Ensembl ID ENSG00000129071 Gene ID 8930 Accession 6919
Gene Symbol MBD4 Alias MED1;UVM1;TPDS2 Full Name methyl-CpG binding domain 4, DNA glycosylase
Position 3 : 129430947 - 129440179 Length 9233 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

ENSG00000129071 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000129071 MBD4 0.55 1.09e-14 HNSC
ENSG00000129071 MBD4 0.38 1.41e-21 BRCA
ENSG00000129071 MBD4 0.49 2.75e-14 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000129071 MBD4 tumors 19179424
ENSG00000129071 MBD4 tumour 30621801
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000129071 MBD4 MESO 0.0082 high
ENSG00000129071 MBD4 CHOL 0.029 low
ENSG00000129071 MBD4 UVM 0.0011 low
ENSG00000129071 MBD4 PAAD 0.00042 high
ENSG00000129071 MBD4 UCEC 0.0076 high
ENSG00000129071 MBD4 ACC 0.033 high
ENSG00000129071 MBD4 LUSC 0.05 high
ENSG00000129071 MBD4 READ 0.036 low
ENSG00000129071 MBD4 KIRP 0.00023 high
ENSG00000129071 MBD4 KICH 0.0082 high
ENSG00000129071 MBD4 LUAD 0.017 low
ENSG00000129071 MBD4 PCPG 0.027 high
ENSG00000129071 MBD4 THYM 0.019 low
ENSG00000129071 MBD4 BRCA 0.034 high
ENSG00000129071 MBD4 COAD 0.0095 high
ENSG00000129071 MBD4 PRAD 0.0025 high
ENSG00000129071 MBD4 TGCT 0.021 high
ENSG00000129071 MBD4 BLCA 0.049 low
ENSG00000129071 MBD4 GBM 0.019 high
ENSG00000129071 MBD4 CESC 0.0027 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000129071 MBD4 GBM Del 0.885379 0.054414 0.486399 0.091854
ENSG00000129071 MBD4 PCPG Del 0.883794 0.062820 0.629836 0.567901
ENSG00000129071 MBD4 PRAD Amp 3.525215 0.083855 0.475289 0.150407
ENSG00000129071 MBD4 UCEC Amp 1.846267 0.129920 0.648681 0.215213