Ensembl ID ENSG00000123908 Gene ID 27161 Accession 3263
Gene Symbol AGO2 Alias PPD;Q10;CASC7;EIF2C2;LESKRES;LINC00980 Full Name argonaute RISC catalytic component 2
Position 8 : 140520156 - 140635633 Length 115478 bases Strand Minus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

ENSG00000123908 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000123908 AGO2 0.94 1.56e-17 COAD
ENSG00000123908 AGO2 0.62 5.75e-12 LUSC
ENSG00000123908 AGO2 1.00 3.27e-20 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000123908 AGO2 ovarian cancer 16754881
ENSG00000123908 AGO2 tumor 17922911
ENSG00000123908 AGO2 tumors 19557174
ENSG00000123908 AGO2 tumor 20146808
ENSG00000123908 AGO2 colorectal cancers 20198652
ENSG00000123908 AGO2 esophageal cancers 20402672
ENSG00000123908 AGO2 lung cancer 20721975
ENSG00000123908 AGO2 HNSCC 20924207
ENSG00000123908 AGO2 cancer 21423624
ENSG00000123908 AGO2 cancer 21535412
ENSG00000123908 AGO2 cancer 21692980
ENSG00000123908 AGO2 breast cancer 21766210
ENSG00000123908 AGO2 breast cancer 21811619
ENSG00000123908 AGO2 tumors 21853135
ENSG00000123908 AGO2 skin cancer 22025453
ENSG00000123908 AGO2 tumor 22101286
ENSG00000123908 AGO2 cancer 22366686
ENSG00000123908 AGO2 tumour 22423322
ENSG00000123908 AGO2 breast cancer 22639842
ENSG00000123908 AGO2 tumor 23201202
ENSG00000123908 AGO2 tumor 23258480
ENSG00000123908 AGO2 tumor 23411422
ENSG00000123908 AGO2 breast cancer 23629745
ENSG00000123908 AGO2 breast cancer 23636329
ENSG00000123908 AGO2 tumor 23775303
ENSG00000123908 AGO2 tumor 23835474
ENSG00000123908 AGO2 basal-like breast cancer 23921383
ENSG00000123908 AGO2 tumours 24169347
ENSG00000123908 AGO2 breast cancer 24398324
ENSG00000123908 AGO2 tumor 24732044
ENSG00000123908 AGO2 prostate cancer 24805183
ENSG00000123908 AGO2 tumour 24886719
ENSG00000123908 AGO2 cancer 24904827
ENSG00000123908 AGO2 prostate cancer 25019555
ENSG00000123908 AGO2 tumor 25069832
ENSG00000123908 AGO2 cancer 25446899
ENSG00000123908 AGO2 bladder cancer 25656609
ENSG00000123908 AGO2 breast cancer 25659536
ENSG00000123908 AGO2 cancer 25680411
ENSG00000123908 AGO2 ovarian cancer 25724890
ENSG00000123908 AGO2 cancer 25788362
ENSG00000123908 AGO2 cancer 25918241
ENSG00000123908 AGO2 breast tumors 26141719
ENSG00000123908 AGO2 cancers 26284139
ENSG00000123908 AGO2 Cervical Cancer 26518874
ENSG00000123908 AGO2 cancer 26545861
ENSG00000123908 AGO2 breast cancer 26820947
ENSG00000123908 AGO2 gastric cancer 27259238
ENSG00000123908 AGO2 tumors 27276678
ENSG00000123908 AGO2 tumor 27325650
ENSG00000123908 AGO2 cancer 27463019
ENSG00000123908 AGO2 tumor 27518285
ENSG00000123908 AGO2 testicular germ-cell tumors 27582469
ENSG00000123908 AGO2 cancer 27840950
ENSG00000123908 AGO2 cancers 27911668
ENSG00000123908 AGO2 breast cancer 28102845
ENSG00000123908 AGO2 cancer 28104913
ENSG00000123908 AGO2 Cancer 28352639
ENSG00000123908 AGO2 Cancer 28529626
ENSG00000123908 AGO2 gastric cancer 28827574
ENSG00000123908 AGO2 tumor 28903378
ENSG00000123908 AGO2 cancer 28964783
