RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000132155	Gene ID	5894	Accession	9829
Symbol	RAF1	Alias	NS5;CRAF;Raf-1;c-Raf;CMD1NN	Full Name	Raf-1 proto-oncogene, serine/threonine kinase
Status	Confidence	Length	82101 bases	Strand	Minus strand
Position	3 : 12582101 - 12664201	RNA binding domain	N.A.
Summary	This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal
20526349	Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma.	Nallasivam Palanisamy	2010-07-01	Nature medicine
24556667	Low false-positives in an mLumin-based bimolecular fluorescence complementation system with a bicistronic expression vector.	Shun Liu	2014-02-19	Sensors (Basel, Switzerland)
26513016	Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6.	Yu-Chun Hsiao	2015-11-10	Oncotarget
16113238	Site-specific biotinylation of RNA molecules by transcription using unnatural base pairs.	Kei Moriyama	2005-08-19	Nucleic acids research

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
RAF1-236	ENST00000688543	4662	615aa	ENSP00000509612
RAF1-214	ENST00000685348	4615	69aa	ENSP00000510285
RAF1-253	ENST00000690585	1586	91aa	ENSP00000510641
RAF1-261	ENST00000691888	1734	273aa	ENSP00000510730
RAF1-201	ENST00000251849	3191	648aa	ENSP00000251849
RAF1-205	ENST00000442415	3251	668aa	ENSP00000401888
RAF1-235	ENST00000688444	4972	No protein	-
RAF1-257	ENST00000691643	3906	No protein	-
RAF1-218	ENST00000685697	3588	No protein	-
RAF1-264	ENST00000692093	3187	615aa	ENSP00000509669
RAF1-259	ENST00000691724	3171	346aa	ENSP00000509255
RAF1-203	ENST00000423275	3034	69aa	ENSP00000401088
RAF1-240	ENST00000688803	4273	No protein	-
RAF1-227	ENST00000687326	5593	374aa	ENSP00000509665
RAF1-206	ENST00000460610	7152	No protein	-
RAF1-249	ENST00000689876	3198	494aa	ENSP00000508535
RAF1-223	ENST00000686455	5552	No protein	-
RAF1-269	ENST00000692830	2808	69aa	ENSP00000509461
RAF1-213	ENST00000684903	3129	69aa	ENSP00000508612
RAF1-272	ENST00000693312	2899	573aa	ENSP00000508686
RAF1-263	ENST00000692069	5746	No protein	-
RAF1-237	ENST00000688625	4704	69aa	ENSP00000509522
RAF1-267	ENST00000692773	3073	69aa	ENSP00000509055
RAF1-252	ENST00000690460	3141	644aa	ENSP00000509106
RAF1-225	ENST00000686762	3140	486aa	ENSP00000509767
RAF1-273	ENST00000693664	3079	499aa	ENSP00000509614
RAF1-262	ENST00000691899	2983	648aa	ENSP00000508763
RAF1-243	ENST00000689097	2877	69aa	ENSP00000509756
RAF1-274	ENST00000693705	2506	69aa	ENSP00000510697
RAF1-233	ENST00000688269	3413	No protein	-
RAF1-231	ENST00000687923	3031	611aa	ENSP00000510255
RAF1-219	ENST00000685738	3261	382aa	ENSP00000510156
RAF1-251	ENST00000690397	3037	611aa	ENSP00000508730
RAF1-260	ENST00000691779	2944	69aa	ENSP00000508592
RAF1-266	ENST00000692558	5400	No protein	-
RAF1-265	ENST00000692311	3641	No protein	-
RAF1-250	ENST00000689914	3215	374aa	ENSP00000509847
RAF1-208	ENST00000471449	1614	No protein	-
RAF1-254	ENST00000690625	3798	No protein	-
RAF1-204	ENST00000432427	2077	421aa	ENSP00000398591
RAF1-245	ENST00000689389	2899	589aa	ENSP00000510213
RAF1-209	ENST00000475353	5001	No protein	-
RAF1-226	ENST00000687257	5175	No protein	-
RAF1-222	ENST00000686409	6107	No protein	-
RAF1-217	ENST00000685653	4402	648aa	ENSP00000509968
RAF1-248	ENST00000689540	5062	No protein	-
RAF1-256	ENST00000691396	3104	80aa	ENSP00000510712
RAF1-230	ENST00000687505	2752	No protein	-
RAF1-215	ENST00000685437	2866	615aa	ENSP00000508794
RAF1-246	ENST00000689418	4974	69aa	ENSP00000509467
RAF1-241	ENST00000688914	1174	No protein	-
RAF1-207	ENST00000465826	1958	No protein	-
RAF1-234	ENST00000688326	1594	156aa	ENSP00000509907
RAF1-212	ENST00000494557	4000	No protein	-
RAF1-232	ENST00000687940	2650	No protein	-
RAF1-247	ENST00000689481	2102	69aa	ENSP00000510248
RAF1-271	ENST00000693069	1356	341aa	ENSP00000510072
RAF1-210	ENST00000491290	2084	No protein	-
RAF1-229	ENST00000687486	385	78aa	ENSP00000509469
RAF1-224	ENST00000686479	2234	No protein	-
RAF1-255	ENST00000691268	535	109aa	ENSP00000509128
RAF1-216	ENST00000685438	701	No protein	-
RAF1-202	ENST00000416093	801	87aa	ENSP00000391265
RAF1-221	ENST00000685959	963	278aa	ENSP00000510452
RAF1-242	ENST00000689033	1048	278aa	ENSP00000508983
RAF1-268	ENST00000692777	1946	No protein	-
RAF1-244	ENST00000689226	1215	287aa	ENSP00000510613
RAF1-228	ENST00000687348	774	152aa	ENSP00000509787
RAF1-211	ENST00000492690	633	No protein	-
RAF1-238	ENST00000688753	659	193aa	ENSP00000508771
RAF1-220	ENST00000685740	1098	193aa	ENSP00000510566
RAF1-258	ENST00000691718	1248	193aa	ENSP00000510160
RAF1-270	ENST00000692959	1429	193aa	ENSP00000509353
RAF1-239	ENST00000688779	568	No protein	-

Gene Model

Click here to download ENSG00000132155's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID
79626	Cardiomegaly	7E-7	21348951
88226	Cholesterol	4E-9	20686565
93203	Cholesterol	2E-9	24097068

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000132155's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000165	involved_in MAPK cascade	1	IBA	Homo_sapiens(9606)	Process
GO:0004672	enables protein kinase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0004674	enables protein serine/threonine kinase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0004709	enables MAP kinase kinase kinase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IEA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	2	IDA,ISS	Homo_sapiens(9606)	Component
GO:0005739	is_active_in mitochondrion	1	IBA	Homo_sapiens(9606)	Component
GO:0005741	located_in mitochondrial outer membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IPI	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0005886	colocalizes_with plasma membrane	3	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0006915	acts_upstream_of_or_within_positive_effect apoptotic process	1	TAS	Homo_sapiens(9606)	Process
GO:0007165	involved_in signal transduction	1	TAS	Homo_sapiens(9606)	Process
GO:0007190	involved_in activation of adenylate cyclase activity	1	IDA	Homo_sapiens(9606)	Process
GO:0008285	involved_in negative regulation of cell population proliferation	1	IDA	Homo_sapiens(9606)	Process
GO:0008286	involved_in insulin receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0008625	involved_in extrinsic apoptotic signaling pathway via death domain receptors	1	IEA	Homo_sapiens(9606)	Process
GO:0019899	enables enzyme binding	1	IPI	Homo_sapiens(9606)	Function
GO:0030154	involved_in cell differentiation	1	IEA	Homo_sapiens(9606)	Process
GO:0030878	involved_in thyroid gland development	1	IEA	Homo_sapiens(9606)	Process
GO:0031143	located_in pseudopodium	1	IEA	Homo_sapiens(9606)	Component
GO:0031267	NOT enables small GTPase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0031333	involved_in negative regulation of protein-containing complex assembly	1	IDA	Homo_sapiens(9606)	Process
GO:0033138	involved_in positive regulation of peptidyl-serine phosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0035019	involved_in somatic stem cell population maintenance	1	IEA	Homo_sapiens(9606)	Process
GO:0035023	involved_in regulation of Rho protein signal transduction	1	TAS	Homo_sapiens(9606)	Process
GO:0035773	involved_in insulin secretion involved in cellular response to glucose stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:0035994	involved_in response to muscle stretch	1	IEA	Homo_sapiens(9606)	Process
GO:0042060	involved_in wound healing	1	TAS	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0042981	involved_in regulation of apoptotic process	1	TAS	Homo_sapiens(9606)	Process
GO:0043066	involved_in negative regulation of apoptotic process	1	IDA	Homo_sapiens(9606)	Process
GO:0043154	involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	1	TAS	Homo_sapiens(9606)	Process
GO:0043410	involved_in positive regulation of MAPK cascade	1	IDA	Homo_sapiens(9606)	Process
GO:0044342	involved_in type B pancreatic cell proliferation	1	IEA	Homo_sapiens(9606)	Process
GO:0045104	involved_in intermediate filament cytoskeleton organization	1	IEA	Homo_sapiens(9606)	Process
GO:0045595	involved_in regulation of cell differentiation	1	TAS	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IEA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0048009	involved_in insulin-like growth factor receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0048011	involved_in neurotrophin TRK receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0048538	involved_in thymus development	1	IEA	Homo_sapiens(9606)	Process
GO:0060324	involved_in face development	1	IEA	Homo_sapiens(9606)	Process
GO:0071550	involved_in death-inducing signaling complex assembly	1	IEA	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1902042	involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	1	IEA	Homo_sapiens(9606)	Process
GO:2000145	involved_in regulation of cell motility	1	TAS	Homo_sapiens(9606)	Process

Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression