RBP Type
Canonical_RBPs
Diseases
CancerCHIKV SARS-COV-OC43 Flaviviruses HIV RV SARS-COV-2 Dengue Zika
Drug
N.A.
Main interacting RNAs
mRNA
Moonlighting functions
N.A.
Localizations
N.A.
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000124193 Gene ID
6431
Accession
10788
Symbol
SRSF6
Alias
B52;SFRS6;SRP55;HEL-S-91
Full Name
serine and arginine rich splicing factor 6
Status
Confidence
Length
8154 bases
Strand
Plus strand
Position
20 : 43457893 - 43466046
RNA binding domain
RRM_1
Summary
The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000499492
RRM_1
PF00076
6.1e-33
1
ENSP00000499492
RRM_1
PF00076
6.1e-33
2
ENSP00000499517
RRM_1
PF00076
1.1e-32
1
ENSP00000499517
RRM_1
PF00076
1.1e-32
2
ENSP00000499666
RRM_1
PF00076
1.2e-32
1
ENSP00000499666
RRM_1
PF00076
1.2e-32
2
ENSP00000244020
RRM_1
PF00076
2.3e-32
1
ENSP00000244020
RRM_1
PF00076
2.3e-32
2
ENSP00000433544
RRM_1
PF00076
7e-17
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
32949230
A putative frameshift variant in the CHM gene is associated with an unexpected splicing alteration in a choroideremia patient.
Tiziana Fioretti
2020-11-01
Molecular genetics & genomic medicine
33376132
The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.
Inês Maria Alvelos
2021-03-01
Life science alliance
33905374
Splicing factor SRSF6 mediates pleural fibrosis.
Li-Mei Liang
2021-05-24
JCI insight
34917618
Targeting Splicing Factor SRSF6 for Cancer Therapy.
Wenting She
2021-01-01
Frontiers in cell and developmental biology
35454897
SRSF6 Regulates the Alternative Splicing of the Apoptotic Fas Gene by Targeting a Novel RNA Sequence.
Namjeong Choi
2022-04-14
Cancers
30262848
Regulatory mechanisms of incomplete huntingtin mRNA splicing.
Andreas Neueder
2018-09-27
Nature communications
34301951
Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.
Masahiko Ajiro
2021-07-23
Nature communications
33397371
LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM.
Feifei Zhang
2021-01-04
Molecular cancer
35947702
Modeling splicing outcome by combining 5'ss strength and splicing regulatory elements.
Lisa Müller
2022-08-26
Nucleic acids research
29114070
SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer.
Ledong Wan
2019-01-01
Gut
28276498
The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells.
Jung-Chun Lin
2017-03-09
Scientific reports
33050987
Relative strength of 5' splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA.
Namjeong Choi
2021-03-01
BMB reports
25056543
BRCA1 EXON 11, a CERES (composite regulatory element of splicing) element involved in splice regulation.
Claudia Tammaro
2014-07-23
International journal of molecular sciences
25889056
Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication.
Steffen Erkelenz
2015-03-28
Retrovirology
Name
Transcript ID
bp
Protein
Translation ID
SRSF6-204
ENST00000668808
1227
276aa
ENSP00000499517
SRSF6-205
ENST00000670741
1077
226aa
ENSP00000499492
SRSF6-203
ENST00000662078
1007
273aa
ENSP00000499666
SRSF6-201
ENST00000244020
4353
344aa
ENSP00000244020
SRSF6-202
ENST00000483871
1680
135aa
ENSP00000433544
SRSF6-206
ENST00000671022
1275
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
59247 Taste Perception 1.3930000E-005 - 85103 Rest 5E-6 27126917 105432 Serologic Tests 5E-8 25758998 105433 Chlamydial Pneumonia 5E-8 25758998
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000124193 homo_sapiens ENSP00000451088 74.2647 64.7059 homo_sapiens ENSP00000244020 58.7209 51.1628 ENSG00000124193 homo_sapiens ENSP00000243189 32.4138 18.9655 homo_sapiens ENSP00000244020 27.3256 15.9884 ENSG00000124193 homo_sapiens ENSP00000362900 54.8583 48.1781 homo_sapiens ENSP00000244020 78.7791 69.186 ENSG00000124193 homo_sapiens ENSP00000258962 59.2742 47.9839 homo_sapiens ENSP00000244020 42.7326 34.593 ENSG00000124193 homo_sapiens ENSP00000229390 56.1086 42.5339 homo_sapiens ENSP00000244020 36.0465 27.3256 ENSG00000124193 homo_sapiens ENSP00000330188 28.341 17.5115 homo_sapiens ENSP00000244020 35.7558 22.093 ENSG00000124193 homo_sapiens ENSP00000325905 53.7815 44.958 homo_sapiens ENSP00000244020 37.2093 31.1047 ENSG00000124193 homo_sapiens ENSP00000362820 59.1463 50 homo_sapiens ENSP00000244020 28.1977 23.8372
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000124193 homo_sapiens ENSP00000244020 100 100 nomascus_leucogenys ENSNLEP00000007938 100 100 ENSG00000124193 homo_sapiens ENSP00000244020 99.7093 99.7093 pan_paniscus ENSPPAP00000022318 100 100 ENSG00000124193 homo_sapiens ENSP00000244020 100 100 pongo_abelii ENSPPYP00000012307 100 100 ENSG00000124193 homo_sapiens ENSP00000244020 99.7093 99.7093 pan_troglodytes ENSPTRP00000073229 99.7093 99.7093 ENSG00000124193 homo_sapiens ENSP00000244020 100 100 gorilla_gorilla ENSGGOP00000009578 100 100 ENSG00000124193 homo_sapiens ENSP00000244020 91.5698 88.9535 ornithorhynchus_anatinus ENSOANP00000014262 90.7781 88.1844 ENSG00000124193 homo_sapiens ENSP00000244020 90.1163 88.3721 sarcophilus_harrisii ENSSHAP00000015006 90.1163 88.3721 ENSG00000124193 homo_sapiens ENSP00000244020 80.5233 78.4884 notamacropus_eugenii ENSMEUP00000013340 91.1184 88.8158 ENSG00000124193 homo_sapiens ENSP00000244020 83.7209 83.7209 choloepus_hoffmanni ENSCHOP00000000499 83.4783 83.4783 ENSG00000124193 homo_sapiens ENSP00000244020 96.5116 96.2209 dasypus_novemcinctus ENSDNOP00000006506 95.9538 95.6647 ENSG00000124193 homo_sapiens ENSP00000244020 60.7558 59.593 erinaceus_europaeus ENSEEUP00000002113 95.8716 94.0367 ENSG00000124193 homo_sapiens ENSP00000244020 94.4767 93.0233 echinops_telfairi ENSETEP00000005046 94.7522 93.2945 ENSG00000124193 homo_sapiens ENSP00000244020 99.1279 99.1279 callithrix_jacchus ENSCJAP00000059311 99.1279 99.1279 ENSG00000124193 homo_sapiens ENSP00000244020 99.4186 99.4186 cercocebus_atys ENSCATP00000013347 99.7085 99.7085 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 98.5465 macaca_fascicularis ENSMFAP00000046410 99.7059 99.7059 ENSG00000124193 homo_sapiens ENSP00000244020 99.4186 99.4186 macaca_mulatta ENSMMUP00000037948 99.7085 99.7085 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.9651 macaca_nemestrina ENSMNEP00000029572 98.8338 98.2507 ENSG00000124193 homo_sapiens ENSP00000244020 99.4186 98.8372 macaca_nemestrina ENSMNEP00000006439 99.7085 99.1254 ENSG00000124193 homo_sapiens ENSP00000244020 99.4186 99.4186 papio_anubis ENSPANP00000054547 99.7085 99.7085 ENSG00000124193 homo_sapiens ENSP00000244020 61.9186 61.9186 mandrillus_leucophaeus ENSMLEP00000014717 99.5327 99.5327 ENSG00000124193 homo_sapiens ENSP00000244020 73.2558 72.3837 tursiops_truncatus ENSTTRP00000014603 97.2973 96.139 ENSG00000124193 homo_sapiens ENSP00000244020 20.3488 17.7326 vulpes_vulpes ENSVVUP00000026261 55.1181 48.0315 ENSG00000124193 homo_sapiens ENSP00000244020 56.686 55.5233 vulpes_vulpes ENSVVUP00000026252 91.9811 90.0943 ENSG00000124193 homo_sapiens ENSP00000244020 97.6744 96.2209 mus_spretus MGP_SPRETEiJ_P0058088 99.115 97.6401 ENSG00000124193 homo_sapiens ENSP00000244020 98.2558 97.093 equus_asinus ENSEASP00005062130 98.2558 97.093 ENSG00000124193 homo_sapiens ENSP00000244020 98.8372 97.9651 capra_hircus ENSCHIP00000015133 98.5507 97.6812 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.3837 capra_hircus ENSCHIP00000005003 98.2609 97.1014 ENSG00000124193 homo_sapiens ENSP00000244020 72.093 71.2209 loxodonta_africana ENSLAFP00000024295 95.0192 93.8697 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.6744 panthera_leo ENSPLOP00000004877 98.5465 97.6744 ENSG00000124193 homo_sapiens ENSP00000244020 79.9419 76.7442 ailuropoda_melanoleuca ENSAMEP00000003922 62.6424 60.1367 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.3837 bos_indicus_hybrid ENSBIXP00005009082 98.2609 97.1014 ENSG00000124193 homo_sapiens ENSP00000244020 61.0465 60.7558 oryctolagus_cuniculus ENSOCUP00000008429 97.6744 97.2093 ENSG00000124193 homo_sapiens ENSP00000244020 98.2558 97.093 equus_caballus ENSECAP00000043604 98.2558 97.093 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.6744 canis_lupus_familiaris ENSCAFP00845017800 98.5465 97.6744 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.6744 panthera_pardus ENSPPRP00000016728 98.5465 97.6744 ENSG00000124193 homo_sapiens ENSP00000244020 61.6279 60.7558 marmota_marmota_marmota ENSMMMP00000015640 99.5305 98.1221 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.3837 marmota_marmota_marmota ENSMMMP00000024677 99.1228 97.9532 ENSG00000124193 homo_sapiens ENSP00000244020 98.2558 97.3837 balaenoptera_musculus ENSBMSP00010025264 97.971 97.1014 ENSG00000124193 homo_sapiens ENSP00000244020 50 45.9302 balaenoptera_musculus ENSBMSP00010021695 76.7857 70.5357 ENSG00000124193 homo_sapiens ENSP00000244020 85.7558 84.593 cavia_porcellus ENSCPOP00000010577 92.7673 91.5094 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.6744 felis_catus ENSFCAP00000026050 98.5465 97.6744 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.6744 ursus_americanus ENSUAMP00000003862 98.5465 97.6744 ENSG00000124193 homo_sapiens ENSP00000244020 84.0116 81.3953 monodelphis_domestica ENSMODP00000049635 82.5714 80 ENSG00000124193 homo_sapiens ENSP00000244020 92.1512 90.9884 bison_bison_bison ENSBBBP00000021874 87.8116 86.7036 ENSG00000124193 homo_sapiens ENSP00000244020 98.2558 97.3837 monodon_monoceros ENSMMNP00015002215 97.971 97.1014 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.093 sus_scrofa ENSSSCP00000032081 98.2609 96.8116 ENSG00000124193 homo_sapiens ENSP00000244020 98.8372 98.2558 microcebus_murinus ENSMICP00000049672 98.5507 97.971 ENSG00000124193 homo_sapiens ENSP00000244020 28.4884 26.4535 octodon_degus ENSODEP00000022499 72.5926 67.4074 ENSG00000124193 homo_sapiens ENSP00000244020 59.593 58.4302 jaculus_jaculus ENSJJAP00000019834 98.0861 96.1722 ENSG00000124193 homo_sapiens ENSP00000244020 98.8372 97.9651 ovis_aries_rambouillet ENSOARP00020021372 98.5507 97.6812 ENSG00000124193 homo_sapiens ENSP00000244020 61.0465 60.7558 ursus_maritimus ENSUMAP00000001177 97.6744 97.2093 ENSG00000124193 homo_sapiens ENSP00000244020 73.2558 72.9651 ochotona_princeps ENSOPRP00000001846 97.6744 97.2868 ENSG00000124193 homo_sapiens ENSP00000244020 91.8605 88.6628 delphinapterus_leucas ENSDLEP00000003598 81.8653 79.0155 ENSG00000124193 homo_sapiens ENSP00000244020 98.2558 97.3837 physeter_catodon ENSPCTP00005027978 97.971 97.1014 ENSG00000124193 homo_sapiens ENSP00000244020 64.8256 57.8488 physeter_catodon ENSPCTP00005027946 76.3699 68.1507 ENSG00000124193 homo_sapiens ENSP00000244020 97.6744 95.9302 mus_caroli MGP_CAROLIEiJ_P0055924 99.115 97.3451 ENSG00000124193 homo_sapiens ENSP00000244020 97.6744 96.2209 mus_musculus ENSMUSP00000119065 99.115 97.6401 ENSG00000124193 homo_sapiens ENSP00000244020 98.8372 98.2558 dipodomys_ordii ENSDORP00000024386 98.8372 98.2558 ENSG00000124193 homo_sapiens ENSP00000244020 82.2674 81.686 mustela_putorius_furo ENSMPUP00000017580 98.2639 97.5694 ENSG00000124193 homo_sapiens ENSP00000244020 99.1279 99.1279 aotus_nancymaae ENSANAP00000012291 99.1279 99.1279 ENSG00000124193 homo_sapiens ENSP00000244020 99.4186 99.1279 saimiri_boliviensis_boliviensis ENSSBOP00000035107 99.4186 99.1279 ENSG00000124193 homo_sapiens ENSP00000244020 69.7674 66.8605 saimiri_boliviensis_boliviensis ENSSBOP00000035870 75.7098 72.5552 ENSG00000124193 homo_sapiens ENSP00000244020 80.5233 79.6512 vicugna_pacos ENSVPAP00000002787 80.2899 79.4203 ENSG00000124193 homo_sapiens ENSP00000244020 99.4186 99.4186 chlorocebus_sabaeus ENSCSAP00000010161 99.7085 99.7085 ENSG00000124193 homo_sapiens ENSP00000244020 86.9186 85.7558 tupaia_belangeri ENSTBEP00000011647 95.5272 94.2492 ENSG00000124193 homo_sapiens ENSP00000244020 28.1977 25.8721 mesocricetus_auratus ENSMAUP00000021312 71.8519 65.9259 ENSG00000124193 homo_sapiens ENSP00000244020 66.2791 62.5 phocoena_sinus ENSPSNP00000014479 80.2817 75.7042 ENSG00000124193 homo_sapiens ENSP00000244020 98.2558 97.3837 phocoena_sinus ENSPSNP00000029783 97.971 97.1014 ENSG00000124193 homo_sapiens ENSP00000244020 98.2558 97.3837 camelus_dromedarius ENSCDRP00005016905 97.971 97.1014 ENSG00000124193 homo_sapiens ENSP00000244020 83.7209 83.1395 carlito_syrichta ENSTSYP00000017975 97.9592 97.2789 ENSG00000124193 homo_sapiens ENSP00000244020 61.0465 60.7558 panthera_tigris_altaica ENSPTIP00000022294 97.6744 97.2093 ENSG00000124193 homo_sapiens ENSP00000244020 97.6744 96.2209 rattus_norvegicus ENSRNOP00000008427 99.115 97.6401 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 98.2558 prolemur_simus ENSPSMP00000000496 98.5465 98.2558 ENSG00000124193 homo_sapiens ENSP00000244020 60.4651 59.8837 microtus_ochrogaster ENSMOCP00000021351 99.0476 98.0952 ENSG00000124193 homo_sapiens ENSP00000244020 72.9651 72.093 sorex_araneus ENSSARP00000001444 98.0469 96.875 ENSG00000124193 homo_sapiens ENSP00000244020 92.4419 88.9535 peromyscus_maniculatus_bairdii ENSPEMP00000032770 93.2551 89.7361 ENSG00000124193 homo_sapiens ENSP00000244020 95.3488 93.8953 bos_mutus ENSBMUP00000018150 96.4706 95 ENSG00000124193 homo_sapiens ENSP00000244020 97.6744 96.2209 mus_spicilegus ENSMSIP00000034121 99.115 97.6401 ENSG00000124193 homo_sapiens ENSP00000244020 97.6744 96.8023 cricetulus_griseus_chok1gshd