RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000116350	Gene ID	6429	Accession	10786
Symbol	SRSF4	Alias	SFRS4;SRP75	Full Name	serine and arginine rich splicing factor 4
Status	Confidence	Length	34158 bases	Strand	Minus strand
Position	1 : 29147743 - 29181900	RNA binding domain	RRM_1
Summary	Enables RNA binding activity. Involved in negative regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Biomarker of Down syndrome; acute myeloid leukemia; clear cell renal cell carcinoma; and colon adenocarcinoma. [provided by Alliance of Genome Resources, Apr 2022]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000362900	RRM_1	PF00076	8.2e-31	1
ENSP00000362900	RRM_1	PF00076	8.2e-31	2
ENSP00000473728	RRM_1	PF00076	0.00017	1
ENSP00000485813	RRM_1	PF00076	3.8e-31	1
ENSP00000485813	RRM_1	PF00076	3.8e-31	2
ENSP00000510182	RRM_1	PF00076	0.00017	1

Showing 1 to 6 of 6 entries

RNA binding proteomes (RBPomes)

Show entries

Search:

Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27040163	serIC_PMID27040163_Hs_K562	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
27040163	serIC_PMID27040163_Hs_K562.1	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
30352994	eRIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30352994	RIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30607034	RIC_PMID_30607034_Hs_HEK293	HEK293	Rayner M L Queiroz	2019 Feb	doi: 10.1038/s41587-018-0001-2.?Epub 2019 Jan 3
30607034	RIC_PMID30607034_Hs_OOPS_MCF10A	MCF10A	Rayner M L Queiroz	2019 Feb	doi: 10.1038/s41587-018-0001-2.?Epub 2019 Jan 3

Showing 1 to 10 of 20 entries

Previous1 2Next

Literatures on RNA binding capacity

Show entries

Search:

Pubmed ID	Title	Author	Time	Journal
25561496	Detained introns are a novel, widespread class of post-transcriptionally spliced introns.	L Paul Boutz	2015-01-01	Genes & development
25576366	Regulation of splicing factors by alternative splicing and NMD is conserved between kingdoms yet evolutionarily flexible.	F Liana Lareau	2015-04-01	Molecular biology and evolution
25884497	Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis.	Maude Gabriel	2015-04-07	BMC cancer
36123433	Stretching muscle cells induces transcriptional and splicing transitions and changes in SR proteins.	R Emma Hinkle	2022-09-19	Communications biology

Showing 1 to 4 of 4 entries

Previous1Next

Transcripts

Show entries

Search:

Name	Transcript ID	bp	Protein	Translation ID
SRSF4-201	ENST00000373795	2300	494aa	ENSP00000362900
SRSF4-202	ENST00000466448	1264	378aa	ENSP00000485813
SRSF4-203	ENST00000477193	206	No protein	-
SRSF4-204	ENST00000497015	516	No protein	-
SRSF4-205	ENST00000605204	1399	160aa	ENSP00000473728
SRSF4-206	ENST00000622143	614	No protein	-
SRSF4-207	ENST00000634348	8128	No protein	-
SRSF4-208	ENST00000691479	2952	160aa	ENSP00000510182

Showing 1 to 8 of 8 entries

Previous1Next

Gene Model

Click here to download ENSG00000116350's gene model file

Phenotypes

Show entries

Search:

ensgID	Trait	pValue	Pubmed ID
44080	Platelet Function Tests	3.3544280E-012	-
44301	Platelet Function Tests	6.9142470E-012	-
47540	Intelligence Tests	5.6152700E-005	-
51227	Child Development Disorders, Pervasive	2.5662800E-005	-

Showing 1 to 4 of 4 entries

Previous1Next

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000116350's PPI file

Paralogs

Show entries

Search:

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000116350	homo_sapiens	ENSP00000244020	78.7791	69.186	homo_sapiens	ENSP00000362900	54.8583	48.1781
ENSG00000116350	homo_sapiens	ENSP00000451088	74.2647	63.9706	homo_sapiens	ENSP00000362900	40.8907	35.2227
ENSG00000116350	homo_sapiens	ENSP00000243189	33.1034	19.3103	homo_sapiens	ENSP00000362900	19.4332	11.336
ENSG00000116350	homo_sapiens	ENSP00000258962	59.6774	48.7903	homo_sapiens	ENSP00000362900	29.9595	24.4939
ENSG00000116350	homo_sapiens	ENSP00000229390	57.0136	42.9864	homo_sapiens	ENSP00000362900	25.5061	19.2308
ENSG00000116350	homo_sapiens	ENSP00000330188	31.5668	18.4332	homo_sapiens	ENSP00000362900	27.7328	16.1943
ENSG00000116350	homo_sapiens	ENSP00000325905	55.8824	44.958	homo_sapiens	ENSP00000362900	26.9231	21.6599
ENSG00000116350	homo_sapiens	ENSP00000362820	61.5854	50	homo_sapiens	ENSP00000362900	20.4453	16.5992

Showing 1 to 8 of 8 entries

Previous1Next

Orthologs

Show entries

Search:

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000116350	homo_sapiens	ENSP00000362900	99.3927	98.9879	nomascus_leucogenys	ENSNLEP00000012090	99.3927	98.9879
ENSG00000116350	homo_sapiens	ENSP00000362900	100	99.7976	pan_paniscus	ENSPPAP00000010263	100	99.7976
ENSG00000116350	homo_sapiens	ENSP00000362900	99.5951	99.1903	pongo_abelii	ENSPPYP00000001880	99.5951	99.1903
ENSG00000116350	homo_sapiens	ENSP00000362900	100	99.7976	pan_troglodytes	ENSPTRP00000000775	100	99.7976
ENSG00000116350	homo_sapiens	ENSP00000362900	100	99.7976	gorilla_gorilla	ENSGGOP00000002404	100	99.7976
ENSG00000116350	homo_sapiens	ENSP00000362900	77.7328	71.4575	ornithorhynchus_anatinus	ENSOANP00000047652	72.4528	66.6038
ENSG00000116350	homo_sapiens	ENSP00000362900	90.8907	85.6275	sarcophilus_harrisii	ENSSHAP00000030718	88.3858	83.2677
ENSG00000116350	homo_sapiens	ENSP00000362900	53.8462	48.583	notamacropus_eugenii	ENSMEUP00000002778	65.5172	59.1133
ENSG00000116350	homo_sapiens	ENSP00000362900	83.1984	79.3522	choloepus_hoffmanni	ENSCHOP00000012277	91.1308	86.918
ENSG00000116350	homo_sapiens	ENSP00000362900	96.5587	94.332	dasypus_novemcinctus	ENSDNOP00000025055	93.7132	91.5521

Showing 1 to 10 of 232 entries

Previous1 2 3 4 5…24Next

Gene Ontology

Show entries

Search:

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003723	enables RNA binding	2	HDA,IBA	Homo_sapiens(9606)	Function
GO:0016607	is_active_in nuclear speck	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0000375	involved_in RNA splicing, via transesterification reactions	1	TAS	Homo_sapiens(9606)	Process
GO:0000398	involved_in mRNA splicing, via spliceosome	1	IBA	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	TAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0006397	involved_in mRNA processing	1	TAS	Homo_sapiens(9606)	Process
GO:0008380	involved_in RNA splicing	1	TAS	Homo_sapiens(9606)	Process
GO:0032868	involved_in response to insulin	1	IEA	Homo_sapiens(9606)	Process

Showing 1 to 10 of 12 entries

Previous1 2Next

Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression