Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000116830 Gene ID 8458 Accession 12398
Symbol TTF2 Alias F2;HuF2;ZGRF6 Full Name transcription termination factor 2
Status Confidence Length 47128 bases Strand Plus strand
Position 1 : 117060326 - 117107453 RNA binding domain ResIII
Summary This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000358478 ResIII PF04851 1.3e-09 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
TTF2-201 ENST00000369466 9439 1162aa ENSP00000358478
TTF2-205 ENST00000470935 849 No protein -
TTF2-204 ENST00000469638 775 No protein -
TTF2-207 ENST00000492682 803 No protein -
TTF2-203 ENST00000463696 662 No protein -
TTF2-202 ENST00000427271 639 143aa ENSP00000408111
TTF2-206 ENST00000480701 983 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
4370Cholesterol, LDL6.2423901013456E-717903299
4560Cholesterol2.41172409736342E-717903299
9692Echocardiography9.86864862322094E-1117903301
9711Echocardiography1.46964834433505E-1217903301

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000116830homo_sapiensENSP0000039202810.97765.87254homo_sapiensENSP0000035847828.313315.1463
ENSG00000116830homo_sapiensENSP0000049524012.5926.89655homo_sapiensENSP0000035847827.96915.3184
ENSG00000116830homo_sapiensENSP0000033262817.259.4homo_sapiensENSP0000035847829.690216.179
ENSG00000116830homo_sapiensENSP0000049760920.886911.6967homo_sapiensENSP0000035847827.96915.6627
ENSG00000116830homo_sapiensENSP0000036016226.074814.486homo_sapiensENSP0000035847824.010313.3391
ENSG00000116830homo_sapiensENSP0000028313125.190114.0684homo_sapiensENSP0000035847822.805512.7367
ENSG00000116830homo_sapiensENSP0000037421211.39935.79571homo_sapiensENSP0000035847830.636815.5766
ENSG00000116830homo_sapiensENSP0000034621728.265115.7895homo_sapiensENSP0000035847824.95713.9415
ENSG00000116830homo_sapiensENSP000002625189.071215.387homo_sapiensENSP0000035847825.215114.9742
ENSG00000116830homo_sapiensENSP0000050758717.51879.88412homo_sapiensENSP0000035847822.11712.4785
ENSG00000116830homo_sapiensENSP0000039634511.08046.07525homo_sapiensENSP0000035847827.624815.1463
ENSG00000116830homo_sapiensENSP0000048366718.59659.76608homo_sapiensENSP0000035847827.366614.3718
ENSG00000116830homo_sapiensENSP0000023902731.980917.3031homo_sapiensENSP0000035847823.063712.4785
ENSG00000116830homo_sapiensENSP0000026577320.314510.8805homo_sapiensENSP0000035847827.796914.8881
ENSG00000116830homo_sapiensENSP0000034808920.428711.7214homo_sapiensENSP0000035847826.247815.0602
ENSG00000116830homo_sapiensENSP0000044054217.991610.3033homo_sapiensENSP0000035847829.604116.9535
ENSG00000116830homo_sapiensENSP0000034389619.732810.8682homo_sapiensENSP0000035847827.96915.4045
ENSG00000116830homo_sapiensENSP0000026599018.496510.7085homo_sapiensENSP0000035847829.43217.0396
ENSG00000116830homo_sapiensENSP0000033467519.211.76homo_sapiensENSP0000035847820.65412.6506
ENSG00000116830homo_sapiensENSP0000030894440.237924.2815homo_sapiensENSP0000035847834.939821.0843
ENSG00000116830homo_sapiensENSP0000033660631.098917.3626homo_sapiensENSP0000035847824.354613.5972
ENSG00000116830homo_sapiensENSP0000035826226.309914.2698homo_sapiensENSP0000035847820.309811.0155
ENSG00000116830homo_sapiensENSP0000036244113.32266.98234homo_sapiensENSP0000035847828.571414.9742
ENSG00000116830homo_sapiensENSP0000026245017.60499.97953homo_sapiensENSP0000035847829.604116.7814
ENSG00000116830homo_sapiensENSP0000037774717.39619.73742homo_sapiensENSP0000035847827.366615.3184
ENSG00000116830homo_sapiensENSP0000027523321.390411.8835homo_sapiensENSP0000035847830.981117.2117
ENSG00000116830homo_sapiensENSP0000034982326.415112.1593homo_sapiensENSP0000035847821.68679.98279
ENSG00000116830homo_sapiensENSP0000026415918.1659.63855homo_sapiensENSP0000035847816.86758.95009
ENSG00000116830homo_sapiensENSP0000036233011.19716.33518homo_sapiensENSP0000035847826.161814.8021
ENSG00000116830homo_sapiensENSP0000036104332.66420.2142homo_sapiensENSP0000035847820.998312.9948

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000116830homo_sapiensENSP0000035847897.590496.6437nomascus_leucogenysENSNLEP0000000633497.674496.727
ENSG00000116830homo_sapiensENSP0000035847899.311599.2255pan_paniscusENSPPAP0000000859999.311599.2255
ENSG00000116830homo_sapiensENSP0000035847898.106797.2461pongo_abeliiENSPPYP0000000113997.519296.6638
ENSG00000116830homo_sapiensENSP0000035847899.397699.1394pan_troglodytesENSPTRP0000000198899.397699.1394
ENSG00000116830homo_sapiensENSP0000035847898.967398.6231gorilla_gorillaENSGGOP0000001541298.967398.6231
ENSG00000116830homo_sapiensENSP0000035847867.469955.0775ornithorhynchus_anatinusENSOANP0000000180069.319256.5871
ENSG00000116830homo_sapiensENSP0000035847873.321961.79sarcophilus_harrisiiENSSHAP0000002147475.198663.3716
ENSG00000116830homo_sapiensENSP0000035847847.676441.136notamacropus_eugeniiENSMEUP0000000005354.960347.4206
ENSG00000116830homo_sapiensENSP0000035847872.11764.8021choloepus_hoffmanniENSCHOP0000000267876.320668.5792
ENSG00000116830homo_sapiensENSP0000035847857.31550.7745erinaceus_europaeusENSEEUP0000001106857.91351.3043
ENSG00000116830homo_sapiensENSP0000035847869.018961.6179echinops_telfairiENSETEP0000001266668.841261.4592
ENSG00000116830homo_sapiensENSP0000035847890.189386.3167callithrix_jacchusENSCJAP0000008792987.18883.4443
ENSG00000116830homo_sapiensENSP0000035847897.160196.0413macaca_mulattaENSMMUP0000002222396.495795.3846
ENSG00000116830homo_sapiensENSP0000035847894.664493.3735macaca_nemestrinaENSMNEP0000003858896.069994.7598
ENSG00000116830homo_sapiensENSP0000035847897.07495.525mandrillus_leucophaeusENSMLEP0000003480396.907295.3608
ENSG00000116830homo_sapiensENSP0000035847882.874474.6988tursiops_truncatusENSTTRP0000001222982.660974.5064
ENSG00000116830homo_sapiensENSP0000035847880.120571.0843mus_spretusMGP_SPRETEiJ_P006188981.738472.5198
ENSG00000116830homo_sapiensENSP0000035847884.767676.9363capra_hircusENSCHIP0000002304081.742774.1909
ENSG00000116830homo_sapiensENSP0000035847811.445810.6713loxodonta_africanaENSLAFP0000000572787.581.5789
ENSG00000116830homo_sapiensENSP0000035847885.542277.2805bos_indicus_hybridENSBIXP0000503875483.599775.5257
ENSG00000116830homo_sapiensENSP0000035847884.079277.2805oryctolagus_cuniculusENSOCUP0000000053784.588777.7489
