Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerFlavivirusesRVSARS-COV-2SINVDengueZika
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations Stress granucleP-body
BulkPerturb-seq DataSet_01_45

Description

Ensembl ID ENSG00000123908 Gene ID 27161 Accession 3263
Symbol AGO2 Alias PPD;Q10;CASC7;EIF2C2;LESKRES;LINC00980 Full Name argonaute RISC catalytic component 2
Status Confidence Length 115478 bases Strand Minus strand
Position 8 : 140520156 - 140635633 RNA binding domain Piwi , PAZ
Summary This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000220592 Piwi PF02171 9.8e-115 1
ENSP00000220592 PAZ PF02170 3.1e-27 2
ENSP00000430176 Piwi PF02171 9.7e-93 1
ENSP00000430176 Piwi PF02171 9.7e-93 2
ENSP00000430176 PAZ PF02170 2.9e-27 3

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25843071 Role of MicroRNA in Visceral Pain. Jian Zhang 2015-03-30 Journal of neurogastroenterology and motility
29017520 The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Roberta Tarallo 2017-10-06 Genome biology
23897118 MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes. Laura Brudecki 2013-09-01 Immunology and cell biology
34488447 RISC in Entamoeba histolytica: Identification of a Protein-Protein Interaction Network for the RNA Interference Pathway in a Deep-Branching Eukaryote. Hanbang Zhang 2021-10-26 mBio
27928054 The influence of the 5΄-terminal nucleotide on AgoshRNA activity and biogenesis: importance of the polymerase III transcription initiation site. Elena Herrera-Carrillo 2017-04-20 Nucleic acids research
27941595 Achieving HIV-1 Control through RNA-Directed Gene Regulation. Vera Klemm 2016-12-07 Genes
31438963 Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis. Zhonglin Zhu 2019-08-22 Molecular cancer
26545861 Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis. Peiyao Li 2015-11-06 BMC cancer
30585246 Extracellular Vesicles as Conduits of Non-Coding RNA Emission and Intercellular Transfer in Brain Tumors. Cristiana Spinelli 2018-12-25 Non-coding RNA
29569941 Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk. L Claire Smillie 2018-06-01 Critical reviews in biochemistry and molecular biology
25394686 Secretion of small/microRNAs including miR-638 into extracellular spaces by sphingomyelin phosphodiesterase 3. Shiori Kubota 2015-01-01 Oncology reports
31920664 The Contrasting Role of Extracellular Vesicles in Vascular Inflammation and Tissue Repair. Silvia Oggero 2019-01-01 Frontiers in pharmacology
21948796 Retroviral GAG proteins recruit AGO2 on viral RNAs without affecting RNA accumulation and translation. Manuella Bouttier 2012-01-01 Nucleic acids research
28082397 Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3΄ variants. Daisuke Yamane 2017-05-05 Nucleic acids research
30713076 Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis. Toni Beltran 2019-03-25 Developmental cell
24152142 Short interfering RNA guide strand modifiers from computational screening. Kazumitsu Onizuka 2013-11-13 Journal of the American Chemical Society
29891014 Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245. Liu Yang 2018-06-11 Respiratory research
35356544 Elucidation of the conformational dynamics and assembly of Argonaute-RNA complexes by distinct yet coordinated actions of the supplementary microRNA. Haiming Zhuang 2022-01-01 Computational and structural biotechnology journal
29121858 Detection of circulating miRNAs: comparative analysis of extracellular vesicle-incorporated miRNAs and cell-free miRNAs in whole plasma of prostate cancer patients. Edgars Endzeliņš 2017-11-09 BMC cancer
22566243 miR-TRAP: a benchtop chemical biology strategy to identify microRNA targets. Huricha Baigude 2012-06-11 Angewandte Chemie (International ed. in English)
32719345 HMGA2 regulates circular RNA ASPH to promote tumor growth in lung adenocarcinoma. Li Xu 2020-07-27 Cell death & disease
29018797 microRNAs Make the Call in Cancer Personalized Medicine. Simone Detassis 2017-01-01 Frontiers in cell and developmental biology
24073250 Differential stability of cell-free circulating microRNAs: implications for their utilization as biomarkers. Verena Köberle 2013-01-01 PloS one
31849488 Exosomes-Derived Long Non-Coding RNA HOTAIR Reduces Laryngeal Cancer Radiosensitivity by Regulating microRNA-454-3p/E2F2 Axis. Xiangyan Cui 2019-01-01 OncoTargets and therapy
35004677 HIF-1α Induces HECTD2 Up-Regulation and Aggravates the Malignant Progression of Renal Cell Cancer via Repressing miR-320a. Dong Lv 2021-01-01 Frontiers in cell and developmental biology

Transcripts

Name Transcript ID bp Protein Translation ID
AGO2-201 ENST00000220592 14595 859aa ENSP00000220592
AGO2-205 ENST00000519980 3141 825aa ENSP00000430176
AGO2-209 ENST00000523609 3050 73aa ENSP00000430164
AGO2-207 ENST00000520628 350 No protein -
AGO2-206 ENST00000520412 614 No protein -
AGO2-204 ENST00000519347 309 No protein -
AGO2-208 ENST00000521325 683 No protein -
AGO2-202 ENST00000517293 422 No protein -
AGO2-210 ENST00000524328 316 36aa ENSP00000431056
AGO2-203 ENST00000518019 421 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
101697Glucose8E-623400010
101698Hydrochlorothiazide8E-623400010

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000123908homo_sapiensENSP0000036228789.069879.8837homo_sapiensENSP0000022059289.173579.9767
ENSG00000123908homo_sapiensENSP0000036230688.269578.1649homo_sapiensENSP0000022059288.47578.3469
ENSG00000123908homo_sapiensENSP0000036230090.781882.2637homo_sapiensENSP0000022059290.570482.0722

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000123908homo_sapiensENSP0000022059294.528594.2957nomascus_leucogenysENSNLEP0000000176195.867895.6316
ENSG00000123908homo_sapiensENSP0000022059299.185199.1851pan_paniscusENSPPAP0000002976097.594597.5945
ENSG00000123908homo_sapiensENSP00000220592100100pongo_abeliiENSPPYP0000002121299.883799.8837
ENSG00000123908homo_sapiensENSP0000022059299.417999.1851pan_troglodytesENSPTRP0000003526397.266597.0387
ENSG00000123908homo_sapiensENSP0000022059299.534399.5343gorilla_gorillaENSGGOP0000001113098.502398.5023
ENSG00000123908homo_sapiensENSP0000022059292.200290.6868ornithorhynchus_anatinusENSOANP0000003781190.102488.6234
ENSG00000123908homo_sapiensENSP0000022059299.185198.7194sarcophilus_harrisiiENSSHAP0000001114798.839998.3759
ENSG00000123908homo_sapiensENSP0000022059275.320174.9709notamacropus_eugeniiENSMEUP0000000127975.849975.4982
ENSG00000123908homo_sapiensENSP0000022059264.144464.1444choloepus_hoffmanniENSCHOP0000000791365.830365.8303
ENSG00000123908homo_sapiensENSP0000022059290.104889.7555dasypus_novemcinctusENSDNOP0000002616898.97798.5934
ENSG00000123908homo_sapiensENSP0000022059261.001260.8848erinaceus_europaeusENSEEUP0000000783261.430261.313
ENSG00000123908homo_sapiensENSP0000022059299.534399.4179callithrix_jacchusENSCJAP0000005689295.637695.5257
ENSG00000123908homo_sapiensENSP0000022059297.671796.624cercocebus_atysENSCATP0000003152497.671796.624
ENSG00000123908homo_sapiensENSP0000022059299.767299.5343macaca_fascicularisENSMFAP0000001322396.50996.2838
ENSG00000123908homo_sapiensENSP0000022059299.534399.5343macaca_mulattaENSMMUP0000000822598.615998.6159
ENSG00000123908homo_sapiensENSP0000022059299.767299.5343macaca_nemestrinaENSMNEP0000000437097.275897.0488
ENSG00000123908homo_sapiensENSP0000022059296.041995.4598papio_anubisENSPANP0000002337792.178891.6201
ENSG00000123908homo_sapiensENSP0000022059299.767299.5343mandrillus_leucophaeusENSMLEP0000002965396.50996.2838
ENSG00000123908homo_sapiensENSP0000022059298.952398.7194tursiops_truncatusENSTTRP0000000269399.765399.5305
ENSG00000123908homo_sapiensENSP0000022059294.528594.5285vulpes_vulpesENSVVUP0000001984099.87799.877
ENSG00000123908homo_sapiensENSP0000022059298.137498.021mus_spretusMGP_SPRETEiJ_P004020699.059998.9424
ENSG00000123908homo_sapiensENSP0000022059294.761494.1793equus_asinusENSEASP0000505455384.703484.1831
ENSG00000123908homo_sapiensENSP00000220592100100capra_hircusENSCHIP0000000655799.883799.8837
