Ensembl ID ENSG00000128829 Gene ID 440275 Accession 19687
Gene Symbol EIF2AK4 Alias GCN2;PVOD2 Full Name eukaryotic translation initiation factor 2 alpha kinase 4
Position 15 : 39934115 - 40035591 Length 101477 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

ENSG00000128829 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000128829 EIF2AK4 0.76 1.11e-17 KICH
ENSG00000128829 EIF2AK4 -0.5 9.17e-11 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000128829 EIF2AK4 tumor 15894280
ENSG00000128829 EIF2AK4 cancer 19783659
ENSG00000128829 EIF2AK4 tumour 20473272
ENSG00000128829 EIF2AK4 tumor 22106287
ENSG00000128829 EIF2AK4 colon cancer 22435535
ENSG00000128829 EIF2AK4 tumor 22509023
ENSG00000128829 EIF2AK4 AML 23259068
ENSG00000128829 EIF2AK4 tumor 23264892
ENSG00000128829 EIF2AK4 tumor 23403946
ENSG00000128829 EIF2AK4 tumor 23700291
ENSG00000128829 EIF2AK4 tumor 23908598
ENSG00000128829 EIF2AK4 tumor 24113185
ENSG00000128829 EIF2AK4 tumor 24403234
ENSG00000128829 EIF2AK4 cancer 25015767
ENSG00000128829 EIF2AK4 Cancer 25375376
ENSG00000128829 EIF2AK4 cancer 25589675
ENSG00000128829 EIF2AK4 tumor 25590801
ENSG00000128829 EIF2AK4 tumor 25628622
ENSG00000128829 EIF2AK4 tumor 25912940
ENSG00000128829 EIF2AK4 tumor 26102367
ENSG00000128829 EIF2AK4 tumor 26123823
ENSG00000128829 EIF2AK4 tumor 26300654
ENSG00000128829 EIF2AK4 tumor 26709701
ENSG00000128829 EIF2AK4 cancer 27129276
ENSG00000128829 EIF2AK4 tumor 27302165
ENSG00000128829 EIF2AK4 cancer 27551491
ENSG00000128829 EIF2AK4 tumor 27705910
ENSG00000128829 EIF2AK4 gastric cancer 27708226
ENSG00000128829 EIF2AK4 colorectal cancer 27965097
ENSG00000128829 EIF2AK4 tumor 28123877
ENSG00000128829 EIF2AK4 tumor 28557618
ENSG00000128829 EIF2AK4 cancer 28894140
ENSG00000128829 EIF2AK4 tumors 29326164
ENSG00000128829 EIF2AK4 triple negative breast cancer 29383104
ENSG00000128829 EIF2AK4 cancer 29660505
ENSG00000128829 EIF2AK4 tumour 29865032
ENSG00000128829 EIF2AK4 cancer 30061420
ENSG00000128829 EIF2AK4 lung tumor 30158316
ENSG00000128829 EIF2AK4 cancers 30364637
ENSG00000128829 EIF2AK4 gastric cancer 30380689
ENSG00000128829 EIF2AK4 cancer 30466445
ENSG00000128829 EIF2AK4 cancer 30524887
ENSG00000128829 EIF2AK4 cancer 30626938
ENSG00000128829 EIF2AK4 tumor 30863482
ENSG00000128829 EIF2AK4 HNSCC 31151143
ENSG00000128829 EIF2AK4 breast cancer 31211507
ENSG00000128829 EIF2AK4 cancer 31249645
ENSG00000128829 EIF2AK4 triple-negative breast cancer 31497357
ENSG00000128829 EIF2AK4 tumors 31523835
ENSG00000128829 EIF2AK4 cancer 31620240
ENSG00000128829 EIF2AK4 tumour 31647517
ENSG00000128829 EIF2AK4 colorectal cancer 31685988
ENSG00000128829 EIF2AK4 tumor 31836669
ENSG00000128829 EIF2AK4 brain tumors 31844909
ENSG00000128829 EIF2AK4 cancer 31868900
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000128829 EIF2AK4 MESO 0.045 high
ENSG00000128829 EIF2AK4 SARC 0.011 high
ENSG00000128829 EIF2AK4 STAD 0.019 high
ENSG00000128829 EIF2AK4 UVM 0.044 high
ENSG00000128829 EIF2AK4 PAAD 0.012 high
ENSG00000128829 EIF2AK4 UCEC 0.05 low
ENSG00000128829 EIF2AK4 THCA 0.0045 high
ENSG00000128829 EIF2AK4 ACC 0.012 high
ENSG00000128829 EIF2AK4 HNSC 0.044 high
ENSG00000128829 EIF2AK4 KIRP 0.014 high
ENSG00000128829 EIF2AK4 KICH 0.025 high
ENSG00000128829 EIF2AK4 PCPG 0.00022 high
ENSG00000128829 EIF2AK4 THYM 0.035 low
ENSG00000128829 EIF2AK4 COAD 0.025 high
ENSG00000128829 EIF2AK4 OV 0.024 high
ENSG00000128829 EIF2AK4 KIRC 0.021 high
ENSG00000128829 EIF2AK4 BLCA 0.00066 high
ENSG00000128829 EIF2AK4 LAML 0.0012 high
ENSG00000128829 EIF2AK4 GBM 0.0066 high
ENSG00000128829 EIF2AK4 SKCM 0.0019 low
ENSG00000128829 EIF2AK4 CESC 0.0017 high
ENSG00000128829 EIF2AK4 LIHC 0.035 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000128829 EIF2AK4 LUSC Del 3.667812 0.100918 0.339475 0.361277
ENSG00000128829 EIF2AK4 LUAD Del 8.459088 0.116658 0.332630 0.536822
ENSG00000128829 EIF2AK4 CESC Del 2.333196 0.096154 0.449422 0.237288
ENSG00000128829 EIF2AK4 COAD Del 5.044551 0.080899 0.477147 0.383592
ENSG00000128829 EIF2AK4 UCS Del 9.244996 0.661190 0.587537 0.767857
ENSG00000128829 EIF2AK4 GBM Del 10.221357 0.126653 0.527118 0.259965
ENSG00000128829 EIF2AK4 SKCM Del 9.593119 0.165200 0.529445 0.242507
ENSG00000128829 EIF2AK4 BLCA Del 0.961221 0.081729 0.354005 0.399510
ENSG00000128829 EIF2AK4 BRCA Del 12.288560 0.123302 0.412285 0.368519
ENSG00000128829 EIF2AK4 STAD Del 2.108460 0.080033 0.337617 0.272109
ENSG00000128829 EIF2AK4 UCEC Del 6.897593 0.101235 0.523410 0.261596
ENSG00000128829 EIF2AK4 MESO Del 8.721970 0.364617 0.592769 0.321839
ENSG00000128829 EIF2AK4 OV Del 17.739795 0.365371 0.602887 0.618307