Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerCHIKVSARS-COV-OC43FlavivirusesSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions E3 ligase
Localizations Stress granucle
BulkPerturb-seq DataSet_02_108 DataSet_02_109 DataSet_02_110 DataSet_02_111

Description

Ensembl ID ENSG00000121060 Gene ID 7706 Accession 12932
Symbol TRIM25 Alias EFP;Z147;RNF147;ZNF147 Full Name tripartite motif containing 25
Status Confidence Length 77694 bases Strand Minus strand
Position 17 : 56836387 - 56914080 RNA binding domain SPRY
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 ligase and is involved in multiple cellular processes, including regulation of antiviral innate immunity. [provided by RefSeq, Sep 2021]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000323889 SPRY PF00622 4.3e-13 1
ENSP00000445961 SPRY PF00622 4.3e-13 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
35800389 The Role of ZAP and TRIM25 RNA Binding in Restricting Viral Translation. Emily Yang 2022-01-01 Frontiers in cellular and infection microbiology
29117863 RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Roy Nila Choudhury 2017-11-08 BMC biology
36171622 Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer. Yongxu Jia 2022-09-29 Journal of experimental & clinical cancer research : CR
26138103 Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness. Gayathri Manokaran 2015-10-09 Science (New York, N.Y.)
31417727 Disease classification via gene network integrating modules and pathways. Zhilong Mi 2019-07-01 Royal Society open science
34781999 CircRNA-DOPEY2 enhances the chemosensitivity of esophageal cancer cells by inhibiting CPEB4-mediated Mcl-1 translation. Zhenchuan Liu 2021-11-15 Journal of experimental & clinical cancer research : CR
30342007 TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense. G Jacint Sanchez 2018-12-07 Journal of molecular biology
31754723 A double-stranded RNA platform is required for the interaction between a host restriction factor and the NS1 protein of influenza A virus. Guifang Chen 2020-01-10 Nucleic acids research
34662337 Network potential identifies therapeutic miRNA cocktails in Ewing sarcoma. T Davis Weaver 2021-10-01 PLoS computational biology
34145268 Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer. Ken-Ichi Takayama 2021-06-18 Nature communications
28576494 Antagonism of type I interferon by flaviviruses. Lisa Miorin 2017-10-28 Biochemical and biophysical research communications
22440909 Cytosolic surveillance and antiviral immunity. K A Vijay Rathinam 2011-12-01 Current opinion in virology
25457611 Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation. Roy Nila Choudhury 2014-11-20 Cell reports
33436560 circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity. Botai Li 2021-01-12 Nature communications
35533151 TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction. Pedro Rui Galão 2022-05-01 PLoS pathogens
33330133 Regulation of Host Innate Immunity by Non-Coding RNAs During Dengue Virus Infection. Roopali Rajput 2020-01-01 Frontiers in cellular and infection microbiology
31842382 Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis. Usman Nasrullah 2019-12-12 Cells
29107643 Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. R Nicholas Meyerson 2017-11-08 Cell host & microbe
35736141 TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway. Roy Nila Choudhury 2022-07-08 Nucleic acids research
33901262 Origin and evolution of the zinc finger antiviral protein. Daniel Gonçalves-Carneiro 2021-04-01 PLoS pathogens
26687707 Phosphorylation of influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity. Abid Omer Kathum 2016-06-01 Cellular microbiology

Transcripts

Name Transcript ID bp Protein Translation ID
TRIM25-210 ENST00000648772 4248 456aa ENSP00000498158
TRIM25-212 ENST00000682766 3366 456aa ENSP00000507876
TRIM25-201 ENST00000316881 5745 630aa ENSP00000323889
TRIM25-207 ENST00000573108 952 No protein -
TRIM25-202 ENST00000537230 2915 630aa ENSP00000445961
TRIM25-205 ENST00000572021 2132 215aa ENSP00000459980
TRIM25-208 ENST00000574234 471 No protein -
TRIM25-203 ENST00000570473 498 No protein -
TRIM25-204 ENST00000570749 614 No protein -
TRIM25-211 ENST00000682509 1663 No protein -
TRIM25-206 ENST00000572550 519 No protein -
TRIM25-209 ENST00000574997 440 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000121060homo_sapiensENSP0000036640432.553620.6628homo_sapiensENSP0000032388926.507916.8254
ENSG00000121060homo_sapiensENSP0000025664925.862114.8276homo_sapiensENSP0000032388923.809513.6508
ENSG00000121060homo_sapiensENSP0000025481622.413815.3605homo_sapiensENSP0000032388922.698415.5556
ENSG00000121060homo_sapiensENSP0000049630127.586217.2414homo_sapiensENSP0000032388924.12715.0794
ENSG00000121060homo_sapiensENSP0000051816432.059420.5945homo_sapiensENSP0000032388923.968315.3968
ENSG00000121060homo_sapiensENSP0000042114233.333320.8068homo_sapiensENSP0000032388924.920615.5556
ENSG00000121060homo_sapiensENSP0000042393420.530711.8715homo_sapiensENSP0000032388923.333313.4921
ENSG00000121060homo_sapiensENSP0000036588433.978520.2151homo_sapiensENSP0000032388925.079414.9206
ENSG00000121060homo_sapiensENSP0000035125013.30976.92103homo_sapiensENSP0000032388923.809512.381
ENSG00000121060homo_sapiensENSP0000026229414.41917.67635homo_sapiensENSP0000032388922.063511.746
ENSG00000121060homo_sapiensENSP0000032799433.264921.1499homo_sapiensENSP0000032388925.714316.3492
ENSG00000121060homo_sapiensENSP0000025443636.842122.3158homo_sapiensENSP0000032388927.777816.8254
ENSG00000121060homo_sapiensENSP0000034312929.081616.8367homo_sapiensENSP0000032388927.142915.7143
ENSG00000121060homo_sapiensENSP0000050713112.70446.41509homo_sapiensENSP0000032388916.03178.09524
ENSG00000121060homo_sapiensENSP0000035561312.13286.64112homo_sapiensENSP0000032388915.07948.25397
ENSG00000121060homo_sapiensENSP0000047467828.318615.708homo_sapiensENSP0000032388920.317511.2698
ENSG00000121060homo_sapiensENSP0000048509728.318615.708homo_sapiensENSP0000032388920.317511.2698
ENSG00000121060homo_sapiensENSP0000040241428.571416.0714homo_sapiensENSP0000032388910.15875.71429
ENSG00000121060homo_sapiensENSP0000029141633.052619.5789homo_sapiensENSP0000032388924.920614.7619
ENSG00000121060homo_sapiensENSP0000036937334.888418.2556homo_sapiensENSP0000032388927.301614.2857
ENSG00000121060homo_sapiensENSP0000026805816.43999.41043homo_sapiensENSP0000032388923.015913.1746
ENSG00000121060homo_sapiensENSP0000031861531.219.2homo_sapiensENSP0000032388912.3817.61905
ENSG00000121060homo_sapiensENSP0000028580531.219.2homo_sapiensENSP0000032388912.3817.61905
ENSG00000121060homo_sapiensENSP0000047400326.444416homo_sapiensENSP0000032388918.888911.4286
ENSG00000121060homo_sapiensENSP0000030516115.8948.47682homo_sapiensENSP0000032388919.047610.1587
ENSG00000121060homo_sapiensENSP0000031267528.511517.1908homo_sapiensENSP0000032388921.587313.0159
ENSG00000121060homo_sapiensENSP0000029941316.86059.59302homo_sapiensENSP000003238899.206355.2381
ENSG00000121060homo_sapiensENSP0000034959633.978521.0753homo_sapiensENSP0000032388925.079415.5556
ENSG00000121060homo_sapiensENSP0000028455134.18821.5812homo_sapiensENSP0000032388925.396816.0317
ENSG00000121060homo_sapiensENSP0000036742431.449619.1646homo_sapiensENSP0000032388920.317512.381
ENSG00000121060homo_sapiensENSP0000040259532.37718.0328homo_sapiensENSP0000032388925.079413.9683
ENSG00000121060homo_sapiensENSP000004954138.548854.31034homo_sapiensENSP0000032388918.88899.52381
ENSG00000121060homo_sapiensENSP0000034079718.951610.7527homo_sapiensENSP0000032388922.38112.6984
ENSG00000121060homo_sapiensENSP0000049271929.14817.4888homo_sapiensENSP0000032388920.634912.381
ENSG00000121060homo_sapiensENSP0000027239528.923817.713homo_sapiensENSP0000032388920.476212.5397
ENSG00000121060homo_sapiensENSP0000034050714.09527.2381homo_sapiensENSP0000032388923.492112.0635
ENSG00000121060homo_sapiensENSP0000037980034.631124.1803homo_sapiensENSP0000032388926.825418.7302
ENSG00000121060homo_sapiensENSP0000048181528.666717.5556homo_sapiensENSP0000032388920.476212.5397
ENSG00000121060homo_sapiensENSP0000033296929.621417.8174homo_sapiensENSP0000032388921.111112.6984
ENSG00000121060homo_sapiensENSP0000048376429.844117.8174homo_sapiensENSP0000032388921.269812.6984
ENSG00000121060homo_sapiensENSP0000033228431.219.8homo_sapiensENSP0000032388924.761915.7143
ENSG00000121060homo_sapiensENSP0000024436035.227323.2955homo_sapiensENSP0000032388919.682513.0159
ENSG00000121060homo_sapiensENSP0000049132035.470120.2991homo_sapiensENSP0000032388926.349215.0794
ENSG00000121060homo_sapiensENSP0000032391321.350411.8613homo_sapiensENSP0000032388918.571410.3175
ENSG00000121060homo_sapiensENSP0000036941530.167615.9218homo_sapiensENSP0000032388917.14299.04762
ENSG00000121060homo_sapiensENSP0000036329826.368214.1791homo_sapiensENSP0000032388916.82549.04762
ENSG00000121060homo_sapiensENSP0000037982631.782918.9922homo_sapiensENSP0000032388913.01597.77778
ENSG00000121060homo_sapiensENSP0000032086926.666716.1905homo_sapiensENSP0000032388926.666716.1905
ENSG00000121060homo_sapiensENSP0000050855321.951215.6794homo_sapiensENSP00000323889107.14286
ENSG00000121060homo_sapiensENSP0000040829222.817813.6294homo_sapiensENSP0000032388923.650814.127
ENSG00000121060homo_sapiensENSP0000026284326.802715.5102homo_sapiensENSP0000032388931.269818.0952
ENSG00000121060homo_sapiensENSP0000034420829.864317.8733homo_sapiensENSP0000032388920.952412.5397
ENSG00000121060homo_sapiensENSP0000037327214.05538.06452homo_sapiensENSP0000032388919.365111.1111
ENSG00000121060homo_sapiensENSP0000039707330.977120.5821homo_sapiensENSP0000032388923.650815.7143
ENSG00000121060homo_sapiensENSP0000049718526.950416.4894homo_sapiensENSP0000032388924.12714.7619
ENSG00000121060homo_sapiensENSP0000028634922.406611.7566homo_sapiensENSP0000032388925.714313.4921
ENSG00000121060homo_sapiensENSP0000033965918.158210.5058homo_sapiensENSP0000032388922.222212.8571
ENSG00000121060homo_sapiensENSP0000035565934.171919.7065homo_sapiensENSP0000032388925.87314.9206
ENSG00000121060homo_sapiensENSP0000025302414.37137.54491homo_sapiensENSP0000032388919.047610
ENSG00000121060homo_sapiensENSP0000027477331.311219.9609homo_sapiensENSP0000032388925.396816.1905
ENSG00000121060homo_sapiensENSP0000050741328.375318.0778homo_sapiensENSP0000032388919.682512.5397
ENSG00000121060homo_sapiensENSP0000041044626.901716.8831homo_sapiensENSP0000032388923.015914.4444
ENSG00000121060homo_sapiensENSP0000030192432.251519.8783homo_sapiensENSP0000032388925.238115.5556
ENSG00000121060homo_sapiensENSP0000036339031.161518.4136homo_sapiensENSP0000032388917.460310.3175
ENSG00000121060homo_sapiensENSP0000036929934.337318.4739homo_sapiensENSP0000032388927.142914.6032
ENSG00000121060homo_sapiensENSP0000031267830.284917.6912homo_sapiensENSP0000032388932.063518.7302
ENSG00000121060homo_sapiensENSP0000032773833.54721.1538homo_sapiensENSP0000032388924.920615.7143
ENSG00000121060homo_sapiensENSP0000033021628.982316.3717homo_sapiensENSP0000032388920.793711.746
ENSG00000121060homo_sapiensENSP0000038829928.761116.3717homo_sapiensENSP0000032388920.634911.746
ENSG00000121060homo_sapiensENSP0000032760428.761116.3717homo_sapiensENSP0000032388920.634911.746
ENSG00000121060homo_sapiensENSP0000026938321.856914.5068homo_sapiensENSP0000032388917.936511.9048
ENSG00000121060homo_sapiensENSP0000030074734.639220.8247homo_sapiensENSP0000032388926.666716.0317
ENSG00000121060homo_sapiensENSP0000039508629.64615.9292homo_sapiensENSP0000032388921.269811.4286
ENSG00000121060homo_sapiensENSP0000049705027.876115.4867homo_sapiensENSP000003238892011.1111
ENSG00000121060homo_sapiensENSP0000027573630.801720.0422homo_sapiensENSP0000032388923.174615.0794
ENSG00000121060homo_sapiensENSP0000033465718.708810.9354homo_sapiensENSP0000032388922.539713.1746
ENSG00000121060homo_sapiensENSP0000035543734.567919.5473homo_sapiensENSP0000032388926.666715.0794
ENSG00000121060homo_sapiensENSP0000036592425.176514.8235homo_sapiensENSP0000032388916.984110
ENSG00000121060homo_sapiensENSP0000021959613.95656.40205homo_sapiensENSP0000032388917.30167.93651
ENSG00000121060homo_sapiensENSP0000036944033.527118.2171homo_sapiensENSP0000032388927.460314.9206

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000121060homo_sapiensENSP0000032388997.460396.5079nomascus_leucogenysENSNLEP0000004460097.460396.5079
ENSG00000121060homo_sapiensENSP0000032388999.206498.7302pan_paniscusENSPPAP0000001857999.206498.7302
ENSG00000121060homo_sapiensENSP0000032388997.460396.0317pongo_abeliiENSPPYP0000000926897.460396.0317
ENSG00000121060homo_sapiensENSP0000032388999.206498.7302pan_troglodytesENSPTRP0000001602099.206498.7302
ENSG00000121060homo_sapiensENSP0000032388999.047698.5714gorilla_gorillaENSGGOP0000001150299.047698.5714
ENSG00000121060homo_sapiensENSP0000032388970.634957.3016sarcophilus_harrisiiENSSHAP0000000245965.925953.4815
ENSG00000121060homo_sapiensENSP0000032388944.285738.0952notamacropus_eugeniiENSMEUP0000001367844.145637.9747
ENSG00000121060homo_sapiensENSP0000032388930.476225.3968choloepus_hoffmanniENSCHOP0000000224453.038744.1989
ENSG00000121060homo_sapiensENSP0000032388983.809574.9206dasypus_novemcinctusENSDNOP0000002882383.676774.8019
ENSG00000121060homo_sapiensENSP0000032388976.507967.619erinaceus_europaeusENSEEUP0000001294075.905567.0866
ENSG00000121060homo_sapiensENSP0000032388971.587363.4921echinops_telfairiENSETEP0000000302579.122870.1754
ENSG00000121060homo_sapiensENSP0000032388991.428686.6667callithrix_jacchusENSCJAP0000008176689.580184.9145
ENSG00000121060homo_sapiensENSP0000032388996.507994.127cercocebus_atysENSCATP0000003617696.507994.127
ENSG00000121060homo_sapiensENSP0000032388996.984194.9206macaca_fascicularisENSMFAP0000006244596.984194.9206
ENSG00000121060homo_sapiensENSP0000032388974.285766.3492macaca_mulattaENSMMUP0000008054752.057846.4961
ENSG00000121060homo_sapiensENSP0000032388996.984194.9206macaca_nemestrinaENSMNEP0000004304296.984194.9206
ENSG00000121060homo_sapiensENSP0000032388996.666794.4444papio_anubisENSPANP0000002033496.666794.4444
ENSG00000121060homo_sapiensENSP0000032388996.666794.127mandrillus_leucophaeusENSMLEP0000001785496.666794.127
ENSG00000121060homo_sapiensENSP0000032388962.063556.6667tursiops_truncatusENSTTRP0000000766582.315875.1579
