Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000129071 Gene ID 8930 Accession 6919
Symbol MBD4 Alias MED1;UVM1;TPDS2 Full Name methyl-CpG binding domain 4, DNA glycosylase
Status Confidence Length 9233 bases Strand Minus strand
Position 3 : 129430947 - 129440179 RNA binding domain MBD
Summary The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000394080 MBD PF01429 2.4e-20 1
ENSP00000424873 MBD PF01429 4.5e-20 1
ENSP00000422327 MBD PF01429 5.1e-20 1
ENSP00000249910 MBD PF01429 5.2e-20 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
33876188 Low-dose decitabine modulates T-cell homeostasis and restores immune tolerance in immune thrombocytopenia. Panpan Han 2021-08-26 Blood

Transcripts

Name Transcript ID bp Protein Translation ID
MBD4-203 ENST00000429544 2394 574aa ENSP00000394080
MBD4-201 ENST00000249910 2470 580aa ENSP00000249910
MBD4-202 ENST00000393278 1684 262aa ENSP00000376959
MBD4-204 ENST00000503197 2099 540aa ENSP00000424873
MBD4-208 ENST00000509828 576 52aa ENSP00000422690
MBD4-206 ENST00000507208 2194 572aa ENSP00000422327
MBD4-209 ENST00000511009 530 No protein -
MBD4-210 ENST00000515266 434 No protein -
MBD4-207 ENST00000509587 643 No protein -
MBD4-205 ENST00000505883 613 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000129071homo_sapiensENSP0000039553533.734919.4779homo_sapiensENSP0000039408029.268316.899

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000129071homo_sapiensENSP0000039408098.257897.2125nomascus_leucogenysENSNLEP0000000647797.577996.5398
ENSG00000129071homo_sapiensENSP0000039408010099.6516pan_paniscusENSPPAP0000002690010099.6516
ENSG00000129071homo_sapiensENSP0000039408098.954797.561pongo_abeliiENSPPYP0000001500599.127497.7312
ENSG00000129071homo_sapiensENSP0000039408099.825899.4773pan_troglodytesENSPTRP0000002648998.793198.4483
ENSG00000129071homo_sapiensENSP0000039408099.303198.6063gorilla_gorillaENSGGOP0000002413798.275997.5862
ENSG00000129071homo_sapiensENSP0000039408065.156852.2648ornithorhynchus_anatinusENSOANP0000000727568.623955.0459
ENSG00000129071homo_sapiensENSP0000039408062.543652.9617sarcophilus_harrisiiENSSHAP0000001518768.121457.685
ENSG00000129071homo_sapiensENSP0000039408033.10127.3519notamacropus_eugeniiENSMEUP0000001424251.630442.663
ENSG00000129071homo_sapiensENSP0000039408065.156859.9303choloepus_hoffmanniENSCHOP0000000299064.930659.7222
ENSG00000129071homo_sapiensENSP0000039408079.790973.1707dasypus_novemcinctusENSDNOP0000003255379.238872.6644
ENSG00000129071homo_sapiensENSP0000039408068.815358.7108erinaceus_europaeusENSEEUP0000001044473.283962.5232
ENSG00000129071homo_sapiensENSP0000039408090.940888.3275callithrix_jacchusENSCJAP0000003183791.418688.7916
ENSG00000129071homo_sapiensENSP0000039408095.99393.7282cercocebus_atysENSCATP0000002330096.328794.0559
ENSG00000129071homo_sapiensENSP0000039408095.121993.2056macaca_mulattaENSMMUP0000001670595.454593.5315
ENSG00000129071homo_sapiensENSP0000039408091.289289.1986macaca_nemestrinaENSMNEP0000001073193.738891.5921
ENSG00000129071homo_sapiensENSP0000039408090.418186.4111papio_anubisENSPANP0000005900277.462774.0299
ENSG00000129071homo_sapiensENSP0000039408095.99393.554mandrillus_leucophaeusENSMLEP0000000574496.328793.8811
ENSG00000129071homo_sapiensENSP0000039408082.752675.4355tursiops_truncatusENSTTRP0000001068185.278377.7379
ENSG00000129071homo_sapiensENSP0000039408085.017476.6551vulpes_vulpesENSVVUP0000001926185.61477.193
ENSG00000129071homo_sapiensENSP0000039408073.867665.5052mus_spretusMGP_SPRETEiJ_P007867076.672767.9928
ENSG00000129071homo_sapiensENSP0000039408083.275376.1324equus_asinusENSEASP0000502164374.687568.2812
ENSG00000129071homo_sapiensENSP0000039408078.745670.5575capra_hircusENSCHIP0000000571681.588473.1047
ENSG00000129071homo_sapiensENSP0000039408083.275375.4355loxodonta_africanaENSLAFP0000000888384.00776.0984
ENSG00000129071homo_sapiensENSP0000039408085.888578.9199panthera_leoENSPLOP0000000287886.339879.3345
ENSG00000129071homo_sapiensENSP0000039408085.714378.9199ailuropoda_melanoleucaENSAMEP0000000480586.467579.6134
ENSG00000129071homo_sapiensENSP0000039408077.526168.8153bos_indicus_hybridENSBIXP0000504241670.300262.4013
ENSG00000129071homo_sapiensENSP0000039408077.526170.7317oryctolagus_cuniculusENSOCUP0000004346869.968663.8365
ENSG00000129071homo_sapiensENSP0000039408082.2375.6098equus_caballusENSECAP0000006674876.375470.2265
ENSG00000129071homo_sapiensENSP0000039408085.017477.0035canis_lupus_familiarisENSCAFP0084503916585.464177.4081
ENSG00000129071homo_sapiensENSP0000039408085.714378.5714panthera_pardusENSPPRP0000002597787.23479.9645
ENSG00000129071homo_sapiensENSP0000039408082.926873.5192marmota_marmota_marmotaENSMMMP0000001234183.950674.4268
ENSG00000129071homo_sapiensENSP0000039408018.815318.4669balaenoptera_musculusENSBMSP0001001440410098.1481
ENSG00000129071homo_sapiensENSP0000039408028.571427.3519cavia_porcellusENSCPOP0000000447493.181889.2045
ENSG00000129071homo_sapiensENSP0000039408085.888579.2683felis_catusENSFCAP0000000007786.339879.6848
ENSG00000129071homo_sapiensENSP0000039408074.738769.8606ursus_americanusENSUAMP0000000082487.372781.6701
ENSG00000129071homo_sapiensENSP0000039408018.815317.9443monodelphis_domesticaENSMODP0000003362110095.3704
ENSG00000129071homo_sapiensENSP0000039408033.797924.0418monodelphis_domesticaENSMODP0000005751052.150537.0968
ENSG00000129071homo_sapiensENSP0000039408080.139471.9512bison_bison_bisonENSBBBP0000000258182.289873.8819
ENSG00000129071homo_sapiensENSP0000039408086.062777.5261monodon_monocerosENSMMNP0001501648685.763977.2569
ENSG00000129071homo_sapiensENSP0000039408084.146375.9582sus_scrofaENSSSCP0000005253385.185276.8959
ENSG00000129071homo_sapiensENSP0000039408088.67682.0557microcebus_murinusENSMICP0000002331788.521781.913
ENSG00000129071homo_sapiensENSP0000039408018.466918.1185octodon_degusENSODEP0000000379298.148196.2963
ENSG00000129071homo_sapiensENSP0000039408029.616728.223jaculus_jaculusENSJJAP0000001416496.590992.0455
ENSG00000129071homo_sapiensENSP0000039408072.473965.331ovis_aries_rambouilletENSOARP0002003354282.051373.9645
ENSG00000129071homo_sapiensENSP0000039408084.494878.3972ursus_maritimusENSUMAP0000002409285.992979.7872
ENSG00000129071homo_sapiensENSP0000039408073.344965.1568ochotona_princepsENSOPRP0000000043774.250465.9612
