RBP Type	Canonical_RBPs
Diseases	CancerFlavivirusesSARS-COV-2Dengue
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000116062	Gene ID	2956	Accession	7329
Symbol	MSH6	Alias	GTBP;HSAP;p160;GTMBP;MSH-6;HNPCC5;LYNCH5;MMRCS3	Full Name	mutS homolog 6
Status	Confidence	Length	114245 bases	Strand	Plus strand
Position	2 : 47695819 - 47810063	RNA binding domain	MutS_II
Summary	This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]