RBP Type
Canonical_RBPs
Diseases
SARS-COV-OC43
Drug
N.A.
Main interacting RNAs
mRNA
Moonlighting functions
N.A.
Localizations
P-body
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000128394 Gene ID
200316 Accession
17356
Symbol
APOBEC3F
Alias
A3F;KA6;ARP8;BK150C2.4.MRNA
Full Name
apolipoprotein B mRNA editing enzyme catalytic subunit 3F
Status
Confidence
Length
15116 bases
Strand
Plus strand
Position
22 : 39040857 - 39055972
RNA binding domain
APOBEC_N , APOBEC_C
Summary
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000309749
APOBEC_N
PF08210 2.4e-105
1
ENSP00000309749
APOBEC_N
PF08210 2.4e-105
2
ENSP00000309749
APOBEC_C
PF05240 1.9e-66
3
ENSP00000309749
APOBEC_C
PF05240 1.9e-66
4
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
36470880 Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
Hanjing Yang
2022-12-05
Nature communications
22915799 HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies.
K Prabhjeet Phalora
2012-11-01
Journal of virology
37293069 Defining distinct RNA-protein interactomes of SARS-CoV-2 genomic and subgenomic RNAs.
T Isabella Whitworth
2023-05-16
bioRxiv : the preprint server for biology
Name
Transcript ID
bp
Protein
Translation ID
APOBEC3F-204
ENST00000491387
570
No protein
-
APOBEC3F-202
ENST00000381565
616
101aa
ENSP00000370977
APOBEC3F-201
ENST00000308521
4496
373aa
ENSP00000309749
APOBEC3F-203
ENST00000476513
730
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000128394 homo_sapiens ENSP00000229335 50.5051 36.8687 homo_sapiens ENSP00000309749 26.8097 19.571 ENSG00000128394 homo_sapiens ENSP00000385057 63.8021 48.9583 homo_sapiens ENSP00000309749 65.6836 50.4021 ENSG00000128394 homo_sapiens ENSP00000411754 50.2732 34.4262 homo_sapiens ENSP00000309749 24.6649 16.8901 ENSG00000128394 homo_sapiens ENSP00000249116 51.7588 38.6935 homo_sapiens ENSP00000309749 27.6139 20.6434 ENSG00000128394 homo_sapiens ENSP00000327459 68.0628 58.6387 homo_sapiens ENSP00000309749 69.7051 60.0536 ENSG00000128394 homo_sapiens ENSP00000229304 40.678 24.5763 homo_sapiens ENSP00000309749 25.7373 15.5496 ENSG00000128394 homo_sapiens ENSP00000244669 50.4464 30.3571 homo_sapiens ENSP00000309749 30.2949 18.2306 ENSG00000128394 homo_sapiens ENSP00000216099 82.1244 76.6839 homo_sapiens ENSP00000309749 84.9866 79.3566 ENSG00000128394 homo_sapiens ENSP00000355340 84.7368 77.8947 homo_sapiens ENSP00000309749 43.1635 39.6783
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000128394 homo_sapiens ENSP00000309749 93.2976 89.2761 pongo_abelii ENSPPYP00000041985 93.2976 89.2761 ENSG00000128394 homo_sapiens ENSP00000309749 98.1233 96.5147 pan_troglodytes ENSPTRP00000090414 98.1233 96.5147 ENSG00000128394 homo_sapiens ENSP00000309749 97.319 95.4424 gorilla_gorilla ENSGGOP00000013413 97.319 95.4424 ENSG00000128394 homo_sapiens ENSP00000309749 21.4477 12.8686 sarcophilus_harrisii ENSSHAP00000043123 27.7778 16.6667 ENSG00000128394 homo_sapiens ENSP00000309749 49.5979 31.0992 dasypus_novemcinctus ENSDNOP00000022598 51.8207 32.493 ENSG00000128394 homo_sapiens ENSP00000309749 91.9571 87.3995 mandrillus_leucophaeus ENSMLEP00000010909 91.9571 87.3995 ENSG00000128394 homo_sapiens ENSP00000309749 28.4182 21.1796 vulpes_vulpes ENSVVUP00000019758 59.887 44.6328 ENSG00000128394 homo_sapiens ENSP00000309749 61.6622 43.4316 equus_asinus ENSEASP00005058077 59.2784 41.7526 ENSG00000128394 homo_sapiens ENSP00000309749 26.8097 20.1072 equus_asinus ENSEASP00005060941 55.5556 41.6667 ENSG00000128394 homo_sapiens ENSP00000309749 38.874 28.9544 equus_asinus ENSEASP00005038789 44.7531 33.3333 ENSG00000128394 homo_sapiens ENSP00000309749 60.5898 43.4316 equus_asinus ENSEASP00005027361 58.2474 41.7526 ENSG00000128394 homo_sapiens ENSP00000309749 31.6354 24.933 panthera_leo ENSPLOP00000027854 63.1016 49.7326 ENSG00000128394 homo_sapiens ENSP00000309749 61.9303 43.6997 equus_caballus ENSECAP00000027876 39.759 28.0551 ENSG00000128394 homo_sapiens ENSP00000309749 31.9035 24.933 panthera_pardus ENSPPRP00000009193 63.6364 49.7326 ENSG00000128394 homo_sapiens ENSP00000309749 28.9544 20.9115 marmota_marmota_marmota ENSMMMP00000015611 53.4653 38.6139 ENSG00000128394 homo_sapiens ENSP00000309749 35.3887 28.1501 balaenoptera_musculus ENSBMSP00010013859 62.5592 49.763 ENSG00000128394 homo_sapiens ENSP00000309749 29.2225 22.5201 ursus_americanus ENSUAMP00000004887 61.236 47.191 ENSG00000128394 homo_sapiens ENSP00000309749 21.4477 10.7239 monodelphis_domestica ENSMODP00000040505 30.7692 15.3846 ENSG00000128394 homo_sapiens ENSP00000309749 33.5121 24.933 sus_scrofa ENSSSCP00000038941 46.6418 34.7015 ENSG00000128394 homo_sapiens ENSP00000309749 35.3887 27.0777 microcebus_murinus ENSMICP00000044232 64.3902 49.2683 ENSG00000128394 homo_sapiens ENSP00000309749 30.563 23.5925 ursus_maritimus ENSUMAP00000019746 54.0284 41.7062 ENSG00000128394 homo_sapiens ENSP00000309749 77.748 69.1689 aotus_nancymaae ENSANAP00000024763 75.1295 66.8394 ENSG00000128394 homo_sapiens ENSP00000309749 65.6836 58.1769 saimiri_boliviensis_boliviensis ENSSBOP00000033207 80.5921 71.3816 ENSG00000128394 homo_sapiens ENSP00000309749 86.059 80.9651 chlorocebus_sabaeus ENSCSAP00000002677 86.7568 81.6216 ENSG00000128394 homo_sapiens ENSP00000309749 34.3164 26.8097 carlito_syrichta ENSTSYP00000028083 69.5652 54.3478 ENSG00000128394 homo_sapiens ENSP00000309749 66.756 51.4745 carlito_syrichta ENSTSYP00000018841 67.1159 51.752 ENSG00000128394 homo_sapiens ENSP00000309749 32.9759 24.6649 carlito_syrichta ENSTSYP00000014121 67.9558 50.8287 ENSG00000128394 homo_sapiens ENSP00000309749 65.1475 47.185 prolemur_simus ENSPSMP00000006323 60.5985 43.8903 ENSG00000128394 homo_sapiens ENSP00000309749 23.0563 16.622 pteropus_vampyrus ENSPVAP00000008915 35.102 25.3061 ENSG00000128394 homo_sapiens ENSP00000309749 51.2064 37.2654 myotis_lucifugus ENSMLUP00000017607 61.8123 44.9838 ENSG00000128394 homo_sapiens ENSP00000309749 22.7882 12.8686 vombatus_ursinus ENSVURP00010031524 28.5235 16.1074 ENSG00000128394 homo_sapiens ENSP00000309749 32.1716 26.0054 rhinolophus_ferrumequinum ENSRFEP00010002335 60.3015 48.7437 ENSG00000128394 homo_sapiens ENSP00000309749 28.9544 21.7158 neovison_vison ENSNVIP00000001831 62.7907 47.093 ENSG00000128394 homo_sapiens ENSP00000309749 58.9812 41.0188 heterocephalus_glaber_female ENSHGLP00000060665 55.5556 38.6364 ENSG00000128394 homo_sapiens ENSP00000309749 32.1716 22.5201 heterocephalus_glaber_female ENSHGLP00000057408 53.3333 37.3333 ENSG00000128394 homo_sapiens ENSP00000309749 86.5952 82.5737 rhinopithecus_bieti ENSRBIP00000037423 91.5014 87.2521 ENSG00000128394 homo_sapiens ENSP00000309749 90.3485 85.5228 rhinopithecus_bieti ENSRBIP00000012693 93.0939 88.1215 ENSG00000128394 homo_sapiens ENSP00000309749 31.6354 23.5925 canis_lupus_dingo ENSCAFP00020003112 62.1053 46.3158 ENSG00000128394 homo_sapiens ENSP00000309749 22.252 13.1367 phascolarctos_cinereus ENSPCIP00000049844 31.9231 18.8462 ENSG00000128394 homo_sapiens ENSP00000309749 56.3003 42.0912 otolemur_garnettii ENSOGAP00000021125 59.8291 44.7293 ENSG00000128394 homo_sapiens ENSP00000309749 62.1984 45.5764 otolemur_garnettii ENSOGAP00000015570 60.8924 44.6194 ENSG00000128394 homo_sapiens ENSP00000309749 57.6408 43.6997 otolemur_garnettii ENSOGAP00000021819 60.9065 46.1756 ENSG00000128394 homo_sapiens ENSP00000309749 44.2359 