ENSG00000129071homo_sapiensENSP0000039408085.714377.5261delphinapterus_leucasENSDLEP0000001135486.164677.9334
ENSG00000129071homo_sapiensENSP0000039408086.062777.5261physeter_catodonENSPCTP0000500839185.763977.2569
ENSG00000129071homo_sapiensENSP0000039408075.609866.3763mus_caroliMGP_CAROLIEiJ_P007559976.950467.5532
ENSG00000129071homo_sapiensENSP0000039408074.041866.0279mus_musculusENSMUSP0000003246976.714868.4116
ENSG00000129071homo_sapiensENSP0000039408058.188251.9164dipodomys_ordiiENSDORP0000000084773.085365.2079
ENSG00000129071homo_sapiensENSP0000039408083.972176.3066mustela_putorius_furoENSMPUP0000001708785.309777.5221
ENSG00000129071homo_sapiensENSP0000039408082.578478.5714aotus_nancymaaeENSANAP0000000069689.43485.0943
ENSG00000129071homo_sapiensENSP0000039408092.682989.1986saimiri_boliviensis_boliviensisENSSBOP0000000350492.844789.3543
ENSG00000129071homo_sapiensENSP0000039408049.825846.5157vicugna_pacosENSVPAP0000000375351.811648.3696
ENSG00000129071homo_sapiensENSP0000039408095.644693.3798chlorocebus_sabaeusENSCSAP0000000528895.97993.7063
ENSG00000129071homo_sapiensENSP0000039408062.543651.7422tupaia_belangeriENSTBEP0000000262162.652751.8325
ENSG00000129071homo_sapiensENSP0000039408028.919927.8746mesocricetus_auratusENSMAUP0000001450494.857191.4286
ENSG00000129071homo_sapiensENSP0000039408086.236978.5714phocoena_sinusENSPSNP0000003155985.788678.1629
ENSG00000129071homo_sapiensENSP0000039408081.184775.0871camelus_dromedariusENSCDRP0000502644479.117173.1749
ENSG00000129071homo_sapiensENSP0000039408018.815318.2927carlito_syrichtaENSTSYP0000001022510097.2222
ENSG00000129071homo_sapiensENSP0000039408018.815318.2927panthera_tigris_altaicaENSPTIP0000001175710097.2222
ENSG00000129071homo_sapiensENSP0000039408074.738766.5505rattus_norvegicusENSRNOP0000009200672.711964.7458
ENSG00000129071homo_sapiensENSP0000039408089.721382.9268prolemur_simusENSPSMP0000000135489.254882.4957
ENSG00000129071homo_sapiensENSP0000039408041.811833.101microtus_ochrogasterENSMOCP0000000309465.753452.0548
ENSG00000129071homo_sapiensENSP0000039408061.846753.6585sorex_araneusENSSARP0000000407561.739153.5652
ENSG00000129071homo_sapiensENSP0000039408074.912965.8537peromyscus_maniculatus_bairdiiENSPEMP0000000411776.785767.5
ENSG00000129071homo_sapiensENSP0000039408079.094171.0801bos_mutusENSBMUP0000001406682.097673.7794
ENSG00000129071homo_sapiensENSP0000039408073.867665.5052mus_spicilegusENSMSIP0000000079176.534367.87
ENSG00000129071homo_sapiensENSP0000039408075.958266.899cricetulus_griseus_chok1gshdENSCGRP0000100301177.857168.5714
ENSG00000129071homo_sapiensENSP0000039408087.282279.9652pteropus_vampyrusENSPVAP0000000495786.979279.6875
ENSG00000129071homo_sapiensENSP0000039408082.578475.4355myotis_lucifugusENSMLUP0000001343987.453979.8893
ENSG00000129071homo_sapiensENSP0000039408018.641117.5958vombatus_ursinusENSVURP0001001869399.074193.5185
ENSG00000129071homo_sapiensENSP0000039408084.320677.3519rhinolophus_ferrumequinumENSRFEP0001002710685.361578.3069
ENSG00000129071homo_sapiensENSP0000039408083.972175.9582neovison_visonENSNVIP0000001158085.008876.8959
ENSG00000129071homo_sapiensENSP0000039408079.094171.6028bos_taurusENSBTAP0000002884481.949574.1877
ENSG00000129071homo_sapiensENSP0000039408081.533172.2997heterocephalus_glaber_femaleENSHGLP0000005533182.539773.1922
ENSG00000129071homo_sapiensENSP0000039408096.167294.4251rhinopithecus_bietiENSRBIP0000000764596.503594.7552
ENSG00000129071homo_sapiensENSP0000039408085.017477.0035canis_lupus_dingoENSCAFP0002000874185.61477.5439
ENSG00000129071homo_sapiensENSP0000039408081.707373.1707sciurus_vulgarisENSSVLP0000502449081.99373.4266
ENSG00000129071homo_sapiensENSP0000039408034.146325.2613phascolarctos_cinereusENSPCIP0000000277252.406438.7701
ENSG00000129071homo_sapiensENSP0000039408018.641117.77phascolarctos_cinereusENSPCIP0000000276799.074194.4444
ENSG00000129071homo_sapiensENSP0000039408075.958268.4669procavia_capensisENSPCAP0000001204979.272771.4545
ENSG00000129071homo_sapiensENSP0000039408024.390223.3449nannospalax_galiliENSNGAP0000001673392.715288.7417
ENSG00000129071homo_sapiensENSP0000039408079.790971.777bos_grunniensENSBGRP0000003803082.671574.3682
ENSG00000129071homo_sapiensENSP0000039408078.571469.8606chinchilla_lanigeraENSCLAP0000001300479.82370.9734
ENSG00000129071homo_sapiensENSP0000039408078.048868.9895cervus_hanglu_yarkandensisENSCHYP0000002216381.306771.8693
ENSG00000129071homo_sapiensENSP0000039408018.815318.2927catagonus_wagneriENSCWAP0000002391410097.2222
ENSG00000129071homo_sapiensENSP0000039408048.606341.9861catagonus_wagneriENSCWAP0000002393776.229565.847
ENSG00000129071homo_sapiensENSP0000039408082.404273.3449ictidomys_tridecemlineatusENSSTOP0000001663384.313775.0446
ENSG00000129071homo_sapiensENSP0000039408082.926876.6551otolemur_garnettiiENSOGAP0000000915887.020180.4388
ENSG00000129071homo_sapiensENSP0000039408092.682989.1986cebus_imitatorENSCCAP0000002402391.882688.4283
ENSG00000129071homo_sapiensENSP0000039408048.954740.7666urocitellus_parryiiENSUPAP0001002927375.335162.7346
ENSG00000129071homo_sapiensENSP0000039408018.815318.2927urocitellus_parryiiENSUPAP0001002926610097.2222
ENSG00000129071homo_sapiensENSP0000039408079.268370.2091moschus_moschiferusENSMMSP0000003264581.395372.093
ENSG00000129071homo_sapiensENSP0000039408096.167294.2509rhinopithecus_roxellanaENSRROP0000000938796.503594.5804
ENSG00000129071homo_sapiensENSP0000039408045.818837.4564mus_pahariMGP_PahariEiJ_P005179865.914853.8847
ENSG00000129071homo_sapiensENSP0000039408018.641118.4669propithecus_coquereliENSPCOP0000001386699.074198.1481
ENSG00000129071homo_sapiensENSP000003940805037.2822xenopus_tropicalisENSXETP0000005604660.805145.339
ENSG00000129071homo_sapiensENSP0000039408061.672546.8641chrysemys_picta_belliiENSCPBP0000002044161.996547.1103
ENSG00000129071homo_sapiensENSP0000039408057.665544.2509sphenodon_punctatusENSSPUP0000002258459.747345.8484
ENSG00000129071homo_sapiensENSP0000039408057.317144.0767crocodylus_porosusENSCPRP0000501807057.922544.5423
ENSG00000129071homo_sapiensENSP0000039408040.243930.3136laticauda_laticaudataENSLLTP0000001427753.846240.5594
ENSG00000129071homo_sapiensENSP0000039408017.7715.5052notechis_scutatusENSNSUP0000000806493.57881.6514
ENSG00000129071homo_sapiensENSP0000039408040.766631.1847pseudonaja_textilisENSPTXP0000000396254.418641.6279
ENSG00000129071homo_sapiensENSP0000039408017.073214.9826anas_platyrhynchos_platyrhynchosENSAPLP0000000372490.740779.6296
ENSG00000129071homo_sapiensENSP0000039408040.418131.8815gallus_gallusENSGALP0001002754952.96841.7808
ENSG00000129071homo_sapiensENSP0000039408031.707328.223meleagris_gallopavoENSMGAP0000001063437.142933.0612
ENSG00000129071homo_sapiensENSP0000039408043.902434.669serinus_canariaENSSCAP0000002214264.781551.1568
ENSG00000129071homo_sapiensENSP0000039408037.10829.4425parus_majorENSPMJP0000000726161.383348.7032
ENSG00000129071homo_sapiensENSP0000039408048.606339.547anolis_carolinensisENSACAP0000001446853.346143.4034
ENSG00000129071homo_sapiensENSP0000039408052.961739.8955podarcis_muralisENSPMRP0000000749155.272741.6364
ENSG00000129071homo_sapiensENSP0000039408017.247414.8084geospiza_fortisENSGFOP0000001399191.666778.7037
ENSG00000129071homo_sapiensENSP0000039408049.651638.5017taeniopygia_guttataENSTGUP0000001080849.738238.5689
ENSG00000129071homo_sapiensENSP0000039408055.574940.9408salvator_merianaeENSSMRP0000000360860.188744.3396
ENSG00000129071homo_sapiensENSP0000039408060.45347.0383pelodiscus_sinensisENSPSIP0000000865759.114145.9966
ENSG00000129071homo_sapiensENSP0000039408061.149847.2125gopherus_evgoodeiENSGEVP0000501044661.471147.4606
ENSG00000129071homo_sapiensENSP0000039408060.801446.8641chelonoidis_abingdoniiENSCABP0000000185059.965646.2199
ENSG00000129071homo_sapiensENSP0000039408051.742239.547struthio_camelus_australisENSSCUP0000001767161.363646.9008
ENSG00000129071homo_sapiensENSP0000039408017.073214.9826anser_brachyrhynchusENSABRP0000000905290.740779.6296
ENSG00000129071homo_sapiensENSP0000039408050.348438.5017strigops_habroptilaENSSHBP0000502260958.148944.4668
ENSG00000129071homo_sapiensENSP0000039408061.498347.2125terrapene_carolina_triunguisENSTMTP0000002697461.821447.4606
ENSG00000129071homo_sapiensENSP0000039408022.125416.899ciona_savignyiENSCSAVP0000000183670.949754.1899
ENSG00000129071homo_sapiensENSP0000039408045.12234.4948aquila_chrysaetos_chrysaetosENSACCP0002001553361.961747.3684
ENSG00000129071homo_sapiensENSP0000039408037.630728.5714ficedula_albicollisENSFALP0000001426463.343148.0938
ENSG00000129071homo_sapiensENSP0000039408037.10831.1847coturnix_japonicaENSCJPP0000502674057.723648.5095

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003677enables DNA binding1IBAHomo_sapiens(9606)Function
GO:0003696enables satellite DNA binding1TASHomo_sapiens(9606)Function
GO:0004520enables DNA endonuclease activity1TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0006281involved_in DNA repair1TASHomo_sapiens(9606)Process
GO:0008263enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity1IDAHomo_sapiens(9606)Function
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0019104enables DNA N-glycosylase activity1TASHomo_sapiens(9606)Function
GO:0032355involved_in response to estradiol1IEAHomo_sapiens(9606)Process
GO:0045008involved_in depyrimidination1TASHomo_sapiens(9606)Process

Expression