ENSG00000116830homo_sapiensENSP0000035847882.013875.7315marmota_marmota_marmotaENSMMMP0000001709984.261777.8073
ENSG00000116830homo_sapiensENSP0000035847886.660978.8296balaenoptera_musculusENSBMSP0001000125886.363678.5592
ENSG00000116830homo_sapiensENSP0000035847880.636872.8916felis_catusENSFCAP0000000183281.125573.3333
ENSG00000116830homo_sapiensENSP0000035847873.063762.0482monodelphis_domesticaENSMODP0000000633273.442962.3702
ENSG00000116830homo_sapiensENSP0000035847885.456177.5387bison_bison_bisonENSBBBP0000000350085.382677.4721
ENSG00000116830homo_sapiensENSP0000035847886.488878.5714monodon_monocerosENSMMNP0001500440286.340278.4364
ENSG00000116830homo_sapiensENSP0000035847884.337375.6454sus_scrofaENSSSCP0000000718168.723761.641
ENSG00000116830homo_sapiensENSP0000035847881.067173.0637jaculus_jaculusENSJJAP0000001207982.342774.2133
ENSG00000116830homo_sapiensENSP0000035847884.251376.5921ovis_aries_rambouilletENSOARP0002000101281.993374.5394
ENSG00000116830homo_sapiensENSP0000035847876.592169.4492ochotona_princepsENSOPRP0000000595477.12369.9307
ENSG00000116830homo_sapiensENSP0000035847886.660978.7435delphinapterus_leucasENSDLEP0000002328986.51278.6082
ENSG00000116830homo_sapiensENSP0000035847886.230678.1411physeter_catodonENSPCTP0000502500885.934877.8731
ENSG00000116830homo_sapiensENSP0000035847880.206570.9983mus_caroliMGP_CAROLIEiJ_P005950081.754472.3684
ENSG00000116830homo_sapiensENSP0000035847880.292671.2565mus_musculusENSMUSP0000007620881.985972.7592
ENSG00000116830homo_sapiensENSP0000035847875.301266.6093dipodomys_ordiiENSDORP0000001295778.545869.4794
ENSG00000116830homo_sapiensENSP0000035847893.975991.3941aotus_nancymaaeENSANAP0000000510393.975991.3941
ENSG00000116830homo_sapiensENSP0000035847892.426889.3287saimiri_boliviensis_boliviensisENSSBOP0000001146092.426889.3287
ENSG00000116830homo_sapiensENSP0000035847869.707463.8554vicugna_pacosENSVPAP0000000769974.311968.0734
ENSG00000116830homo_sapiensENSP0000035847875.04368.9329tupaia_belangeriENSTBEP000000030488073.4862
ENSG00000116830homo_sapiensENSP0000035847886.488878.5714phocoena_sinusENSPSNP0000000457186.414478.5039
ENSG00000116830homo_sapiensENSP0000035847879.604170.654rattus_norvegicusENSRNOP0000007453280.998271.8914
ENSG00000116830homo_sapiensENSP0000035847889.586984.2513prolemur_simusENSPSMP0000002140489.896484.5423
ENSG00000116830homo_sapiensENSP0000035847878.485469.105microtus_ochrogasterENSMOCP0000000843481.138871.4413
ENSG00000116830homo_sapiensENSP0000035847874.440664.5439sorex_araneusENSSARP0000000690876.010565.9051
ENSG00000116830homo_sapiensENSP0000035847878.055170.654bos_mutusENSBMUP0000002183484.766476.729
ENSG00000116830homo_sapiensENSP0000035847880.292671.2565mus_spicilegusENSMSIP0000002066081.91472.6953
ENSG00000116830homo_sapiensENSP0000035847884.853777.2805pteropus_vampyrusENSPVAP0000001402586.415478.7029
ENSG00000116830homo_sapiensENSP0000035847886.660979.6902myotis_lucifugusENSMLUP0000001266586.363679.4168
ENSG00000116830homo_sapiensENSP0000035847869.793559.9828vombatus_ursinusENSVURP0001001081872.346162.1766
ENSG00000116830homo_sapiensENSP0000035847881.067172.031neovison_visonENSNVIP0000000031281.487972.4048
ENSG00000116830homo_sapiensENSP0000035847885.3777.1084bos_taurusENSBTAP0000003362085.296677.0421
ENSG00000116830homo_sapiensENSP0000035847883.390775.8176heterocephalus_glaber_femaleENSHGLP0000001739884.407776.7422
ENSG00000116830homo_sapiensENSP0000035847896.98895.4389rhinopithecus_bietiENSRBIP0000003825596.324894.7863
ENSG00000116830homo_sapiensENSP0000035847876.247869.7074sciurus_vulgarisENSSVLP0000500164181.65974.6544
ENSG00000116830homo_sapiensENSP0000035847884.681678.8296sciurus_vulgarisENSSVLP0000500158986.619780.6338
ENSG00000116830homo_sapiensENSP0000035847873.666162.1343phascolarctos_cinereusENSPCIP0000000422974.176862.565
ENSG00000116830homo_sapiensENSP0000035847853.614548.0207procavia_capensisENSPCAP0000000514654.505748.8189
ENSG00000116830homo_sapiensENSP0000035847883.82176.2478nannospalax_galiliENSNGAP0000001889885.66477.9244
ENSG00000116830homo_sapiensENSP0000035847885.542277.3666bos_grunniensENSBGRP0000001476585.468677.3001
ENSG00000116830homo_sapiensENSP0000035847885.28477.2805cervus_hanglu_yarkandensisENSCHYP0000001962984.991477.0154
ENSG00000116830homo_sapiensENSP0000035847885.28476.5921catagonus_wagneriENSCWAP0000000342684.991476.3293
ENSG00000116830homo_sapiensENSP0000035847877.194571.0843ictidomys_tridecemlineatusENSSTOP0000000981882.369175.8494
ENSG00000116830homo_sapiensENSP0000035847886.058578.6575otolemur_garnettiiENSOGAP0000000811085.910778.5223
ENSG00000116830homo_sapiensENSP0000035847893.631791.222cebus_imitatorENSCCAP0000002923793.551291.1436
ENSG00000116830homo_sapiensENSP0000035847883.046576.8503urocitellus_parryiiENSUPAP0001001661584.797978.471
ENSG00000116830homo_sapiensENSP0000035847884.767676.42moschus_moschiferusENSMMSP0000001726684.62276.2887
ENSG00000116830homo_sapiensENSP0000035847897.07495.6971rhinopithecus_roxellanaENSRROP0000000336096.990595.6148
ENSG00000116830homo_sapiensENSP0000035847879.43270.4819mus_pahariMGP_PahariEiJ_P007046781.03671.9052
ENSG00000116830homo_sapiensENSP0000035847889.414884.5095propithecus_coquereliENSPCOP0000000027589.184584.2918
ENSG00000116830homo_sapiensENSP0000035847845.52529.6902drosophila_melanogasterFBpp008125549.858632.5165
ENSG00000116830homo_sapiensENSP000003584787.659215.16351ciona_intestinalisENSCINP0000002537354.601236.8098
ENSG00000116830homo_sapiensENSP0000035847811.798.34768ciona_intestinalisENSCINP0000001324763.425944.9074
ENSG00000116830homo_sapiensENSP0000035847819.449214.5439eptatretus_burgeriENSEBUP0000002158169.96952.322
ENSG00000116830homo_sapiensENSP0000035847858.77845.2668callorhinchus_miliiENSCMIP0000000209558.727445.2279
ENSG00000116830homo_sapiensENSP0000035847857.659243.9759clupea_harengusENSCHAP0000005441462.910847.9812
ENSG00000116830homo_sapiensENSP0000035847850.946637.9518electrophorus_electricusENSEEEP0000004396659.677444.4556
ENSG00000116830homo_sapiensENSP0000035847855.249640.5336poecilia_reticulataENSPREP0000000180062.451445.8171
ENSG00000116830homo_sapiensENSP0000035847859.294344.5783cyclopterus_lumpusENSCLMP0000504350961.408246.1676
ENSG00000116830homo_sapiensENSP0000035847860.929447.5904xenopus_tropicalisENSXETP0000010500663.956649.9548
