ENSOGAP00000000641	99.2908	96.4539
ENSG00000132661	homo_sapiens	ENSP00000254998	100	99.2857	cebus_imitator	ENSCCAP00000002583	100	99.2857
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	97.1429	urocitellus_parryii	ENSUPAP00010012043	99.2857	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	99.2857	96.4286	moschus_moschiferus	ENSMMSP00000025054	99.2857	96.4286
ENSG00000132661	homo_sapiens	ENSP00000254998	100	100	rhinopithecus_roxellana	ENSRROP00000006912	100	100
ENSG00000132661	homo_sapiens	ENSP00000254998	100	97.1429	mus_pahari	MGP_PahariEiJ_P0066059	100	97.1429
ENSG00000132661	homo_sapiens	ENSP00000254998	100	98.5714	propithecus_coquereli	ENSPCOP00000026493	99.2908	97.8723
ENSG00000132661	homo_sapiens	ENSP00000254998	53.5714	28.5714	caenorhabditis_elegans	Y71F9AM.5a.1	54.7445	29.1971
ENSG00000132661	homo_sapiens	ENSP00000254998	57.8571	38.5714	drosophila_melanogaster	FBpp0072150	60.9023	40.6015
ENSG00000132661	homo_sapiens	ENSP00000254998	53.5714	32.8571	ciona_intestinalis	ENSCINP00000034522	53.9568	33.0935
ENSG00000132661	homo_sapiens	ENSP00000254998	82.8571	66.4286	podarcis_muralis	ENSPMRP00000016438	84.058	67.3913

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	2	IDA,ISS	Homo_sapiens(9606)	Component
GO:0005643	part_of nuclear pore	1	TAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006406	involved_in mRNA export from nucleus	2	IDA,ISS	Homo_sapiens(9606)	Process
GO:0006611	involved_in protein export from nucleus	1	IEA	Homo_sapiens(9606)	Process
GO:0016607	located_in nuclear speck	1	IEA	Homo_sapiens(9606)	Component
GO:0016973	involved_in poly(A)+ mRNA export from nucleus	1	IBA	Homo_sapiens(9606)	Process
GO:0031267	enables small GTPase binding	1	IEA	Homo_sapiens(9606)	Function
GO:0042272	part_of nuclear RNA export factor complex	2	IPI,ISS	Homo_sapiens(9606)	Component
GO:0044613	part_of nuclear pore central transport channel	1	IBA	Homo_sapiens(9606)	Component