Ensembl ID ENSG00000130826 Gene ID 1736 Accession 2890
Gene Symbol DKC1 Alias DKC;CBF5;DKCX;NAP57;NOLA4;CHINE1;XAP101 Full Name dyskerin pseudouridine synthase 1
Position X : 154762756 - 154777689 Length 14934 bases Strand Plus strand
Status Confidence Main interacting RNAssnoRNARBP type Canonical_RBPs
Summary This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

ENSG00000130826 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000130826 DKC1 0.71 6.04e-31 BRCA
ENSG00000130826 DKC1 1.47 4.77e-73 COAD
ENSG00000130826 DKC1 1.39 2.04e-21 READ
ENSG00000130826 DKC1 1.78 2.14e-89 LUSC
ENSG00000130826 DKC1 0.46 9.63e-19 PRAD
ENSG00000130826 DKC1 0.54 7.29e-11 LIHC
ENSG00000130826 DKC1 1.24 1.67e-28 STAD
ENSG00000130826 DKC1 0.61 5.44e-11 UCEC
ENSG00000130826 DKC1 1.12 1.53e-47 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000130826 DKC1 tumor 12522253
ENSG00000130826 DKC1 cancer 12915101
ENSG00000130826 DKC1 cancer 15613268
ENSG00000130826 DKC1 cancer 16690864
ENSG00000130826 DKC1 breast cancer 16841302
ENSG00000130826 DKC1 tumour 17539775
ENSG00000130826 DKC1 cancers 17822678
ENSG00000130826 DKC1 colorectal cancer 18607840
ENSG00000130826 DKC1 tumors 18851746
ENSG00000130826 DKC1 Breast Cancer 18936525
ENSG00000130826 DKC1 prostate cancer 19755982
ENSG00000130826 DKC1 acute myeloid leukemia (AML) 19796246
ENSG00000130826 DKC1 colon cancer 20127035
ENSG00000130826 DKC1 tumor 20332657
ENSG00000130826 DKC1 cancer 20501855
ENSG00000130826 DKC1 tumor 20587522
ENSG00000130826 DKC1 cancer 20925138
ENSG00000130826 DKC1 cancer 21241452
ENSG00000130826 DKC1 tumor 21480387
ENSG00000130826 DKC1 tumor 21502955
ENSG00000130826 DKC1 tumor 21820037
ENSG00000130826 DKC1 cancer 21931702
ENSG00000130826 DKC1 tumor 22652042
ENSG00000130826 DKC1 prostate cancer 22912812
ENSG00000130826 DKC1 lung cancer 23233094
ENSG00000130826 DKC1 cancer 23348390
ENSG00000130826 DKC1 breast cancer 23821664
ENSG00000130826 DKC1 cancers 24468621
ENSG00000130826 DKC1 cancers 24690175
ENSG00000130826 DKC1 cancer 25010840
ENSG00000130826 DKC1 tumor 25232701
ENSG00000130826 DKC1 turban tumor syndrome 25802699
ENSG00000130826 DKC1 cancer 25934701
ENSG00000130826 DKC1 cancer 26286192
ENSG00000130826 DKC1 lung cancer 26301749
ENSG00000130826 DKC1 cancer 26366868
ENSG00000130826 DKC1 tumor 27197171
ENSG00000130826 DKC1 cancer 27252909
ENSG00000130826 DKC1 tumor 27824399
ENSG00000130826 DKC1 cancer 27911188
ENSG00000130826 DKC1 breast cancer 28054974
ENSG00000130826 DKC1 tumour 28443573
ENSG00000130826 DKC1 tumor 28666010
ENSG00000130826 DKC1 cancer 29051281
ENSG00000130826 DKC1 tumor 29104216
ENSG00000130826 DKC1 cancers 29132127
ENSG00000130826 DKC1 tumor 29874862
ENSG00000130826 DKC1 Cancer 29901172
ENSG00000130826 DKC1 Cancer 30340325
ENSG00000130826 DKC1 tumor 30847721
ENSG00000130826 DKC1 tumors 30862090
ENSG00000130826 DKC1 rectal cancer 30914599
ENSG00000130826 DKC1 cancer 31026227
ENSG00000130826 DKC1 rectal cancer 31027506
ENSG00000130826 DKC1 cancers 31157162
ENSG00000130826 DKC1 cancer 31479877
ENSG00000130826 DKC1 prostate cancer 31511832
ENSG00000130826 DKC1 cancer 31750255
ENSG00000130826 DKC1 colorectal cancer 31857720
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000130826 DKC1 MESO 2e-04 high
ENSG00000130826 DKC1 SARC 0.001 high
ENSG00000130826 DKC1 CHOL 0.031 high
ENSG00000130826 DKC1 PAAD 0.0057 high
ENSG00000130826 DKC1 LGG 0.00016 high
ENSG00000130826 DKC1 LUSC 0.034 low
ENSG00000130826 DKC1 HNSC 0.00023 high
ENSG00000130826 DKC1 READ 0.029 low
ENSG00000130826 DKC1 KICH 0.00047 high
ENSG00000130826 DKC1 LUAD 0.044 high
ENSG00000130826 DKC1 BRCA 0.012 high
ENSG00000130826 DKC1 COAD 0.048 high
ENSG00000130826 DKC1 UCS 0.032 high
ENSG00000130826 DKC1 ESCA 0.0012 high
ENSG00000130826 DKC1 OV 0.029 low
ENSG00000130826 DKC1 PRAD 0.0027 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency