Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs tRNA
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000128829 Gene ID 440275 Accession 19687
Symbol EIF2AK4 Alias GCN2;PVOD2 Full Name eukaryotic translation initiation factor 2 alpha kinase 4
Status Confidence Length 101477 bases Strand Plus strand
Position 15 : 39934115 - 40035591 RNA binding domain tRNA-synt_His , HGTP_anticodon2
Summary This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000453575 tRNA-synt_His PF13393 2.4e-12 1
ENSP00000453575 HGTP_anticodon2 PF12745 1.8e-17 2
ENSP00000263791 tRNA-synt_His PF13393 1.2e-11 1
ENSP00000263791 HGTP_anticodon2 PF12745 2.3e-17 2

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34722178 Development and Validation of an RNA Binding Protein-associated Prognostic Model for Hepatocellular Carcinoma. Hao Zhang 2021-10-28 Journal of clinical and translational hepatology
30545973 Genetics and genomics of pulmonary arterial hypertension. W Nicholas Morrell 2019-01-01 The European respiratory journal

Transcripts

Name Transcript ID bp Protein Translation ID
EIF2AK4-201 ENST00000263791 5538 1649aa ENSP00000263791
EIF2AK4-208 ENST00000559624 3548 616aa ENSP00000453148
EIF2AK4-209 ENST00000560648 687 136aa ENSP00000453968
EIF2AK4-210 ENST00000560855 4789 1427aa ENSP00000453575
EIF2AK4-211 ENST00000624709 1314 No protein -
EIF2AK4-203 ENST00000558629 4374 No protein -
EIF2AK4-207 ENST00000559311 535 No protein -
EIF2AK4-202 ENST00000558557 2449 No protein -
EIF2AK4-204 ENST00000558743 581 No protein -
EIF2AK4-206 ENST00000559032 1089 No protein -
EIF2AK4-205 ENST00000558823 638 80aa ENSP00000454210

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
61357Body Mass Index1E-624827717
73055Endometrial Neoplasms2E-827135401
77975Carcinoma, Endometrioid2E-727135401
83564Corneal Topography6E-622969067
87501Haloperidol9E-624751813
87502Psychotic Disorders9E-624751813

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000128829homo_sapiensENSP0000037089134.082418.7266homo_sapiensENSP0000026379111.0376.06428
ENSG00000128829homo_sapiensENSP0000019938941.269825.873homo_sapiensENSP0000026379115.76719.88478
ENSG00000128829homo_sapiensENSP0000030723532.437318.8172homo_sapiensENSP0000026379121.952712.735
ENSG00000128829homo_sapiensENSP0000038067534.391518.6949homo_sapiensENSP0000026379111.82536.42814
ENSG00000128829homo_sapiensENSP0000036338741.34921.9941homo_sapiensENSP000002637918.550644.54821
ENSG00000128829homo_sapiensENSP0000023305743.738726.6788homo_sapiensENSP0000026379114.61498.91449
ENSG00000128829homo_sapiensENSP0000026230035.470920.2405homo_sapiensENSP0000026379110.73386.12492
ENSG00000128829homo_sapiensENSP0000040208433.746118.1115homo_sapiensENSP0000026379113.22017.09521

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000128829homo_sapiensENSP0000026379197.210496.5434nomascus_leucogenysENSNLEP0000003654897.624896.9549
ENSG00000128829homo_sapiensENSP0000026379199.818199.6361pan_paniscusENSPPAP0000001694994.92594.752
ENSG00000128829homo_sapiensENSP0000026379199.757499.4542pongo_abeliiENSPPYP0000000718199.757499.4542
ENSG00000128829homo_sapiensENSP0000026379199.939499.8787pan_troglodytesENSPTRP0000001179899.939499.8787
ENSG00000128829homo_sapiensENSP0000026379199.636199.6361gorilla_gorillaENSGGOP0000002426499.636199.6361
ENSG00000128829homo_sapiensENSP0000026379186.173476.8344ornithorhynchus_anatinusENSOANP0000001321585.65476.3713
ENSG00000128829homo_sapiensENSP0000026379191.206884.2935sarcophilus_harrisiiENSSHAP0000001215090.276183.4334
ENSG00000128829homo_sapiensENSP0000026379157.5553.9721notamacropus_eugeniiENSMEUP0000001288157.58554.0049
ENSG00000128829homo_sapiensENSP0000026379173.741771.0734choloepus_hoffmanniENSCHOP0000000470776.719273.9432
ENSG00000128829homo_sapiensENSP0000026379195.573192.6622dasypus_novemcinctusENSDNOP0000000863395.573192.6622
ENSG00000128829homo_sapiensENSP0000026379177.380274.3481erinaceus_europaeusENSEEUP0000001147281.533578.3387
ENSG00000128829homo_sapiensENSP0000026379187.628982.0497echinops_telfairiENSETEP0000001229088.109882.5
ENSG00000128829homo_sapiensENSP0000026379198.665997.8169callithrix_jacchusENSCJAP0000003893098.665997.8169
ENSG00000128829homo_sapiensENSP0000026379199.454298.8478cercocebus_atysENSCATP0000004266299.454298.8478
ENSG00000128829homo_sapiensENSP0000026379195.573194.7847macaca_fascicularisENSMFAP0000004870995.169194.3841
ENSG00000128829homo_sapiensENSP0000026379199.332998.8478macaca_mulattaENSMMUP0000006109496.694296.222
ENSG00000128829homo_sapiensENSP0000026379199.332998.8478macaca_nemestrinaENSMNEP0000000516999.332998.8478
ENSG00000128829homo_sapiensENSP0000026379199.454298.9084papio_anubisENSPANP0000001631599.454298.9084
ENSG00000128829homo_sapiensENSP0000026379199.090498.4839mandrillus_leucophaeusENSMLEP0000002788399.391798.7835
ENSG00000128829homo_sapiensENSP0000026379196.482793.6931tursiops_truncatusENSTTRP0000000003196.482793.6931
ENSG00000128829homo_sapiensENSP0000026379194.90690.4184vulpes_vulpesENSVVUP0000003691994.619190.1451
ENSG00000128829homo_sapiensENSP0000026379194.966690.4791mus_spretusMGP_SPRETEiJ_P005583295.024390.534
ENSG00000128829homo_sapiensENSP0000026379196.907294.057equus_asinusENSEASP0000502454596.789893.9431
ENSG00000128829homo_sapiensENSP0000026379196.785993.6325capra_hircusENSCHIP0000000299496.785993.6325
ENSG00000128829homo_sapiensENSP0000026379191.631388.2959loxodonta_africanaENSLAFP0000002069094.79391.3425
ENSG00000128829homo_sapiensENSP0000026379191.267487.4469panthera_leoENSPLOP0000000194694.121390.1814
ENSG00000128829homo_sapiensENSP0000026379194.784790.9036ailuropoda_melanoleucaENSAMEP0000001820994.384190.5193
ENSG00000128829homo_sapiensENSP0000026379196.725393.8144bos_indicus_hybridENSBIXP0000501210996.084393.1928
ENSG00000128829homo_sapiensENSP0000026379196.967994.7847oryctolagus_cuniculusENSOCUP0000000563396.850494.6699
ENSG00000128829homo_sapiensENSP0000026379197.028594.2389equus_caballusENSECAP0000000123096.91194.1248
ENSG00000128829homo_sapiensENSP0000026379135.839934.0206canis_lupus_familiarisENSCAFP0084503734696.097691.2195
ENSG00000128829homo_sapiensENSP0000026379194.117690.4184panthera_pardusENSPPRP0000001755095.156391.4163
ENSG00000128829homo_sapiensENSP0000026379197.028594.6028marmota_marmota_marmotaENSMMMP0000002428797.087494.6602
ENSG00000128829homo_sapiensENSP0000026379191.691988.7204balaenoptera_musculusENSBMSP0001000797694.915391.8393
ENSG00000128829homo_sapiensENSP0000026379196.179593.0261cavia_porcellusENSCPOP0000002671696.06392.9134
ENSG00000128829homo_sapiensENSP0000026379194.481590.7216felis_catusENSFCAP0000002032994.252990.5021
ENSG00000128829homo_sapiensENSP0000026379150.394248.0898ursus_americanusENSUAMP0000003076594.539290.2162
ENSG00000128829homo_sapiensENSP0000026379190.600483.8084monodelphis_domesticaENSMODP0000000074189.837683.1028
ENSG00000128829homo_sapiensENSP0000026379196.725393.6931bison_bison_bisonENSBBBP0000000668696.78493.75
ENSG00000128829homo_sapiensENSP0000026379196.543493.6325monodon_monocerosENSMMNP0001500944696.543493.6325
ENSG00000128829homo_sapiensENSP0000026379197.271193.9964sus_scrofaENSSSCP0000004827495.990492.7588
ENSG00000128829homo_sapiensENSP0000026379197.271194.7241microcebus_murinusENSMICP0000000693597.212194.6667
ENSG00000128829homo_sapiensENSP0000026379190.782387.0224octodon_degusENSODEP0000002332395.350391.4013
ENSG00000128829homo_sapiensENSP0000026379194.966690.9642jaculus_jaculusENSJJAP0000002489495.08291.0747
ENSG00000128829homo_sapiensENSP0000026379196.664693.6931ovis_aries_rambouilletENSOARP0002001183296.664693.6931
ENSG00000128829homo_sapiensENSP0000026379190.964287.0831ursus_maritimusENSUMAP0000001788594.043990.0313
ENSG00000128829homo_sapiensENSP0000026379184.839381.6859ochotona_princepsENSOPRP0000000785084.890881.7354
ENSG00000128829homo_sapiensENSP0000026379189.448286.7799delphinapterus_leucasENSDLEP0000000469196.405293.5294
ENSG00000128829homo_sapiensENSP0000026379196.543493.6325physeter_catodonENSPCTP0000502856996.426493.5191
ENSG00000128829homo_sapiensENSP0000026379194.663490.2971mus_caroliMGP_CAROLIEiJ_P005373294.720990.3519
ENSG00000128829homo_sapiensENSP0000026379194.966690.5397mus_musculusENSMUSP0000000523395.024390.5947
ENSG00000128829homo_sapiensENSP0000026379190.479185.8096dipodomys_ordiiENSDORP0000000110593.308388.4928
ENSG00000128829homo_sapiensENSP0000026379193.814489.6907mustela_putorius_furoENSMPUP0000000823793.361589.2577
ENSG00000128829homo_sapiensENSP0000026379198.423397.6349aotus_nancymaaeENSANAP0000002774498.423397.6349
ENSG00000128829homo_sapiensENSP0000026379198.059497.2104saimiri_boliviensis_boliviensisENSSBOP0000000304998.657797.8035
ENSG00000128829homo_sapiensENSP0000026379187.810885.1425vicugna_pacosENSVPAP0000000956490.049887.3134
ENSG00000128829homo_sapiensENSP0000026379199.332998.7265chlorocebus_sabaeusENSCSAP0000000359599.332998.7265
ENSG00000128829homo_sapiensENSP0000026379159.126757.3681tupaia_belangeriENSTBEP0000000624163.976462.0735
ENSG00000128829homo_sapiensENSP0000026379186.234182.5349mesocricetus_auratusENSMAUP0000000442694.172290.1325
ENSG00000128829homo_sapiensENSP0000026379196.422193.208phocoena_sinusENSPSNP0000000514396.305393.0951
ENSG00000128829homo_sapiensENSP0000026379195.75592.7835camelus_dromedariusENSCDRP0000500150495.75592.7835
ENSG00000128829homo_sapiensENSP0000026379194.542192.6016carlito_syrichtaENSTSYP0000000868596.175294.2011
ENSG00000128829homo_sapiensENSP0000026379192.35988.3566panthera_tigris_altaicaENSPTIP0000002114394.128690.0494
ENSG00000128829homo_sapiensENSP0000026379194.784790.6004rattus_norvegicusENSRNOP0000000922294.784790.6004
ENSG00000128829homo_sapiensENSP0000026379197.271194.8454prolemur_simusENSPSMP0000001283497.330194.9029
ENSG00000128829homo_sapiensENSP0000026379195.451891.51microtus_ochrogasterENSMOCP0000002412695.451891.51
ENSG00000128829homo_sapiensENSP0000026379174.408770.8308sorex_araneusENSSARP0000000959974.725971.1328
ENSG00000128829homo_sapiensENSP0000026379195.451891.9951peromyscus_maniculatus_bairdiiENSPEMP0000002066495.451891.9951
ENSG00000128829homo_sapiensENSP0000026379196.664693.7538bos_mutusENSBMUP0000000065696.664693.7538
ENSG00000128829homo_sapiensENSP0000026379195.027390.5397mus_spicilegusENSMSIP0000001494795.08590.5947
ENSG00000128829homo_sapiensENSP0000026379195.269991.51cricetulus_griseus_chok1gshdENSCGRP0000100361095.212191.4545
ENSG00000128829homo_sapiensENSP0000026379188.477986.1128pteropus_vampyrusENSPVAP0000000206489.895387.4923
ENSG00000128829homo_sapiensENSP0000026379192.237789.4482myotis_lucifugusENSMLUP0000000957995.241192.3607
ENSG00000128829homo_sapiensENSP0000026379185.142578.4718vombatus_ursinusENSVURP0001001089291.764784.5752
ENSG00000128829homo_sapiensENSP0000026379193.814490.1759rhinolophus_ferrumequinumENSRFEP0001000580893.757690.1212
ENSG00000128829homo_sapiensENSP0000026379188.781184.9606neovison_visonENSNVIP0000002081090.818986.9107
ENSG00000128829homo_sapiensENSP0000026379196.664693.6931bos_taurusENSBTAP0000001908396.664693.6931
