Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43SARS-COV-2
Drug N.A.
Main interacting RNAs snoRNA
Moonlighting functions Transmemebrane
Localizations Stress granucleFibrillar center
BulkPerturb-seq DataSet_01_264 DataSet_01_386

Description

Ensembl ID ENSG00000130826 Gene ID 1736 Accession 2890
Symbol DKC1 Alias DKC;CBF5;DKCX;NAP57;NOLA4;CHINE1;XAP101 Full Name dyskerin pseudouridine synthase 1
Status Confidence Length 14934 bases Strand Plus strand
Position X : 154762756 - 154777689 RNA binding domain PUA , TruB_N , DKCLD
Summary This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000512732 TruB_N PF01509 1.4e-21 1
ENSP00000512732 DKCLD PF08068 1.1e-30 2
ENSP00000512764 TruB_N PF01509 3.3e-21 1
ENSP00000512764 PUA PF01472 1e-17 2
ENSP00000512764 DKCLD PF08068 4.4e-31 3
ENSP00000512733 TruB_N PF01509 4.5e-21 1
ENSP00000512733 PUA PF01472 1e-17 2
ENSP00000512733 DKCLD PF08068 7.4e-26 3
ENSP00000512736 TruB_N PF01509 5.1e-21 1
ENSP00000512736 PUA PF01472 1.1e-17 2
ENSP00000512736 DKCLD PF08068 5.7e-31 3
ENSP00000512730 TruB_N PF01509 5.3e-21 1
ENSP00000512730 PUA PF01472 1.1e-17 2
ENSP00000512730 DKCLD PF08068 5.9e-31 3
ENSP00000358563 TruB_N PF01509 5.6e-21 1
ENSP00000358563 PUA PF01472 1.1e-17 2
ENSP00000358563 DKCLD PF08068 6e-31 3
ENSP00000512731 TruB_N PF01509 6.5e-21 1
ENSP00000512731 PUA PF01472 1.3e-17 2
ENSP00000512731 DKCLD PF08068 5.8e-31 3
ENSP00000512765 TruB_N PF01509 6.7e-21 1
ENSP00000512765 PUA PF01472 1.3e-17 2
ENSP00000512765 DKCLD PF08068 5.9e-31 3
ENSP00000512735 TruB_N PF01509 1.4e-19 1
ENSP00000512735 DKCLD PF08068 7.1e-31 2
ENSP00000400542 TruB_N PF01509 6.1e-19 1
ENSP00000400542 PUA PF01472 1e-17 2
ENSP00000400542 DKCLD PF08068 3.7e-31 3
ENSP00000512737 TruB_N PF01509 4.2e-15 1
ENSP00000512737 PUA PF01472 9.9e-18 2
ENSP00000512737 DKCLD PF08068 4.9e-31 3
ENSP00000407253 TruB_N PF01509 7e-12 1
ENSP00000407253 DKCLD PF08068 5.5e-31 2
ENSP00000513251 PUA PF01472 1.3e-17 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
27197171 MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin. Rosemary O'Brien 2016-06-15 Cancer research
32868896 The nucleolar-related protein Dyskerin pseudouridine synthase 1 (DKC1) predicts poor prognosis in breast cancer. A Khloud Elsharawy 2020-11-01 British journal of cancer
22500192 Telomeres in disease. Rodrigo Calado 2012-01-01 F1000 medicine reports
22287629 DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster. Yuliang Wu 2012-05-01 Nucleic acids research
37626880 An Update on Nucleolar Stress: The Transcriptional Control of Autophagy. S Astrid Pfister 2023-08-15 Cells
34699328 Pseudogene fms-related tyrosine kinase 1 pseudogene 1 (FLT1P1) cooperates with RNA binding protein dyskeratosis congenita 1 (DKC1) to restrain trophoblast cell proliferation and angiogenesis by targeting fms-related tyrosine kinase 1 (FLT1) in preeclampsia. Zhenjing Chi 2021-12-01 Bioengineered
30047419 Evaluation and Management of Hematopoietic Failure in Dyskeratosis Congenita. Suneet Agarwal 2018-08-01 Hematology/oncology clinics of North America
29055871 Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening. Santiago José Ibáñez-Cabellos 2018-04-01 Redox biology
34638933 RNA Modifications and Epigenetics in Modulation of Lung Cancer and Pulmonary Diseases. Pai-Chi Teng 2021-09-30 International journal of molecular sciences
20164838 Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Suneet Agarwal 2010-03-11 Nature
33461542 The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities. Paz Nombela 2021-01-18 Molecular cancer
25407680 The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells. W Yick Fong 2014-11-19 eLife
35348914 Functions of ADP-ribose transferases in the maintenance of telomere integrity. Daniela Muoio 2022-03-29 Cellular and molecular life sciences : CMLS
34095104 PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins. V Nikita Savelyev 2021-01-01 Frontiers in cell and developmental biology
31026227 Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging. Zsofia Turi 2019-04-26 Aging
36732018 Loss of dyskerin facilitates the acquisition of metastatic traits by altering the mevalonate pathway. Evelyn Andrades 2023-04-01 Life science alliance
31080456 Small Non-coding RNAs: New Class of Biomarkers and Potential Therapeutic Targets in Neurodegenerative Disease. N Callum Watson 2019-01-01 Frontiers in genetics
35463902 Case Report: A Missense Mutation in Dyskeratosis Congenita 1 Leads to a Benign Form of Dyskeratosis Congenita Syndrome With the Mucocutaneous Triad. Liqing Wang 2022-01-01 Frontiers in pediatrics
35205419 Epigenetic and Epitranscriptomic Control in Prostate Cancer. Judith López 2022-02-18 Genes
25992652 Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients. Bai-Wei Gu 2015-01-01 PloS one
32778592 Epigenetic loss of the transfer RNA-modifying enzyme TYW2 induces ribosome frameshifts in colon cancer. Margalida Rosselló-Tortella 2020-08-25 Proceedings of the National Academy of Sciences of the United States of America

Transcripts

Name Transcript ID bp Protein Translation ID
DKC1-212 ENST00000620277 3079 No protein -
DKC1-203 ENST00000413910 2516 380aa ENSP00000400542
DKC1-204 ENST00000426673 2571 183aa ENSP00000407253
DKC1-207 ENST00000475423 587 No protein -
DKC1-213 ENST00000696575 2004 509aa ENSP00000512730
DKC1-214 ENST00000696576 1181 No protein -
DKC1-215 ENST00000696577 2867 504aa ENSP00000512731
DKC1-216 ENST00000696578 2322 308aa ENSP00000512732
DKC1-217 ENST00000696579 3357 No protein -
DKC1-201 ENST00000369550 2469 514aa ENSP00000358563
DKC1-218 ENST00000696580 2354 485aa ENSP00000512733
DKC1-219 ENST00000696581 2553 49aa ENSP00000512734
DKC1-220 ENST00000696582 2292 220aa ENSP00000512735
DKC1-221 ENST00000696583 2384 501aa ENSP00000512736
DKC1-206 ENST00000473552 656 No protein -
DKC1-231 ENST00000696627 2419 390aa ENSP00000512764
DKC1-232 ENST00000696628 2412 508aa ENSP00000512765
DKC1-222 ENST00000696584 2363 No protein -
DKC1-223 ENST00000696585 2482 No protein -
DKC1-224 ENST00000696586 2256 No protein -
DKC1-225 ENST00000696587 2236 474aa ENSP00000512737
DKC1-226 ENST00000696588 3463 311aa ENSP00000513251
DKC1-205 ENST00000437719 686 No protein -
DKC1-202 ENST00000412124 670 No protein -
DKC1-210 ENST00000484317 2617 No protein -
DKC1-227 ENST00000696589 2116 No protein -
DKC1-228 ENST00000696590 3368 No protein -
DKC1-208 ENST00000475966 902 No protein -
DKC1-229 ENST00000696591 1687 No protein -
DKC1-230 ENST00000696592 5107 No protein -
DKC1-209 ENST00000481062 819 No protein -
DKC1-211 ENST00000492372 1303 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000130826

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000130826homo_sapiensENSP0000035856399.805599.6109nomascus_leucogenysENSNLEP0000001743199.805599.6109
ENSG00000130826homo_sapiensENSP0000035856399.805599.6109pan_paniscusENSPPAP0000000588799.805599.6109
ENSG00000130826homo_sapiensENSP0000035856399.805599.8055pongo_abeliiENSPPYP0000002338799.805599.8055
ENSG00000130826homo_sapiensENSP00000358563100100pan_troglodytesENSPTRP00000038696100100
ENSG00000130826homo_sapiensENSP0000035856398.832798.6381pan_troglodytesENSPTRP0000007021885.95685.7868
ENSG00000130826homo_sapiensENSP00000358563100100gorilla_gorillaENSGGOP00000017399100100
ENSG00000130826homo_sapiensENSP0000035856389.299685.7977ornithorhynchus_anatinusENSOANP0000001388188.953585.4651
ENSG00000130826homo_sapiensENSP0000035856388.521481.323sarcophilus_harrisiiENSSHAP0000000278576.858170.6081
ENSG00000130826homo_sapiensENSP0000035856377.431973.5409notamacropus_eugeniiENSMEUP0000000098687.089782.7133
ENSG00000130826homo_sapiensENSP0000035856395.136292.4125dasypus_novemcinctusENSDNOP0000000324895.321692.5926
ENSG00000130826homo_sapiensENSP0000035856378.210175.4864erinaceus_europaeusENSEEUP0000000304294.811391.5094
ENSG00000130826homo_sapiensENSP0000035856386.96583.463echinops_telfairiENSETEP0000001305690.853787.1951
ENSG00000130826homo_sapiensENSP0000035856399.027299.0272callithrix_jacchusENSCJAP0000005565994.259394.2593
ENSG00000130826homo_sapiensENSP0000035856399.805599.2218cercocebus_atysENSCATP0000001964599.805599.2218
ENSG00000130826homo_sapiensENSP0000035856310099.4163macaca_mulattaENSMMUP0000007262292.44691.9065
ENSG00000130826homo_sapiensENSP0000035856310099.4163macaca_nemestrinaENSMNEP0000002153810099.4163
ENSG00000130826homo_sapiensENSP0000035856392.023390.856papio_anubisENSPANP0000005513299.78998.5232
ENSG00000130826homo_sapiensENSP0000035856310099.4163papio_anubisENSPANP0000001492310099.4163
ENSG00000130826homo_sapiensENSP0000035856310099.4163mandrillus_leucophaeusENSMLEP0000002047110099.4163
ENSG00000130826homo_sapiensENSP0000035856369.066167.5097tursiops_truncatusENSTTRP0000000766470.29768.7129
ENSG00000130826homo_sapiensENSP0000035856380.933973.5409vulpes_vulpesENSVVUP0000002963185.071677.3006
ENSG00000130826homo_sapiensENSP0000035856394.747192.0233vulpes_vulpesENSVVUP0000002832583.965581.5517
ENSG00000130826homo_sapiensENSP0000035856394.163491.0506mus_spretusMGP_SPRETEiJ_P009573194.90291.7647
ENSG00000130826homo_sapiensENSP0000035856384.046782.6848equus_asinusENSEASP000050105499694.4444
ENSG00000130826homo_sapiensENSP0000035856394.163492.0233capra_hircusENSCHIP0000001763395.652293.4783
ENSG00000130826homo_sapiensENSP0000035856393.968990.6615loxodonta_africanaENSLAFP0000000017893.968990.6615
ENSG00000130826homo_sapiensENSP0000035856394.941692.8016panthera_leoENSPLOP0000001415794.390792.2631
ENSG00000130826homo_sapiensENSP0000035856392.217990.0778ailuropoda_melanoleucaENSAMEP0000002698786.338884.3352
ENSG00000130826homo_sapiensENSP0000035856394.552592.0233bos_indicus_hybridENSBIXP0000500613996.047493.4783
ENSG00000130826homo_sapiensENSP0000035856396.498193.7743oryctolagus_cuniculusENSOCUP0000001972896.87594.1406
ENSG00000130826homo_sapiensENSP0000035856392.023390.6615equus_caballusENSECAP0000002115094.789693.3868
ENSG00000130826homo_sapiensENSP0000035856394.941692.2179canis_lupus_familiarisENSCAFP0084504151494.390791.6828
ENSG00000130826homo_sapiensENSP0000035856395.136292.9961panthera_pardusENSPPRP0000001696796.449794.2801
ENSG00000130826homo_sapiensENSP0000035856329.57228.5992marmota_marmota_marmotaENSMMMP0000000318797.435994.2308
ENSG00000130826homo_sapiensENSP0000035856353.696550.5837marmota_marmota_marmotaENSMMMP0000000050091.694486.3787
ENSG00000130826homo_sapiensENSP0000035856395.525393.3852balaenoptera_musculusENSBMSP0001002958297.227795.0495
ENSG00000130826homo_sapiensENSP0000035856395.914493.9689cavia_porcellusENSCPOP0000000792396.101494.152
ENSG00000130826homo_sapiensENSP0000035856389.299685.6031felis_catusENSFCAP0000005572280.809977.4648
ENSG00000130826homo_sapiensENSP0000035856392.412590.4669ursus_americanusENSUAMP0000002986388.454486.5922
ENSG00000130826homo_sapiensENSP0000035856385.797779.9611monodelphis_domesticaENSMODP0000001153976.695771.4783
ENSG00000130826homo_sapiensENSP0000035856395.330792.8016monodon_monocerosENSMMNP0001501856997.029794.4554
ENSG00000130826homo_sapiensENSP0000035856395.525393.1907sus_scrofaENSSSCP0000001363394.241891.9386
ENSG00000130826homo_sapiensENSP0000035856378.988376.4591microcebus_murinusENSMICP0000000256992.482989.5216
ENSG00000130826homo_sapiensENSP0000035856395.330793.3852microcebus_murinusENSMICP0000001666494.412392.4855
ENSG00000130826homo_sapiensENSP0000035856394.35890.856octodon_degusENSODEP0000001605595.09891.5686
ENSG00000130826homo_sapiensENSP000003585635049.6109octodon_degusENSODEP0000000065698.846298.0769
ENSG00000130826homo_sapiensENSP0000035856323.540921.5953jaculus_jaculusENSJJAP0000000403993.798486.0465
ENSG00000130826homo_sapiensENSP0000035856349.805449.0272jaculus_jaculusENSJJAP0000000513598.841797.2973
ENSG00000130826homo_sapiensENSP0000035856391.634288.9105ovis_aries_rambouilletENSOARP0002001983187.546584.9442
ENSG00000130826homo_sapiensENSP0000035856392.023390.0778ursus_maritimusENSUMAP0000002351388.081986.2197
ENSG00000130826homo_sapiensENSP0000035856379.182975.4864ochotona_princepsENSOPRP0000000482581.237577.4451
ENSG00000130826homo_sapiensENSP0000035856384.241280.9339delphinapterus_leucasENSDLEP0000001580385.573182.2134
ENSG00000130826homo_sapiensENSP0000035856395.136292.9961physeter_catodonENSPCTP0000502086096.831794.6535
ENSG00000130826homo_sapiensENSP0000035856385.603182.2957mus_caroliMGP_CAROLIEiJ_P009197092.43788.8655
ENSG00000130826homo_sapiensENSP0000035856393.968991.0506mus_musculusENSMUSP0000003377694.891991.945
ENSG00000130826homo_sapiensENSP0000035856349.805448.4436dipodomys_ordiiENSDORP0000001275998.461595.7692
ENSG00000130826homo_sapiensENSP0000035856394.941692.8016mustela_putorius_furoENSMPUP0000001602990.53888.4972
ENSG00000130826homo_sapiensENSP0000035856398.832797.6654aotus_nancymaaeENSANAP0000000950298.832797.6654
ENSG00000130826homo_sapiensENSP0000035856399.027298.8327saimiri_boliviensis_boliviensisENSSBOP0000003520498.83598.6408
ENSG00000130826homo_sapiensENSP0000035856337.743237.5486vicugna_pacosENSVPAP0000000301563.606663.2787
ENSG00000130826homo_sapiensENSP0000035856310099.4163chlorocebus_sabaeusENSCSAP0000000299210099.4163
ENSG00000130826homo_sapiensENSP0000035856368.482566.3424tupaia_belangeriENSTBEP0000000973396.969793.9394
ENSG00000130826homo_sapiensENSP0000035856349.805448.8327mesocricetus_auratusENSMAUP0000001764398.461596.5385
ENSG00000130826homo_sapiensENSP0000035856395.330792.607phocoena_sinusENSPSNP0000003110397.029794.2574
ENSG00000130826homo_sapiensENSP0000035856395.136292.9961camelus_dromedariusENSCDRP0000502477895.882493.7255
ENSG00000130826homo_sapiensENSP0000035856398.24995.3307carlito_syrichtaENSTSYP0000000704896.37493.5115
ENSG00000130826homo_sapiensENSP0000035856390.85689.2996panthera_tigris_altaicaENSPTIP0000001980694.343492.7273
ENSG00000130826homo_sapiensENSP0000035856390.077881.9066rattus_norvegicusENSRNOP0000007400590.962782.7112
ENSG00000130826homo_sapiensENSP0000035856395.525393.5798prolemur_simusENSPSMP0000001739594.60592.6782
ENSG00000130826homo_sapiensENSP0000035856348.443647.0817microtus_ochrogasterENSMOCP0000000152498.031595.2756
ENSG00000130826homo_sapiensENSP0000035856386.96582.2957sorex_araneusENSSARP0000000166589.221684.4311
ENSG00000130826homo_sapiensENSP0000035856391.245188.1323peromyscus_maniculatus_bairdiiENSPEMP0000001327291.42388.3041
ENSG00000130826homo_sapiensENSP0000035856379.766579.3774bos_mutusENSBMUP0000000888297.61997.1429
ENSG00000130826homo_sapiensENSP0000035856317.898817.7043mus_spicilegusENSMSIP0000000223597.872396.8085
ENSG00000130826homo_sapiensENSP0000035856394.941691.6342cricetulus_griseus_chok1gshdENSCGRP0000101344495.126791.8129
ENSG00000130826homo_sapiensENSP0000035856370.817163.4241cricetulus_griseus_chok1gshdENSCGRP0000101647588.564579.3187
ENSG00000130826homo_sapiensENSP0000035856392.217990.2724pteropus_vampyrusENSPVAP0000000869894.892.8
ENSG00000130826homo_sapiensENSP0000035856389.688785.7977myotis_lucifugusENSMLUP0000001086788.996185.1351
ENSG00000130826homo_sapiensENSP0000035856387.743281.5175vombatus_ursinusENSVURP0001002493875.041669.7171
ENSG00000130826homo_sapiensENSP0000035856393.190790.4669rhinolophus_ferrumequinumENSRFEP0001000375995.99293.1864
ENSG00000130826homo_sapiensENSP0000035856391.245187.7432neovison_visonENSNVIP0000003066372.713269.9225
ENSG00000130826homo_sapiensENSP0000035856394.552592.0233bos_taurusENSBTAP0000001733996.047493.4783
ENSG00000130826homo_sapiensENSP0000035856395.914493.3852heterocephalus_glaber_femaleENSHGLP0000003220473.363171.4286
ENSG00000130826homo_sapiensENSP0000035856310099.4163rhinopithecus_bietiENSRBIP0000000918386.097285.5946
ENSG00000130826homo_sapiensENSP0000035856385.603178.0156canis_lupus_dingoENSCAFP0002001164786.44478.7819
ENSG00000130826homo_sapiensENSP0000035856394.941692.2179canis_lupus_dingoENSCAFP0002001102494.390791.6828
ENSG00000130826homo_sapiensENSP0000035856398.054596.1089sciurus_vulgarisENSSVLP0000502081998.054596.1089
ENSG00000130826homo_sapiensENSP0000035856385.992280.1556phascolarctos_cinereusENSPCIP0000002205874.161169.1275
ENSG00000130826homo_sapiensENSP0000035856373.9372.3735procavia_capensisENSPCAP0000001406374.074172.5146
ENSG00000130826homo_sapiensENSP0000035856349.416348.8327nannospalax_galiliENSNGAP0000001440998.069596.9112
ENSG00000130826homo_sapiensENSP0000035856394.35892.2179bos_grunniensENSBGRP0000002856995.660893.4911
ENSG00000130826homo_sapiensENSP0000035856394.552592.8016chinchilla_lanigeraENSCLAP0000000092695.85894.0828
ENSG00000130826homo_sapiensENSP0000035856395.525393.1907cervus_hanglu_yarkandensisENSCHYP0000003085696.274593.9216
ENSG00000130826homo_sapiensENSP0000035856395.136293.3852catagonus_wagneriENSCWAP0000000037095.694793.9335
ENSG00000130826homo_sapiensENSP0000035856392.023390.4669ictidomys_tridecemlineatusENSSTOP0000000095897.125395.4825
ENSG00000130826homo_sapiensENSP0000035856386.96584.0467ictidomys_tridecemlineatusENSSTOP0000001067390.669487.6268
ENSG00000130826homo_sapiensENSP0000035856389.105186.3813ictidomys_tridecemlineatusENSSTOP0000001693094.43391.5464
ENSG00000130826homo_sapiensENSP0000035856396.498193.9689otolemur_garnettiiENSOGAP0000000303494.837592.3518
ENSG00000130826homo_sapiensENSP0000035856390.661590.6615cebus_imitatorENSCCAP0000001916099.148999.1489
ENSG00000130826homo_sapiensENSP0000035856397.665495.7198urocitellus_parryiiENSUPAP0001000344395.61993.7143
ENSG00000130826homo_sapiensENSP0000035856394.163491.8288moschus_moschiferusENSMMSP0000001464694.90292.549
ENSG00000130826homo_sapiensENSP0000035856310099.4163rhinopithecus_roxellanaENSRROP0000004347610099.4163
ENSG00000130826homo_sapiensENSP0000035856394.35891.0506mus_pahariMGP_PahariEiJ_P008959894.911991.5851
ENSG00000130826homo_sapiensENSP0000035856397.081794.7471propithecus_coquereliENSPCOP0000002846997.081794.7471
ENSG00000130826homo_sapiensENSP0000035856368.67756.2257caenorhabditis_elegansK01G5.5.179.325864.9438
ENSG00000130826homo_sapiensENSP0000035856378.599265.3697drosophila_melanogasterFBpp029008379.527666.1417
ENSG00000130826homo_sapiensENSP0000035856381.517570.2335ciona_intestinalisENSCINP0000000950279.356168.3712
ENSG00000130826homo_sapiensENSP0000035856318.67715.3696eptatretus_burgeriENSEBUP0000002253462.745151.634
ENSG00000130826homo_sapiensENSP0000035856359.533151.5564eptatretus_burgeriENSEBUP0000002589387.179575.4986
ENSG00000130826homo_sapiensENSP0000035856338.71632.4903eptatretus_burgeriENSEBUP0000002605770.818559.4306
ENSG00000130826homo_sapiensENSP0000035856383.657675.6809callorhinchus_miliiENSCMIP0000000856780.524372.8464
ENSG00000130826homo_sapiensENSP0000035856384.824977.821latimeria_chalumnaeENSLACP0000001592786.16679.0514
ENSG00000130826homo_sapiensENSP0000035856385.21477.2374lepisosteus_oculatusENSLOCP0000001692781.412673.7918
ENSG00000130826homo_sapiensENSP0000035856383.073974.1245clupea_harengusENSCHAP0000002110779.220870.6865
ENSG00000130826homo_sapiensENSP0000035856384.824975.2918danio_rerioENSDARP0000000762886.16676.4822
ENSG00000130826homo_sapiensENSP0000035856383.852175.8755carassius_auratusENSCARP0000003055478.079770.6522
ENSG00000130826homo_sapiensENSP0000035856385.408677.0428carassius_auratusENSCARP0000009155383.778675.5725
ENSG00000130826homo_sapiensENSP0000035856384.630376.07astyanax_mexicanusENSAMXP0000001765884.139375.6286
ENSG00000130826homo_sapiensENSP0000035856383.268574.5136ictalurus_punctatusENSIPUP0000001515571.812164.2617
ENSG00000130826homo_sapiensENSP0000035856381.517572.9572esox_luciusENSELUP0000004509280.732272.2543
ENSG00000130826homo_sapiensENSP0000035856381.906674.1245electrophorus_electricusENSEEEP0000004332280.190572.5714
ENSG00000130826homo_sapiensENSP0000035856384.824974.9027oncorhynchus_kisutchENSOKIP0000510745682.575872.9167
ENSG00000130826homo_sapiensENSP0000035856384.046774.1245oncorhynchus_kisutchENSOKIP0000510642274.8766.0312
ENSG00000130826homo_sapiensENSP0000035856383.852173.7354oncorhynchus_mykissENSOMYP0000010585986.372775.9519
ENSG00000130826homo_sapiensENSP0000035856383.268572.9572oncorhynchus_mykissENSOMYP0000005254478.821469.0608
ENSG00000130826homo_sapiensENSP0000035856382.879473.7354salmo_salarENSSSAP0000007264385.542276.1044
ENSG00000130826homo_sapiensENSP0000035856385.019574.5136salmo_salarENSSSAP0000010990179.454569.6364