ENSG00000116830homo_sapiensENSP0000035847859.896747.4182sphenodon_punctatusENSSPUP0000001126764.206650.8303
ENSG00000116830homo_sapiensENSP0000035847862.478548.6231laticauda_laticaudataENSLLTP0000000490364.19149.9558
ENSG00000116830homo_sapiensENSP0000035847861.531848.4509notechis_scutatusENSNSUP0000001415562.995649.6035
ENSG00000116830homo_sapiensENSP0000035847861.531848.6231pseudonaja_textilisENSPTXP0000002336062.609549.4746
ENSG00000116830homo_sapiensENSP0000035847863.855450.4303anas_platyrhynchos_platyrhynchosENSAPLP0000002849561.423848.5099
ENSG00000116830homo_sapiensENSP0000035847861.617948.537meleagris_gallopavoENSMGAP0000001518764.504550.8108
ENSG00000116830homo_sapiensENSP0000035847856.024142.7711neolamprologus_brichardiENSNBRP0000001541063.76148.6778
ENSG00000116830homo_sapiensENSP0000035847863.597250.6885podarcis_muralisENSPMRP0000001136763.324850.4713
ENSG00000116830homo_sapiensENSP0000035847851.46344.148pelodiscus_sinensisENSPSIP0000000567575.409864.691
ENSG00000116830homo_sapiensENSP0000035847861.445846.5577seriola_dumeriliENSSDUP0000001868663.693148.2605
ENSG00000116830homo_sapiensENSP0000035847857.917447.2461struthio_camelus_australisENSSCUP0000001126672.914459.48
ENSG00000116830homo_sapiensENSP0000035847867.297853.7866terrapene_carolina_triunguisENSTMTP0000002399167.182153.6942
ENSG00000116830homo_sapiensENSP0000035847857.573242.4268hucho_huchoENSHHUP0000009052458.890843.3979
ENSG00000116830homo_sapiensENSP0000035847837.177325.1291ciona_savignyiENSCSAVP0000000479356.103937.9221
ENSG00000116830homo_sapiensENSP0000035847857.831343.4596nothobranchius_furzeriENSNFUP0001501756063.098647.4178
ENSG00000116830homo_sapiensENSP0000035847862.736747.2461cyprinus_carpio_carpioENSCCRP0000000377962.790747.2868
ENSG00000116830homo_sapiensENSP0000035847862.822747.6764sinocyclocheilus_grahamiENSSGRP0000009089962.607247.5129
ENSG00000116830homo_sapiensENSP0000035847860.585245.9552tetraodon_nigroviridisENSTNIP0000001875462.689247.5512
ENSG00000116830homo_sapiensENSP0000035847862.650647.5904scophthalmus_maximusENSSMAP0000001221164.254248.8085

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0004386enables helicase activity1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005681part_of spliceosomal complex1IEAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0006281involved_in DNA repair1IBAHomo_sapiens(9606)Process
GO:0006338involved_in chromatin remodeling1IEAHomo_sapiens(9606)Process
GO:0006353involved_in DNA-templated transcription termination1TASHomo_sapiens(9606)Process
GO:0006369involved_in termination of RNA polymerase II transcription1TASHomo_sapiens(9606)Process
GO:0006397involved_in mRNA processing1IEAHomo_sapiens(9606)Process
GO:0008023part_of transcription elongation factor complex1TASHomo_sapiens(9606)Component
GO:0008094enables ATP-dependent activity, acting on DNA2IBA,IDAHomo_sapiens(9606)Function
GO:0008270enables zinc ion binding1IEAHomo_sapiens(9606)Function
GO:0008380involved_in RNA splicing1IEAHomo_sapiens(9606)Process
GO:0016787enables hydrolase activity1IEAHomo_sapiens(9606)Function
GO:0140658enables ATP-dependent chromatin remodeler activity1IEAHomo_sapiens(9606)Function

Expression