Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq DataSet_01_358

Description

Ensembl ID ENSG00000113360 Gene ID 29102 Accession 17904
Symbol DROSHA Alias RN3;ETOHI2;RNASEN;RANSE3L;RNASE3L;HSA242976 Full Name drosha ribonuclease III
Status Confidence Length 131703 bases Strand Minus strand
Position 5 : 31400494 - 31532196 RNA binding domain dsrm , Ribonucleas_3_3 , Ribonuclease_3
Summary This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000424161 dsrm PF00035 8.8e-14 1
ENSP00000424161 Ribonuclease_3 PF00636 6e-42 2
ENSP00000424161 Ribonuclease_3 PF00636 6e-42 3
ENSP00000424161 Ribonucleas_3_3 PF14622 7.5e-43 4
ENSP00000424161 Ribonucleas_3_3 PF14622 7.5e-43 5
ENSP00000339845 dsrm PF00035 8.9e-14 1
ENSP00000339845 Ribonuclease_3 PF00636 6.2e-42 2
ENSP00000339845 Ribonuclease_3 PF00636 6.2e-42 3
ENSP00000339845 Ribonucleas_3_3 PF14622 8.2e-43 4
ENSP00000339845 Ribonucleas_3_3 PF14622 8.2e-43 5
ENSP00000425979 dsrm PF00035 8.9e-14 1
ENSP00000425979 Ribonuclease_3 PF00636 6.2e-42 2
ENSP00000425979 Ribonuclease_3 PF00636 6.2e-42 3
ENSP00000425979 Ribonucleas_3_3 PF14622 8.2e-43 4
ENSP00000425979 Ribonucleas_3_3 PF14622 8.2e-43 5

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
29020972 SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis. Haihua Yuan 2017-10-11 Molecular cancer
29023106 Noncoding RNA Surveillance: The Ends Justify the Means. Cedric Belair 2018-04-25 Chemical reviews
25372759 Update on non-canonical microRNAs. Maher Ahmed Abdelfattah 2014-08-01 Biomolecular concepts
26582366 SUMOylation of TARBP2 regulates miRNA/siRNA efficiency. Cheng Chen 2015-11-19 Nature communications
30915102 Blood Circulating miRNAs as Cancer Biomarkers for Diagnosis and Surgical Treatment Response. Samantha Filipów 2019-01-01 Frontiers in genetics
30901915 MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer. Heidi Schwarzenbach 2019-03-21 Non-coding RNA
28694799 A Tiny RNA that Packs a Big Punch: The Critical Role of a Viral miR-155 Ortholog in Lymphomagenesis in Marek's Disease. Guoqing Zhuang 2017-01-01 Frontiers in microbiology
20882107 Myc: Maestro of MicroRNAs. V Thi Bui 2010-06-01 Genes & cancer
26769856 Structural and functional insights into the fly microRNA biogenesis factor Loquacious. Leonhard Jakob 2016-03-01 RNA (New York, N.Y.)
31655261 Aberrant MicroRNAomics in Pulmonary Complications: Implications in Lung Health and Diseases. Kumar Rajib Dutta 2019-12-06 Molecular therapy. Nucleic acids
28250203 Microprocessor dynamics shows co- and post-transcriptional processing of pri-miRNAs. Annita Louloupi 2017-06-01 RNA (New York, N.Y.)
22306316 Smad-mediated regulation of microRNA biosynthesis. T Matthew Blahna 2012-07-04 FEBS letters
34968247 One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies. Antonia Kalushkova 2021-10-08 Epigenomes
34957212 Cervical Cancer, Papillomavirus, and miRNA Dysfunction. Gabriela Evelyn Bañuelos-Villegas 2021-01-01 Frontiers in molecular biosciences
25243170 The potential of microRNAs in personalized medicine against cancers. Anne Saumet 2014-01-01 BioMed research international
35333566 PRP4KA phosphorylates SERRATE for degradation via 20S proteasome to fine-tune miRNA production in Arabidopsis. Lin Wang 2022-03-25 Science advances
31949213 Endogenous and artificial miRNAs explore a rich variety of conformations: a potential relationship between secondary structure and biological functionality. A M C Gangemi 2020-01-16 Scientific reports
28380355 DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing. C Philamer Calses 2017-04-04 Cell reports
22162940 Computational methods for the identification of microRNA targets. Yang Dai 2010-05-01 Open access bioinformatics
32138313 Regulatory Mechanism of MicroRNA Expression in Cancer. Zainab Z Ali 2020-03-03 International journal of molecular sciences
27001519 Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer. Yu Chen 2016-05-19 Nucleic acids research
26425937 Structures and Energetics of Four Adjacent G·U Pairs That Stabilize an RNA Helix. Xiaobo Gu 2015-10-22 The journal of physical chemistry. B
34572006 Towards Understanding the Pathogenicity of DROSHA Mutations in Oncohematology. S Dmitrii Bug 2021-09-08 Cells