ENSG00000123908homo_sapiensENSP0000022059298.719498.7194loxodonta_africanaENSLAFP0000001079299.413899.4138
ENSG00000123908homo_sapiensENSP0000022059299.417999.4179panthera_leoENSPLOP0000000190196.171296.1712
ENSG00000123908homo_sapiensENSP0000022059299.417999.3015ailuropoda_melanoleucaENSAMEP0000000538493.129893.0207
ENSG00000123908homo_sapiensENSP00000220592100100bos_indicus_hybridENSBIXP0000504604378.375978.3759
ENSG00000123908homo_sapiensENSP0000022059284.749784.4005oryctolagus_cuniculusENSOCUP0000003094685.345884.9941
ENSG00000123908homo_sapiensENSP0000022059299.534399.1851equus_caballusENSECAP0000006083893.544993.2166
ENSG00000123908homo_sapiensENSP0000022059299.185199.0687canis_lupus_familiarisENSCAFP0084501706593.216693.1072
ENSG00000123908homo_sapiensENSP0000022059299.068799.0687panthera_pardusENSPPRP0000000742699.532299.5322
ENSG00000123908homo_sapiensENSP0000022059298.719498.7194marmota_marmota_marmotaENSMMMP0000000596699.530599.5305
ENSG00000123908homo_sapiensENSP0000022059299.650899.5343balaenoptera_musculusENSBMSP0001002056699.534999.4186
ENSG00000123908homo_sapiensENSP0000022059299.068799.0687cavia_porcellusENSCPOP0000003242099.299999.2999
ENSG00000123908homo_sapiensENSP0000022059299.767299.7672felis_catusENSFCAP0000000255799.651299.6512
ENSG00000123908homo_sapiensENSP0000022059299.417999.3015ursus_americanusENSUAMP0000001318793.743193.6334
ENSG00000123908homo_sapiensENSP0000022059299.185198.7194monodelphis_domesticaENSMODP0000000089998.839998.3759
ENSG00000123908homo_sapiensENSP0000022059294.412194.1793bison_bison_bisonENSBBBP0000001026196.893796.6547
ENSG00000123908homo_sapiensENSP0000022059299.301599.0687monodon_monocerosENSMMNP0001500424993.633493.4138
ENSG00000123908homo_sapiensENSP0000022059298.719498.7194sus_scrofaENSSSCP0000005962497.025297.0252
ENSG00000123908homo_sapiensENSP0000022059299.417999.1851microcebus_murinusENSMICP0000000403597.045596.8182
ENSG00000123908homo_sapiensENSP0000022059299.185199.1851octodon_degusENSODEP0000001917298.954798.9547
ENSG00000123908homo_sapiensENSP0000022059299.301599.3015jaculus_jaculusENSJJAP0000001705898.726998.7269
ENSG00000123908homo_sapiensENSP00000220592100100ovis_aries_rambouilletENSOARP0002000657099.883799.8837
ENSG00000123908homo_sapiensENSP0000022059294.412193.9464ursus_maritimusENSUMAP0000002777892.159191.7045
ENSG00000123908homo_sapiensENSP0000022059286.495986.2631ochotona_princepsENSOPRP0000000806488.137687.9004
ENSG00000123908homo_sapiensENSP0000022059299.417999.1851delphinapterus_leucasENSDLEP0000002156894.678594.4568
ENSG00000123908homo_sapiensENSP0000022059299.767299.6508physeter_catodonENSPCTP0000502430499.651299.5349
ENSG00000123908homo_sapiensENSP0000022059299.185199.0687mus_caroliMGP_CAROLIEiJ_P003841699.069898.9535
ENSG00000123908homo_sapiensENSP0000022059299.185199.0687mus_musculusENSMUSP0000004220799.069898.9535
ENSG00000123908homo_sapiensENSP0000022059298.60398.4866dipodomys_ordiiENSDORP0000001056499.064398.9474
ENSG00000123908homo_sapiensENSP0000022059298.835998.8359mustela_putorius_furoENSMPUP0000000191499.647999.6479
ENSG00000123908homo_sapiensENSP0000022059299.883699.8836aotus_nancymaaeENSANAP0000001926399.883699.8836
ENSG00000123908homo_sapiensENSP0000022059299.417999.1851saimiri_boliviensis_boliviensisENSSBOP0000000517497.711797.4828
ENSG00000123908homo_sapiensENSP0000022059299.767299.5343chlorocebus_sabaeusENSCSAP0000000583094.800994.5796
ENSG00000123908homo_sapiensENSP0000022059262.281762.2817tupaia_belangeriENSTBEP0000000297477.988377.9883
ENSG00000123908homo_sapiensENSP0000022059291.152590.3376mesocricetus_auratusENSMAUP0000000572995.487894.6341
ENSG00000123908homo_sapiensENSP0000022059299.767299.6508phocoena_sinusENSPSNP0000001904399.651299.5349
ENSG00000123908homo_sapiensENSP0000022059299.417999.4179camelus_dromedariusENSCDRP0000501326699.649999.6499
ENSG00000123908homo_sapiensENSP0000022059299.534399.1851carlito_syrichtaENSTSYP0000000668397.602797.2603
ENSG00000123908homo_sapiensENSP0000022059297.904597.6717panthera_tigris_altaicaENSPTIP0000000517197.904597.6717
ENSG00000123908homo_sapiensENSP0000022059298.952398.8359rattus_norvegicusENSRNOP0000009540596.590996.4773
ENSG00000123908homo_sapiensENSP0000022059299.883699.8836prolemur_simusENSPSMP0000003446799.767499.7674
ENSG00000123908homo_sapiensENSP0000022059298.952398.7194microtus_ochrogasterENSMOCP0000000037299.067698.8345
ENSG00000123908homo_sapiensENSP0000022059272.409863.5623sorex_araneusENSSARP0000000654783.37873.1903
ENSG00000123908homo_sapiensENSP0000022059299.185199.1851peromyscus_maniculatus_bairdiiENSPEMP0000000577399.069899.0698
ENSG00000123908homo_sapiensENSP0000022059298.137498.021bos_mutusENSBMUP0000001929796.453196.3387
ENSG00000123908homo_sapiensENSP000002205929.313168.61467mus_spicilegusENSMSIP0000000269483.333377.0833
ENSG00000123908homo_sapiensENSP0000022059298.486698.3702mus_spicilegusENSMSIP0000002321499.295899.1784
ENSG00000123908homo_sapiensENSP0000022059299.068798.9523cricetulus_griseus_chok1gshdENSCGRP0000101210598.953598.8372
ENSG00000123908homo_sapiensENSP0000022059283.585683.2363pteropus_vampyrusENSPVAP0000001248483.780683.4306
ENSG00000123908homo_sapiensENSP0000022059258.905757.9744myotis_lucifugusENSMLUP0000000414489.716388.2979
ENSG00000123908homo_sapiensENSP0000022059299.185198.7194vombatus_ursinusENSVURP0001002468198.839998.3759
ENSG00000123908homo_sapiensENSP0000022059299.650899.5343rhinolophus_ferrumequinumENSRFEP0001001873899.534999.4186
ENSG00000123908homo_sapiensENSP0000022059294.528594.5285neovison_visonENSNVIP0000002008599.87799.877
ENSG00000123908homo_sapiensENSP00000220592100100bos_taurusENSBTAP0000000206899.883799.8837
ENSG00000123908homo_sapiensENSP0000022059224.214222.7008heterocephalus_glaber_femaleENSHGLP0000003373787.029381.59
ENSG00000123908homo_sapiensENSP0000022059299.301599.1851heterocephalus_glaber_femaleENSHGLP0000003771196.166996.0541
ENSG00000123908homo_sapiensENSP0000022059299.301599.3015rhinopithecus_bietiENSRBIP0000000925297.042197.0421
ENSG00000123908homo_sapiensENSP0000022059299.185199.0687canis_lupus_dingoENSCAFP0002001930093.216693.1072
ENSG00000123908homo_sapiensENSP0000022059299.767299.7672sciurus_vulgarisENSSVLP0000502543399.651299.6512
ENSG00000123908homo_sapiensENSP0000022059297.322596.8568phascolarctos_cinereusENSPCIP0000004204095.871695.4128
ENSG00000123908homo_sapiensENSP0000022059292.782392.5495procavia_capensisENSPCAP0000000274693.654593.4195
ENSG00000123908homo_sapiensENSP0000022059298.719498.4866nannospalax_galiliENSNGAP0000001281999.530599.2958
ENSG00000123908homo_sapiensENSP00000220592100100bos_grunniensENSBGRP0000003893299.883799.8837
ENSG00000123908homo_sapiensENSP0000022059299.417999.4179chinchilla_lanigeraENSCLAP0000000186899.766499.7664
ENSG00000123908homo_sapiensENSP0000022059299.417999.3015cervus_hanglu_yarkandensisENSCHYP0000002916997.045596.9318
ENSG00000123908homo_sapiensENSP0000022059299.767299.7672catagonus_wagneriENSCWAP0000001173299.651299.6512
ENSG00000123908homo_sapiensENSP0000022059298.952398.9523ictidomys_tridecemlineatusENSSTOP0000000728298.607998.6079
ENSG00000123908homo_sapiensENSP0000022059299.185199.1851otolemur_garnettiiENSOGAP0000000710299.882899.8828
ENSG00000123908homo_sapiensENSP0000022059299.185199.1851cebus_imitatorENSCCAP0000003465297.260397.2603
ENSG00000123908homo_sapiensENSP0000022059298.952398.9523urocitellus_parryiiENSUPAP0001000780398.152498.1524
ENSG00000123908homo_sapiensENSP0000022059210099.8836moschus_moschiferusENSMMSP0000000018699.883799.7674
ENSG00000123908homo_sapiensENSP0000022059299.534399.4179rhinopithecus_roxellanaENSRROP0000000097398.843998.7283
ENSG00000123908homo_sapiensENSP0000022059298.952398.8359mus_pahariMGP_PahariEiJ_P004177898.837298.7209
ENSG00000123908homo_sapiensENSP0000022059299.185199.1851propithecus_coquereliENSPCOP0000002201798.043798.0437
ENSG00000123908homo_sapiensENSP0000022059279.860366.8219caenorhabditis_elegansT07D3.7a.175.384663.0769
ENSG00000123908homo_sapiensENSP0000022059281.955869.7322caenorhabditis_elegansF48F7.1b.168.817258.5533
ENSG00000123908homo_sapiensENSP0000022059285.215474.9709drosophila_melanogasterFBpp029404374.390265.4472
ENSG00000123908homo_sapiensENSP0000022059283.934871.8277ciona_intestinalisENSCINP0000001504283.642771.5777
ENSG00000123908homo_sapiensENSP0000022059236.204928.638petromyzon_marinusENSPMAP0000000910178.337561.9647
ENSG00000123908homo_sapiensENSP0000022059230.849829.6857petromyzon_marinusENSPMAP0000000704194.982191.3979
ENSG00000123908homo_sapiensENSP0000022059263.445949.4761eptatretus_burgeriENSEBUP0000002385576.977460.0282
ENSG00000123908homo_sapiensENSP0000022059296.274791.6182callorhinchus_miliiENSCMIP0000003875494.839490.2523
ENSG00000123908homo_sapiensENSP0000022059292.083887.8929latimeria_chalumnaeENSLACP0000000142791.869987.6887
ENSG00000123908homo_sapiensENSP0000022059296.507691.7346lepisosteus_oculatusENSLOCP0000000944195.39790.6789
ENSG00000123908homo_sapiensENSP0000022059296.041990.8033clupea_harengusENSCHAP0000005195893.7588.6364
ENSG00000123908homo_sapiensENSP0000022059296.507691.9674danio_rerioENSDARP0000008162194.959990.4926
ENSG00000123908homo_sapiensENSP0000022059296.740491.7346carassius_auratusENSCARP0000009733793.581188.7387
ENSG00000123908homo_sapiensENSP0000022059296.507691.7346carassius_auratusENSCARP0000009332495.068890.367
ENSG00000123908homo_sapiensENSP0000022059296.740492.0838astyanax_mexicanusENSAMXP0000005481195.298290.711
ENSG00000123908homo_sapiensENSP0000022059296.62491.6182ictalurus_punctatusENSIPUP0000000145496.849591.832
ENSG00000123908homo_sapiensENSP0000022059296.740491.6182esox_luciusENSELUP0000003924294.004589.0272
ENSG00000123908homo_sapiensENSP0000022059296.740491.3853electrophorus_electricusENSEEEP0000004676296.180690.8565
ENSG00000123908homo_sapiensENSP0000022059296.274791.2689oncorhynchus_kisutchENSOKIP0000508466993.764288.8889
ENSG00000123908homo_sapiensENSP0000022059296.158391.3853oncorhynchus_kisutchENSOKIP0000505162293.01888.4009
ENSG00000123908homo_sapiensENSP0000022059295.459890.5704oncorhynchus_mykissENSOMYP0000001647595.794490.8878
ENSG00000123908homo_sapiensENSP0000022059296.391291.3853oncorhynchus_mykissENSOMYP0000002487595.063190.1263
ENSG00000123908homo_sapiensENSP0000022059296.62491.6182salmo_salarENSSSAP0000005058294.425589.5336
ENSG00000123908homo_sapiensENSP0000022059294.179389.5227salmo_salarENSSSAP0000005022397.235692.4279
ENSG00000123908homo_sapiensENSP0000022059296.62491.6182salmo_truttaENSSTUP0000005383693.468588.6261
ENSG00000123908homo_sapiensENSP0000022059296.62491.6182salmo_truttaENSSTUP0000009311294.104389.229
ENSG00000123908homo_sapiensENSP0000022059296.507691.1525gadus_morhuaENSGMOP0000003890196.060390.73
ENSG00000123908homo_sapiensENSP0000022059293.015188.3586fundulus_heteroclitusENSFHEP0000001446595.4690.681
ENSG00000123908homo_sapiensENSP0000022059296.856891.9674poecilia_reticulataENSPREP0000000284993.064988.3669
ENSG00000123908homo_sapiensENSP0000022059296.62491.851xiphophorus_maculatusENSXMAP0000000081395.622190.8986
ENSG00000123908homo_sapiensENSP0000022059293.597288.5914oryzias_latipesENSORLP0000000580585.259880.6999
ENSG00000123908homo_sapiensENSP0000022059295.692791.0361cyclopterus_lumpusENSCLMP0000503973693.197388.6621
ENSG00000123908homo_sapiensENSP0000022059296.740492.3167oreochromis_niloticusENSONIP0000004675192.026687.8184
ENSG00000123908homo_sapiensENSP0000022059296.740492.3167haplochromis_burtoniENSHBUP0000001646995.517291.1494
ENSG00000123908homo_sapiensENSP0000022059212.456311.0594astatotilapia_callipteraENSACLP0000003640881.679472.5191
ENSG00000123908homo_sapiensENSP0000022059279.045475.9022astatotilapia_callipteraENSACLP0000003647196.861693.01
ENSG00000123908homo_sapiensENSP0000022059296.274791.7346sparus_aurataENSSAUP0001004588591.079386.7841
ENSG00000123908homo_sapiensENSP0000022059296.62492.2002lates_calcariferENSLCAP0001003895092.119987.9023
ENSG00000123908homo_sapiensENSP0000022059298.253896.5076xenopus_tropicalisENSXETP0000009930696.34794.6347
ENSG00000123908homo_sapiensENSP0000022059299.534399.1851chrysemys_picta_belliiENSCPBP0000002707298.050597.7064
ENSG00000123908homo_sapiensENSP0000022059299.185198.7194sphenodon_punctatusENSSPUP0000000853099.069898.6047
ENSG00000123908homo_sapiensENSP0000022059298.835998.2538crocodylus_porosusENSCPRP0000501767398.835998.2538
ENSG00000123908homo_sapiensENSP0000022059228.172328.0559laticauda_laticaudataENSLLTP0000000191410099.5868
ENSG00000123908homo_sapiensENSP0000022059273.806870.4307laticauda_laticaudataENSLLTP0000000188985.907981.9783
ENSG00000123908homo_sapiensENSP0000022059297.206196.2747notechis_scutatusENSNSUP0000002488599.64298.6873
ENSG00000123908homo_sapiensENSP0000022059298.02196.8568pseudonaja_textilisENSPTXP0000002263195.141294.0113
ENSG00000123908homo_sapiensENSP0000022059299.417998.8359anas_platyrhynchos_platyrhynchosENSAPLP0000001026198.842698.2639
ENSG00000123908homo_sapiensENSP0000022059299.417998.7194gallus_gallusENSGALP0001001237098.957198.2619
ENSG00000123908homo_sapiensENSP0000022059290.803390.2212meleagris_gallopavoENSMGAP0000001365299.87299.2318
ENSG00000123908homo_sapiensENSP0000022059294.528594.0629serinus_canariaENSSCAP0000001177299.87799.385
ENSG00000123908homo_sapiensENSP0000022059299.301598.8359parus_majorENSPMJP0000001550991.327690.8994
ENSG00000123908homo_sapiensENSP0000022059299.068798.603anolis_carolinensisENSACAP0000000018397.816197.3563
ENSG00000123908homo_sapiensENSP0000022059296.740492.3167neolamprologus_brichardiENSNBRP0000000786495.517291.1494
ENSG00000123908homo_sapiensENSP0000022059297.671796.7404naja_najaENSNNAP0000001213699.525598.5765
ENSG00000123908homo_sapiensENSP0000022059298.835997.9045podarcis_muralisENSPMRP0000001008198.606397.6771
ENSG00000123908homo_sapiensENSP0000022059297.671797.0896geospiza_fortisENSGFOP0000000916795.66795.0969
ENSG00000123908homo_sapiensENSP0000022059299.301598.7194taeniopygia_guttataENSTGUP0000001302998.726998.1481
ENSG00000123908homo_sapiensENSP0000022059296.274791.851erpetoichthys_calabaricusENSECRP0000002183894.191389.8633
ENSG00000123908homo_sapiensENSP0000022059296.274791.851kryptolebias_marmoratusENSKMAP0000002698296.725192.2807
ENSG00000123908homo_sapiensENSP0000022059298.486697.6717salvator_merianaeENSSMRP0000000976396.685795.8857
ENSG00000123908homo_sapiensENSP0000022059295.692791.1525oryzias_javanicusENSOJAP0000001323694.374389.8967
ENSG00000123908homo_sapiensENSP0000022059280.675277.0664amphilophus_citrinellusENSACIP0000000146095.718291.4365
ENSG00000123908homo_sapiensENSP0000022059295.925591.2689dicentrarchus_labraxENSDLAP0000502176991.251486.8217
ENSG00000123908homo_sapiensENSP0000022059296.740492.3167amphiprion_perculaENSAPEP0000002594694.971490.6286
ENSG00000123908homo_sapiensENSP0000022059296.274791.6182oryzias_sinensisENSOSIP0000003257591.991187.5417
ENSG00000123908homo_sapiensENSP0000022059298.137496.9732pelodiscus_sinensisENSPSIP0000000434097.909496.748
ENSG00000123908homo_sapiensENSP0000022059299.068798.7194gopherus_evgoodeiENSGEVP0000501961492.802692.4755
ENSG00000123908homo_sapiensENSP0000022059298.719498.3702chelonoidis_abingdoniiENSCABP0000000058396.803696.4612
ENSG00000123908homo_sapiensENSP0000022059296.856892.4331seriola_dumeriliENSSDUP0000000783295.632291.2644
ENSG00000123908homo_sapiensENSP0000022059296.391291.7346cottoperca_gobioENSCGOP0000002482292.929388.44
ENSG00000123908homo_sapiensENSP0000022059298.952398.3702struthio_camelus_australisENSSCUP0000002323995.291594.7309
ENSG00000123908homo_sapiensENSP0000022059298.370297.4389anser_brachyrhynchusENSABRP0000001188896.241595.3303
ENSG00000123908homo_sapiensENSP0000022059296.507691.9674gasterosteus_aculeatusENSGACP0000000906295.727591.224
ENSG00000123908homo_sapiensENSP0000022059296.507691.851cynoglossus_semilaevisENSCSEP0000001916892.833188.3539
ENSG00000123908homo_sapiensENSP0000022059296.973291.9674poecilia_formosaENSPFOP0000000542895.967791.0138
ENSG00000123908homo_sapiensENSP0000022059295.576290.6868myripristis_murdjanENSMMDP0000504756694.367889.5402
ENSG00000123908homo_sapiensENSP0000022059296.041991.5017sander_luciopercaENSSLUP0000001521290.659386.3736
ENSG00000123908homo_sapiensENSP0000022059293.8392.5495strigops_habroptilaENSSHBP0000500135495.610994.3061
ENSG00000123908homo_sapiensENSP0000022059296.740492.3167amphiprion_ocellarisENSAOCP0000001101794.971490.6286
ENSG00000123908homo_sapiensENSP0000022059299.068798.7194terrapene_carolina_triunguisENSTMTP0000002743798.609598.2619
ENSG00000123908homo_sapiensENSP0000022059295.809191.0361hucho_huchoENSHHUP0000002633195.920791.1422
ENSG00000123908homo_sapiensENSP0000022059295.343490.6868hucho_huchoENSHHUP0000002120896.239791.5394
ENSG00000123908homo_sapiensENSP0000022059296.62491.851betta_splendensENSBSLP0000000638594.857190.1714
ENSG00000123908homo_sapiensENSP0000022059296.856892.4331pygocentrus_nattereriENSPNAP0000003735995.412891.055
ENSG00000123908homo_sapiensENSP0000022059296.158391.851anabas_testudineusENSATEP0000006427091.574387.4723
ENSG00000123908homo_sapiensENSP0000022059284.167671.9441ciona_savignyiENSCSAVP0000000890985.46173.0496
ENSG00000123908homo_sapiensENSP0000022059295.809191.7346seriola_lalandi_dorsalisENSSLDP0000003344897.859793.698
ENSG00000123908homo_sapiensENSP0000022059296.62491.851labrus_bergyltaENSLBEP0000000665095.402390.6897
ENSG00000123908homo_sapiensENSP0000022059296.740492.3167pundamilia_nyerereiENSPNYP0000002646195.517291.1494
ENSG00000123908homo_sapiensENSP0000022059295.692791.5017mastacembelus_armatusENSMAMP0000005812995.692791.5017
ENSG00000123908homo_sapiensENSP0000022059296.856892.4331stegastes_partitusENSSPAP0000002593295.085790.7429
ENSG00000123908homo_sapiensENSP0000022059296.274791.5017oncorhynchus_tshawytschaENSOTSP0000501130196.162891.3953
ENSG00000123908homo_sapiensENSP0000022059296.62491.6182oncorhynchus_tshawytschaENSOTSP0000502892794.640889.7377
ENSG00000123908homo_sapiensENSP0000022059296.740491.851acanthochromis_polyacanthusENSAPOP0000001462394.971490.1714
ENSG00000123908homo_sapiensENSP0000022059296.391295.1106aquila_chrysaetos_chrysaetosENSACCP0002000646495.391794.1244
ENSG00000123908homo_sapiensENSP0000022059293.713689.1735nothobranchius_furzeriENSNFUP0001504599394.15289.5906
ENSG00000123908homo_sapiensENSP0000022059296.391291.3853cyprinodon_variegatusENSCVAP0000002455395.281990.3337
ENSG00000123908homo_sapiensENSP0000022059290.803385.681denticeps_clupeoidesENSDCDP0000003538994.660289.3204
ENSG00000123908homo_sapiensENSP0000022059296.62492.0838larimichthys_croceaENSLCRP0000505321295.402390.9195
ENSG00000123908homo_sapiensENSP0000022059298.835998.2538ficedula_albicollisENSFALP0000000295898.263997.6852
ENSG00000123908homo_sapiensENSP0000022059296.391292.0838hippocampus_comesENSHCOP0000000467997.183192.8404
ENSG00000123908homo_sapiensENSP0000022059293.8388.7078cyprinus_carpio_carpioENSCCRP0000017299292.009186.9863
ENSG00000123908homo_sapiensENSP0000022059296.507691.7346cyprinus_carpio_carpioENSCCRP0000006655994.311789.6473
ENSG00000123908homo_sapiensENSP0000022059298.60396.7404coturnix_japonicaENSCJPP0000501223996.2594.4318
ENSG00000123908homo_sapiensENSP0000022059296.973291.9674poecilia_latipinnaENSPLAP0000000586095.967791.0138
ENSG00000123908homo_sapiensENSP0000022059296.274791.5017sinocyclocheilus_grahamiENSSGRP0000008270394.839490.1376
ENSG00000123908homo_sapiensENSP0000022059287.194482.1886sinocyclocheilus_grahamiENSSGRP0000010930494.810189.3671
ENSG00000123908homo_sapiensENSP0000022059296.740492.3167maylandia_zebraENSMZEP0000501202495.517291.1494
ENSG00000123908homo_sapiensENSP0000022059296.274791.6182tetraodon_nigroviridisENSTNIP0000002091196.274791.6182
ENSG00000123908homo_sapiensENSP0000022059296.391291.1525paramormyrops_kingsleyaeENSPKIP0000001496496.055790.8353
ENSG00000123908homo_sapiensENSP0000022059296.740491.9674scleropages_formosusENSSFOP0001507268194.539289.8749
ENSG00000123908homo_sapiensENSP0000022059293.480886.8452leptobrachium_leishanenseENSLLEP0000002467292.939886.3426
ENSG00000123908homo_sapiensENSP0000022059294.761489.4063scophthalmus_maximusENSSMAP0000002317892.710787.4715