ENSG00000121060homo_sapiensENSP0000032388969.841362.381vulpes_vulpesENSVVUP0000001591184.778475.7225
ENSG00000121060homo_sapiensENSP0000032388982.222272.381mus_spretusMGP_SPRETEiJ_P003056281.703571.9243
ENSG00000121060homo_sapiensENSP0000032388967.460357.3016equus_asinusENSEASP0000505150567.246857.1203
ENSG00000121060homo_sapiensENSP000003238898070.6349equus_asinusENSEASP0000504047781.159471.6586
ENSG00000121060homo_sapiensENSP0000032388986.190576.3492capra_hircusENSCHIP0000000974685.78275.9874
ENSG00000121060homo_sapiensENSP0000032388949.365144.7619loxodonta_africanaENSLAFP0000001639984.510976.6304
ENSG00000121060homo_sapiensENSP0000032388981.428673.8095panthera_leoENSPLOP0000002031884.37576.4803
ENSG00000121060homo_sapiensENSP0000032388986.031778.5714ailuropoda_melanoleucaENSAMEP0000003075785.48978.0757
ENSG00000121060homo_sapiensENSP0000032388985.714376.3492bos_indicus_hybridENSBIXP0000502498485.578476.2282
ENSG00000121060homo_sapiensENSP0000032388949.206343.1746oryctolagus_cuniculusENSOCUP0000000975684.239173.913
ENSG00000121060homo_sapiensENSP0000032388979.841371.4286equus_caballusENSECAP0000002189381.260172.6979
ENSG00000121060homo_sapiensENSP0000032388986.666778.5714equus_caballusENSECAP0000002073785.714377.708
ENSG00000121060homo_sapiensENSP0000032388984.761976.1905canis_lupus_familiarisENSCAFP0084502514084.627676.0697
ENSG00000121060homo_sapiensENSP0000032388981.428673.8095panthera_pardusENSPPRP0000000163784.37576.4803
ENSG00000121060homo_sapiensENSP0000032388982.857170.7936marmota_marmota_marmotaENSMMMP0000002375280.930269.1473
ENSG00000121060homo_sapiensENSP0000032388986.825479.5238balaenoptera_musculusENSBMSP0001002757886.413979.1469
ENSG00000121060homo_sapiensENSP0000032388979.523869.2064cavia_porcellusENSCPOP0000001211280.1669.76
ENSG00000121060homo_sapiensENSP0000032388981.587374.2857felis_catusENSFCAP0000000743984.539576.9737
ENSG00000121060homo_sapiensENSP0000032388972.539759.2063monodelphis_domesticaENSMODP0000001852768.00655.506
ENSG00000121060homo_sapiensENSP0000032388970.793659.6825bison_bison_bisonENSBBBP0000000201774.832263.0872
ENSG00000121060homo_sapiensENSP0000032388986.666779.0476monodon_monocerosENSMMNP0001502112886.119978.5489
ENSG00000121060homo_sapiensENSP0000032388984.603276.6667sus_scrofaENSSSCP0000006792284.202276.3033
ENSG00000121060homo_sapiensENSP0000032388988.412782.0635microcebus_murinusENSMICP0000002811687.854981.5457
ENSG00000121060homo_sapiensENSP0000032388978.730268.7302octodon_degusENSODEP0000001607183.361372.7731
ENSG00000121060homo_sapiensENSP000003238898070jaculus_jaculusENSJJAP0000002127582.487772.1768
ENSG00000121060homo_sapiensENSP0000032388979.523868.4127ovis_aries_rambouilletENSOARP0002002928968.724359.1221
ENSG00000121060homo_sapiensENSP0000032388967.301659.3651ursus_maritimusENSUMAP0000000094386.530676.3265
ENSG00000121060homo_sapiensENSP0000032388952.222243.4921ochotona_princepsENSOPRP0000001501774.099161.7117
ENSG00000121060homo_sapiensENSP0000032388986.825479.2064delphinapterus_leucasENSDLEP0000000890786.277678.7066
ENSG00000121060homo_sapiensENSP0000032388987.142979.6825physeter_catodonENSPCTP0000501709381.333374.3704
ENSG00000121060homo_sapiensENSP0000032388982.539772.2222mus_caroliMGP_CAROLIEiJ_P002914881.889871.6535
ENSG00000121060homo_sapiensENSP0000032388982.38173.0159mus_musculusENSMUSP0000010352881.861272.5552
ENSG00000121060homo_sapiensENSP0000032388978.412767.3016dipodomys_ordiiENSDORP0000002388182.608770.903
ENSG00000121060homo_sapiensENSP0000032388985.87377.9365mustela_putorius_furoENSMPUP0000001527882.848475.1914
ENSG00000121060homo_sapiensENSP0000032388991.111186.8254aotus_nancymaaeENSANAP0000002679792.580688.2258
ENSG00000121060homo_sapiensENSP0000032388987.777883.6508saimiri_boliviensis_boliviensisENSSBOP0000000160892.785288.4228
ENSG00000121060homo_sapiensENSP0000032388945.079440.4762vicugna_pacosENSVPAP0000000802365.588958.8915
ENSG00000121060homo_sapiensENSP0000032388996.984194.2857chlorocebus_sabaeusENSCSAP0000000189996.984194.2857
ENSG00000121060homo_sapiensENSP0000032388952.063545.7143tupaia_belangeriENSTBEP0000001015882.412172.3618
ENSG00000121060homo_sapiensENSP0000032388976.984167.9365mesocricetus_auratusENSMAUP0000000553780.564871.0963
ENSG00000121060homo_sapiensENSP0000032388986.190578.5714phocoena_sinusENSPSNP0000001847485.511877.9528
ENSG00000121060homo_sapiensENSP0000032388985.714377.7778camelus_dromedariusENSCDRP0000503252585.308177.4092
ENSG00000121060homo_sapiensENSP0000032388987.936582.0635carlito_syrichtaENSTSYP0000001497289.499283.5218
ENSG00000121060homo_sapiensENSP0000032388970.317563.0159panthera_tigris_altaicaENSPTIP0000000289282.649374.0672
ENSG00000121060homo_sapiensENSP0000032388982.539772.6984rattus_norvegicusENSRNOP0000005253380.870971.2286
ENSG00000121060homo_sapiensENSP0000032388988.25482.381prolemur_simusENSPSMP0000002952188.25482.381
ENSG00000121060homo_sapiensENSP0000032388982.063572.8571microtus_ochrogasterENSMOCP0000000440881.545772.3975
ENSG00000121060homo_sapiensENSP0000032388949.523842.381sorex_araneusENSSARP0000001115070.112460
ENSG00000121060homo_sapiensENSP0000032388982.539772.5397peromyscus_maniculatus_bairdiiENSPEMP0000002663781.632771.7425
ENSG00000121060homo_sapiensENSP0000032388968.571460bos_mutusENSBMUP0000003359268.789860.1911
ENSG00000121060homo_sapiensENSP0000032388982.222272.6984mus_spicilegusENSMSIP0000003692181.703572.2397
ENSG00000121060homo_sapiensENSP0000032388982.38172.8571cricetulus_griseus_chok1gshdENSCGRP0000101350081.732372.2835
ENSG00000121060homo_sapiensENSP0000032388987.777881.1111pteropus_vampyrusENSPVAP0000000370987.580.8544
ENSG00000121060homo_sapiensENSP0000032388986.666777.619myotis_lucifugusENSMLUP0000000978986.255977.2512
ENSG00000121060homo_sapiensENSP0000032388922.063517.1429vombatus_ursinusENSVURP0001000010072.774956.5445
ENSG00000121060homo_sapiensENSP0000032388954.603239.6825vombatus_ursinusENSVURP0001001777235.610825.8799
ENSG00000121060homo_sapiensENSP0000032388969.365155.3968vombatus_ursinusENSVURP0001001776168.602854.7881
ENSG00000121060homo_sapiensENSP0000032388987.936580rhinolophus_ferrumequinumENSRFEP0001002532987.381779.4953
ENSG00000121060homo_sapiensENSP0000032388985.714378.0952neovison_visonENSNVIP0000001568584.905777.3585
ENSG00000121060homo_sapiensENSP0000032388985.714376.3492bos_taurusENSBTAP0000001312185.578476.2282
ENSG00000121060homo_sapiensENSP0000032388981.587370.3175heterocephalus_glaber_femaleENSHGLP0000001604781.847170.5414
ENSG00000121060homo_sapiensENSP0000032388996.984194.4444rhinopithecus_bietiENSRBIP0000003861896.984194.4444
ENSG00000121060homo_sapiensENSP0000032388984.761976.1905canis_lupus_dingoENSCAFP0002003296784.627676.0697
ENSG00000121060homo_sapiensENSP0000032388981.904871.4286sciurus_vulgarisENSSVLP0000501137383.091872.4638
ENSG00000121060homo_sapiensENSP0000032388970.952455.3968phascolarctos_cinereusENSPCIP0000004720466.716452.0896
ENSG00000121060homo_sapiensENSP0000032388937.936527.3016phascolarctos_cinereusENSPCIP0000005453463.903745.9893
ENSG00000121060homo_sapiensENSP0000032388982.698473.9683procavia_capensisENSPCAP0000000478583.226874.4409