36.7292 cebus_imitator ENSCCAP00000026256 74.6606 61.991 ENSG00000128394 homo_sapiens ENSP00000309749 86.5952 82.5737 rhinopithecus_roxellana ENSRROP00000011299 91.5014 87.2521 ENSG00000128394 homo_sapiens ENSP00000309749 92.2252 87.6676 rhinopithecus_roxellana ENSRROP00000009246 92.2252 87.6676 ENSG00000128394 homo_sapiens ENSP00000309749 26.0054 20.1072 propithecus_coquereli ENSPCOP00000020218 74.0458 57.2519 ENSG00000128394 homo_sapiens ENSP00000309749 26.0054 20.6434 propithecus_coquereli ENSPCOP00000012935 73.4848 58.3333 ENSG00000128394 homo_sapiens ENSP00000309749 20.3753 11.5282 callorhinchus_milii ENSCMIP00000004961 36.1905 20.4762 ENSG00000128394 homo_sapiens ENSP00000309749 19.0349 11.7962 latimeria_chalumnae ENSLACP00000018020 20.6395 12.7907 ENSG00000128394 homo_sapiens ENSP00000309749 20.3753 13.4048 lepisosteus_oculatus ENSLOCP00000004258 27.8388 18.315 ENSG00000128394 homo_sapiens ENSP00000309749 22.5201 13.1367 xenopus_tropicalis ENSXETP00000073758 37.8378 22.0721 ENSG00000128394 homo_sapiens ENSP00000309749 20.3753 10.992 anolis_carolinensis ENSACAP00000018261 28.2528 15.2416 ENSG00000128394 homo_sapiens ENSP00000309749 19.8391 10.7239 podarcis_muralis ENSPMRP00000035742 35.2381 19.0476 ENSG00000128394 homo_sapiens ENSP00000309749 20.3753 12.6005 erpetoichthys_calabaricus ENSECRP00000021015 29.1188 18.0077 ENSG00000128394 homo_sapiens ENSP00000309749 18.7668 12.6005 paramormyrops_kingsleyae ENSPKIP00000029857 33.8164 22.7053 ENSG00000128394 homo_sapiens ENSP00000309749 19.8391 14.2091 scleropages_formosus ENSSFOP00015009596 37.3737 26.7677
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000932 is_active_in P-body 2 IBA,IDA Homo_sapiens(9606) Component GO:0002230 involved_in positive regulation of defense response to virus by host 1 IDA Homo_sapiens(9606) Process GO:0003723 enables RNA binding 3 HDA,IBA,IDA Homo_sapiens(9606) Function GO:0004126 enables cytidine deaminase activity 2 IBA,IDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 1 IBA Homo_sapiens(9606) Component GO:0005737 is_active_in cytoplasm 2 IBA,IDA Homo_sapiens(9606) Component GO:0008270 enables zinc ion binding 1 IDA Homo_sapiens(9606) Function GO:0009972 involved_in cytidine deamination 1 IEA Homo_sapiens(9606) Process GO:0010526 involved_in retrotransposon silencing 1 IDA Homo_sapiens(9606) Process GO:0016553 involved_in base conversion or substitution editing 1 IDA Homo_sapiens(9606) Process GO:0016554 involved_in cytidine to uridine editing 1 IBA Homo_sapiens(9606) Process GO:0030895 part_of apolipoprotein B mRNA editing enzyme complex 1 TAS Homo_sapiens(9606) Component GO:0042802 enables identical protein binding 1 IPI Homo_sapiens(9606) Function GO:0044355 involved_in clearance of foreign intracellular DNA 1 IDA Homo_sapiens(9606) Process GO:0045071 involved_in negative regulation of viral genome replication 1 IDA Homo_sapiens(9606) Process GO:0045087 involved_in innate immune response 1 IDA Homo_sapiens(9606) Process GO:0045869 involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 2 IBA,IDA Homo_sapiens(9606) Process GO:0047844 enables deoxycytidine deaminase activity 1 IBA Homo_sapiens(9606) Function GO:0048525 involved_in negative regulation of viral process 1 IDA Homo_sapiens(9606) Process GO:0051607 involved_in defense response to virus 2 IBA,IDA Homo_sapiens(9606) Process GO:0070383 involved_in DNA cytosine deamination 2 IBA,IDA Homo_sapiens(9606) Process GO:0080111 involved_in DNA demethylation 2 IBA,IDA Homo_sapiens(9606) Process GO:1990904 part_of ribonucleoprotein complex 1 IDA Homo_sapiens(9606) Component
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