ENSG00000128829homo_sapiensENSP0000026379196.058292.2377heterocephalus_glaber_femaleENSHGLP0000000871195.941992.126
ENSG00000128829homo_sapiensENSP0000026379195.876395.0273rhinopithecus_bietiENSRBIP0000002557898.936298.0601
ENSG00000128829homo_sapiensENSP0000026379187.446983.02canis_lupus_dingoENSCAFP0002000742194.371789.5942
ENSG00000128829homo_sapiensENSP0000026379196.967994.2996sciurus_vulgarisENSSVLP0000500879096.909194.2424
ENSG00000128829homo_sapiensENSP0000026379191.691984.7787phascolarctos_cinereusENSPCIP0000003409290.756383.9136
ENSG00000128829homo_sapiensENSP0000026379181.989177.8654procavia_capensisENSPCAP0000001258682.338678.1973
ENSG00000128829homo_sapiensENSP0000026379189.205685.8702nannospalax_galiliENSNGAP0000001819095.643792.0676
ENSG00000128829homo_sapiensENSP0000026379196.785993.8751chinchilla_lanigeraENSCLAP0000001403996.727393.8182
ENSG00000128829homo_sapiensENSP0000026379196.846693.8751cervus_hanglu_yarkandensisENSCHYP0000001116096.846693.8751
ENSG00000128829homo_sapiensENSP0000026379196.967994.057catagonus_wagneriENSCWAP0000002068796.909194
ENSG00000128829homo_sapiensENSP0000026379195.936993.4506ictidomys_tridecemlineatusENSSTOP0000001398296.995794.4819
ENSG00000128829homo_sapiensENSP0000026379196.785994.6028otolemur_garnettiiENSOGAP0000000795796.551794.3739
ENSG00000128829homo_sapiensENSP0000026379198.544697.8775cebus_imitatorENSCCAP0000000742198.425297.7589
ENSG00000128829homo_sapiensENSP0000026379196.967994.3602urocitellus_parryiiENSUPAP0001002080797.026794.4175
ENSG00000128829homo_sapiensENSP0000026379196.907294.057moschus_moschiferusENSMMSP0000001901896.907294.057
ENSG00000128829homo_sapiensENSP0000026379199.514998.8478rhinopithecus_roxellanaENSRROP0000000566599.514998.8478
ENSG00000128829homo_sapiensENSP0000026379194.845490.1152mus_pahariMGP_PahariEiJ_P006471194.787990.0606
ENSG00000128829homo_sapiensENSP0000026379197.210494.4815propithecus_coquereliENSPCOP0000002117497.151594.4242
ENSG00000128829homo_sapiensENSP0000026379150.75831.4736drosophila_melanogasterFBpp030661952.608432.621
ENSG00000128829homo_sapiensENSP000002637916.064284.245ciona_intestinalisENSCINP0000002943964.102644.8718
ENSG00000128829homo_sapiensENSP0000026379170.224451.607petromyzon_marinusENSPMAP0000000770468.561350.3848
ENSG00000128829homo_sapiensENSP0000026379162.583444.9363eptatretus_burgeriENSEBUP0000001284461.39244.0809
ENSG00000128829homo_sapiensENSP000002637913.577932.85021callorhinchus_miliiENSCMIP0000000854276.623461.039
ENSG00000128829homo_sapiensENSP000002637915.700424.12371callorhinchus_miliiENSCMIP0000001064071.755751.9084
ENSG00000128829homo_sapiensENSP000002637918.489997.03457callorhinchus_miliiENSCMIP0000000855072.164959.7938
ENSG00000128829homo_sapiensENSP0000026379163.129249.5452latimeria_chalumnaeENSLACP0000000076373.829857.9433
ENSG00000128829homo_sapiensENSP0000026379128.138322.1346lepisosteus_oculatusENSLOCP0000001556574.478358.5875
ENSG00000128829homo_sapiensENSP0000026379115.100111.7647lepisosteus_oculatusENSLOCP0000001556982.178264.0264
ENSG00000128829homo_sapiensENSP0000026379170.770256.7617clupea_harengusENSCHAP0000006082273.81459.203
ENSG00000128829homo_sapiensENSP0000026379159.4348.2717danio_rerioENSDARP0000013737872.378158.7888
ENSG00000128829homo_sapiensENSP0000026379173.135258.5203carassius_auratusENSCARP0000012012873.716458.9853
ENSG00000128829homo_sapiensENSP0000026379172.771458.2777carassius_auratusENSCARP0000002376770.963956.8303
ENSG00000128829homo_sapiensENSP0000026379169.314756.2159astyanax_mexicanusENSAMXP0000000881875.946861.5947
ENSG00000128829homo_sapiensENSP000002637916.428144.42693ictalurus_punctatusENSIPUP0000002720675.177351.773