ENSG00000130826homo_sapiensENSP0000035856384.435874.7082salmo_truttaENSSTUP0000002356185.770875.8893
ENSG00000130826homo_sapiensENSP0000035856384.630374.1245salmo_truttaENSSTUP0000005035882.699672.4335
ENSG00000130826homo_sapiensENSP0000035856379.57271.5953gadus_morhuaENSGMOP0000006292977.169869.434
ENSG00000130826homo_sapiensENSP0000035856380.544771.5953fundulus_heteroclitusENSFHEP0000000372277.673569.0432
ENSG00000130826homo_sapiensENSP0000035856381.906673.93poecilia_reticulataENSPREP0000000598276.130268.7161
ENSG00000130826homo_sapiensENSP0000035856379.766571.7899xiphophorus_maculatusENSXMAP0000002356182.329374.0964
ENSG00000130826homo_sapiensENSP0000035856380.933971.2062oryzias_latipesENSORLP0000002341782.051372.1893
ENSG00000130826homo_sapiensENSP0000035856381.517572.7626cyclopterus_lumpusENSCLMP0000503240585.510276.3265
ENSG00000130826homo_sapiensENSP0000035856384.046776.2646oreochromis_niloticusENSONIP0000001746286.227578.2435
ENSG00000130826homo_sapiensENSP0000035856384.435875.4864haplochromis_burtoniENSHBUP0000002858686.877.6
ENSG00000130826homo_sapiensENSP0000035856378.404771.0117astatotilapia_callipteraENSACLP0000002302682.077474.3381
ENSG00000130826homo_sapiensENSP0000035856381.128472.7626lates_calcariferENSLCAP0001004824282.248573.7673
ENSG00000130826homo_sapiensENSP0000035856386.96576.6537xenopus_tropicalisENSXETP0000009078172.801364.1694
ENSG00000130826homo_sapiensENSP0000035856385.992278.9883chrysemys_picta_belliiENSCPBP0000000744180.072573.5507
ENSG00000130826homo_sapiensENSP0000035856388.71681.9066sphenodon_punctatusENSSPUP0000002468186.69280.038
ENSG00000130826homo_sapiensENSP0000035856388.132380.5447crocodylus_porosusENSCPRP0000501428680.60573.6655
ENSG00000130826homo_sapiensENSP0000035856385.797778.4047laticauda_laticaudataENSLLTP0000000214285.964978.5575
ENSG00000130826homo_sapiensENSP0000035856385.992278.2101notechis_scutatusENSNSUP0000000011786.159878.3626
ENSG00000130826homo_sapiensENSP0000035856378.599273.1517pseudonaja_textilisENSPTXP0000000627987.06981.0345
ENSG00000130826homo_sapiensENSP0000035856324.319122.179anas_platyrhynchos_platyrhynchosENSAPLP0000002081791.240983.2117
ENSG00000130826homo_sapiensENSP0000035856389.688781.1284gallus_gallusENSGALP0001002164083.666175.6806
ENSG00000130826homo_sapiensENSP0000035856386.96578.7938meleagris_gallopavoENSMGAP0000000955380.685973.1047
ENSG00000130826homo_sapiensENSP0000035856379.961173.5409serinus_canariaENSSCAP0000002372085.803878.9144
ENSG00000130826homo_sapiensENSP0000035856384.630376.07parus_majorENSPMJP0000001599684.960976.3672
ENSG00000130826homo_sapiensENSP0000035856387.159579.9611anolis_carolinensisENSACAP0000001538077.374870.9845
ENSG00000130826homo_sapiensENSP0000035856378.015669.4553neolamprologus_brichardiENSNBRP0000000720081.010172.1212
ENSG00000130826homo_sapiensENSP0000035856386.186879.1829naja_najaENSNNAP0000001764286.186879.1829
ENSG00000130826homo_sapiensENSP0000035856378.015670.8171podarcis_muralisENSPMRP0000003162076.091169.0702
ENSG00000130826homo_sapiensENSP0000035856376.653770.0389geospiza_fortisENSGFOP0000000306888.93981.2641
ENSG00000130826homo_sapiensENSP0000035856389.494279.9611taeniopygia_guttataENSTGUP0000000698389.320479.8058
ENSG00000130826homo_sapiensENSP0000035856385.992278.7938erpetoichthys_calabaricusENSECRP0000002301183.712176.7045
ENSG00000130826homo_sapiensENSP0000035856382.295773.5409kryptolebias_marmoratusENSKMAP0000001067185.110776.0563
ENSG00000130826homo_sapiensENSP0000035856385.992279.9611salvator_merianaeENSSMRP0000001687885.992279.9611
ENSG00000130826homo_sapiensENSP0000035856379.766569.4553oryzias_javanicusENSOJAP0000000966675.091665.3846
ENSG00000130826homo_sapiensENSP0000035856381.128472.9572amphilophus_citrinellusENSACIP0000002924486.87578.125
ENSG00000130826homo_sapiensENSP0000035856384.824975.6809dicentrarchus_labraxENSDLAP0000501202886.507977.1825
ENSG00000130826homo_sapiensENSP0000035856384.630375.6809amphiprion_perculaENSAPEP0000000319285.629976.5748
