Ensembl ID
ENSG00000131747
Gene ID
7153
Accession
11989
Gene Symbol
TOP2A
Alias
TOP2;TP2A;TOPIIA;TOP2alpha
Full Name
DNA topoisomerase II alpha
Position
17 : 40388525 - 40417896
Length
29372 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs N.A. RBP type
Non-canonical_RBPs
Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
ENSG00000131747 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000131747
TOP2A
2.31
4.74e-58
KIRC
ENSG00000131747
TOP2A
1.33
1.42e-23
HNSC
ENSG00000131747
TOP2A
2.01
3.98e-16
BLCA
ENSG00000131747
TOP2A
3.50
1.57e-162
BRCA
ENSG00000131747
TOP2A
1.42
1.38e-34
COAD
ENSG00000131747
TOP2A
4.22
4.92e-223
LUSC
ENSG00000131747
TOP2A
1.35
1.67e-12
PRAD
ENSG00000131747
TOP2A
7.16
1.85e-51
GBM
ENSG00000131747
TOP2A
3.26
2.51e-30
KIRP
ENSG00000131747
TOP2A
3.90
8.32e-81
LIHC
ENSG00000131747
TOP2A
2.46
4.73e-30
STAD
ENSG00000131747
TOP2A
3.41
1.08e-80
UCEC
ENSG00000131747
TOP2A
2.65
1.51e-13
ESCA
ENSG00000131747
TOP2A
4.32
7.55e-27
CHOL
ENSG00000131747
TOP2A
5.75
4.71e-56
CESC
ENSG00000131747
TOP2A
3.85
3.50e-124
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000131747
TOP2A
tumors
10469452
ENSG00000131747
TOP2A
lung cancer
10699927
ENSG00000131747
TOP2A
tumor
11425459
ENSG00000131747
TOP2A
tumours
12165855
ENSG00000131747
TOP2A
tumour
12173052
ENSG00000131747
TOP2A
ovarian tumors
12532422
ENSG00000131747
TOP2A
tumor
12647367
ENSG00000131747
TOP2A
urinary bladder cancer
12691100
ENSG00000131747
TOP2A
tumors
12692309
ENSG00000131747
TOP2A
breast tumors
12871052
ENSG00000131747
TOP2A
breast cancers
12915875
ENSG00000131747
TOP2A
tumor
14566826
ENSG00000131747
TOP2A
cancer
14632727
ENSG00000131747
TOP2A
breast cancer
14632728
ENSG00000131747
TOP2A
tumors
14673046
ENSG00000131747
TOP2A
breast tumor
14978790
ENSG00000131747
TOP2A
gastric cancer
14991576
ENSG00000131747
TOP2A
breast cancer
15034864
ENSG00000131747
TOP2A
breast cancer
15068318
ENSG00000131747
TOP2A
tumor
15260889
ENSG00000131747
TOP2A
breast cancer
15628907
ENSG00000131747
TOP2A
tumours
15682439
ENSG00000131747
TOP2A
pancreatic cancer
15762277
ENSG00000131747
TOP2A
breast cancer
15891995
ENSG00000131747
TOP2A
breast cancer
16234514
ENSG00000131747
TOP2A
tumors
16280042
ENSG00000131747
TOP2A
breast tumor
16502015
ENSG00000131747
TOP2A
AML
16507781
ENSG00000131747
TOP2A
ovarian cancer
16533424
ENSG00000131747
TOP2A
tumour
16556665
ENSG00000131747
TOP2A
tumors
16682728
ENSG00000131747
TOP2A
tumors
16773180
ENSG00000131747
TOP2A
tumors
16849520
ENSG00000131747
TOP2A
breast cancer
16864174
ENSG00000131747
TOP2A
colorectal cancer
16882699
ENSG00000131747
TOP2A
Tumours
16935488
ENSG00000131747
TOP2A
breast cancer
17013533
ENSG00000131747
TOP2A
AML
17033956
ENSG00000131747
TOP2A
tumours
17088909
ENSG00000131747
TOP2A
breast cancer
17089011
ENSG00000131747
TOP2A
cancer
17100565
ENSG00000131747
TOP2A
tumours
17260090
ENSG00000131747
TOP2A
prostate cancer
17363613
ENSG00000131747
TOP2A
breast cancers
17453369
ENSG00000131747
TOP2A
cancers
17468948
ENSG00000131747
TOP2A
tumor
17493384
ENSG00000131747
TOP2A
tumors
17624412
ENSG00000131747
TOP2A
tumor
17638622
ENSG00000131747
TOP2A
breast cancer
17922046
ENSG00000131747
TOP2A
cancer
17922188
ENSG00000131747
TOP2A
cancers
17949785
ENSG00000131747
TOP2A
lung cancer
18078328
ENSG00000131747
TOP2A
breast cancers
18280644
ENSG00000131747
TOP2A
breast cancer
18332872
ENSG00000131747
TOP2A
cancers
18333132
ENSG00000131747
TOP2A
breast cancer
18340528
ENSG00000131747
TOP2A
tumor
18348204
ENSG00000131747
TOP2A
breast cancer
18413646
ENSG00000131747
TOP2A
breast cancer
18465341
ENSG00000131747
TOP2A
benign tumors
18522746
ENSG00000131747
TOP2A
tumors
18702822
ENSG00000131747
TOP2A
tumors
19003983
ENSG00000131747
TOP2A
tumor
19043454
ENSG00000131747
TOP2A
tumor
19061514
ENSG00000131747
TOP2A
tumors
19111388
ENSG00000131747
TOP2A
tumors
19158039
ENSG00000131747
TOP2A
breast-cancer
19261255
ENSG00000131747
TOP2A
Triple negative breast cancer
19365520
ENSG00000131747
TOP2A
cancer
19377506
ENSG00000131747
TOP2A
breast cancer
19390941
ENSG00000131747
TOP2A
tumors
19401546
ENSG00000131747
TOP2A
tumor
19417146
ENSG00000131747
TOP2A
tumors
19619298
ENSG00000131747
TOP2A
breast cancer
19620488
ENSG00000131747
TOP2A
tumors
19657712
ENSG00000131747
TOP2A
tumours
19754664
ENSG00000131747
TOP2A
breast cancer
19767729
ENSG00000131747
TOP2A
tumours
19886180
ENSG00000131747
TOP2A
tumors
19945923
ENSG00000131747
TOP2A
breast cancer
19996222
ENSG00000131747
TOP2A
breast cancer
20038724
ENSG00000131747
TOP2A
tumors
20066894
ENSG00000131747
TOP2A
cancer
20069504
ENSG00000131747
TOP2A
tumours
20079691
ENSG00000131747
TOP2A
breast cancer
20089371
ENSG00000131747
TOP2A
breast cancer
20100636
ENSG00000131747
TOP2A
breast cancer
20130985
ENSG00000131747
TOP2A
breast cancer
20371687
ENSG00000131747
TOP2A
breast cancer
20441774
ENSG00000131747
TOP2A
tumors
20459607
ENSG00000131747
TOP2A
tumours
20464479
ENSG00000131747
TOP2A
breast cancer
20525369
ENSG00000131747
TOP2A
tumors
20576644
ENSG00000131747
TOP2A
tumor
20649994
ENSG00000131747
TOP2A
tumor
20813715
ENSG00000131747
TOP2A
gastric cancer
20965966
ENSG00000131747
TOP2A
cancer
21060876
ENSG00000131747
TOP2A
cancer
21062978
ENSG00000131747
TOP2A
breast cancer
21082037
ENSG00000131747
TOP2A
cancer
21165954
ENSG00000131747
TOP2A
tumors
21172013
ENSG00000131747
TOP2A
tumor
21188112
ENSG00000131747
TOP2A
breast cancers
21189395
ENSG00000131747
TOP2A
tumor
21288332
ENSG00000131747
TOP2A
tumours
21338529
ENSG00000131747
TOP2A
tumors
21422418
ENSG00000131747
TOP2A
breast cancer
21435434
ENSG00000131747
TOP2A
tumors
21461646
ENSG00000131747
TOP2A
tumor
21475936
ENSG00000131747
TOP2A
breast cancer
21501481
ENSG00000131747
TOP2A
breast cancer
21614903
ENSG00000131747
TOP2A
prostate cancer
21629784
ENSG00000131747
TOP2A
tumor
21667123
ENSG00000131747
TOP2A
tumour
21681601
ENSG00000131747
TOP2A
breast cancers
21698407
ENSG00000131747
TOP2A
breast cancer
21705665
ENSG00000131747
TOP2A
tumor
21720419
ENSG00000131747
TOP2A
tumor
21734419
ENSG00000131747
TOP2A
triple-negative breast cancer
21737670
ENSG00000131747
TOP2A
tumours
21741827
ENSG00000131747
TOP2A
cancers
21768308
ENSG00000131747
TOP2A
cancer
21778401
ENSG00000131747
TOP2A
tumor
21785684
ENSG00000131747
TOP2A
GBM
21859839
ENSG00000131747
TOP2A
breast cancer
21875466
ENSG00000131747
TOP2A
tumor
21887332
ENSG00000131747
TOP2A
breast cancer
21917518
ENSG00000131747
TOP2A
tumor
22016618
ENSG00000131747
TOP2A
breast cancer
22037783
ENSG00000131747
TOP2A
breast cancer
22042366
ENSG00000131747
TOP2A
breast cancer
22083232
ENSG00000131747
TOP2A
GBM
22102081
ENSG00000131747
TOP2A
cancer
22111588
ENSG00000131747
TOP2A
breast cancer
22153616
ENSG00000131747
TOP2A
breast cancer
22160637
ENSG00000131747
TOP2A
tumors
22203181
ENSG00000131747
TOP2A
breast cancer
22204715
ENSG00000131747
TOP2A
breast cancer
22240029
ENSG00000131747
TOP2A
breast cancer
22285073
ENSG00000131747
TOP2A
cancer
22292074
ENSG00000131747
TOP2A
tumor
22300273
ENSG00000131747
TOP2A
cancer
22306066
ENSG00000131747
TOP2A
breast cancer
22318550
ENSG00000131747
TOP2A
breast cancers
22323914
ENSG00000131747
TOP2A
breast cancer
22333602
ENSG00000131747
TOP2A
prostate cancer
22349817
ENSG00000131747
TOP2A
breast cancer
22374418
ENSG00000131747
TOP2A
tumors
22425911
ENSG00000131747
TOP2A
breast cancer
22426810
ENSG00000131747
TOP2A
tumours
22452920
ENSG00000131747
TOP2A
tumors
22493625
ENSG00000131747
TOP2A
cervical cancer
22545419
ENSG00000131747
TOP2A
tumor
22554015
ENSG00000131747
TOP2A
breast cancer
22578285
ENSG00000131747
TOP2A
breast cancer
22612507
ENSG00000131747
TOP2A
tumour
22627319
ENSG00000131747
TOP2A
breast cancer
22706628
ENSG00000131747
TOP2A
pituitary tumor
22785131
ENSG00000131747
TOP2A
cancer
22829791
ENSG00000131747
TOP2A
ovarian cancer
22862954
ENSG00000131747
TOP2A
breast cancer
22864769
ENSG00000131747
TOP2A
breast cancer
22871798
ENSG00000131747
TOP2A
tumors
22900064
ENSG00000131747
TOP2A
cancer
22952714
ENSG00000131747
TOP2A
cancer
22998676
ENSG00000131747