ENSCGRP00001024394 99.115 98.2301 ENSG00000124193 homo_sapiens ENSP00000244020 94.7674 92.7326 pteropus_vampyrus ENSPVAP00000014356 95.0437 93.0029 ENSG00000124193 homo_sapiens ENSP00000244020 85.7558 81.686 myotis_lucifugus ENSMLUP00000015144 85.5072 81.4493 ENSG00000124193 homo_sapiens ENSP00000244020 89.8256 88.0814 vombatus_ursinus ENSVURP00010025608 90.6158 88.8563 ENSG00000124193 homo_sapiens ENSP00000244020 95.3488 93.8953 rhinolophus_ferrumequinum ENSRFEP00010011321 95.0725 93.6232 ENSG00000124193 homo_sapiens ENSP00000244020 60.7558 60.4651 neovison_vison ENSNVIP00000015567 97.2093 96.7442 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.3837 bos_taurus ENSBTAP00000011240 98.2609 97.1014 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.3837 heterocephalus_glaber_female ENSHGLP00000047930 98.8338 97.6676 ENSG00000124193 homo_sapiens ENSP00000244020 97.6744 97.6744 rhinopithecus_bieti ENSRBIP00000035568 99.4083 99.4083 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.6744 canis_lupus_dingo ENSCAFP00020016934 98.5465 97.6744 ENSG00000124193 homo_sapiens ENSP00000244020 98.8372 98.5465 sciurus_vulgaris ENSSVLP00005029465 99.4152 99.1228 ENSG00000124193 homo_sapiens ENSP00000244020 89.8256 88.0814 phascolarctos_cinereus ENSPCIP00000004616 90.6158 88.8563 ENSG00000124193 homo_sapiens ENSP00000244020 88.9535 86.0465 procavia_capensis ENSPCAP00000010238 92.1687 89.1566 ENSG00000124193 homo_sapiens ENSP00000244020 97.093 96.2209 nannospalax_galili ENSNGAP00000017008 99.7015 98.806 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.3837 bos_grunniens ENSBGRP00000018723 98.2609 97.1014 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.3837 chinchilla_lanigera ENSCLAP00000014860 98.8338 97.6676 ENSG00000124193 homo_sapiens ENSP00000244020 88.6628 87.7907 cervus_hanglu_yarkandensis ENSCHYP00000037172 97.7564 96.7949 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.093 catagonus_wagneri ENSCWAP00000008738 98.2609 96.8116 ENSG00000124193 homo_sapiens ENSP00000244020 98.8372 98.2558 ictidomys_tridecemlineatus ENSSTOP00000009749 99.4152 98.8304 ENSG00000124193 homo_sapiens ENSP00000244020 97.9651 97.093 otolemur_garnettii ENSOGAP00000012965 97.6812 96.8116 ENSG00000124193 homo_sapiens ENSP00000244020 99.4186 99.4186 cebus_imitator ENSCCAP00000016454 99.4186 99.4186 ENSG00000124193 homo_sapiens ENSP00000244020 71.8023 68.8953 cebus_imitator ENSCCAP00000003550 84.8797 81.4433 ENSG00000124193 homo_sapiens ENSP00000244020 72.6744 68.8953 urocitellus_parryii ENSUPAP00010000629 79.6178 75.4777 ENSG00000124193 homo_sapiens ENSP00000244020 98.5465 97.6744 moschus_moschiferus ENSMMSP00000026966 98.2609 97.3913 ENSG00000124193 homo_sapiens ENSP00000244020 99.4186 99.4186 rhinopithecus_roxellana ENSRROP00000011277 99.7085 99.7085 ENSG00000124193 homo_sapiens ENSP00000244020 97.6744 95.9302 mus_pahari MGP_PahariEiJ_P0066909 99.115 97.3451 ENSG00000124193 homo_sapiens ENSP00000244020 98.8372 98.5465 propithecus_coquereli ENSPCOP00000027659 98.5507 98.2609 ENSG00000124193 homo_sapiens ENSP00000244020 73.2558 65.9884 callorhinchus_milii ENSCMIP00000037859 68.6648 61.8529 ENSG00000124193 homo_sapiens ENSP00000244020 81.3953 77.6163 latimeria_chalumnae ENSLACP00000006161 82.8402 78.9941 ENSG00000124193 homo_sapiens ENSP00000244020 72.093 62.7907 lepisosteus_oculatus ENSLOCP00000005020 52.5424 45.7627 ENSG00000124193 homo_sapiens ENSP00000244020 80.5233 71.8023 clupea_harengus ENSCHAP00000046927 76.7313 68.4211 ENSG00000124193 homo_sapiens ENSP00000244020 44.7674 38.9535 clupea_harengus ENSCHAP00000060581 66.3793 57.7586 ENSG00000124193 homo_sapiens ENSP00000244020 26.1628 23.5465 clupea_harengus ENSCHAP00000060579 88.2353 79.4118 ENSG00000124193 homo_sapiens ENSP00000244020 79.6512 71.8023 danio_rerio ENSDARP00000022089 77.1831 69.5775 ENSG00000124193 homo_sapiens ENSP00000244020 73.5465 66.2791 danio_rerio ENSDARP00000094522 72.9107 65.7061 ENSG00000124193 homo_sapiens ENSP00000244020 77.907 69.7674 carassius_auratus ENSCARP00000058031 82.716 74.0741 ENSG00000124193 homo_sapiens ENSP00000244020 77.6163 71.2209 carassius_auratus ENSCARP00000033112 74.581 68.4358 ENSG00000124193 homo_sapiens ENSP00000244020 73.8372 65.1163 carassius_auratus ENSCARP00000067490 75.3709 66.4688 ENSG00000124193 homo_sapiens ENSP00000244020 81.3953 75 carassius_auratus ENSCARP00000118775 80 73.7143 ENSG00000124193 homo_sapiens ENSP00000244020 79.9419 72.6744 astyanax_mexicanus ENSAMXP00000003171 73.1383 66.4894 ENSG00000124193 homo_sapiens ENSP00000244020 79.6512 71.2209 astyanax_mexicanus ENSAMXP00000040373 80.826 72.2714 ENSG00000124193 homo_sapiens ENSP00000244020 69.7674 63.3721 ictalurus_punctatus ENSIPUP00000006881 84.8057 77.0318 ENSG00000124193 homo_sapiens ENSP00000244020 74.7093 66.8605 ictalurus_punctatus ENSIPUP00000024940 76.0355 68.0473 ENSG00000124193 homo_sapiens ENSP00000244020 74.7093 67.7326 esox_lucius ENSELUP00000013229 77.4096 70.1807 ENSG00000124193 homo_sapiens ENSP00000244020 78.7791 69.7674 esox_lucius ENSELUP00000025440 74.4505 65.9341 ENSG00000124193 homo_sapiens ENSP00000244020 72.9651 66.8605 electrophorus_electricus ENSEEEP00000018133 71.3068 65.3409 ENSG00000124193 homo_sapiens ENSP00000244020 45.9302 40.1163 electrophorus_electricus ENSEEEP00000022814 79.397 69.3467 ENSG00000124193 homo_sapiens ENSP00000244020 25.2907 23.2558 electrophorus_electricus ENSEEEP00000022812 86.1386 79.2079 ENSG00000124193 homo_sapiens ENSP00000244020 27.3256 23.5465 oncorhynchus_kisutch ENSOKIP00005055599 84.6847 72.973 ENSG00000124193 homo_sapiens ENSP00000244020 77.0349 68.314 oncorhynchus_kisutch ENSOKIP00005116808 79.3413 70.3593 ENSG00000124193 homo_sapiens ENSP00000244020 56.1047 50.2907 oncorhynchus_kisutch ENSOKIP00005055647 74.5174 66.7954 ENSG00000124193 homo_sapiens ENSP00000244020 47.6744 40.9884 oncorhynchus_kisutch ENSOKIP00005092520 56.1644 48.2877 ENSG00000124193 homo_sapiens ENSP00000244020 27.3256 23.5465 oncorhynchus_mykiss ENSOMYP00000096007 84.6847 72.973 ENSG00000124193 homo_sapiens ENSP00000244020 76.7442 68.0233 oncorhynchus_mykiss ENSOMYP00000093285 79.0419 70.0599 ENSG00000124193 homo_sapiens ENSP00000244020 52.3256 45.9302 oncorhynchus_mykiss ENSOMYP00000142408 64.9819 57.0397 ENSG00000124193 homo_sapiens ENSP00000244020 56.1047 50 oncorhynchus_mykiss ENSOMYP00000096014 73.9464 65.9004 ENSG00000124193 homo_sapiens ENSP00000244020 53.4884 48.8372 salmo_salar ENSSSAP00000030451 73.8956 67.4699 ENSG00000124193 homo_sapiens ENSP00000244020 53.1977 48.5465 salmo_salar ENSSSAP00000009664 74.0891 67.6113 ENSG00000124193 homo_sapiens ENSP00000244020 48.8372 40.407 salmo_salar ENSSSAP00000160683 62.4535 51.6729 ENSG00000124193 homo_sapiens ENSP00000244020 76.4535 69.186 salmo_trutta ENSSTUP00000024225 78.5075 71.0448 ENSG00000124193 homo_sapiens ENSP00000244020 76.7442 68.6047 salmo_trutta ENSSTUP00000105250 79.0419 70.6587 ENSG00000124193 homo_sapiens ENSP00000244020 23.8372 21.5116 gadus_morhua ENSGMOP00000032092 79.6116 71.8447 ENSG00000124193 homo_sapiens ENSP00000244020 79.0698 71.5116 fundulus_heteroclitus ENSFHEP00000035037 81.194 73.4328 ENSG00000124193 homo_sapiens ENSP00000244020 33.4302 31.1047 poecilia_reticulata ENSPREP00000001423 77.1812 71.8121 ENSG00000124193 homo_sapiens ENSP00000244020 78.1977 69.186 xiphophorus_maculatus ENSXMAP00000037196 81.2689 71.9033 ENSG00000124193 homo_sapiens ENSP00000244020 72.3837 64.5349 oryzias_latipes ENSORLP00000004399 75.4545 67.2727 ENSG00000124193 homo_sapiens ENSP00000244020 72.9651 66.5698 cyclopterus_lumpus ENSCLMP00005001454 80.4487 73.3974 ENSG00000124193 homo_sapiens ENSP00000244020 78.7791 69.7674 oreochromis_niloticus ENSONIP00000002413 79.0087 69.9708 ENSG00000124193 homo_sapiens ENSP00000244020 25 22.093 oreochromis_niloticus ENSONIP00000048038 92.4731 81.7204 ENSG00000124193 homo_sapiens ENSP00000244020 71.8023 63.9535 haplochromis_burtoni ENSHBUP00000005017 78.9137 70.2875 ENSG00000124193 homo_sapiens ENSP00000244020 24.4186 22.093 astatotilapia_calliptera ENSACLP00000035990 88.4211 80 ENSG00000124193 homo_sapiens ENSP00000244020 74.4186 66.8605 sparus_aurata ENSSAUP00010029161 75.7396 68.0473 ENSG00000124193 homo_sapiens ENSP00000244020 25 22.3837 lates_calcarifer ENSLCAP00010019648 67.1875 60.1562 ENSG00000124193 homo_sapiens ENSP00000244020 80.5233 73.5465 lates_calcarifer ENSLCAP00010002006 79.3696 72.4928 ENSG00000124193 homo_sapiens ENSP00000244020 81.686 75.2907 xenopus_tropicalis ENSXETP00000107903 49.4718 45.5986 ENSG00000124193 homo_sapiens ENSP00000244020 89.2442 86.3372 chrysemys_picta_bellii ENSCPBP00000025601 88.7283 85.8382 ENSG00000124193 homo_sapiens ENSP00000244020 88.6628 85.4651 sphenodon_punctatus ENSSPUP00000006442 89.4428 86.217 ENSG00000124193 homo_sapiens ENSP00000244020 52.907 50.5814 crocodylus_porosus ENSCPRP00005019582 84.2593 80.5556 ENSG00000124193 homo_sapiens ENSP00000244020 62.5 60.7558 laticauda_laticaudata ENSLLTP00000014726 95.9821 93.3036 ENSG00000124193 homo_sapiens ENSP00000244020 27.907 26.1628 notechis_scutatus ENSNSUP00000001271 81.3559 76.2712 ENSG00000124193 homo_sapiens ENSP00000244020 60.4651 58.7209 pseudonaja_textilis ENSPTXP00000010992 93.2735 90.583 ENSG00000124193 homo_sapiens ENSP00000244020 90.407 87.5 anas_platyrhynchos_platyrhynchos ENSAPLP00000014318 89.3678 86.4943 ENSG00000124193 homo_sapiens ENSP00000244020 89.8256 86.6279 gallus_gallus ENSGALP00010036763 89.8256 86.6279 ENSG00000124193 homo_sapiens ENSP00000244020 68.314 66.2791 meleagris_gallopavo ENSMGAP00000000267 73.2087 71.028 ENSG00000124193 homo_sapiens ENSP00000244020 51.7442 48.2558 serinus_canaria ENSSCAP00000014706 87.2549 81.3726 ENSG00000124193 homo_sapiens ENSP00000244020 90.6977 87.7907 parus_major ENSPMJP00000002368 64.8649 62.7859 ENSG00000124193 homo_sapiens ENSP00000244020 88.6628 84.3023 anolis_carolinensis ENSACAP00000002019 87.3925 83.0946 ENSG00000124193 homo_sapiens ENSP00000244020 74.1279 65.407 neolamprologus_brichardi ENSNBRP00000019070 81.4697 71.885 ENSG00000124193 homo_sapiens ENSP00000244020 80.814 72.9651 neolamprologus_brichardi ENSNBRP00000002302 77.4373 69.9164 ENSG00000124193 homo_sapiens ENSP00000244020 60.4651 58.7209 naja_naja ENSNNAP00000004055 93.2735 90.583 ENSG00000124193 homo_sapiens ENSP00000244020 55.814 53.4884 geospiza_fortis ENSGFOP00000008864 88.4793 84.7926 ENSG00000124193 homo_sapiens ENSP00000244020 90.6977 87.7907 taeniopygia_guttata ENSTGUP00000030256 89.6552 86.7816 ENSG00000124193 homo_sapiens ENSP00000244020 78.4884 71.2209 erpetoichthys_calabaricus ENSECRP00000018819 76.2712 69.209 ENSG00000124193 homo_sapiens ENSP00000244020 71.5116 64.8256 kryptolebias_marmoratus ENSKMAP00000015986 85.4167 77.4306 ENSG00000124193 homo_sapiens ENSP00000244020 88.0814 84.3023 salvator_merianae ENSSMRP00000000797 88.3382 84.5481 ENSG00000124193 homo_sapiens ENSP00000244020 77.0349 68.8953 oryzias_javanicus ENSOJAP00000049541 73.6111 65.8333 ENSG00000124193 homo_sapiens ENSP00000244020 75.8721 67.7326 amphilophus_citrinellus ENSACIP00000030591 81.3084 72.5857 ENSG00000124193 homo_sapiens ENSP00000244020 72.3837 64.2442 amphilophus_citrinellus ENSACIP00000026058 76.6154 68 ENSG00000124193 homo_sapiens ENSP00000244020 71.2209 63.6628 dicentrarchus_labrax ENSDLAP00005038431 74.0181 66.1631 ENSG00000124193 homo_sapiens ENSP00000244020 78.1977 70.9302 amphiprion_percula ENSAPEP00000018335 77.2989 70.1149 ENSG00000124193 homo_sapiens ENSP00000244020 65.6977 58.1395 amphiprion_percula ENSAPEP00000029221 79.8587 70.6714 ENSG00000124193 homo_sapiens ENSP00000244020 24.4186 22.9651 oryzias_sinensis ENSOSIP00000022829 88.4211 83.1579 ENSG00000124193 homo_sapiens ENSP00000244020 24.4186 22.9651 oryzias_sinensis ENSOSIP00000002320 88.4211 83.1579 ENSG00000124193 homo_sapiens ENSP00000244020 88.9535 86.0465 gopherus_evgoodei ENSGEVP00005016937 88.4393 85.5491 ENSG00000124193 homo_sapiens ENSP00000244020 89.5349 86.3372 chelonoidis_abingdonii ENSCABP00000001105 89.0173 85.8382 ENSG00000124193 homo_sapiens ENSP00000244020 79.3605 72.9651 seriola_dumerili ENSSDUP00000022127 78.2235 71.9198 ENSG00000124193 homo_sapiens ENSP00000244020 24.7093 22.6744 seriola_dumerili ENSSDUP00000015113 92.3913 84.7826 ENSG00000124193 homo_sapiens ENSP00000244020 26.4535 24.1279 cottoperca_gobio ENSCGOP00000015262 87.5 79.8077 ENSG00000124193 homo_sapiens ENSP00000244020 44.7674 38.6628 cottoperca_gobio ENSCGOP00000015266 66.9565 57.8261 ENSG00000124193 homo_sapiens ENSP00000244020 82.5581 79.6512 struthio_camelus_australis ENSSCUP00000015289 85.5422 82.5301 ENSG00000124193 homo_sapiens ENSP00000244020 90.6977 88.0814 anser_brachyrhynchus ENSABRP00000009097 89.6552 87.069 ENSG00000124193 homo_sapiens ENSP00000244020 79.9419 69.186 gasterosteus_aculeatus ENSGACP00000008077 69.797 60.4061 ENSG00000124193 homo_sapiens ENSP00000244020 33.4302 31.3953 cynoglossus_semilaevis ENSCSEP00000030885 86.4662 81.203 ENSG00000124193 homo_sapiens ENSP00000244020 44.4767 39.8256 cynoglossus_semilaevis ENSCSEP00000030892 64.2857 57.563 ENSG00000124193 homo_sapiens ENSP00000244020 81.3953 73.8372 poecilia_formosa ENSPFOP00000006405 73.4908 66.6667 ENSG00000124193 homo_sapiens ENSP00000244020 24.4186 22.093 myripristis_murdjan ENSMMDP00005037409 95.4545 86.3636 ENSG00000124193 homo_sapiens ENSP00000244020 72.093 63.6628 myripristis_murdjan ENSMMDP00005012527 68.3196 60.3306 ENSG00000124193 homo_sapiens ENSP00000244020 78.4884 70.9302 sander_lucioperca ENSSLUP00000010625 75.419 68.1564 ENSG00000124193 homo_sapiens ENSP00000244020 90.6977 88.0814 strigops_habroptila ENSSHBP00005007788 89.6552 87.069 ENSG00000124193 homo_sapiens ENSP00000244020 74.1279 65.9884 amphiprion_ocellaris ENSAOCP00000001335 80.6962 71.8354 ENSG00000124193 homo_sapiens ENSP00000244020 47.093 40.407 amphiprion_ocellaris ENSAOCP00000029237 67.5 57.9167 ENSG00000124193 homo_sapiens ENSP00000244020 27.0349 24.4186 amphiprion_ocellaris ENSAOCP00000014716 81.5789 73.6842 ENSG00000124193 homo_sapiens ENSP00000244020 89.2442 86.3372 terrapene_carolina_triunguis ENSTMTP00000024126 88.7283 85.8382 ENSG00000124193 homo_sapiens ENSP00000244020 24.4186 21.5116 hucho_hucho ENSHHUP00000012016 74.3363 65.4867 ENSG00000124193 homo_sapiens ENSP00000244020 78.4884 70.3488 betta_splendens ENSBSLP00000006738 76.9231 68.9459 ENSG00000124193 homo_sapiens ENSP00000244020 33.4302 32.2674 pygocentrus_nattereri ENSPNAP00000034100 88.4615 85.3846 ENSG00000124193 homo_sapiens ENSP00000244020 46.8023 41.8605 pygocentrus_nattereri ENSPNAP00000007692 68.8034 61.5385 ENSG00000124193 homo_sapiens ENSP00000244020 45.9302 40.407 pygocentrus_nattereri ENSPNAP00000016959 65.0206 57.2016 ENSG00000124193 homo_sapiens ENSP00000244020 78.4884 70.3488 anabas_testudineus ENSATEP00000010456 84.375 75.625 ENSG00000124193 homo_sapiens ENSP00000244020 24.7093 21.8023 anabas_testudineus ENSATEP00000041341 91.3979 80.6452 ENSG00000124193 homo_sapiens ENSP00000244020 80.2326 73.2558 seriola_lalandi_dorsalis ENSSLDP00000029666 79.5389 72.6225 ENSG00000124193 homo_sapiens ENSP00000244020 24.7093 22.6744 seriola_lalandi_dorsalis ENSSLDP00000018910 92.3913 84.7826 ENSG00000124193 homo_sapiens ENSP00000244020 77.907 70.3488 labrus_bergylta ENSLBEP00000009503 74.6518 67.4095 ENSG00000124193 homo_sapiens ENSP00000244020 72.093 63.9535 pundamilia_nyererei ENSPNYP00000006439 79.2332 70.2875 ENSG00000124193 homo_sapiens ENSP00000244020 81.3953 72.3837 pundamilia_nyererei ENSPNYP00000014866 76.7123 68.2192 ENSG00000124193 homo_sapiens ENSP00000244020 61.9186 56.1047 mastacembelus_armatus ENSMAMP00000042079 83.2031 75.3906 ENSG00000124193 homo_sapiens ENSP00000244020 81.1047 74.4186 mastacembelus_armatus ENSMAMP00000025571 79.9427 73.3524 ENSG00000124193 homo_sapiens ENSP00000244020 80.2326 72.093 stegastes_partitus ENSSPAP00000003241 75.6164 67.9452 ENSG00000124193 homo_sapiens ENSP00000244020 25.2907 22.3837 stegastes_partitus ENSSPAP00000029132 90.625 80.2083 ENSG00000124193 homo_sapiens ENSP00000244020 55.814 49.4186 oncorhynchus_tshawytscha ENSOTSP00005023603 72.1805 63.9098 ENSG00000124193 homo_sapiens ENSP00000244020 26.7442 22.9651 oncorhynchus_tshawytscha ENSOTSP00005023601 82.8829 71.1712 ENSG00000124193 homo_sapiens ENSP00000244020 52.907 45.0581 oncorhynchus_tshawytscha ENSOTSP00005023124 58.147 49.5208 ENSG00000124193 homo_sapiens ENSP00000244020 77.0349 68.314 oncorhynchus_tshawytscha ENSOTSP00005100768 79.3413 70.3593 ENSG00000124193 homo_sapiens ENSP00000244020 46.5116 39.8256 acanthochromis_polyacanthus ENSAPOP00000013831 68.0851 58.2979 ENSG00000124193 homo_sapiens ENSP00000244020 36.6279 33.4302 acanthochromis_polyacanthus ENSAPOP00000013795 78.2609 71.4286 ENSG00000124193 homo_sapiens ENSP00000244020 90.6977 88.0814 aquila_chrysaetos_chrysaetos ENSACCP00020004556 89.6552 87.069 ENSG00000124193 homo_sapiens ENSP00000244020 59.0116 55.814 nothobranchius_furzeri ENSNFUP00015028973 89.823 84.9557 ENSG00000124193 homo_sapiens ENSP00000244020 33.4302 31.9767 cyprinodon_variegatus ENSCVAP00000000909 88.4615 84.6154 ENSG00000124193 homo_sapiens ENSP00000244020 44.186 38.3721 cyprinodon_variegatus ENSCVAP00000020455 58.2375 50.5747 ENSG00000124193 homo_sapiens ENSP00000244020 79.3605 72.3837 denticeps_clupeoides ENSDCDP00000047448 78.6744 71.7579 ENSG00000124193 homo_sapiens ENSP00000244020 72.093 66.2791 larimichthys_crocea ENSLCRP00005029058 74.2515 68.2635 ENSG00000124193 homo_sapiens ENSP00000244020 77.3256 69.4767 takifugu_rubripes ENSTRUP00000058711 75.1412 67.5141 ENSG00000124193 homo_sapiens ENSP00000244020 72.3837 