ENSG00000130826homo_sapiensENSP0000035856382.295772.179oryzias_sinensisENSOSIP0000002646975.942666.6068
ENSG00000130826homo_sapiensENSP0000035856371.400865.9533pelodiscus_sinensisENSPSIP0000001538888.009681.295
ENSG00000130826homo_sapiensENSP0000035856385.797779.1829gopherus_evgoodeiENSGEVP0000501247080.036373.8657
ENSG00000130826homo_sapiensENSP0000035856384.630376.6537chelonoidis_abingdoniiENSCABP0000001832480.85573.2342
ENSG00000130826homo_sapiensENSP0000035856384.046775.2918seriola_dumeriliENSSDUP0000001370686.055877.0916
ENSG00000130826homo_sapiensENSP0000035856381.906672.7626cottoperca_gobioENSCGOP0000002735584.368774.9499
ENSG00000130826homo_sapiensENSP0000035856374.319168.2879struthio_camelus_australisENSSCUP0000002618386.621379.5918
ENSG00000130826homo_sapiensENSP0000035856385.21477.6265anser_brachyrhynchusENSABRP0000002439884.55677.027
ENSG00000130826homo_sapiensENSP0000035856373.735467.8988gasterosteus_aculeatusENSGACP0000000578591.545984.2995
ENSG00000130826homo_sapiensENSP0000035856378.793871.0117cynoglossus_semilaevisENSCSEP0000001980085.987377.4947
ENSG00000130826homo_sapiensENSP0000035856381.906673.93poecilia_formosaENSPFOP0000001877184.276
ENSG00000130826homo_sapiensENSP0000035856382.490373.3463myripristis_murdjanENSMMDP0000501584967.948760.4167
ENSG00000130826homo_sapiensENSP0000035856377.237468.2879sander_luciopercaENSSLUP0000001007179.718970.4819
ENSG00000130826homo_sapiensENSP0000035856388.910580.3502strigops_habroptilaENSSHBP0000502342583.853275.7798
ENSG00000130826homo_sapiensENSP0000035856384.630375.6809amphiprion_ocellarisENSAOCP0000000906881.005672.4395
ENSG00000130826homo_sapiensENSP0000035856388.521481.7121terrapene_carolina_triunguisENSTMTP0000000502788.178381.3953
ENSG00000130826homo_sapiensENSP0000035856384.046774.3191hucho_huchoENSHHUP0000003539086.055876.0956
ENSG00000130826homo_sapiensENSP0000035856384.630374.1245hucho_huchoENSHHUP0000001646186.138675.4455
ENSG00000130826homo_sapiensENSP0000035856382.684874.1245betta_splendensENSBSLP0000001391583.497174.8527
ENSG00000130826homo_sapiensENSP0000035856385.21476.4591pygocentrus_nattereriENSPNAP0000000379284.069175.4319
ENSG00000130826homo_sapiensENSP0000035856378.988371.0117anabas_testudineusENSATEP0000004312982.020273.7374
ENSG00000130826homo_sapiensENSP0000035856377.82166.9261ciona_savignyiENSCSAVP0000001708978.431467.451
ENSG00000130826homo_sapiensENSP0000035856372.17958.7549saccharomyces_cerevisiaeYLR175W76.811662.5259
ENSG00000130826homo_sapiensENSP0000035856380.155672.3735seriola_lalandi_dorsalisENSSLDP0000002489685.833377.5
ENSG00000130826homo_sapiensENSP0000035856380.739373.7354labrus_bergyltaENSLBEP0000002502785.215677.8234
ENSG00000130826homo_sapiensENSP0000035856380.544772.5681pundamilia_nyerereiENSPNYP0000002663482.470174.3028
ENSG00000130826homo_sapiensENSP0000035856381.712172.3735mastacembelus_armatusENSMAMP0000006058178.212369.2737
ENSG00000130826homo_sapiensENSP0000035856380.544772.3735stegastes_partitusENSSPAP0000000355679.007670.9924
ENSG00000130826homo_sapiensENSP0000035856384.824974.7082oncorhynchus_tshawytschaENSOTSP0000506415082.889773.0038
ENSG00000130826homo_sapiensENSP0000035856380.350270.8171oncorhynchus_tshawytschaENSOTSP0000500981576.058967.035
ENSG00000130826homo_sapiensENSP0000035856384.824975.8755acanthochromis_polyacanthusENSAPOP0000000603085.826876.7717
ENSG00000130826homo_sapiensENSP0000035856378.599272.179aquila_chrysaetos_chrysaetosENSACCP0002002149289.183281.8985
ENSG00000130826homo_sapiensENSP0000035856379.766571.0117nothobranchius_furzeriENSNFUP0001501187084.362175.1029
ENSG00000130826homo_sapiensENSP0000035856381.517573.5409cyprinodon_variegatusENSCVAP0000000836381.996173.9726
ENSG00000130826homo_sapiensENSP0000035856376.848367.8988denticeps_clupeoidesENSDCDP0000001911880.777171.3701
ENSG00000130826homo_sapiensENSP0000035856380.544771.9844larimichthys_croceaENSLCRP0000504404081.017672.407
ENSG00000130826homo_sapiensENSP0000035856382.684873.7354takifugu_rubripesENSTRUP0000001048885.513176.2575
ENSG00000130826homo_sapiensENSP0000035856382.295773.5409ficedula_albicollisENSFALP0000002733066.300959.2477
ENSG00000130826homo_sapiensENSP0000035856384.046774.5136hippocampus_comesENSHCOP0000000011085.714375.9921
ENSG00000130826homo_sapiensENSP0000035856384.435876.2646cyprinus_carpio_carpioENSCCRP0000013964179.341971.6636
ENSG00000130826homo_sapiensENSP0000035856384.630376.07cyprinus_carpio_carpioENSCCRP0000014670480.70572.5417
ENSG00000130826homo_sapiensENSP0000035856381.712174.5136coturnix_japonicaENSCJPP0000501269879.847972.8137
ENSG00000130826homo_sapiensENSP0000035856381.906673.93poecilia_latipinnaENSPLAP0000002039276.130268.7161
ENSG00000130826homo_sapiensENSP0000035856379.766571.7899sinocyclocheilus_grahamiENSSGRP0000007870084.188975.77
ENSG00000130826homo_sapiensENSP0000035856385.21476.07sinocyclocheilus_grahamiENSSGRP0000008237486.220576.9685
ENSG00000130826homo_sapiensENSP0000035856384.435875.6809maylandia_zebraENSMZEP0000501933186.877.8
ENSG00000130826homo_sapiensENSP0000035856373.151762.8405tetraodon_nigroviridisENSTNIP0000000513474.308363.834
ENSG00000130826homo_sapiensENSP0000035856383.657676.07paramormyrops_kingsleyaeENSPKIP0000002567776.106269.2035
ENSG00000130826homo_sapiensENSP0000035856380.739372.5681scleropages_formosusENSSFOP0001504881779.198571.1832
ENSG00000130826homo_sapiensENSP0000035856383.268573.3463leptobrachium_leishanenseENSLLEP0000004824584.418174.359
ENSG00000130826homo_sapiensENSP0000035856381.517572.179scophthalmus_maximusENSSMAP0000000415280.114770.9369
ENSG00000130826homo_sapiensENSP0000035856380.544771.7899oryzias_melastigmaENSOMEP0000002486776.102967.8309

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000455involved_in enzyme-directed rRNA pseudouridine synthesis1IMPHomo_sapiens(9606)Process
GO:0000495involved_in box H/ACA RNA 3-end processing1IBAHomo_sapiens(9606)Process
GO:0001650located_in fibrillar center1IDAHomo_sapiens(9606)Component
GO:0003720contributes_to telomerase activity2IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding2HDA,IPIHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005697part_of telomerase holoenzyme complex3IDA,NAS,TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IEAHomo_sapiens(9606)Component
GO:0006364involved_in rRNA processing1TASHomo_sapiens(9606)Process
GO:0006396involved_in RNA processing1TASHomo_sapiens(9606)Process
GO:0007004involved_in telomere maintenance via telomerase3IDA,IMP,NASHomo_sapiens(9606)Process
GO:0009982enables pseudouridine synthase activity2IBA,IMPHomo_sapiens(9606)Function
GO:0031118involved_in rRNA pseudouridine synthesis1IBAHomo_sapiens(9606)Process
GO:0031120involved_in snRNA pseudouridine synthesis1IBAHomo_sapiens(9606)Process
GO:0031429part_of box H/ACA snoRNP complex3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0032212involved_in positive regulation of telomere maintenance via telomerase1IEAHomo_sapiens(9606)Process
GO:0034513enables box H/ACA snoRNA binding1IPIHomo_sapiens(9606)Function
GO:0051973involved_in positive regulation of telomerase activity1IMPHomo_sapiens(9606)Process
GO:0070034enables telomerase RNA binding2IC,IPIHomo_sapiens(9606)Function
GO:0072589part_of box H/ACA scaRNP complex1TASHomo_sapiens(9606)Component
GO:0090661part_of box H/ACA telomerase RNP complex2IDA,TASHomo_sapiens(9606)Component
GO:0090666involved_in scaRNA localization to Cajal body1IMPHomo_sapiens(9606)Process
GO:0090669involved_in telomerase RNA stabilization1IMPHomo_sapiens(9606)Process
GO:1904851involved_in positive regulation of establishment of protein localization to telomere1IMPHomo_sapiens(9606)Process
GO:1904871involved_in positive regulation of protein localization to Cajal body1HMPHomo_sapiens(9606)Process
GO:1904872involved_in regulation of telomerase RNA localization to Cajal body1IMPHomo_sapiens(9606)Process
GO:1904874involved_in positive regulation of telomerase RNA localization to Cajal body2HMP,IMPHomo_sapiens(9606)Process
GO:1990481involved_in mRNA pseudouridine synthesis1IBAHomo_sapiens(9606)Process

Expression