TOP2A
tumours
23047592
ENSG00000131747
TOP2A
tumor
23071490
ENSG00000131747
TOP2A
tumors
23092535
ENSG00000131747
TOP2A
breast cancer
23135572
ENSG00000131747
TOP2A
prostate cancers
23145101
ENSG00000131747
TOP2A
cancer
23163854
ENSG00000131747
TOP2A
tumors
23181561
ENSG00000131747
TOP2A
tumor
23222298
ENSG00000131747
TOP2A
breast cancers
23226023
ENSG00000131747
TOP2A
cancer
23229142
ENSG00000131747
TOP2A
tumour
23239665
ENSG00000131747
TOP2A
tumors
23276504
ENSG00000131747
TOP2A
cancer
23302999
ENSG00000131747
TOP2A
tumor
23398928
ENSG00000131747
TOP2A
cervical cancer
23405241
ENSG00000131747
TOP2A
tumors
23470717
ENSG00000131747
TOP2A
cancers
23504136
ENSG00000131747
TOP2A
tumours
23505375
ENSG00000131747
TOP2A
tumors
23532817
ENSG00000131747
TOP2A
tumor
23537287
ENSG00000131747
TOP2A
tumor
23570501
ENSG00000131747
TOP2A
breast cancer
23628726
ENSG00000131747
TOP2A
tumors
23646114
ENSG00000131747
TOP2A
tumour
23698369
ENSG00000131747
TOP2A
breast cancer
23769286
ENSG00000131747
TOP2A
breast cancer
23778266
ENSG00000131747
TOP2A
tumor
23897556
ENSG00000131747
TOP2A
cancers
23928695
ENSG00000131747
TOP2A
cancer
24002654
ENSG00000131747
TOP2A
breast cancer
24007746
ENSG00000131747
TOP2A
tumors
24040940
ENSG00000131747
TOP2A
tumors
24072219
ENSG00000131747
TOP2A
tumor
24103454
ENSG00000131747
TOP2A
breast cancer
24106899
ENSG00000131747
TOP2A
cancer
24116135
ENSG00000131747
TOP2A
colorectal cancer
24138107
ENSG00000131747
TOP2A
breast cancer
24144752
ENSG00000131747
TOP2A
tumors
24165483
ENSG00000131747
TOP2A
tumor
24185117
ENSG00000131747
TOP2A
cancers
24216996
ENSG00000131747
TOP2A
breast cancer
24272208
ENSG00000131747
TOP2A
invasive breast cancer
24292870
ENSG00000131747
TOP2A
AML
24327541
ENSG00000131747
TOP2A
tumours
24381055
ENSG00000131747
TOP2A
cervical cancer
24383054
ENSG00000131747
TOP2A
breast cancer
24402422
ENSG00000131747
TOP2A
tumours
24403186
ENSG00000131747
TOP2A
breast cancer
24492650
ENSG00000131747
TOP2A
cancers
24573252
ENSG00000131747
TOP2A
Cancer
24637229
ENSG00000131747
TOP2A
lung cancer
24649266
ENSG00000131747
TOP2A
tumors
24665131
ENSG00000131747
TOP2A
breast cancer
24675496
ENSG00000131747
TOP2A
tumor
24682655
ENSG00000131747
TOP2A
cancer
24905608
ENSG00000131747
TOP2A
tumor
24926347
ENSG00000131747
TOP2A
non-small cell lung cancer
24975429
ENSG00000131747
TOP2A
tumor
25005255
ENSG00000131747
TOP2A
bladder cancer
25026175
ENSG00000131747
TOP2A
breast cancer
25042383
ENSG00000131747
TOP2A
tumor
25048628
ENSG00000131747
TOP2A
breast cancer
25051718
ENSG00000131747
TOP2A
breast cancer
25098819
ENSG00000131747
TOP2A
breast cancer
25202398
ENSG00000131747
TOP2A
prostate cancer
25237769
ENSG00000131747
TOP2A
cancer
25328138
ENSG00000131747
TOP2A
cancer
25372714
ENSG00000131747
TOP2A
breast cancer
25379022
ENSG00000131747
TOP2A
tumor
25406834
ENSG00000131747
TOP2A
breast tumors
25445497
ENSG00000131747
TOP2A
breast cancer
25481507
ENSG00000131747
TOP2A
tumor
25484594
ENSG00000131747
TOP2A
tumor
25546409
ENSG00000131747
TOP2A
tumour
25546926
ENSG00000131747
TOP2A
gastric cancer
25558650
ENSG00000131747
TOP2A
breast cancer
25642443
ENSG00000131747
TOP2A
breast cancer
25693082
ENSG00000131747
TOP2A
breast cancers
25695068
ENSG00000131747
TOP2A
tumors
25724086
ENSG00000131747
TOP2A
gastric cancers
25743022
ENSG00000131747
TOP2A
malignant peripheral nerve sheath tumours
25769404
ENSG00000131747
TOP2A
tumors
25777966
ENSG00000131747
TOP2A
tumor
25778705
ENSG00000131747
TOP2A
breast cancer
25846735
ENSG00000131747
TOP2A
tumors
25897160
ENSG00000131747
TOP2A
DLBCL
25931012
ENSG00000131747
TOP2A
cancer
25945730
ENSG00000131747
TOP2A
breast cancer
26008969
ENSG00000131747
TOP2A
breast cancer
26022247
ENSG00000131747
TOP2A
colorectal cancer
26040697
ENSG00000131747
TOP2A
gastric cancer
26050197
ENSG00000131747
TOP2A
cancers
26051240
ENSG00000131747
TOP2A
ovarian cancer
26100858
ENSG00000131747
TOP2A
breast cancer
26178217
ENSG00000131747
TOP2A
breast cancer
26252353
ENSG00000131747
TOP2A
tumor
26408707
ENSG00000131747
TOP2A
cancer
26409325
ENSG00000131747
TOP2A
tumors
26484051
ENSG00000131747
TOP2A
cancer
26527623
ENSG00000131747
TOP2A
tumours
26537449
ENSG00000131747
TOP2A
tumor
26560244
ENSG00000131747
TOP2A
Endometrial Cancer
26588239
ENSG00000131747
TOP2A
breast cancer
26608463
ENSG00000131747
TOP2A
non-small cell lung cancer
26617887
ENSG00000131747
TOP2A
cancer
26801902
ENSG00000131747
TOP2A
tumor
26824188
ENSG00000131747
TOP2A
tumor
26867764
ENSG00000131747
TOP2A
Breast cancer
26892392
ENSG00000131747
TOP2A
Gastrointestinal stromal tumors
26952515
ENSG00000131747
TOP2A
tumours
26994023
ENSG00000131747
TOP2A
breast cancer
27004791
ENSG00000131747
TOP2A
breast cancer
27009862
ENSG00000131747
TOP2A
triple negative breast cancer
27045718
ENSG00000131747
TOP2A
tumor
27072583
ENSG00000131747
TOP2A
tumour
27099339
ENSG00000131747
TOP2A
lung cancer
27121056
ENSG00000131747
TOP2A
cancer
27127018
ENSG00000131747
TOP2A
cervical cancer
27175798
ENSG00000131747
TOP2A
tumors
27184134
ENSG00000131747
TOP2A
tumor
27259241
ENSG00000131747
TOP2A
tumor
27315793
ENSG00000131747
TOP2A
Tumors
27329168
ENSG00000131747
TOP2A
cancer
27347171
ENSG00000131747
TOP2A
breast cancer
27441238
ENSG00000131747
TOP2A
tumor
27470985
ENSG00000131747
TOP2A
tumor
27503929
ENSG00000131747
TOP2A
breast cancer
27530622
ENSG00000131747
TOP2A
cancer
27557643
ENSG00000131747
TOP2A
tumour
27558965
ENSG00000131747
TOP2A
breast cancer
27576528
ENSG00000131747
TOP2A
breast cancer
27612420
ENSG00000131747
TOP2A
breast cancer
27695115
ENSG00000131747
TOP2A
breast cancer
27799773
ENSG00000131747
TOP2A
neuroblastic tumors
27821228
ENSG00000131747
TOP2A
tumor
27895586
ENSG00000131747
TOP2A
tumor
27924308
ENSG00000131747
TOP2A
tumour
27958275
ENSG00000131747
TOP2A
tumor
28025079
ENSG00000131747
TOP2A
tumor
28036271
ENSG00000131747
TOP2A
tumor
28052097
ENSG00000131747
TOP2A
gastric cancer
28056823
ENSG00000131747
TOP2A
cancer
28069330
ENSG00000131747
TOP2A
colorectal cancer
28072746
ENSG00000131747
TOP2A
breast cancer
28075472
ENSG00000131747
TOP2A
gastric cancer
28078044
ENSG00000131747
TOP2A
gastric cancer
28078605
ENSG00000131747
TOP2A
tumors
28079792
ENSG00000131747
TOP2A
tumor
28106765
ENSG00000131747
TOP2A
breast cancer
28127549
ENSG00000131747
TOP2A
pancreatic cancer
28223795
ENSG00000131747
TOP2A
tumor
28231233
ENSG00000131747
TOP2A
cancer
28260099
ENSG00000131747
TOP2A
cancers
28265354
ENSG00000131747
TOP2A
tumors
28355294
ENSG00000131747
TOP2A
triple-negative breast cancer
28409241
ENSG00000131747
TOP2A
cancer
28410543
ENSG00000131747
TOP2A
tumors
28432084
ENSG00000131747
TOP2A
Cancer
28454340
ENSG00000131747
TOP2A
tumor
28479381
ENSG00000131747
TOP2A
cancer
28503091
ENSG00000131747
TOP2A
cancer
28611105
ENSG00000131747
TOP2A
Breast Cancer
28661759
ENSG00000131747
TOP2A
breast cancer
28721363
ENSG00000131747
TOP2A
gallbladder cancers
28728050
ENSG00000131747
TOP2A
Colon Cancer
28736844
ENSG00000131747
TOP2A
breast cancer
28754978
ENSG00000131747
TOP2A
tumors
28755093
ENSG00000131747
TOP2A
breast cancer
28794467
ENSG00000131747
TOP2A
cancer
28794488
ENSG00000131747
TOP2A
malignant peripheral nerve sheath tumors
28813519
ENSG00000131747
TOP2A
breast cancer
28832682
ENSG00000131747
TOP2A
cancer
28839115
ENSG00000131747
TOP2A
Prostate Cancer
28899973
ENSG00000131747
TOP2A
tumor
28901457
ENSG00000131747
TOP2A
gastric cancer
28915696
ENSG00000131747
TOP2A
Cancer
28969025
ENSG00000131747
TOP2A
liver cancer
28977866
ENSG00000131747
TOP2A
pancreatic cancer
29045811
ENSG00000131747
TOP2A
cervical cancer
29103025
ENSG00000131747
TOP2A
Cancer
29108454
ENSG00000131747
TOP2A
tumor
29283334
ENSG00000131747
TOP2A
breast cancers
29323058
ENSG00000131747
TOP2A
breast cancer
29330624
ENSG00000131747
TOP2A
cancer
29335461
ENSG00000131747
TOP2A
tumor
29338072
ENSG00000131747
TOP2A
breast cancer
29417930
ENSG00000131747
TOP2A
laryngeal cancer
29439529
ENSG00000131747
TOP2A
tumors
29456350
ENSG00000131747
TOP2A
tumor
29487694
ENSG00000131747
TOP2A
cancer
29516929
ENSG00000131747
TOP2A
breast cancer
29530933
ENSG00000131747
TOP2A
pancreatic cancer
29546614
ENSG00000131747
TOP2A
tumor
29559845
ENSG00000131747
TOP2A
cancer
29574079
ENSG00000131747
TOP2A
luminal breast cancer
29587760
ENSG00000131747
TOP2A
cancer
29651323
ENSG00000131747
TOP2A
prostate cancer
29666839
ENSG00000131747
TOP2A
cancer
29670361
ENSG00000131747
TOP2A
tumour
29757235
ENSG00000131747
TOP2A
colon cancer
29761838
ENSG00000131747
TOP2A
tumor
29805517
ENSG00000131747
TOP2A
liver cancers
29843214
ENSG00000131747
TOP2A
tumor
29846894
ENSG00000131747
TOP2A
tumors
29869738
ENSG00000131747
TOP2A
cancers
29923182
ENSG00000131747
TOP2A
breast cancer
29928479
ENSG00000131747
TOP2A
cancer
29937926
ENSG00000131747
TOP2A
cancers
29966298
ENSG00000131747
TOP2A
GBM
29988316
ENSG00000131747
TOP2A
tumor
30001383
ENSG00000131747
TOP2A
breast cancer
30038716
ENSG00000131747
TOP2A
tumors
30054102
ENSG00000131747
TOP2A
AML
30066086
ENSG00000131747
TOP2A
cancer
30110445
ENSG00000131747
TOP2A
tumor
30132517
ENSG00000131747
TOP2A
cancer
30214555
ENSG00000131747
TOP2A
AML
30223465
ENSG00000131747
TOP2A
liver cancer
30296239
ENSG00000131747
TOP2A
gastric cancer
30336538
ENSG00000131747
TOP2A
cancer
30369945
ENSG00000131747
TOP2A
tumors
30385370
ENSG00000131747
TOP2A
GBM
30405856
ENSG00000131747
TOP2A
cancers
30410353
ENSG00000131747
TOP2A
tumour
30423952
ENSG00000131747
TOP2A
ovarian cancer
30453999
ENSG00000131747
TOP2A
tumor
30519354
ENSG00000131747
TOP2A
Breast Cancer
30520947
ENSG00000131747
TOP2A
cancer
30522956
ENSG00000131747
TOP2A
tumor
30538542
ENSG00000131747
TOP2A
tumor
30544723
ENSG00000131747
TOP2A
tumor
30583686
ENSG00000131747
TOP2A
bladder cancer
30588253
ENSG00000131747
TOP2A
cancer
30672125
ENSG00000131747
TOP2A
epithelial ovarian cancers
30760286
ENSG00000131747
TOP2A
tumors
30774662
ENSG00000131747
TOP2A
cancer
30886771
ENSG00000131747
TOP2A
tumor
30903644
ENSG00000131747
TOP2A
Cancer
30998359
ENSG00000131747
TOP2A
liver cancer
31001331
ENSG00000131747
TOP2A
pancreatic cancer
31061236
ENSG00000131747
TOP2A
tumor
31083655
ENSG00000131747
TOP2A
cancer
31089686
ENSG00000131747
TOP2A
colon cancer
31105744
ENSG00000131747
TOP2A
cancer
31139019
ENSG00000131747
TOP2A
ER+ breast cancer
31186766
ENSG00000131747
TOP2A
bladder cancer
31216997
ENSG00000131747
TOP2A
tumors
31251311
ENSG00000131747
TOP2A
cancer
31258761
ENSG00000131747
TOP2A
cancer
31271486
ENSG00000131747
TOP2A
cancer
31277155
ENSG00000131747
TOP2A
bladder cancer
31289523
ENSG00000131747
TOP2A
cancer
31292488
ENSG00000131747
TOP2A
breast cancer
31293425
ENSG00000131747
TOP2A
tumors
31301170
ENSG00000131747
TOP2A
tumour
31301217
ENSG00000131747
TOP2A
tumor
31318878
ENSG00000131747
TOP2A
tumor
31412643
ENSG00000131747
TOP2A
tumors
31422942
ENSG00000131747
TOP2A
breast cancer
31423162
ENSG00000131747
TOP2A
breast cancer
31428132
ENSG00000131747
TOP2A
tumor
31479512
ENSG00000131747
TOP2A
tumor
31505165
ENSG00000131747
TOP2A
cancer
31523390
ENSG00000131747
TOP2A
non-small cell lung cancer
31528121
ENSG00000131747
TOP2A
tumours
31537838
ENSG00000131747
TOP2A
prostate cancer
31545448
ENSG00000131747
TOP2A
cancers
31545466
ENSG00000131747
TOP2A
GBM
31611967
ENSG00000131747
TOP2A
papillary thyroid cancer
31614754
ENSG00000131747
TOP2A
tumor
31662984
ENSG00000131747
TOP2A
cancers
31675229
ENSG00000131747
TOP2A
esophageal cancer
31720085
ENSG00000131747
TOP2A
cancer
31729978
ENSG00000131747
TOP2A
tumor
31737106
ENSG00000131747
TOP2A
tumor
31771612
ENSG00000131747
TOP2A
breast cancer
31777591
ENSG00000131747
TOP2A
non-small cell lung cancer
31797573
ENSG00000131747
TOP2A
lung cancer
31816603
ENSG00000131747
TOP2A
cancers
31938217
ENSG00000131747
TOP2A
tumors
31949927
ENSG00000131747
TOP2A
prostate cancer
31967940
ENSG00000131747
TOP2A
tumor
31980218
ENSG00000131747
TOP2A
cancers
9795238
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000131747
TOP2A
SARC
0.00055
high
show
ENSG00000131747
TOP2A
CHOL
0.039
high
show
ENSG00000131747
TOP2A
UVM
0.00012
high
show
ENSG00000131747
TOP2A
UCEC
0.0081
high
show
ENSG00000131747
TOP2A
LUSC
0.0036
low
show
ENSG00000131747
TOP2A
HNSC
0.012
high
show
ENSG00000131747
TOP2A
READ
0.00011
low
show
ENSG00000131747
TOP2A
LUAD
3e-04
high
show
ENSG00000131747
TOP2A
PCPG
0.00062
high
show
ENSG00000131747
TOP2A
THYM
0.0018
low
show
ENSG00000131747
TOP2A
COAD
0.019
low
show
ENSG00000131747
TOP2A
OV
0.034
low
show
ENSG00000131747
TOP2A
BLCA
0.027
high
show
ENSG00000131747
TOP2A
SKCM
0.026
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000131747
TOP2A
ACC
Del
2.749976
0.173224
0.594263
0.277778
ENSG00000131747
TOP2A
READ
Amp
1.221755
0.151875
0.617296
0.254545
ENSG00000131747
TOP2A
COAD
Amp
5.196879
0.144112
0.587511
0.243902
ENSG00000131747
TOP2A
SARC
Del
0.964450
0.129749
0.446833
0.256809
ENSG00000131747
TOP2A
ESCA
Amp
7.224665
0.565367
0.865368
0.380435
ENSG00000131747
TOP2A
PCPG
Del
4.109698
0.118290
0.652802
0.216049
ENSG00000131747
TOP2A
BRCA
Amp
14.084582
0.301616
0.827692
0.245370
ENSG00000131747
TOP2A
BRCA
Del
3.671016
0.085409
0.426148
0.298148
ENSG00000131747
TOP2A
STAD
Amp
24.009647
0.526140
0.913016
0.285714
ENSG00000131747
TOP2A
UCEC
Amp
0.701571
0.102683
0.784791
0.079777
ENSG00000131747
TOP2A
UCEC
Del
3.104082
0.073516
0.566221
0.194805
Copyright © 2023, Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.