Transcripts

Name Transcript ID bp Protein Translation ID
DROSHA-201 ENST00000344624 5416 1374aa ENSP00000339845
DROSHA-211 ENST00000511367 5305 1374aa ENSP00000425979
DROSHA-219 ENST00000513349 4681 1337aa ENSP00000424161
DROSHA-220 ENST00000514927 567 No protein -
DROSHA-212 ENST00000511778 1261 No protein -
DROSHA-216 ENST00000512166 257 No protein -
DROSHA-207 ENST00000509067 726 No protein -
DROSHA-202 ENST00000504133 617 No protein -
DROSHA-209 ENST00000510178 379 No protein -
DROSHA-204 ENST00000505601 552 No protein -
DROSHA-205 ENST00000507174 572 No protein -
DROSHA-208 ENST00000509608 409 No protein -
DROSHA-215 ENST00000512124 555 No protein -
DROSHA-213 ENST00000511803 717 No protein -
DROSHA-210 ENST00000510375 579 No protein -
DROSHA-218 ENST00000512885 437 No protein -
DROSHA-214 ENST00000512076 1124 375aa ENSP00000422745
DROSHA-217 ENST00000512302 585 195aa ENSP00000428782
DROSHA-206 ENST00000507438 860 201aa ENSP00000430921
DROSHA-203 ENST00000504361 583 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
10018Blood Vessels4.14943798233188E-617903301
10030Blood Vessels8.02227759964565E-717903301
32045Vital Capacity2.1580000E-005-
44971Platelet Function Tests1.3907700E-005-
50618Child Development Disorders, Pervasive2.3413100E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000113360