ENSG00000123908 AGO2 cancer 29017520
ENSG00000123908 AGO2 tumors 29458013
ENSG00000123908 AGO2 breast cancer 29657266
ENSG00000123908 AGO2 tumor 29857476
ENSG00000123908 AGO2 tumor 29872500
ENSG00000123908 AGO2 breast cancer 29941603
ENSG00000123908 AGO2 breast cancer 30057418
ENSG00000123908 AGO2 ovarian cancer 30081720
ENSG00000123908 AGO2 colorectal cancer 30266084
ENSG00000123908 AGO2 lung cancer 30305728
ENSG00000123908 AGO2 cancer 30341421
ENSG00000123908 AGO2 cancer 30356106
ENSG00000123908 AGO2 colorectal cancer 30381824
ENSG00000123908 AGO2 breast cancer 30454010
ENSG00000123908 AGO2 breast cancer 30545127
ENSG00000123908 AGO2 tumors 30591524
ENSG00000123908 AGO2 gastric cancer 30621629
ENSG00000123908 AGO2 breast cancer 30897768
ENSG00000123908 AGO2 breast cancer 30999843
ENSG00000123908 AGO2 breast cancer 31280346
ENSG00000123908 AGO2 cancers 31408800
ENSG00000123908 AGO2 cervical cancer 31474757
ENSG00000123908 AGO2 cancer 31516620
ENSG00000123908 AGO2 tumors 31800303
ENSG00000123908 AGO2 tumor 31903115
ENSG00000123908 AGO2 tumor 31941754
ENSG00000123908 AGO2 tumor 31981897
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000123908 AGO2 MESO 0.00015 high
ENSG00000123908 AGO2 SARC 0.0044 high
ENSG00000123908 AGO2 CHOL 0.0098 low
ENSG00000123908 AGO2 UVM 0.00013 high
ENSG00000123908 AGO2 PAAD 0.047 high
ENSG00000123908 AGO2 UCEC 0.00027 high
ENSG00000123908 AGO2 THCA 0.042 high
ENSG00000123908 AGO2 LGG 0.0014 high
ENSG00000123908 AGO2 KIRP 6e-04 high
ENSG00000123908 AGO2 KICH 0.00023 high
ENSG00000123908 AGO2 THYM 0.029 low
ENSG00000123908 AGO2 BRCA 0.014 high
ENSG00000123908 AGO2 CESC 0.0027 high
ENSG00000123908 AGO2 LIHC 0.00013 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000123908 AGO2 LUSC Amp 6.787705 0.341177 0.566192 0.660679
ENSG00000123908 AGO2 LUAD Amp 8.446918 0.254863 0.640381 0.577519
ENSG00000123908 AGO2 LGG Amp 11.503040 0.164995 0.694707 0.185185
ENSG00000123908 AGO2 CESC Amp 3.095636 0.214837 0.633163 0.410169
ENSG00000123908 AGO2 READ Amp 3.803492 0.261551 0.845003 0.618182
ENSG00000123908 AGO2 COAD Amp 6.595515 0.164909 0.783330 0.556541
ENSG00000123908 AGO2 PAAD Amp 3.269535 0.163926 0.465357 0.358696
ENSG00000123908 AGO2 ESCA Amp 5.877441 0.511913 0.738918 0.673913
ENSG00000123908 AGO2 SKCM Amp 4.049481 0.218584 0.773528 0.520436
ENSG00000123908 AGO2 HNSC Amp 10.551926 0.285374 0.611428 0.724138
ENSG00000123908 AGO2 LIHC Amp 17.061531 0.384059 1.167273 0.602703
ENSG00000123908 AGO2 DLBC Amp 1.416472 0.258396 0.609102 0.291667
ENSG00000123908 AGO2 BLCA Amp 2.878057 0.235969 0.595406 0.578431
ENSG00000123908 AGO2 BRCA Amp 35.845997 0.460372 1.012500 0.580556
ENSG00000123908 AGO2 STAD Amp 5.060011 0.238873 0.604805 0.641723
ENSG00000123908 AGO2 PRAD Amp 1.637075 0.059110 0.716574 0.272358
ENSG00000123908 AGO2 UCEC Amp 1.241825 0.116807 0.743613 0.332096
ENSG00000123908 AGO2 UVM Amp 11.732583 0.660526 1.518657 0.762500
ENSG00000123908 AGO2 OV Amp 105.192213 1.536646 1.247860 0.753022