RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000129521	Gene ID	112399	Accession	14661
Symbol	EGLN3	Alias	PHD3;HIFPH3;HIFP4H3	Full Name	egl-9 family hypoxia inducible factor 3
Status	Confidence	Length	298651 bases	Strand	Minus strand
Position	14 : 33924227 - 34222877	RNA binding domain	2OG-FeII_Oxy
Summary	Enables peptidyl-proline 4-dioxygenase activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and response to hypoxia. Located in cytosol and nucleus. Implicated in renal cell carcinoma. Biomarker of clear cell renal cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

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Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000447470	2OG-FeII_Oxy	PF03171	1.9e-05	1

Showing 1 to 1 of 1 entries

Pubmed ID	Full Name	Cell	Author	Time	Doi
No data available in table

Pubmed ID	Title	Author	Time	Journal
No data available in table

Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
EGLN3-201	ENST00000250457	2706	239aa	ENSP00000250457
EGLN3-202	ENST00000464521	352	No protein	-
EGLN3-203	ENST00000487915	848	79aa	ENSP00000451316
EGLN3-204	ENST00000546681	581	No protein	-
EGLN3-205	ENST00000547327	2849	148aa	ENSP00000446572
EGLN3-206	ENST00000548285	535	No protein	-
EGLN3-207	ENST00000550114	566	No protein	-
EGLN3-208	ENST00000551935	575	No protein	-
EGLN3-209	ENST00000553215	1004	145aa	ENSP00000447470
EGLN3-210	ENST00000556785	864	No protein	-

Showing 1 to 10 of 11 entries

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Gene Model

Click here to download ENSG00000129521's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
6448	Fibrinogen	5.07816651189167E-5	17903294
6464	Fibrinogen	2.38174494351447E-6	17903294
8497	Varicose Veins	8.3543782868123E-5	-
10782	Osteoporosis	6.49678632189676E-5	17903295
11587	Mental Competency	1.84886412635623E-6	17903295
15931	Stroke	5.5631319E-005	19369658
16872	Neuroblastoma	1.71e-005	23222812
23879	Waist-Hip Ratio	4.4450000E-006	-
25328	Waist-Hip Ratio	1.0540000E-005	-
30420	Basophils	4.4380000E-005	-

Showing 1 to 10 of 24 entries

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GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000129521	rs1958581	14	34332393	Age-related hearing impairment	24939585	0.1353	EFO_0005782
ENSG00000129521	rs57574493	14	34149063	Daytime sleep phenotypes	27126917	0.6878	EFO_0007828
ENSG00000129521	rs797324	14	34136247	Daytime sleep phenotypes	27126917	0.5679	EFO_0007828
ENSG00000129521	rs1958589	14	34375170	Celiac disease	23936387		EFO_0001060
ENSG00000129521	rs191936903	14	34027246	3-hydroxy-1-methylpropylmercapturic acid levels in smokers	26053186	1.1003	EFO_0004318\|EFO_0007015
ENSG00000129521	rs10142635	14	34423401	Heart rate response to beta blockers (atenolol add-on therapy)	29478026	6.61	EFO_0007766\|EFO_0004326
ENSG00000129521	rs76827035	14	34324633	Eotaxin levels	27989323	0.1776	EFO_0008122
ENSG00000129521	rs797343	14	34177063	Hematocrit	27863252	0.02249192	EFO_0004348
ENSG00000129521	rs12879626	14	34251928	Intraocular pressure	29785010	0.079	EFO_0004695
ENSG00000129521	rs74412765	14	34053698	Reasoning	29907492	1.7	EFO_0004350

Showing 1 to 10 of 12 entries

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000129521's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
No data available in table

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
No data available in table

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0018401	involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0031545	enables peptidyl-proline 4-dioxygenase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0001666	involved_in response to hypoxia	1	IEP	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0006915	involved_in apoptotic process	1	IEP	Homo_sapiens(9606)	Process
GO:0006919	involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	1	IEP	Homo_sapiens(9606)	Process

Showing 1 to 10 of 18 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression