RBP Type
Canonical_RBPs
Diseases
Cancer
Drug
N.A.
Main interacting RNAs
N.A.
Moonlighting functions
TF
Localizations
N.A.
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000129071 Gene ID
8930
Accession
6919
Symbol
MBD4
Alias
MED1;UVM1;TPDS2
Full Name
methyl-CpG binding domain 4, DNA glycosylase
Status
Confidence
Length
9233 bases
Strand
Minus strand
Position
3 : 129430947 - 129440179
RNA binding domain
MBD
Summary
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000394080
MBD
PF01429
2.4e-20
1
ENSP00000424873
MBD
PF01429
4.5e-20
1
ENSP00000422327
MBD
PF01429
5.1e-20
1
ENSP00000249910
MBD
PF01429
5.2e-20
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
33876188
Low-dose decitabine modulates T-cell homeostasis and restores immune tolerance in immune thrombocytopenia.
Panpan Han
2021-08-26
Blood
Name
Transcript ID
bp
Protein
Translation ID
MBD4-203
ENST00000429544
2394
574aa
ENSP00000394080
MBD4-201
ENST00000249910
2470
580aa
ENSP00000249910
MBD4-202
ENST00000393278
1684
262aa
ENSP00000376959
MBD4-204
ENST00000503197
2099
540aa
ENSP00000424873
MBD4-208
ENST00000509828
576
52aa
ENSP00000422690
MBD4-206
ENST00000507208
2194
572aa
ENSP00000422327
MBD4-209
ENST00000511009
530
No protein
-
MBD4-210
ENST00000515266
434
No protein
-
MBD4-207
ENST00000509587
643
No protein
-
MBD4-205
ENST00000505883
613
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000129071 homo_sapiens ENSP00000395535 33.7349 19.4779 homo_sapiens ENSP00000394080 29.2683 16.899
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000129071 homo_sapiens ENSP00000394080 98.2578 97.2125 nomascus_leucogenys ENSNLEP00000006477 97.5779 96.5398 ENSG00000129071 homo_sapiens ENSP00000394080 100 99.6516 pan_paniscus ENSPPAP00000026900 100 99.6516 ENSG00000129071 homo_sapiens ENSP00000394080 98.9547 97.561 pongo_abelii ENSPPYP00000015005 99.1274 97.7312 ENSG00000129071 homo_sapiens ENSP00000394080 99.8258 99.4773 pan_troglodytes ENSPTRP00000026489 98.7931 98.4483 ENSG00000129071 homo_sapiens ENSP00000394080 99.3031 98.6063 gorilla_gorilla ENSGGOP00000024137 98.2759 97.5862 ENSG00000129071 homo_sapiens ENSP00000394080 65.1568 52.2648 ornithorhynchus_anatinus ENSOANP00000007275 68.6239 55.0459 ENSG00000129071 homo_sapiens ENSP00000394080 62.5436 52.9617 sarcophilus_harrisii ENSSHAP00000015187 68.1214 57.685 ENSG00000129071 homo_sapiens ENSP00000394080 33.101 27.3519 notamacropus_eugenii ENSMEUP00000014242 51.6304 42.663 ENSG00000129071 homo_sapiens ENSP00000394080 65.1568 59.9303 choloepus_hoffmanni ENSCHOP00000002990 64.9306 59.7222 ENSG00000129071 homo_sapiens ENSP00000394080 79.7909 73.1707 dasypus_novemcinctus ENSDNOP00000032553 79.2388 72.6644 ENSG00000129071 homo_sapiens ENSP00000394080 68.8153 58.7108 erinaceus_europaeus ENSEEUP00000010444 73.2839 62.5232 ENSG00000129071 homo_sapiens ENSP00000394080 90.9408 88.3275 callithrix_jacchus ENSCJAP00000031837 91.4186 88.7916 ENSG00000129071 homo_sapiens ENSP00000394080 95.993 93.7282 cercocebus_atys ENSCATP00000023300 96.3287 94.0559 ENSG00000129071 homo_sapiens ENSP00000394080 95.1219 93.2056 macaca_mulatta ENSMMUP00000016705 95.4545 93.5315 ENSG00000129071 homo_sapiens ENSP00000394080 91.2892 89.1986 macaca_nemestrina ENSMNEP00000010731 93.7388 91.5921 ENSG00000129071 homo_sapiens ENSP00000394080 90.4181 86.4111 papio_anubis ENSPANP00000059002 77.4627 74.0299 ENSG00000129071 homo_sapiens ENSP00000394080 95.993 93.554 mandrillus_leucophaeus ENSMLEP00000005744 96.3287 93.8811 ENSG00000129071 homo_sapiens ENSP00000394080 82.7526 75.4355 tursiops_truncatus ENSTTRP00000010681 85.2783 77.7379 ENSG00000129071 homo_sapiens ENSP00000394080 85.0174 76.6551 vulpes_vulpes ENSVVUP00000019261 85.614 77.193 ENSG00000129071 homo_sapiens ENSP00000394080 73.8676 65.5052 mus_spretus MGP_SPRETEiJ_P0078670 76.6727 67.9928 ENSG00000129071 homo_sapiens ENSP00000394080 83.2753 76.1324 equus_asinus ENSEASP00005021643 74.6875 68.2812 ENSG00000129071 homo_sapiens ENSP00000394080 78.7456 70.5575 capra_hircus ENSCHIP00000005716 81.5884 73.1047 ENSG00000129071 homo_sapiens ENSP00000394080 83.2753 75.4355 loxodonta_africana ENSLAFP00000008883 84.007 76.0984 ENSG00000129071 homo_sapiens ENSP00000394080 85.8885 78.9199 panthera_leo ENSPLOP00000002878 86.3398 79.3345 ENSG00000129071 homo_sapiens ENSP00000394080 85.7143 78.9199 ailuropoda_melanoleuca ENSAMEP00000004805 86.4675 79.6134 ENSG00000129071 homo_sapiens ENSP00000394080 77.5261 68.8153 bos_indicus_hybrid ENSBIXP00005042416 70.3002 62.4013 ENSG00000129071 homo_sapiens ENSP00000394080 77.5261 70.7317 oryctolagus_cuniculus ENSOCUP00000043468 69.9686 63.8365 ENSG00000129071 homo_sapiens ENSP00000394080 82.23 75.6098 equus_caballus ENSECAP00000066748 76.3754 70.2265 ENSG00000129071 homo_sapiens ENSP00000394080 85.0174 77.0035 canis_lupus_familiaris ENSCAFP00845039165 85.4641 77.4081 ENSG00000129071 homo_sapiens ENSP00000394080 85.7143 78.5714 panthera_pardus ENSPPRP00000025977 87.234 79.9645 ENSG00000129071 homo_sapiens ENSP00000394080 82.9268 73.5192 marmota_marmota_marmota ENSMMMP00000012341 83.9506 74.4268 ENSG00000129071 homo_sapiens ENSP00000394080 18.8153 18.4669 balaenoptera_musculus ENSBMSP00010014404 100 98.1481 ENSG00000129071 homo_sapiens ENSP00000394080 28.5714 27.3519 cavia_porcellus ENSCPOP00000004474 93.1818 89.2045 ENSG00000129071 homo_sapiens ENSP00000394080 85.8885 79.2683 felis_catus ENSFCAP00000000077 86.3398 79.6848 ENSG00000129071 homo_sapiens ENSP00000394080 74.7387 69.8606 ursus_americanus ENSUAMP00000000824 87.3727 81.6701 ENSG00000129071 homo_sapiens ENSP00000394080 18.8153 17.9443 monodelphis_domestica ENSMODP00000033621 100 95.3704 ENSG00000129071 homo_sapiens ENSP00000394080 33.7979 24.0418 monodelphis_domestica ENSMODP00000057510 52.1505 37.0968 ENSG00000129071 homo_sapiens ENSP00000394080 80.1394 71.9512 bison_bison_bison ENSBBBP00000002581 82.2898 73.8819 ENSG00000129071 homo_sapiens ENSP00000394080 86.0627 77.5261 monodon_monoceros ENSMMNP00015016486 85.7639 77.2569 ENSG00000129071 homo_sapiens ENSP00000394080 84.1463 75.9582 sus_scrofa ENSSSCP00000052533 85.1852 76.8959 ENSG00000129071 homo_sapiens ENSP00000394080 88.676 82.0557 microcebus_murinus ENSMICP00000023317 88.5217 81.913 ENSG00000129071 homo_sapiens ENSP00000394080 18.4669 18.1185 octodon_degus ENSODEP00000003792 98.1481 96.2963 ENSG00000129071 homo_sapiens ENSP00000394080 29.6167 28.223 jaculus_jaculus ENSJJAP00000014164 96.5909 92.0455 ENSG00000129071 homo_sapiens ENSP00000394080 72.4739 65.331 ovis_aries_rambouillet ENSOARP00020033542 82.0513 73.9645 ENSG00000129071 homo_sapiens ENSP00000394080 84.4948 78.3972 ursus_maritimus ENSUMAP00000024092 85.9929 79.7872 ENSG00000129071 homo_sapiens ENSP00000394080 73.3449 65.1568 ochotona_princeps ENSOPRP00000000437 74.2504 65.9612 ENSG00000129071 homo_sapiens ENSP00000394080 85.7143 77.5261 delphinapterus_leucas ENSDLEP00000011354 86.1646 77.9334 ENSG00000129071 homo_sapiens ENSP00000394080 86.0627 77.5261 physeter_catodon ENSPCTP00005008391 85.7639 77.2569 ENSG00000129071 homo_sapiens ENSP00000394080 75.6098 66.3763 mus_caroli MGP_CAROLIEiJ_P0075599 76.9504 67.5532 ENSG00000129071 homo_sapiens ENSP00000394080 74.0418 66.0279 mus_musculus ENSMUSP00000032469 76.7148 68.4116 ENSG00000129071 homo_sapiens ENSP00000394080 58.1882 51.9164 dipodomys_ordii ENSDORP00000000847 73.0853 65.2079 ENSG00000129071 homo_sapiens ENSP00000394080 83.9721 76.3066 mustela_putorius_furo ENSMPUP00000017087 85.3097 77.5221 ENSG00000129071 homo_sapiens ENSP00000394080 82.5784 78.5714 aotus_nancymaae ENSANAP00000000696 89.434 85.0943 ENSG00000129071 homo_sapiens ENSP00000394080 92.6829 89.1986 saimiri_boliviensis_boliviensis ENSSBOP00000003504 92.8447 89.3543 ENSG00000129071 homo_sapiens ENSP00000394080 49.8258 46.5157 vicugna_pacos ENSVPAP00000003753 51.8116 48.3696 ENSG00000129071 homo_sapiens ENSP00000394080 95.6446 93.3798 chlorocebus_sabaeus ENSCSAP00000005288 95.979 93.7063 ENSG00000129071 homo_sapiens ENSP00000394080 62.5436 51.7422 tupaia_belangeri ENSTBEP00000002621 62.6527 51.8325 ENSG00000129071 homo_sapiens ENSP00000394080 28.9199 27.8746 mesocricetus_auratus ENSMAUP00000014504 94.8571 91.4286 ENSG00000129071 homo_sapiens ENSP00000394080 86.2369 78.5714 phocoena_sinus ENSPSNP00000031559 85.7886 78.1629 ENSG00000129071 homo_sapiens ENSP00000394080 81.1847 75.0871 camelus_dromedarius ENSCDRP00005026444 79.1171 73.1749 ENSG00000129071 homo_sapiens ENSP00000394080 18.8153 18.2927 carlito_syrichta ENSTSYP00000010225 100 97.2222 ENSG00000129071 homo_sapiens ENSP00000394080 18.8153 18.2927 panthera_tigris_altaica ENSPTIP00000011757 100 97.2222 ENSG00000129071 homo_sapiens ENSP00000394080 74.7387 66.5505 rattus_norvegicus ENSRNOP00000092006 72.7119 64.7458 ENSG00000129071 homo_sapiens ENSP00000394080 89.7213 82.9268 prolemur_simus ENSPSMP00000001354 89.2548 82.4957 ENSG00000129071 homo_sapiens ENSP00000394080 41.8118 33.101 microtus_ochrogaster ENSMOCP00000003094 65.7534 52.0548 ENSG00000129071 homo_sapiens ENSP00000394080 61.8467 53.6585 sorex_araneus ENSSARP00000004075 61.7391 53.5652 ENSG00000129071 homo_sapiens ENSP00000394080 74.9129 65.8537 peromyscus_maniculatus_bairdii ENSPEMP00000004117 76.7857 67.5 ENSG00000129071 homo_sapiens ENSP00000394080 79.0941 71.0801 bos_mutus ENSBMUP00000014066 82.0976 73.7794 ENSG00000129071 homo_sapiens ENSP00000394080 73.8676 65.5052 mus_spicilegus ENSMSIP00000000791 76.5343 67.87 ENSG00000129071 homo_sapiens ENSP00000394080 75.9582 66.899 cricetulus_griseus_chok1gshd ENSCGRP00001003011 77.8571 68.5714 ENSG00000129071 homo_sapiens ENSP00000394080 87.2822 79.9652 pteropus_vampyrus ENSPVAP00000004957 86.9792 79.6875 ENSG00000129071 homo_sapiens ENSP00000394080 82.5784 75.4355 myotis_lucifugus ENSMLUP00000013439 87.4539 79.8893 ENSG00000129071 homo_sapiens ENSP00000394080 18.6411 17.5958 vombatus_ursinus ENSVURP00010018693 99.0741 93.5185 ENSG00000129071 homo_sapiens ENSP00000394080 84.3206 77.3519 rhinolophus_ferrumequinum ENSRFEP00010027106 85.3615 78.3069 ENSG00000129071 homo_sapiens ENSP00000394080 83.9721 75.9582 neovison_vison ENSNVIP00000011580 85.0088 76.8959 ENSG00000129071 homo_sapiens ENSP00000394080 79.0941 71.6028 bos_taurus ENSBTAP00000028844 81.9495 74.1877 ENSG00000129071 homo_sapiens ENSP00000394080 81.5331 72.2997 heterocephalus_glaber_female ENSHGLP00000055331 82.5397 73.1922 ENSG00000129071 homo_sapiens ENSP00000394080 96.1672 94.4251 rhinopithecus_bieti ENSRBIP00000007645 96.5035 94.7552 ENSG00000129071 homo_sapiens ENSP00000394080 85.0174 77.0035 canis_lupus_dingo ENSCAFP00020008741 85.614 77.5439 ENSG00000129071 homo_sapiens ENSP00000394080 81.7073 73.1707 sciurus_vulgaris ENSSVLP00005024490 81.993 73.4266 ENSG00000129071 homo_sapiens ENSP00000394080 34.1463 25.2613 phascolarctos_cinereus ENSPCIP00000002772 52.4064 38.7701 ENSG00000129071 homo_sapiens ENSP00000394080 18.6411 17.77 phascolarctos_cinereus ENSPCIP00000002767 99.0741 94.4444 ENSG00000129071 homo_sapiens ENSP00000394080 75.9582 68.4669 procavia_capensis ENSPCAP00000012049 79.2727 71.4545 ENSG00000129071 homo_sapiens ENSP00000394080 24.3902 23.3449 nannospalax_galili ENSNGAP00000016733 92.7152 88.7417 ENSG00000129071 homo_sapiens ENSP00000394080 79.7909 71.777 bos_grunniens ENSBGRP00000038030 82.6715 74.3682 ENSG00000129071 homo_sapiens ENSP00000394080 