ENSG00000128829homo_sapiensENSP0000026379165.433653.6689ictalurus_punctatusENSIPUP0000002717177.292363.3954
ENSG00000128829homo_sapiensENSP0000026379172.225658.1565esox_luciusENSELUP0000007888074.251959.788
ENSG00000128829homo_sapiensENSP0000026379126.804121.1643electrophorus_electricusENSEEEP0000004717770.60755.7508
ENSG00000128829homo_sapiensENSP0000026379140.5733.8993electrophorus_electricusENSEEEP0000000481475.507963.0926
ENSG00000128829homo_sapiensENSP0000026379162.401550.2122oncorhynchus_kisutchENSOKIP0000502771571.657457.6602
ENSG00000128829homo_sapiensENSP0000026379173.741758.8235oncorhynchus_kisutchENSOKIP0000503726570.167355.9723
ENSG00000128829homo_sapiensENSP0000026379176.955761.5525oncorhynchus_mykissENSOMYP0000004964976.584261.2553
ENSG00000128829homo_sapiensENSP0000026379170.103156.2765salmo_salarENSSSAP0000001022673.818659.2593
ENSG00000128829homo_sapiensENSP0000026379176.713261.795salmo_salarENSSSAP0000003952275.612760.9085
ENSG00000128829homo_sapiensENSP0000026379172.225658.2171salmo_truttaENSSTUP0000003610576.739761.8557
ENSG00000128829homo_sapiensENSP0000026379165.918752.3954salmo_truttaENSSTUP0000010683970.12955.7419
ENSG00000128829homo_sapiensENSP0000026379175.621660.0364gadus_morhuaENSGMOP0000005663374.98559.531
ENSG00000128829homo_sapiensENSP0000026379176.349361.9163fundulus_heteroclitusENSFHEP0000002964076.118561.7291
ENSG00000128829homo_sapiensENSP0000026379175.803560.8854poecilia_reticulataENSPREP0000003005575.665960.7748
ENSG00000128829homo_sapiensENSP0000026379175.864261.0673xiphophorus_maculatusENSXMAP0000000685975.726460.9564
ENSG00000128829homo_sapiensENSP0000026379175.560961.128oryzias_latipesENSORLP0000002118575.378160.98
ENSG00000128829homo_sapiensENSP0000026379175.924861.0067cyclopterus_lumpusENSCLMP0000502031175.512760.6755
ENSG00000128829homo_sapiensENSP0000026379176.106760.6428oreochromis_niloticusENSONIP0000001527475.511460.1685
ENSG00000128829homo_sapiensENSP0000026379176.288761.1886haplochromis_burtoniENSHBUP0000001474175.828860.8198
ENSG00000128829homo_sapiensENSP0000026379167.980654.9424astatotilapia_callipteraENSACLP0000000345474.584260.2794
ENSG00000128829homo_sapiensENSP000002637915.457853.94178astatotilapia_callipteraENSACLP0000000342963.829846.0993
ENSG00000128829homo_sapiensENSP0000026379176.713261.4918sparus_aurataENSSAUP0001004713476.250861.1212
ENSG00000128829homo_sapiensENSP0000026379173.013958.6416lates_calcariferENSLCAP0001002926975.391460.551
ENSG00000128829homo_sapiensENSP0000026379181.443367.7987xenopus_tropicalisENSXETP0000007111880.22766.7861
ENSG00000128829homo_sapiensENSP0000026379186.355475.1364chrysemys_picta_belliiENSCPBP0000003552387.148175.8262
ENSG00000128829homo_sapiensENSP000002637916.124925.39721sphenodon_punctatusENSSPUP0000002487877.099267.9389
ENSG00000128829homo_sapiensENSP0000026379160.218352.6986sphenodon_punctatusENSSPUP0000002487282.81972.4771
ENSG00000128829homo_sapiensENSP0000026379181.564672.0437crocodylus_porosusENSCPRP0000502705081.416571.9128
ENSG00000128829homo_sapiensENSP0000026379179.684768.6477laticauda_laticaudataENSLLTP0000000953483.854572.24
ENSG00000128829homo_sapiensENSP0000026379179.260268.4657notechis_scutatusENSNSUP0000001002082.931571.6371
ENSG00000128829homo_sapiensENSP0000026379183.808472.4682pseudonaja_textilisENSPTXP0000000043883.202971.9446
ENSG00000128829homo_sapiensENSP000002637916.306855.70042anas_platyrhynchos_platyrhynchosENSAPLP0000003144578.195570.6767
ENSG00000128829homo_sapiensENSP0000026379174.5364.1601anas_platyrhynchos_platyrhynchosENSAPLP0000000280985.58573.6769