ENSG00000121060homo_sapiensENSP0000032388980.952470.7936bos_grunniensENSBGRP0000002745170.539461.6874
ENSG00000121060homo_sapiensENSP0000032388982.063570.9524chinchilla_lanigeraENSCLAP0000002481282.19471.0652
ENSG00000121060homo_sapiensENSP0000032388985.396876.5079cervus_hanglu_yarkandensisENSCHYP0000002006184.992176.1453
ENSG00000121060homo_sapiensENSP0000032388983.333374.6032catagonus_wagneriENSCWAP0000001120282.547273.8994
ENSG00000121060homo_sapiensENSP0000032388982.38171.1111ictidomys_tridecemlineatusENSSTOP0000000837080.590169.5652
ENSG00000121060homo_sapiensENSP0000032388982.698475.2381otolemur_garnettiiENSOGAP0000000344183.094175.5981
ENSG00000121060homo_sapiensENSP0000032388989.365184.7619cebus_imitatorENSCCAP0000002159090.806486.129
ENSG00000121060homo_sapiensENSP0000032388982.063570.1587urocitellus_parryiiENSUPAP0001001901481.417369.6063
ENSG00000121060homo_sapiensENSP0000032388986.349277.3016moschus_moschiferusENSMMSP0000001799085.9476.9352
ENSG00000121060homo_sapiensENSP0000032388996.984194.2857rhinopithecus_roxellanaENSRROP0000002638296.984194.2857
ENSG00000121060homo_sapiensENSP0000032388982.222271.5873mus_pahariMGP_PahariEiJ_P003586281.574871.0236
ENSG00000121060homo_sapiensENSP0000032388988.571483.4921propithecus_coquereliENSPCOP0000002673288.151783.0964
ENSG00000121060homo_sapiensENSP0000032388955.396837.7778latimeria_chalumnaeENSLACP0000000640653.120236.2253
ENSG00000121060homo_sapiensENSP0000032388954.920638.8889xenopus_tropicalisENSXETP0000010530954.23238.4013
ENSG00000121060homo_sapiensENSP0000032388966.190550.6349chrysemys_picta_belliiENSCPBP0000000568965.669350.2362
ENSG00000121060homo_sapiensENSP0000032388964.285748.7302sphenodon_punctatusENSSPUP0000000696363.98148.4992
ENSG00000121060homo_sapiensENSP0000032388965.555649.2063crocodylus_porosusENSCPRP0000500286364.531248.4375
ENSG00000121060homo_sapiensENSP0000032388943.174629.0476laticauda_laticaudataENSLLTP0000000803461.67841.4966
ENSG00000121060homo_sapiensENSP0000032388959.047643.9683notechis_scutatusENSNSUP0000000233261.691545.937
ENSG00000121060homo_sapiensENSP0000032388959.523844.2857pseudonaja_textilisENSPTXP0000000948861.983546.1157
ENSG00000121060homo_sapiensENSP0000032388965.555649.2063anas_platyrhynchos_platyrhynchosENSAPLP0000001887363.734647.8395
ENSG00000121060homo_sapiensENSP0000032388964.444447.1429gallus_gallusENSGALP0001004420360.416744.1964
ENSG00000121060homo_sapiensENSP0000032388963.809547.619meleagris_gallopavoENSMGAP0000002331161.941446.225
ENSG00000121060homo_sapiensENSP0000032388959.682543.9683serinus_canariaENSSCAP0000001985760.256444.391
ENSG00000121060homo_sapiensENSP0000032388961.269845.5556parus_majorENSPMJP0000002462561.46545.7006
ENSG00000121060homo_sapiensENSP0000032388963.492148.0952anolis_carolinensisENSACAP0000000903462.305347.1963
ENSG00000121060homo_sapiensENSP0000032388956.507942.2222naja_najaENSNNAP0000000524461.91346.2609
ENSG00000121060homo_sapiensENSP0000032388935.555629.5238podarcis_muralisENSPMRP0000000909360.869650.5435
ENSG00000121060homo_sapiensENSP0000032388949.682535.7143geospiza_fortisENSGFOP0000001497363.488845.6389
ENSG00000121060homo_sapiensENSP0000032388962.063546.0317taeniopygia_guttataENSTGUP0000002224861.285345.4545
ENSG00000121060homo_sapiensENSP0000032388963.174648.254salvator_merianaeENSSMRP0000002814561.801247.205
ENSG00000121060homo_sapiensENSP0000032388966.507951.746pelodiscus_sinensisENSPSIP0000000968861.799448.0826
ENSG00000121060homo_sapiensENSP0000032388966.507951.1111gopherus_evgoodeiENSGEVP0000501825165.984350.7087
ENSG00000121060homo_sapiensENSP0000032388966.507951.4286chelonoidis_abingdoniiENSCABP0000000691267.255252.0064
ENSG00000121060homo_sapiensENSP0000032388954.761939.8413struthio_camelus_australisENSSCUP0000001570567.514749.1194
ENSG00000121060homo_sapiensENSP0000032388963.968349.2063anser_brachyrhynchusENSABRP0000001419060.239246.3378
ENSG00000121060homo_sapiensENSP0000032388960.793743.6508strigops_habroptilaENSSHBP0000502521361.378244.0705
ENSG00000121060homo_sapiensENSP0000032388963.174647.4603terrapene_carolina_triunguisENSTMTP0000001206668.150751.1986
ENSG00000121060homo_sapiensENSP0000032388963.809547.1429aquila_chrysaetos_chrysaetosENSACCP0002000835263.009446.5517
ENSG00000121060homo_sapiensENSP0000032388961.74645.3968ficedula_albicollisENSFALP0000000236956.62341.6303
ENSG00000121060homo_sapiensENSP0000032388964.761947.1429coturnix_japonicaENSCJPP0000502764563.949846.5517
ENSG00000121060homo_sapiensENSP0000032388955.87338.8889leptobrachium_leishanenseENSLLEP0000004933250.574735.2011

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0002753involved_in cytosolic pattern recognition receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0003713enables transcription coactivator activity1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0004842enables ubiquitin-protein transferase activity1EXPHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006511involved_in ubiquitin-dependent protein catabolic process1IMPHomo_sapiens(9606)Process
GO:0006513involved_in protein monoubiquitination1IMPHomo_sapiens(9606)Process
GO:0006979involved_in response to oxidative stress1IDAHomo_sapiens(9606)Process
GO:0010494located_in cytoplasmic stress granule1IDAHomo_sapiens(9606)Component
GO:0016604located_in nuclear body1IDAHomo_sapiens(9606)Component
GO:0016874enables ligase activity1IEAHomo_sapiens(9606)Function
GO:0019076involved_in viral release from host cell1IMPHomo_sapiens(9606)Process
GO:0030433involved_in ubiquitin-dependent ERAD pathway1IMPHomo_sapiens(9606)Process
GO:0032880involved_in regulation of protein localization1ISSHomo_sapiens(9606)Process
GO:0033280involved_in response to vitamin D1IEAHomo_sapiens(9606)Process
GO:0039529NOT involved_in RIG-I signaling pathway1IMPHomo_sapiens(9606)Process
GO:0039552enables RIG-I binding1IPIHomo_sapiens(9606)Function
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:0043627involved_in response to estrogen1IDAHomo_sapiens(9606)Process
GO:0044790involved_in suppression of viral release by host1IEAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response2IDA,TASHomo_sapiens(9606)Process
GO:0045296enables cadherin binding1HDAHomo_sapiens(9606)Function
GO:0045893involved_in positive regulation of DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0046596involved_in regulation of viral entry into host cell1IDAHomo_sapiens(9606)Process
GO:0046597involved_in negative regulation of viral entry into host cell1IEAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0051091involved_in positive regulation of DNA-binding transcription factor activity1IMPHomo_sapiens(9606)Process
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IMPHomo_sapiens(9606)Process
GO:0061630enables ubiquitin protein ligase activity2IDA,IMPHomo_sapiens(9606)Function
GO:0070936involved_in protein K48-linked ubiquitination1IDAHomo_sapiens(9606)Process
GO:0140374involved_in antiviral innate immune response1IDAHomo_sapiens(9606)Process
GO:1990830involved_in cellular response to leukemia inhibitory factor1IEAHomo_sapiens(9606)Process

Expression