78.5714 69.8606 chinchilla_lanigera ENSCLAP00000013004 79.823 70.9734 ENSG00000129071 homo_sapiens ENSP00000394080 78.0488 68.9895 cervus_hanglu_yarkandensis ENSCHYP00000022163 81.3067 71.8693 ENSG00000129071 homo_sapiens ENSP00000394080 18.8153 18.2927 catagonus_wagneri ENSCWAP00000023914 100 97.2222 ENSG00000129071 homo_sapiens ENSP00000394080 48.6063 41.9861 catagonus_wagneri ENSCWAP00000023937 76.2295 65.847 ENSG00000129071 homo_sapiens ENSP00000394080 82.4042 73.3449 ictidomys_tridecemlineatus ENSSTOP00000016633 84.3137 75.0446 ENSG00000129071 homo_sapiens ENSP00000394080 82.9268 76.6551 otolemur_garnettii ENSOGAP00000009158 87.0201 80.4388 ENSG00000129071 homo_sapiens ENSP00000394080 92.6829 89.1986 cebus_imitator ENSCCAP00000024023 91.8826 88.4283 ENSG00000129071 homo_sapiens ENSP00000394080 48.9547 40.7666 urocitellus_parryii ENSUPAP00010029273 75.3351 62.7346 ENSG00000129071 homo_sapiens ENSP00000394080 18.8153 18.2927 urocitellus_parryii ENSUPAP00010029266 100 97.2222 ENSG00000129071 homo_sapiens ENSP00000394080 79.2683 70.2091 moschus_moschiferus ENSMMSP00000032645 81.3953 72.093 ENSG00000129071 homo_sapiens ENSP00000394080 96.1672 94.2509 rhinopithecus_roxellana ENSRROP00000009387 96.5035 94.5804 ENSG00000129071 homo_sapiens ENSP00000394080 45.8188 37.4564 mus_pahari MGP_PahariEiJ_P0051798 65.9148 53.8847 ENSG00000129071 homo_sapiens ENSP00000394080 18.6411 18.4669 propithecus_coquereli ENSPCOP00000013866 99.0741 98.1481 ENSG00000129071 homo_sapiens ENSP00000394080 50 37.2822 xenopus_tropicalis ENSXETP00000056046 60.8051 45.339 ENSG00000129071 homo_sapiens ENSP00000394080 61.6725 46.8641 chrysemys_picta_bellii ENSCPBP00000020441 61.9965 47.1103 ENSG00000129071 homo_sapiens ENSP00000394080 57.6655 44.2509 sphenodon_punctatus ENSSPUP00000022584 59.7473 45.8484 ENSG00000129071 homo_sapiens ENSP00000394080 57.3171 44.0767 crocodylus_porosus ENSCPRP00005018070 57.9225 44.5423 ENSG00000129071 homo_sapiens ENSP00000394080 40.2439 30.3136 laticauda_laticaudata ENSLLTP00000014277 53.8462 40.5594 ENSG00000129071 homo_sapiens ENSP00000394080 17.77 15.5052 notechis_scutatus ENSNSUP00000008064 93.578 81.6514 ENSG00000129071 homo_sapiens ENSP00000394080 40.7666 31.1847 pseudonaja_textilis ENSPTXP00000003962 54.4186 41.6279 ENSG00000129071 homo_sapiens ENSP00000394080 17.0732 14.9826 anas_platyrhynchos_platyrhynchos ENSAPLP00000003724 90.7407 79.6296 ENSG00000129071 homo_sapiens ENSP00000394080 40.4181 31.8815 gallus_gallus ENSGALP00010027549 52.968 41.7808 ENSG00000129071 homo_sapiens ENSP00000394080 31.7073 28.223 meleagris_gallopavo ENSMGAP00000010634 37.1429 33.0612 ENSG00000129071 homo_sapiens ENSP00000394080 43.9024 34.669 serinus_canaria ENSSCAP00000022142 64.7815 51.1568 ENSG00000129071 homo_sapiens ENSP00000394080 37.108 29.4425 parus_major ENSPMJP00000007261 61.3833 48.7032 ENSG00000129071 homo_sapiens ENSP00000394080 48.6063 39.547 anolis_carolinensis ENSACAP00000014468 53.3461 43.4034 ENSG00000129071 homo_sapiens ENSP00000394080 52.9617 39.8955 podarcis_muralis ENSPMRP00000007491 55.2727 41.6364 ENSG00000129071 homo_sapiens ENSP00000394080 17.2474 14.8084 geospiza_fortis ENSGFOP00000013991 91.6667 78.7037 ENSG00000129071 homo_sapiens ENSP00000394080 49.6516 38.5017 taeniopygia_guttata ENSTGUP00000010808 49.7382 38.5689 ENSG00000129071 homo_sapiens ENSP00000394080 55.5749 40.9408 salvator_merianae ENSSMRP00000003608 60.1887 44.3396 ENSG00000129071 homo_sapiens ENSP00000394080 60.453 47.0383 pelodiscus_sinensis ENSPSIP00000008657 59.1141 45.9966 ENSG00000129071 homo_sapiens ENSP00000394080 61.1498 47.2125 gopherus_evgoodei ENSGEVP00005010446 61.4711 47.4606 ENSG00000129071 homo_sapiens ENSP00000394080 60.8014 46.8641 chelonoidis_abingdonii ENSCABP00000001850 59.9656 46.2199 ENSG00000129071 homo_sapiens ENSP00000394080 51.7422 39.547 struthio_camelus_australis ENSSCUP00000017671 61.3636 46.9008 ENSG00000129071 homo_sapiens ENSP00000394080 17.0732 14.9826 anser_brachyrhynchus ENSABRP00000009052 90.7407 79.6296 ENSG00000129071 homo_sapiens ENSP00000394080 50.3484 38.5017 strigops_habroptila ENSSHBP00005022609 58.1489 44.4668 ENSG00000129071 homo_sapiens ENSP00000394080 61.4983 47.2125 terrapene_carolina_triunguis ENSTMTP00000026974 61.8214 47.4606 ENSG00000129071 homo_sapiens ENSP00000394080 22.1254 16.899 ciona_savignyi ENSCSAVP00000001836 70.9497 54.1899 ENSG00000129071 homo_sapiens ENSP00000394080 45.122 34.4948 aquila_chrysaetos_chrysaetos ENSACCP00020015533 61.9617 47.3684 ENSG00000129071 homo_sapiens ENSP00000394080 37.6307 28.5714 ficedula_albicollis ENSFALP00000014264 63.3431 48.0938 ENSG00000129071 homo_sapiens ENSP00000394080 37.108 31.1847 coturnix_japonica ENSCJPP00005026740 57.7236 48.5095
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0003677 enables DNA binding 1 IBA Homo_sapiens(9606) Function GO:0003696 enables satellite DNA binding 1 TAS Homo_sapiens(9606) Function GO:0004520 enables DNA endonuclease activity 1 TAS Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 1 IBA Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 1 TAS Homo_sapiens(9606) Component GO:0006281 involved_in DNA repair 1 TAS Homo_sapiens(9606) Process GO:0008263 enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity 1 IDA Homo_sapiens(9606) Function GO:0016607 located_in nuclear speck 1 IDA Homo_sapiens(9606) Component GO:0019104 enables DNA N-glycosylase activity 1 TAS Homo_sapiens(9606) Function GO:0032355 involved_in response to estradiol 1 IEA Homo_sapiens(9606) Process GO:0045008 involved_in depyrimidination 1 TAS Homo_sapiens(9606) Process
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