ENSG00000128829homo_sapiensENSP0000026379181.625269.7999gallus_gallusENSGALP0001003469983.810771.6687
ENSG00000128829homo_sapiensENSP0000026379181.928470.3457serinus_canariaENSSCAP0000001692184.279572.3643
ENSG00000128829homo_sapiensENSP0000026379184.050972.6501parus_majorENSPMJP0000002041179.154868.418
ENSG00000128829homo_sapiensENSP0000026379185.263874.4087anolis_carolinensisENSACAP0000001432585.367374.4991
ENSG00000128829homo_sapiensENSP0000026379170.830857.0042neolamprologus_brichardiENSNBRP0000000249776.741161.7608
ENSG00000128829homo_sapiensENSP0000026379178.168667.3135naja_najaENSNNAP0000000443781.376370.0758
ENSG00000128829homo_sapiensENSP000002637914.912074.245podarcis_muralisENSPMRP0000002887553.642446.3576
ENSG00000128829homo_sapiensENSP000002637916.003645.45785podarcis_muralisENSPMRP0000003418571.22364.7482
ENSG00000128829homo_sapiensENSP0000026379179.260268.9509podarcis_muralisENSPMRP0000002895585.035873.9753
ENSG00000128829homo_sapiensENSP0000026379178.714467.6167geospiza_fortisENSGFOP0000000890284.781272.8282
ENSG00000128829homo_sapiensENSP0000026379183.990372.2862taeniopygia_guttataENSTGUP0000001196983.685872.0242
ENSG00000128829homo_sapiensENSP0000026379177.440963.3717erpetoichthys_calabaricusENSECRP0000001761277.487963.4102
ENSG00000128829homo_sapiensENSP0000026379171.315958.6416kryptolebias_marmoratusENSKMAP0000000056976.165862.6295
ENSG00000128829homo_sapiensENSP0000026379181.685969.8605salvator_merianaeENSSMRP0000001980984.082471.9101
ENSG00000128829homo_sapiensENSP0000026379166.525254.6392amphilophus_citrinellusENSACIP0000001775374.676761.3342
ENSG00000128829homo_sapiensENSP0000026379168.101955.1243amphiprion_perculaENSAPEP0000000144976.970562.3029
ENSG00000128829homo_sapiensENSP0000026379176.22861.6737oryzias_sinensisENSOSIP0000001390476.181861.6364
ENSG00000128829homo_sapiensENSP0000026379186.476775.2577pelodiscus_sinensisENSPSIP0000001035386.371975.1666
ENSG00000128829homo_sapiensENSP0000026379187.386376.0461gopherus_evgoodeiENSGEVP0000500938187.227675.908
ENSG00000128829homo_sapiensENSP0000026379187.325775.9854chelonoidis_abingdoniiENSCABP0000000910187.167175.8475
ENSG00000128829homo_sapiensENSP0000026379176.955761.977seriola_dumeriliENSSDUP0000001333576.445861.5663
ENSG00000128829homo_sapiensENSP0000026379181.746570.5276struthio_camelus_australisENSSCUP0000000881285.10173.4217
ENSG00000128829homo_sapiensENSP0000026379181.079470.2244anser_brachyrhynchusENSABRP0000000738484.035272.7844
ENSG00000128829homo_sapiensENSP0000026379172.468257.9745gasterosteus_aculeatusENSGACP0000000815475.489660.3917
ENSG00000128829homo_sapiensENSP0000026379168.344555.5488cynoglossus_semilaevisENSCSEP0000000020475.739361.5591
ENSG00000128829homo_sapiensENSP000002637915.0943.88114cynoglossus_semilaevisENSCSEP0000000020563.636448.4848
ENSG00000128829homo_sapiensENSP0000026379175.864261.1886poecilia_formosaENSPFOP0000001098675.726461.0775
ENSG00000128829homo_sapiensENSP0000026379177.198361.795myripristis_murdjanENSMMDP0000502954176.964961.6082
ENSG00000128829homo_sapiensENSP0000026379171.861757.9139sander_luciopercaENSSLUP0000001402976.550461.6925
ENSG00000128829homo_sapiensENSP0000026379180.169869.618strigops_habroptilaENSSHBP0000502269982.573471.7052
ENSG00000128829homo_sapiensENSP0000026379176.955761.795amphiprion_ocellarisENSAOCP0000001502476.630461.5338
ENSG00000128829homo_sapiensENSP0000026379187.083175.9248terrapene_carolina_triunguisENSTMTP0000000949187.030375.8788
ENSG00000128829homo_sapiensENSP000002637915.579144.73014hucho_huchoENSHHUP0000004457654.117645.8824
ENSG00000128829homo_sapiensENSP0000026379123.590118.4354hucho_huchoENSHHUP0000004745171.245455.6777
