Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerCHIKVSARS-COV-OC43FlavivirusesHIVIAVDengue
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations P-bodyNucleoli
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000131747 Gene ID 7153 Accession 11989
Symbol TOP2A Alias TOP2;TP2A;TOPIIA;TOP2alpha Full Name DNA topoisomerase II alpha
Status Confidence Length 29372 bases Strand Minus strand
Position 17 : 40388525 - 40417896 RNA binding domain N.A.
Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36322662 Untangling the roles of TOP2A and TOP2B in transcription and cancer. Liis Uusküla-Reimand 2022-11-04 Science advances
25695068 TOP2A amplification and overexpression in hepatocellular carcinoma tissues. Ravat Panvichian 2015-01-01 BioMed research international
35182904 A systems genetics approach delineates the role of Bcl2 in leukemia pathogenesis. Xinfeng Wang 2022-03-01 Leukemia research
37445918 Extensive Bioinformatics Analyses Reveal a Phylogenetically Conserved Winged Helix (WH) Domain (Zτ) of Topoisomerase IIα, Elucidating Its Very High Affinity for Left-Handed Z-DNA and Suggesting Novel Putative Functions. Martin Bartas 2023-06-27 International journal of molecular sciences
36029179 Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37. Shangyao Qin 2022-09-09 Nucleic acids research

Transcripts

Name Transcript ID bp Protein Translation ID
TOP2A-201 ENST00000423485 5695 1531aa ENSP00000411532
TOP2A-202 ENST00000577541 420 27aa ENSP00000464055
TOP2A-204 ENST00000578412 882 No protein -
TOP2A-203 ENST00000577706 554 No protein -
TOP2A-205 ENST00000581055 579 147aa ENSP00000462908

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
63168Hip9E-825673412
75801Hip1E-925673412
75802Body Mass Index1E-925673412
78683Hip3E-725673412
78684Body Mass Index3E-725673412
96902Hip4E-825673412

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000131747homo_sapiensENSP0000026433176.875866.5437homo_sapiensENSP0000041153281.64670.6728

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000131747homo_sapiensENSP0000041153296.538295.7544nomascus_leucogenysENSNLEP0000000228598.402197.6032
ENSG00000131747homo_sapiensENSP0000041153299.150999.0856pan_paniscusENSPPAP0000004214099.802899.737
ENSG00000131747homo_sapiensENSP0000041153299.542899.2815pongo_abeliiENSPPYP0000000950899.542899.2815
ENSG00000131747homo_sapiensENSP0000041153299.80499.6734pan_troglodytesENSPTRP0000001555499.80499.6734
ENSG00000131747homo_sapiensENSP0000041153299.673499.4775gorilla_gorillaENSGGOP0000002276099.673499.4775
ENSG00000131747homo_sapiensENSP0000041153287.459279.9477ornithorhynchus_anatinusENSOANP0000000483685.559178.2109
ENSG00000131747homo_sapiensENSP0000041153291.247684.9118sarcophilus_harrisiiENSSHAP0000003872788.361882.2264
ENSG00000131747homo_sapiensENSP0000041153232.854329.1313notamacropus_eugeniiENSMEUP0000000305040.111635.5662
ENSG00000131747homo_sapiensENSP0000041153257.478854.7355choloepus_hoffmanniENSCHOP0000000041458.627655.8294
ENSG00000131747homo_sapiensENSP0000041153295.493192.6192dasypus_novemcinctusENSDNOP0000002765395.493192.6192
ENSG00000131747homo_sapiensENSP0000041153254.931452.0575erinaceus_europaeusENSEEUP0000000470452.23649.5031
ENSG00000131747homo_sapiensENSP0000041153255.584651.4696echinops_telfairiENSETEP0000001269052.857148.9441