67.7326 ficedula_albicollis ENSFALP00000026730 80.8442 75.6494 ENSG00000124193 homo_sapiens ENSP00000244020 74.7093 65.1163 hippocampus_comes ENSHCOP00000018300 82.3718 71.7949 ENSG00000124193 homo_sapiens ENSP00000244020 72.6744 65.9884 cyprinus_carpio_carpio ENSCCRP00000111209 73.3138 66.5689 ENSG00000124193 homo_sapiens ENSP00000244020 79.6512 70.3488 cyprinus_carpio_carpio ENSCCRP00000109735 83.5366 73.7805 ENSG00000124193 homo_sapiens ENSP00000244020 80.814 74.1279 cyprinus_carpio_carpio ENSCCRP00000129737 77.6536 71.229 ENSG00000124193 homo_sapiens ENSP00000244020 79.3605 70.9302 cyprinus_carpio_carpio ENSCCRP00000128271 77.5568 69.3182 ENSG00000124193 homo_sapiens ENSP00000244020 89.5349 86.6279 coturnix_japonica ENSCJPP00005024878 89.0173 86.1272 ENSG00000124193 homo_sapiens ENSP00000244020 78.4884 69.186 poecilia_latipinna ENSPLAP00000006924 76.0563 67.0423 ENSG00000124193 homo_sapiens ENSP00000244020 73.5465 64.8256 sinocyclocheilus_grahami ENSSGRP00000080350 70.0831 61.7729 ENSG00000124193 homo_sapiens ENSP00000244020 56.1047 49.4186 sinocyclocheilus_grahami ENSSGRP00000051452 74.2308 65.3846 ENSG00000124193 homo_sapiens ENSP00000244020 68.6047 61.0465 sinocyclocheilus_grahami ENSSGRP00000093722 74.6835 66.4557 ENSG00000124193 homo_sapiens ENSP00000244020 80.5233 71.8023 sinocyclocheilus_grahami ENSSGRP00000037925 81.7109 72.8614 ENSG00000124193 homo_sapiens ENSP00000244020 74.1279 65.6977 maylandia_zebra ENSMZEP00005010679 80.6962 71.519 ENSG00000124193 homo_sapiens ENSP00000244020 70.6395 63.0814 maylandia_zebra ENSMZEP00005027707 84.669 75.6098 ENSG00000124193 homo_sapiens ENSP00000244020 75.8721 69.186 tetraodon_nigroviridis ENSTNIP00000002311 79.5732 72.561 ENSG00000124193 homo_sapiens ENSP00000244020 73.8372 66.5698 paramormyrops_kingsleyae ENSPKIP00000011506 69.9725 63.0854 ENSG00000124193 homo_sapiens ENSP00000244020 35.7558 32.8488 paramormyrops_kingsleyae ENSPKIP00000037410 87.8571 80.7143 ENSG00000124193 homo_sapiens ENSP00000244020 44.7674 38.9535 paramormyrops_kingsleyae ENSPKIP00000037426 63.6364 55.3719 ENSG00000124193 homo_sapiens ENSP00000244020 79.9419 72.9651 scleropages_formosus ENSSFOP00015030697 73.9247 67.4731 ENSG00000124193 homo_sapiens ENSP00000244020 45.6395 39.8256 scleropages_formosus ENSSFOP00015023643 65.9664 57.563 ENSG00000124193 homo_sapiens ENSP00000244020 26.1628 22.9651 scleropages_formosus ENSSFOP00015031682 87.3786 76.699 ENSG00000124193 homo_sapiens ENSP00000244020 84.593 77.0349 leptobrachium_leishanense ENSLLEP00000048939 65.5405 59.6847 ENSG00000124193 homo_sapiens ENSP00000244020 67.4419 57.5581 scophthalmus_maximus ENSSMAP00000028562 46.493 39.6794 ENSG00000124193 homo_sapiens ENSP00000244020 78.1977 70.3488 scophthalmus_maximus ENSSMAP00000024276 73.9011 66.4835 ENSG00000124193 homo_sapiens ENSP00000244020 73.5465 64.2442 oryzias_melastigma ENSOMEP00000005008 73.9766 64.6199
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000380 involved_in alternative mRNA splicing, via spliceosome 1 IDA Homo_sapiens(9606) Process GO:0000381 acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome 2 IDA,IMP Homo_sapiens(9606) Process GO:0000398 involved_in mRNA splicing, via spliceosome 1 IBA Homo_sapiens(9606) Process GO:0003723 enables RNA binding 3 HDA,IBA,IDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005654 located_in nucleoplasm 1 TAS Homo_sapiens(9606) Component GO:0006376 involved_in mRNA splice site recognition 1 IMP Homo_sapiens(9606) Process GO:0010837 involved_in regulation of keratinocyte proliferation 1 IMP Homo_sapiens(9606) Process GO:0016607 is_active_in nuclear speck 2 IBA,IDA Homo_sapiens(9606) Component GO:0032868 involved_in response to insulin 1 IEA Homo_sapiens(9606) Process GO:0036002 enables pre-mRNA binding 1 IDA Homo_sapiens(9606) Function GO:0045617 involved_in negative regulation of keratinocyte differentiation 1 IMP Homo_sapiens(9606) Process GO:0048025 involved_in negative regulation of mRNA splicing, via spliceosome 1 IDA Homo_sapiens(9606) Process GO:0060501 acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis 1 IDA Homo_sapiens(9606) Process GO:0061041 involved_in regulation of wound healing 1 IMP Homo_sapiens(9606) Process GO:2000675 involved_in negative regulation of type B pancreatic cell apoptotic process 1 IEA Homo_sapiens(9606) Process
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