ENSG00000128829homo_sapiensENSP000002637919.399647.88357hucho_huchoENSHHUP0000004456573.113261.3208
ENSG00000128829homo_sapiensENSP000002637915.882354.85143hucho_huchoENSHHUP0000004456774.045861.0687
ENSG00000128829homo_sapiensENSP000002637915.761074.54821hucho_huchoENSHHUP0000004455783.333365.7895
ENSG00000128829homo_sapiensENSP0000026379173.074658.8235betta_splendensENSBSLP0000003533374.566860.0248
ENSG00000128829homo_sapiensENSP0000026379176.288762.2195pygocentrus_nattereriENSPNAP0000003194476.196262.1442
ENSG00000128829homo_sapiensENSP0000026379176.409960.8854anabas_testudineusENSATEP0000000582175.584960.228
ENSG00000128829homo_sapiensENSP0000026379170.770257.6713seriola_lalandi_dorsalisENSSLDP0000000595875.7361.7132
ENSG00000128829homo_sapiensENSP000002637914.790783.69921seriola_lalandi_dorsalisENSSLDP0000000950169.911553.9823
ENSG00000128829homo_sapiensENSP0000026379177.137761.2492labrus_bergyltaENSLBEP0000003535276.85861.0272
ENSG00000128829homo_sapiensENSP000002637913.941782.85021pundamilia_nyerereiENSPNYP0000000050954.621839.4958
ENSG00000128829homo_sapiensENSP0000026379165.554952.9412pundamilia_nyerereiENSPNYP0000000057075.912961.3062
ENSG00000128829homo_sapiensENSP0000026379168.647755.6701mastacembelus_armatusENSMAMP0000005499172.985259.1876
ENSG00000128829homo_sapiensENSP0000026379175.864260.4609stegastes_partitusENSSPAP0000002576875.452460.1327
ENSG00000128829homo_sapiensENSP0000026379154.699844.5725oncorhynchus_tshawytschaENSOTSP0000501540874.730760.8948
ENSG00000128829homo_sapiensENSP0000026379171.861757.3681oncorhynchus_tshawytschaENSOTSP0000503183275.477760.2548
ENSG00000128829homo_sapiensENSP0000026379168.58755.1243acanthochromis_polyacanthusENSAPOP0000002802574.950360.2386
ENSG00000128829homo_sapiensENSP0000026379184.475472.832aquila_chrysaetos_chrysaetosENSACCP0002000514884.27172.6558
ENSG00000128829homo_sapiensENSP0000026379176.652562.0376cyprinodon_variegatusENSCVAP0000001602376.420861.8501
ENSG00000128829homo_sapiensENSP0000026379171.376657.55denticeps_clupeoidesENSDCDP0000004544075.111760.5616
ENSG00000128829homo_sapiensENSP0000026379171.376657.55larimichthys_croceaENSLCRP0000505019873.839459.5358
ENSG00000128829homo_sapiensENSP0000026379175.864261.8557takifugu_rubripesENSTRUP0000003578975.406961.4828
ENSG00000128829homo_sapiensENSP0000026379178.471867.3742ficedula_albicollisENSFALP0000003251283.376371.5851
ENSG00000128829homo_sapiensENSP000002637916.973925.15464hippocampus_comesENSHCOP0000002714858.080842.9293
ENSG00000128829homo_sapiensENSP0000026379167.9254.6998hippocampus_comesENSHCOP0000001516475.778161.0284
ENSG00000128829homo_sapiensENSP0000026379175.682260.5822cyprinus_carpio_carpioENSCCRP0000002972773.282458.6612
ENSG00000128829homo_sapiensENSP0000026379184.778772.6501coturnix_japonicaENSCJPP0000502070084.420372.343
ENSG00000128829homo_sapiensENSP0000026379175.682261.0673poecilia_latipinnaENSPLAP0000003037675.544860.9564
ENSG00000128829homo_sapiensENSP0000026379161.431249.4845sinocyclocheilus_grahamiENSSGRP0000000271174.375959.9119
ENSG00000128829homo_sapiensENSP0000026379166.22254.0934maylandia_zebraENSMZEP0000503619676.739362.6845
ENSG00000128829homo_sapiensENSP000002637915.457853.94178maylandia_zebraENSMZEP0000503619563.829846.0993
ENSG00000128829homo_sapiensENSP0000026379175.864261.3705tetraodon_nigroviridisENSTNIP0000002059375.270860.8905
ENSG00000128829homo_sapiensENSP0000026379175.803561.6131paramormyrops_kingsleyaeENSPKIP0000001657875.987861.7629
ENSG00000128829homo_sapiensENSP0000026379176.773862.0982scleropages_formosusENSSFOP0001501436276.357161.7612
ENSG00000128829homo_sapiensENSP0000026379182.110466.9497leptobrachium_leishanenseENSLLEP0000003310280.643265.7534