ENSG00000131747homo_sapiensENSP0000041153298.497797.1261callithrix_jacchusENSCJAP0000002487698.497797.1261
ENSG00000131747homo_sapiensENSP0000041153296.538294.7093cercocebus_atysENSCATP0000001186896.601394.7712
ENSG00000131747homo_sapiensENSP0000041153299.477598.2365macaca_fascicularisENSMFAP0000000523599.477598.2365
ENSG00000131747homo_sapiensENSP0000041153299.477598.3018macaca_mulattaENSMMUP0000001173199.477598.3018
ENSG00000131747homo_sapiensENSP0000041153299.477598.3671macaca_nemestrinaENSMNEP0000001292199.477598.3671
ENSG00000131747homo_sapiensENSP0000041153299.477598.3018papio_anubisENSPANP0000002059499.477598.3018
ENSG00000131747homo_sapiensENSP0000041153299.477598.3018mandrillus_leucophaeusENSMLEP0000003343299.477598.3018
ENSG00000131747homo_sapiensENSP0000041153292.031389.0268tursiops_truncatusENSTTRP0000001602893.808390.7457
ENSG00000131747homo_sapiensENSP0000041153296.146393.5336vulpes_vulpesENSVVUP0000000096796.146393.5336
ENSG00000131747homo_sapiensENSP0000041153294.121589.5493mus_spretusMGP_SPRETEiJ_P003115894.121589.5493
ENSG00000131747homo_sapiensENSP0000041153296.734294.5787equus_asinusENSEASP0000500481796.797494.6405
ENSG00000131747homo_sapiensENSP0000041153295.427892.4886capra_hircusENSCHIP0000000997794.993592.0676
ENSG00000131747homo_sapiensENSP0000041153296.472993.403loxodonta_africanaENSLAFP0000002755896.096393.0384
ENSG00000131747homo_sapiensENSP0000041153296.799594.5787panthera_leoENSPLOP0000001750996.610294.3937
ENSG00000131747homo_sapiensENSP0000041153296.734294.644ailuropoda_melanoleucaENSAMEP0000000850496.60894.5205
ENSG00000131747homo_sapiensENSP0000041153295.689192.8152bos_indicus_hybridENSBIXP0000504648795.626692.7546
ENSG00000131747homo_sapiensENSP0000041153294.8492.6845oryctolagus_cuniculusENSOCUP0000000244895.968393.7872
ENSG00000131747homo_sapiensENSP0000041153296.734294.644equus_caballusENSECAP0000007718096.54594.4589
ENSG00000131747homo_sapiensENSP0000041153296.146393.2724canis_lupus_familiarisENSCAFP0084501152895.522492.6671
ENSG00000131747homo_sapiensENSP0000041153296.799594.5787panthera_pardusENSPPRP0000001885896.610294.3937
ENSG00000131747homo_sapiensENSP0000041153296.668894.3174marmota_marmota_marmotaENSMMMP0000000829996.479894.133
ENSG00000131747homo_sapiensENSP0000041153296.930194.3174balaenoptera_musculusENSBMSP0001002099396.803694.1944
ENSG00000131747homo_sapiensENSP0000041153293.076488.1123cavia_porcellusENSCPOP0000000612892.532587.5974
ENSG00000131747homo_sapiensENSP0000041153296.668894.5134felis_catusENSFCAP0000000894496.479894.3286
ENSG00000131747homo_sapiensENSP0000041153293.990991.7048ursus_americanusENSUAMP0000000076995.614693.289
ENSG00000131747homo_sapiensENSP0000041153290.529185.1078monodelphis_domesticaENSMODP0000001646189.017383.6866
ENSG00000131747homo_sapiensENSP0000041153295.689192.8152bison_bison_bisonENSBBBP0000001667595.751692.8758
ENSG00000131747homo_sapiensENSP0000041153296.668893.9909monodon_monocerosENSMMNP0001502809496.668893.9909
ENSG00000131747homo_sapiensENSP0000041153296.472994.3174sus_scrofaENSSSCP0000001851896.34794.1944
ENSG00000131747homo_sapiensENSP0000041153293.533690.9863microcebus_murinusENSMICP0000003097295.785993.1773
ENSG00000131747homo_sapiensENSP0000041153291.639587.3939octodon_degusENSODEP0000002463692.852488.5506
ENSG00000131747homo_sapiensENSP0000041153288.112384.5852jaculus_jaculusENSJJAP0000000369694.53490.7498