ENSG00000123908homo_sapiensENSP0000022059296.507691.851oryzias_melastigmaENSOMEP0000003235297.072692.3888

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000340enables RNA 7-methylguanosine cap binding1IDAHomo_sapiens(9606)Function
GO:0000932located_in P-body1IDAHomo_sapiens(9606)Component
GO:0000993enables RNA polymerase II complex binding1IDAHomo_sapiens(9606)Function
GO:0001046enables core promoter sequence-specific DNA binding1IMPHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003725enables double-stranded RNA binding1IDAHomo_sapiens(9606)Function
GO:0003727enables single-stranded RNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0003743enables translation initiation factor activity1NASHomo_sapiens(9606)Function
GO:0004521enables RNA endonuclease activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IC,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005844part_of polysome1IDAHomo_sapiens(9606)Component
GO:0005845part_of mRNA cap binding complex1IDAHomo_sapiens(9606)Component
GO:0006412involved_in translation1NASHomo_sapiens(9606)Process
GO:0006413involved_in translational initiation1IEAHomo_sapiens(9606)Process
GO:0009791involved_in post-embryonic development1IEAHomo_sapiens(9606)Process
GO:0010501involved_in RNA secondary structure unwinding2IDA,IMPHomo_sapiens(9606)Process
GO:0010586involved_in miRNA metabolic process1IEAHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016442part_of RISC complex3IDA,IGI,IPIHomo_sapiens(9606)Component
GO:0030422involved_in siRNA processing1IDAHomo_sapiens(9606)Process
GO:0030425located_in dendrite1IEAHomo_sapiens(9606)Component
GO:0031047involved_in regulatory ncRNA-mediated gene silencing1ISSHomo_sapiens(9606)Process
GO:0031054involved_in pre-miRNA processing1IDAHomo_sapiens(9606)Process
GO:0035194involved_in regulatory ncRNA-mediated post-transcriptional gene silencing1TASHomo_sapiens(9606)Process
GO:0035196involved_in miRNA processing1IDAHomo_sapiens(9606)Process
GO:0035197contributes_to siRNA binding2IDAHomo_sapiens(9606)Function
GO:0035198enables miRNA binding4IBA,IDA,IPI,TASHomo_sapiens(9606)Function
GO:0035278involved_in miRNA-mediated gene silencing by inhibition of translation2IDA,IMPHomo_sapiens(9606)Process
GO:0035279involved_in miRNA-mediated gene silencing by mRNA destabilization2IDA,IMPHomo_sapiens(9606)Process
GO:0035925enables mRNA 3-UTR AU-rich region binding1IDAHomo_sapiens(9606)Function
GO:0036464located_in cytoplasmic ribonucleoprotein granule1IDAHomo_sapiens(9606)Component
GO:0042985involved_in negative regulation of amyloid precursor protein biosynthetic process1ISSHomo_sapiens(9606)Process
GO:0045727involved_in positive regulation of translation1IDAHomo_sapiens(9606)Process
GO:0045766involved_in positive regulation of angiogenesis1IDAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IMPHomo_sapiens(9606)Process
GO:0045947involved_in negative regulation of translational initiation1IDAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0060213involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening1ISSHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1IDAHomo_sapiens(9606)Component
GO:0070551enables endoribonuclease activity, cleaving siRNA-paired mRNA1IDAHomo_sapiens(9606)Function
GO:0070578part_of RISC-loading complex2IDA,IPIHomo_sapiens(9606)Component
GO:0070922involved_in RISC complex assembly1IDAHomo_sapiens(9606)Process
GO:0090624enables endoribonuclease activity, cleaving miRNA-paired mRNA2IDA,IMPHomo_sapiens(9606)Function
GO:0090625involved_in siRNA-mediated gene silencing by mRNA destabilization2IDA,IMPHomo_sapiens(9606)Process
GO:0098808enables mRNA cap binding1IPIHomo_sapiens(9606)Function
GO:1900153involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay1ISSHomo_sapiens(9606)Process
GO:1901165involved_in positive regulation of trophoblast cell migration1IMPHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex1IDAHomo_sapiens(9606)Component

Expression