ENSG00000128829homo_sapiensENSP0000026379176.167460.6428scophthalmus_maximusENSSMAP0000001024675.571660.1685
ENSG00000128829homo_sapiensENSP0000026379147.119538.3869oryzias_melastigmaENSOMEP0000001714380.351665.4602
ENSG00000128829homo_sapiensENSP0000026379124.742318.9812oryzias_melastigmaENSOMEP0000003308067.774151.9934

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000049enables tRNA binding1ISSHomo_sapiens(9606)Function
GO:0000077involved_in DNA damage checkpoint signaling1IEAHomo_sapiens(9606)Process
GO:0002230involved_in positive regulation of defense response to virus by host1ISSHomo_sapiens(9606)Process
GO:0002250involved_in adaptive immune response1IEAHomo_sapiens(9606)Process
GO:0002286involved_in T cell activation involved in immune response1ISSHomo_sapiens(9606)Process
GO:0002821involved_in positive regulation of adaptive immune response1ISSHomo_sapiens(9606)Process
GO:0004674enables protein serine/threonine kinase activity1ISSHomo_sapiens(9606)Function
GO:0004694enables eukaryotic translation initiation factor 2alpha kinase activity4IBA,IDA,IMP,ISSHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol1IBAHomo_sapiens(9606)Component
GO:0005844part_of polysome1ISSHomo_sapiens(9606)Component
GO:0006446involved_in regulation of translational initiation1ISSHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation1ISSHomo_sapiens(9606)Process
GO:0007049involved_in cell cycle1IEAHomo_sapiens(9606)Process
GO:0007612involved_in learning1ISSHomo_sapiens(9606)Process
GO:0007616involved_in long-term memory1ISSHomo_sapiens(9606)Process
GO:0010998involved_in regulation of translational initiation by eIF2 alpha phosphorylation3IBA,IMP,ISSHomo_sapiens(9606)Process
GO:0019081involved_in viral translation1ISSHomo_sapiens(9606)Process
GO:0022626located_in cytosolic ribosome1ISSHomo_sapiens(9606)Component
GO:0032057involved_in negative regulation of translational initiation in response to stress1ISSHomo_sapiens(9606)Process
GO:0032792involved_in negative regulation of CREB transcription factor activity1ISSHomo_sapiens(9606)Process
GO:0034198involved_in cellular response to amino acid starvation1IMPHomo_sapiens(9606)Process
GO:0034644involved_in cellular response to UV1ISSHomo_sapiens(9606)Process
GO:0036492involved_in eiF2alpha phosphorylation in response to endoplasmic reticulum stress1IMPHomo_sapiens(9606)Process
GO:0044828involved_in negative regulation by host of viral genome replication1ISSHomo_sapiens(9606)Process
GO:0045665involved_in negative regulation of neuron differentiation1ISSHomo_sapiens(9606)Process
GO:0045947involved_in negative regulation of translational initiation1ISSHomo_sapiens(9606)Process
GO:0046777involved_in protein autophosphorylation1ISSHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus1IEAHomo_sapiens(9606)Process
GO:0060259involved_in regulation of feeding behavior1ISSHomo_sapiens(9606)Process
GO:0070417involved_in cellular response to cold1IMPHomo_sapiens(9606)Process
GO:0071264involved_in positive regulation of translational initiation in response to starvation1ISSHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:0140469involved_in GCN2-mediated signaling3IDA,IMP,ISSHomo_sapiens(9606)Process
GO:1900273involved_in positive regulation of long-term synaptic potentiation1ISSHomo_sapiens(9606)Process
GO:1990138involved_in neuron projection extension1ISSHomo_sapiens(9606)Process
GO:1990253involved_in cellular response to leucine starvation1ISSHomo_sapiens(9606)Process
GO:1990625involved_in negative regulation of cytoplasmic translational initiation in response to stress1IBAHomo_sapiens(9606)Process

Expression