ENSG00000131747homo_sapiensENSP0000041153294.578791.1822ovis_aries_rambouilletENSOARP0002001045594.087190.7083
ENSG00000131747homo_sapiensENSP0000041153296.407694.1215ursus_maritimusENSUMAP0000002459196.281893.9987
ENSG00000131747homo_sapiensENSP0000041153269.88964.8596ochotona_princepsENSOPRP0000000086771.143666.0239
ENSG00000131747homo_sapiensENSP0000041153296.146393.4683delphinapterus_leucasENSDLEP0000001801595.584492.9221
ENSG00000131747homo_sapiensENSP0000041153296.799594.0562physeter_catodonENSPCTP0000501474796.673293.9335
ENSG00000131747homo_sapiensENSP0000041153279.098675.1143mus_caroliMGP_CAROLIEiJ_P002974093.010788.3257
ENSG00000131747homo_sapiensENSP0000041153293.990989.484mus_musculusENSMUSP0000006889694.175489.6597
ENSG00000131747homo_sapiensENSP0000041153293.272489.8106dipodomys_ordiiENSDORP0000001509994.569591.0596
ENSG00000131747homo_sapiensENSP0000041153293.468390.8557mustela_putorius_furoENSMPUP0000001457194.705592.0582
ENSG00000131747homo_sapiensENSP0000041153298.628397.5833aotus_nancymaaeENSANAP0000001459198.628397.5833
ENSG00000131747homo_sapiensENSP0000041153295.035994.2521saimiri_boliviensis_boliviensisENSSBOP0000000362198.71197.8969
ENSG00000131747homo_sapiensENSP0000041153291.508888.7002vicugna_pacosENSVPAP0000000109094.153291.2634
ENSG00000131747homo_sapiensENSP0000041153299.412198.1711chlorocebus_sabaeusENSCSAP0000001525599.412198.1711
ENSG00000131747homo_sapiensENSP0000041153272.37169.3664tupaia_belangeriENSTBEP0000000463274.966271.8539
ENSG00000131747homo_sapiensENSP0000041153259.895556.7603mesocricetus_auratusENSMAUP0000000880591.975987.1615
ENSG00000131747homo_sapiensENSP0000041153296.668893.8602phocoena_sinusENSPSNP0000001440496.542793.7378
ENSG00000131747homo_sapiensENSP0000041153296.08193.6643camelus_dromedariusENSCDRP0000501025396.45994.0328
ENSG00000131747homo_sapiensENSP0000041153296.799594.1868carlito_syrichtaENSTSYP0000000332996.799594.1868
ENSG00000131747homo_sapiensENSP0000041153296.799594.5787panthera_tigris_altaicaENSPTIP0000002043296.610294.3937
ENSG00000131747homo_sapiensENSP0000041153293.468389.2227rattus_norvegicusENSRNOP0000006996393.651889.3979
ENSG00000131747homo_sapiensENSP0000041153297.909995.4278prolemur_simusENSPSMP0000001604398.102195.6152
ENSG00000131747homo_sapiensENSP0000041153293.990990.8557microtus_ochrogasterENSMOCP0000001337294.237191.0937
ENSG00000131747homo_sapiensENSP0000041153268.321463.096sorex_araneusENSSARP0000001118064.647759.7033
ENSG00000131747homo_sapiensENSP0000041153294.121590.921peromyscus_maniculatus_bairdiiENSPEMP0000001756394.36891.1591
ENSG00000131747homo_sapiensENSP0000041153295.689192.8152bos_mutusENSBMUP0000000517795.751692.8758
ENSG00000131747homo_sapiensENSP0000041153293.729689.288mus_spicilegusENSMSIP0000003122793.729689.288
ENSG00000131747homo_sapiensENSP0000041153294.252190.725cricetulus_griseus_chok1gshdENSCGRP0000102239694.560991.0223
ENSG00000131747homo_sapiensENSP0000041153267.929564.0758pteropus_vampyrusENSPVAP0000000810369.658465.7066
ENSG00000131747homo_sapiensENSP0000041153295.297292.9458myotis_lucifugusENSMLUP0000000721595.797893.434
ENSG00000131747homo_sapiensENSP0000041153290.594484.128vombatus_ursinusENSVURP0001000664289.024482.6701
ENSG00000131747homo_sapiensENSP0000041153295.297291.3129rhinolophus_ferrumequinumENSRFEP0001002673995.359591.3726
ENSG00000131747homo_sapiensENSP0000041153296.472994.0562neovison_visonENSNVIP0000000294896.409993.9948
ENSG00000131747homo_sapiensENSP0000041153295.819792.8805bos_taurusENSBTAP0000005385895.757292.8198
ENSG00000131747homo_sapiensENSP0000041153294.709391.7048heterocephalus_glaber_femaleENSHGLP0000004193694.957491.945
ENSG00000131747homo_sapiensENSP0000041153297.191496.0157rhinopithecus_bietiENSRBIP0000000803798.217897.0297
ENSG00000131747homo_sapiensENSP0000041153293.794991.2476canis_lupus_dingoENSCAFP0002002376597.620794.9694
ENSG00000131747homo_sapiensENSP0000041153296.995494.9053sciurus_vulgarisENSSVLP0000500369696.932194.8433
ENSG00000131747homo_sapiensENSP0000041153291.835485.4997phascolarctos_cinereusENSPCIP0000003476390.243984.018
ENSG00000131747homo_sapiensENSP0000041153263.487958.9157procavia_capensisENSPCAP0000000170365.542860.8227
ENSG00000131747homo_sapiensENSP0000041153295.493192.9458nannospalax_galiliENSNGAP0000000630395.80693.2503
ENSG00000131747homo_sapiensENSP0000041153295.689192.8152bos_grunniensENSBGRP0000002900195.626692.7546
ENSG00000131747homo_sapiensENSP0000041153289.679986.3488chinchilla_lanigeraENSCLAP0000002158794.299590.7967
ENSG00000131747homo_sapiensENSP0000041153295.950492.6192cervus_hanglu_yarkandensisENSCHYP0000000656695.887792.5587
ENSG00000131747homo_sapiensENSP0000041153296.276993.5336catagonus_wagneriENSCWAP0000002080396.276993.5336
ENSG00000131747homo_sapiensENSP0000041153296.472994.2521ictidomys_tridecemlineatusENSSTOP0000000434896.284294.0678
ENSG00000131747homo_sapiensENSP0000041153297.191493.5336otolemur_garnettiiENSOGAP0000000146397.064693.4116
ENSG00000131747homo_sapiensENSP0000041153298.497797.4526cebus_imitatorENSCCAP0000001630398.497797.4526
ENSG00000131747homo_sapiensENSP0000041153296.472994.1215urocitellus_parryiiENSUPAP0001001035696.284293.9374
ENSG00000131747homo_sapiensENSP0000041153296.015792.6845moschus_moschiferusENSMMSP0000003193095.95392.624
ENSG00000131747homo_sapiensENSP0000041153299.412198.3671rhinopithecus_roxellanaENSRROP0000002188699.412198.3671
ENSG00000131747homo_sapiensENSP0000041153288.373684.2587mus_pahariMGP_PahariEiJ_P003646593.698189.3352
ENSG00000131747homo_sapiensENSP0000041153296.734294.2521propithecus_coquereliENSPCOP0000002616497.051194.5609
ENSG00000131747homo_sapiensENSP0000041153259.830249.5754petromyzon_marinusENSPMAP0000000786174.41161.6572
ENSG00000131747homo_sapiensENSP0000041153240.104534.8138eptatretus_burgeriENSEBUP0000001497489.63577.8102
ENSG00000131747homo_sapiensENSP0000041153215.022911.0385callorhinchus_miliiENSCMIP0000001897645.634933.5317
ENSG00000131747homo_sapiensENSP0000041153279.751869.0398latimeria_chalumnaeENSLACP0000001050077.820367.3678
ENSG00000131747homo_sapiensENSP0000041153279.163968.8439lepisosteus_oculatusENSLOCP0000001589277.444167.3482
ENSG00000131747homo_sapiensENSP0000041153277.857666.2312clupea_harengusENSCHAP0000002849174.40763.2959
ENSG00000131747homo_sapiensENSP0000041153279.098667.7335danio_rerioENSDARP0000013935377.133866.051
ENSG00000131747homo_sapiensENSP0000041153279.163968.1907carassius_auratusENSCARP0000001638077.246766.5392
ENSG00000131747homo_sapiensENSP0000041153277.204465.1208astyanax_mexicanusENSAMXP0000004334278.538266.2458
ENSG00000131747homo_sapiensENSP0000041153278.77267.4722ictalurus_punctatusENSIPUP0000003091376.280865.3384
ENSG00000131747homo_sapiensENSP0000041153277.596366.8191esox_luciusENSELUP0000001067178.989468.0186
ENSG00000131747homo_sapiensENSP0000041153278.184267.0803electrophorus_electricusENSEEEP0000004475574.95364.3081
ENSG00000131747homo_sapiensENSP0000041153276.224764.7943oncorhynchus_kisutchENSOKIP0000504207275.7364.3738
ENSG00000131747homo_sapiensENSP0000041153278.706767.2763oncorhynchus_mykissENSOMYP0000003711877.293166.068
ENSG00000131747homo_sapiensENSP0000041153278.380167.3416salmo_salarENSSSAP0000009251376.238965.5019
ENSG00000131747homo_sapiensENSP0000041153278.77267.7988salmo_truttaENSSTUP0000002214476.864266.1568
ENSG00000131747homo_sapiensENSP0000041153277.792364.8596gadus_morhuaENSGMOP0000004309476.248463.5723
ENSG00000131747homo_sapiensENSP0000041153276.2965.1861fundulus_heteroclitusENSFHEP0000002453076.590265.4426
ENSG00000131747homo_sapiensENSP0000041153279.294668.5173poecilia_reticulataENSPREP0000003032076.981666.5187
ENSG00000131747homo_sapiensENSP0000041153278.314867.7335xiphophorus_maculatusENSXMAP0000001138878.059967.513
ENSG00000131747homo_sapiensENSP0000041153278.837467.4722oryzias_latipesENSORLP0000000553076.8365.7543
ENSG00000131747homo_sapiensENSP0000041153241.476236.1855cyclopterus_lumpusENSCLMP0000501410688.072176.8377
ENSG00000131747homo_sapiensENSP0000041153274.526563.8145cyclopterus_lumpusENSCLMP0000501369083.467471.4704
ENSG00000131747homo_sapiensENSP0000041153212.67159.92815cyclopterus_lumpusENSCLMP0000501064069.53454.4803
ENSG00000131747homo_sapiensENSP0000041153279.425268.5173oreochromis_niloticusENSONIP0000002509476.767766.2247
ENSG00000131747homo_sapiensENSP0000041153279.555868.3867haplochromis_burtoniENSHBUP0000000296276.991166.182
ENSG00000131747homo_sapiensENSP0000041153277.335166.7538astatotilapia_callipteraENSACLP0000001924578.775867.9973
ENSG00000131747homo_sapiensENSP0000041153279.621268.1254sparus_aurataENSSAUP0001003311076.8665.7629
ENSG00000131747homo_sapiensENSP0000041153279.294668.5826lates_calcariferENSLCAP0001002347577.324866.879
ENSG00000131747homo_sapiensENSP0000041153282.037970.6728xenopus_tropicalisENSXETP0000004620874.01363.7596
ENSG00000131747homo_sapiensENSP0000041153284.977176.3553chrysemys_picta_belliiENSCPBP0000000622083.077974.6488
ENSG00000131747homo_sapiensENSP0000041153279.098670.8034sphenodon_punctatusENSSPUP0000000318987.436878.2672
ENSG00000131747homo_sapiensENSP0000041153283.866874.1999crocodylus_porosusENSCPRP0000500407985.315675.4817
ENSG00000131747homo_sapiensENSP0000041153222.207717.9621laticauda_laticaudataENSLLTP0000001931284.78868.5786
ENSG00000131747homo_sapiensENSP0000041153237.753133.2462laticauda_laticaudataENSLLTP0000000639490.880580.0314
ENSG00000131747homo_sapiensENSP0000041153220.836116.917notechis_scutatusENSNSUP0000000194788.121571.547
ENSG00000131747homo_sapiensENSP0000041153220.378816.5251pseudonaja_textilisENSPTXP0000002437985.950469.697
ENSG00000131747homo_sapiensENSP0000041153237.295933.3769pseudonaja_textilisENSPTXP0000002500685.47976.497
ENSG00000131747homo_sapiensENSP0000041153220.378816.5251pseudonaja_textilisENSPTXP0000002286685.950469.697
ENSG00000131747homo_sapiensENSP0000041153281.058173.1548anas_platyrhynchos_platyrhynchosENSAPLP0000000616482.954574.8663
ENSG00000131747homo_sapiensENSP0000041153281.254173.2854gallus_gallusENSGALP0001003308180.10372.2473
ENSG00000131747homo_sapiensENSP0000041153280.470372.5016meleagris_gallopavoENSMGAP0000001876682.573774.3968
ENSG00000131747homo_sapiensENSP0000041153283.866875.8328serinus_canariaENSSCAP0000001026983.322575.3407
ENSG00000131747homo_sapiensENSP0000041153283.801475.5062parus_majorENSPMJP0000000010983.528675.2604
ENSG00000131747homo_sapiensENSP0000041153282.952372.6323anolis_carolinensisENSACAP0000000228481.462571.3278
ENSG00000131747homo_sapiensENSP0000041153218.615315.4801neolamprologus_brichardiENSNBRP0000002909986.363671.8182
ENSG00000131747homo_sapiensENSP0000041153214.239113.194neolamprologus_brichardiENSNBRP0000002911790.456483.8174
ENSG00000131747homo_sapiensENSP0000041153245.329840.4964naja_najaENSNNAP0000002313790.364680.7292
ENSG00000131747homo_sapiensENSP0000041153220.705416.7864naja_najaENSNNAP0000002306187.569170.9945
ENSG00000131747homo_sapiensENSP0000041153282.821773.1548podarcis_muralisENSPMRP0000002590781.753772.2115
ENSG00000131747homo_sapiensENSP0000041153282.691174.6571geospiza_fortisENSGFOP0000001037782.691174.6571
ENSG00000131747homo_sapiensENSP0000041153283.148374.7224taeniopygia_guttataENSTGUP0000003269582.341573.9974
ENSG00000131747homo_sapiensENSP0000041153213.977812.5408erpetoichthys_calabaricusENSECRP0000003339482.625574.1313
ENSG00000131747homo_sapiensENSP0000041153221.358617.4396erpetoichthys_calabaricusENSECRP0000003337488.140271.9677
ENSG00000131747homo_sapiensENSP0000041153220.901417.3743erpetoichthys_calabaricusENSECRP0000003341588.154373.2782
ENSG00000131747homo_sapiensENSP0000041153213.651212.2796erpetoichthys_calabaricusENSECRP0000003343685.655777.0492
ENSG00000131747homo_sapiensENSP0000041153278.902767.211kryptolebias_marmoratusENSKMAP0000001378478.492566.8616
ENSG00000131747homo_sapiensENSP0000041153277.792368.3867salvator_merianaeENSSMRP0000000671181.296971.4676
ENSG00000131747homo_sapiensENSP0000041153211.495810.1241salvator_merianaeENSSMRP0000001339487.562277.1144
ENSG00000131747homo_sapiensENSP0000041153278.837467.211oryzias_javanicusENSOJAP0000002609476.8365.4997
ENSG00000131747homo_sapiensENSP0000041153219.79116.3945amphilophus_citrinellusENSACIP0000000102385.352170.7042
ENSG00000131747homo_sapiensENSP0000041153213.324612.0836amphilophus_citrinellusENSACIP0000000098789.867881.4978
ENSG00000131747homo_sapiensENSP0000041153279.555868.1254dicentrarchus_labraxENSDLAP0000506072277.088666.0127
ENSG00000131747homo_sapiensENSP0000041153279.555868.5826amphiprion_perculaENSAPEP0000000741777.186366.5399
ENSG00000131747homo_sapiensENSP0000041153265.382159.9608pelodiscus_sinensisENSPSIP0000000247194.167486.3594
ENSG00000131747homo_sapiensENSP0000041153283.213674.9837gopherus_evgoodeiENSGEVP0000502635686.490277.9362
ENSG00000131747homo_sapiensENSP0000041153279.751871.9791chelonoidis_abingdoniiENSCABP0000001503883.687575.5312
ENSG00000131747homo_sapiensENSP0000041153279.686568.3867seriola_dumeriliENSSDUP0000000467877.020266.0985
ENSG00000131747homo_sapiensENSP0000041153276.747263.9451cottoperca_gobioENSCGOP0000002469878.595365.4849
ENSG00000131747homo_sapiensENSP0000041153276.681969.0398struthio_camelus_australisENSSCUP0000001677481.584473.4538
ENSG00000131747homo_sapiensENSP0000041153281.058173.0895anser_brachyrhynchusENSABRP0000001884082.954574.7995
ENSG00000131747homo_sapiensENSP0000041153278.314866.5578gasterosteus_aculeatusENSGACP0000001126076.418164.9458
ENSG00000131747homo_sapiensENSP0000041153277.988266.5578cynoglossus_semilaevisENSCSEP0000001986877.08265.7844
ENSG00000131747homo_sapiensENSP0000041153276.812566.1006poecilia_formosaENSPFOP0000001661577.368466.5789
ENSG00000131747homo_sapiensENSP0000041153279.359968.9745myripristis_murdjanENSMMDP0000504439876.850166.7932
ENSG00000131747homo_sapiensENSP0000041153279.033368.1907sander_luciopercaENSSLUP0000004142375.577865.2092
ENSG00000131747homo_sapiensENSP0000041153282.821773.9386strigops_habroptilaENSSHBP0000502369381.595972.8443
ENSG00000131747homo_sapiensENSP0000041153278.510867.7335amphiprion_ocellarisENSAOCP0000001702177.498466.8601
ENSG00000131747homo_sapiensENSP0000041153246.636242.8478terrapene_carolina_triunguisENSTMTP0000001163494.444486.7725
ENSG00000131747homo_sapiensENSP0000041153221.489219.0072terrapene_carolina_triunguisENSTMTP0000001166991.135780.6094
ENSG00000131747homo_sapiensENSP0000041153278.77267.2763hucho_huchoENSHHUP0000007149277.1165.8568
ENSG00000131747homo_sapiensENSP0000041153278.902768.256betta_splendensENSBSLP0000002945676.747166.3914
ENSG00000131747homo_sapiensENSP0000041153279.359967.9948pygocentrus_nattereriENSPNAP0000002287976.75365.7612
ENSG00000131747homo_sapiensENSP0000041153279.425268.7133anabas_testudineusENSATEP0000002110777.108466.7089
ENSG00000131747homo_sapiensENSP0000041153278.380167.5376seriola_lalandi_dorsalisENSSLDP0000002894177.669966.9256
ENSG00000131747homo_sapiensENSP0000041153275.179664.1411labrus_bergyltaENSLBEP0000002036479.930668.1944
ENSG00000131747homo_sapiensENSP0000041153277.269866.5578pundamilia_nyerereiENSPNYP0000002459978.292567.4388
ENSG00000131747homo_sapiensENSP0000041153277.073865.1861mastacembelus_armatusENSMAMP0000000250177.174665.2714
ENSG00000131747homo_sapiensENSP0000041153279.686568.7133stegastes_partitusENSSPAP0000003117577.756567.0491
ENSG00000131747homo_sapiensENSP0000041153278.902767.4722oncorhynchus_tshawytschaENSOTSP0000509876577.435966.2179
ENSG00000131747homo_sapiensENSP0000041153279.817168.6479acanthochromis_polyacanthusENSAPOP0000003015077.439866.6033
ENSG00000131747homo_sapiensENSP0000041153283.148374.9837aquila_chrysaetos_chrysaetosENSACCP0002000460084.248875.9762
ENSG00000131747homo_sapiensENSP0000041153278.706767.0803nothobranchius_furzeriENSNFUP0001502260775.59664.4291
ENSG00000131747homo_sapiensENSP0000041153279.033367.8641cyprinodon_variegatusENSCVAP0000002277977.963966.9459
ENSG00000131747homo_sapiensENSP0000041153277.988267.015denticeps_clupeoidesENSDCDP0000000925377.78566.8404
ENSG00000131747homo_sapiensENSP0000041153279.425267.8641larimichthys_croceaENSLCRP0000503813977.010865.8011
ENSG00000131747homo_sapiensENSP0000041153279.686568.452takifugu_rubripesENSTRUP0000004192378.005167.0077
ENSG00000131747homo_sapiensENSP0000041153283.866875.8328ficedula_albicollisENSFALP0000000039983.160675.1943
ENSG00000131747homo_sapiensENSP0000041153277.857667.6029hippocampus_comesENSHCOP0000001447376.655966.5595
ENSG00000131747homo_sapiensENSP0000041153279.098667.4069cyprinus_carpio_carpioENSCCRP0000008471977.182965.7744
ENSG00000131747homo_sapiensENSP0000041153283.017674.7224coturnix_japonicaENSCJPP0000500457380.239972.2222
ENSG00000131747homo_sapiensENSP0000041153279.490568.452poecilia_latipinnaENSPLAP0000001709377.318966.582
ENSG00000131747homo_sapiensENSP0000041153279.163967.2763sinocyclocheilus_grahamiENSSGRP0000009234577.345265.7307
ENSG00000131747homo_sapiensENSP0000041153277.792366.7538maylandia_zebraENSMZEP0000501332378.926467.727
ENSG00000131747homo_sapiensENSP0000041153278.706768.1254tetraodon_nigroviridisENSTNIP0000000341177.342866.9448
ENSG00000131747homo_sapiensENSP0000041153279.229367.9948paramormyrops_kingsleyaeENSPKIP0000000589877.261166.3057
ENSG00000131747homo_sapiensENSP0000041153274.918465.1208scleropages_formosusENSSFOP0001504463781.52170.86
ENSG00000131747homo_sapiensENSP0000041153279.555868.5173leptobrachium_leishanenseENSLLEP0000003496179.039668.0727
ENSG00000131747homo_sapiensENSP0000041153279.163967.9295scophthalmus_maximusENSSMAP0000004094675.939865.1629
ENSG00000131747homo_sapiensENSP0000041153278.641467.0803oryzias_melastigmaENSOMEP0000000405776.982165.665

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000228colocalizes_with nuclear chromosome1IDAHomo_sapiens(9606)Component
GO:0000287enables magnesium ion binding1IDAHomo_sapiens(9606)Function
GO:0000712involved_in resolution of meiotic recombination intermediates1IBAHomo_sapiens(9606)Process
GO:0000775located_in chromosome, centromeric region1IEAHomo_sapiens(9606)Component
GO:0000793located_in condensed chromosome1IEAHomo_sapiens(9606)Component
GO:0000819involved_in sister chromatid segregation1IBAHomo_sapiens(9606)Process
GO:0001673located_in male germ cell nucleus1IEAHomo_sapiens(9606)Component
GO:0002244involved_in hematopoietic progenitor cell differentiation1IEAHomo_sapiens(9606)Process
GO:0003677enables DNA binding1IDAHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003918enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity2IDA,IMPHomo_sapiens(9606)Function
GO:0005080enables protein kinase C binding1IPIHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005730NOT located_in nucleolus2IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005814colocalizes_with centriole1IDAHomo_sapiens(9606)Component
GO:0006265involved_in DNA topological change2IDA,IMPHomo_sapiens(9606)Process
GO:0006266involved_in DNA ligation1IDAHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1IDAHomo_sapiens(9606)Process
GO:0007059involved_in chromosome segregation1IMPHomo_sapiens(9606)Process
GO:0007143involved_in female meiotic nuclear division1IEAHomo_sapiens(9606)Process
GO:0008094enables ATP-dependent activity, acting on DNA1IDAHomo_sapiens(9606)Function
GO:0008301enables DNA binding, bending1IDAHomo_sapiens(9606)Function
GO:0009330part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex1IDAHomo_sapiens(9606)Component
GO:0030263involved_in apoptotic chromosome condensation2IBA,IDAHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0040016involved_in embryonic cleavage1IEAHomo_sapiens(9606)Process
GO:0042752involved_in regulation of circadian rhythm1ISSHomo_sapiens(9606)Process
GO:0042803enables protein homodimerization activity1IPIHomo_sapiens(9606)Function
GO:0043065involved_in positive regulation of apoptotic process1IDAHomo_sapiens(9606)Process
GO:0043130enables ubiquitin binding1IMPHomo_sapiens(9606)Function
GO:0045870involved_in positive regulation of single stranded viral RNA replication via double stranded DNA intermediate1IMPHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0046982enables protein heterodimerization activity1IPIHomo_sapiens(9606)Function
GO:0048511involved_in rhythmic process1IEAHomo_sapiens(9606)Process
GO:1905463involved_in negative regulation of DNA duplex unwinding1IMPHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex1IDAHomo_sapiens(9606)Component

Expression