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000113360homo_sapiensENSP0000033984596.215495.9971nomascus_leucogenysENSNLEP0000003547999.848999.6224
ENSG00000113360homo_sapiensENSP0000033984597.889497.3071pan_paniscusENSPPAP0000002930398.246997.6625
ENSG00000113360homo_sapiensENSP0000033984599.927299.9272pongo_abeliiENSPPYP0000001716699.927299.9272
ENSG00000113360homo_sapiensENSP0000033984598.6998.1805pan_troglodytesENSPTRP0000007696398.260997.7536
ENSG00000113360homo_sapiensENSP0000033984598.835598.3261gorilla_gorillaENSGGOP0000004136598.405897.8986
ENSG00000113360homo_sapiensENSP0000033984587.700182.6783ornithorhynchus_anatinusENSOANP0000002481474.382770.1235
ENSG00000113360homo_sapiensENSP0000033984591.411986.6812sarcophilus_harrisiiENSSHAP0000003140287.587283.0544
ENSG00000113360homo_sapiensENSP0000033984565.356662.5182notamacropus_eugeniiENSMEUP0000000188467.773664.8302
ENSG00000113360homo_sapiensENSP0000033984565.211164.2649choloepus_hoffmanniENSCHOP0000001043066.518265.5531
ENSG00000113360homo_sapiensENSP0000033984593.959292.2853dasypus_novemcinctusENSDNOP0000000119394.233692.5547
ENSG00000113360homo_sapiensENSP0000033984572.125271.2518erinaceus_europaeusENSEEUP0000000589072.230371.3557
ENSG00000113360homo_sapiensENSP0000033984581.513879.5488echinops_telfairiENSETEP0000000635181.692279.7228
ENSG00000113360homo_sapiensENSP0000033984599.708999.4178callithrix_jacchusENSCJAP0000007383396.751496.4689
ENSG00000113360homo_sapiensENSP0000033984598.617298.3988cercocebus_atysENSCATP0000000645798.330998.1132
ENSG00000113360homo_sapiensENSP0000033984599.781799.6361macaca_fascicularisENSMFAP0000005244296.82296.6808
ENSG00000113360homo_sapiensENSP0000033984597.01696.9432macaca_mulattaENSMMUP0000006138096.664396.5917
ENSG00000113360homo_sapiensENSP0000033984596.943296.7977macaca_nemestrinaENSMNEP0000002905996.591796.4467
ENSG00000113360homo_sapiensENSP0000033984599.781799.7817papio_anubisENSPANP0000002385096.82296.822
ENSG00000113360homo_sapiensENSP0000033984594.759894.6143mandrillus_leucophaeusENSMLEP0000000576198.412798.2615
ENSG00000113360homo_sapiensENSP0000033984598.762797.0888tursiops_truncatusENSTTRP0000000396398.834797.1595
ENSG00000113360homo_sapiensENSP0000033984599.490598.8355vulpes_vulpesENSVVUP0000003043999.490598.8355
ENSG00000113360homo_sapiensENSP0000033984597.743895.0509mus_spretusMGP_SPRETEiJ_P003968997.81595.1202
ENSG00000113360homo_sapiensENSP0000033984596.797795.9971equus_asinusENSEASP0000501007499.179798.3594
ENSG00000113360homo_sapiensENSP0000033984598.544497.0888capra_hircusENSCHIP0000002552998.7697.3012
ENSG00000113360homo_sapiensENSP0000033984597.743896.5793loxodonta_africanaENSLAFP0000001923798.172597.0029
ENSG00000113360homo_sapiensENSP0000033984599.417898.69panthera_leoENSPLOP0000002040599.417898.69
ENSG00000113360homo_sapiensENSP0000033984599.417898.2533ailuropoda_melanoleucaENSAMEP0000002766799.417898.2533
ENSG00000113360homo_sapiensENSP0000033984598.617297.3071bos_indicus_hybridENSBIXP0000502790798.473897.1657
ENSG00000113360homo_sapiensENSP0000033984594.03292.2853oryctolagus_cuniculusENSOCUP0000000032794.65292.8938
ENSG00000113360homo_sapiensENSP0000033984599.34598.7627equus_caballusENSECAP0000001212299.34598.7627
ENSG00000113360homo_sapiensENSP0000033984599.34598.5444canis_lupus_familiarisENSCAFP0084500368199.34598.5444
ENSG00000113360homo_sapiensENSP0000033984599.417898.69panthera_pardusENSPPRP0000000760999.417898.69
ENSG00000113360homo_sapiensENSP0000033984595.196594.3231marmota_marmota_marmotaENSMMMP0000000415499.392198.4802
ENSG00000113360homo_sapiensENSP0000033984598.908397.3799balaenoptera_musculusENSBMSP0001002528498.908397.3799
ENSG00000113360homo_sapiensENSP0000033984591.775890.7569cavia_porcellusENSCPOP0000001356797.374596.2934
ENSG00000113360homo_sapiensENSP0000033984599.417898.69felis_catusENSFCAP0000005072599.417898.69
ENSG00000113360homo_sapiensENSP0000033984596.943296.1426ursus_americanusENSUAMP0000003313099.62698.8033
ENSG00000113360homo_sapiensENSP0000033984591.120886.6812monodelphis_domesticaENSMODP0000004872489.30184.9501
ENSG00000113360homo_sapiensENSP0000033984598.398897.0888bison_bison_bisonENSBBBP0000002621598.255896.9477
ENSG00000113360homo_sapiensENSP0000033984598.981197.3799monodon_monocerosENSMMNP0001501022296.18194.6252
ENSG00000113360homo_sapiensENSP0000033984596.069994.9054sus_scrofaENSSSCP0000001780594.488293.3429
ENSG00000113360homo_sapiensENSP0000033984598.326197.5983microcebus_murinusENSMICP0000000205697.969597.2444
ENSG00000113360homo_sapiensENSP0000033984599.199498.0349octodon_degusENSODEP0000000245499.055297.8924
ENSG00000113360homo_sapiensENSP0000033984598.544497.0888jaculus_jaculusENSJJAP0000001852498.68897.2303
ENSG00000113360homo_sapiensENSP0000033984596.36194.9054ovis_aries_rambouilletENSOARP0002001439597.352995.8824
ENSG00000113360homo_sapiensENSP0000033984594.468793.377ursus_maritimusENSUMAP0000002081595.581794.4772
ENSG00000113360homo_sapiensENSP0000033984582.751181.5866ochotona_princepsENSOPRP0000000993582.751181.5866
ENSG00000113360homo_sapiensENSP0000033984596.652195.0509delphinapterus_leucasENSDLEP0000002078299.401297.7545
ENSG00000113360homo_sapiensENSP0000033984598.908397.4527physeter_catodonENSPCTP0000501337298.908397.4527
ENSG00000113360homo_sapiensENSP0000033984597.962295.5604mus_caroliMGP_CAROLIEiJ_P003792498.033595.63
ENSG00000113360homo_sapiensENSP0000033984597.889495.5604mus_musculusENSMUSP0000012927997.960795.63
ENSG00000113360homo_sapiensENSP0000033984593.522692.1397dipodomys_ordiiENSDORP0000000526798.016896.5675
ENSG00000113360homo_sapiensENSP0000033984599.272298.4716mustela_putorius_furoENSMPUP0000001512899.272298.4716
ENSG00000113360homo_sapiensENSP0000033984597.889497.016aotus_nancymaaeENSANAP0000000546698.318797.4415
ENSG00000113360homo_sapiensENSP0000033984599.490599.0539saimiri_boliviensis_boliviensisENSSBOP0000001450699.490599.0539
ENSG00000113360homo_sapiensENSP0000033984575.254774.818vicugna_pacosENSVPAP0000001048493.574793.0317
ENSG00000113360homo_sapiensENSP0000033984597.01697.016chlorocebus_sabaeusENSCSAP0000001324096.664396.6643
ENSG00000113360homo_sapiensENSP0000033984585.516784.7889tupaia_belangeriENSTBEP0000000047688.545687.792
ENSG00000113360homo_sapiensENSP0000033984597.962295.9243mesocricetus_auratusENSMAUP0000000295397.890995.8545
ENSG00000113360homo_sapiensENSP0000033984574.454172.1252phocoena_sinusENSPSNP0000001036096.146693.1391
ENSG00000113360homo_sapiensENSP0000033984584.206782.46camelus_dromedariusENSCDRP0000500328687.057985.2521
ENSG00000113360homo_sapiensENSP0000033984515.647714.9927carlito_syrichtaENSTSYP0000003378092.672488.7931
ENSG00000113360homo_sapiensENSP0000033984599.417898.69panthera_tigris_altaicaENSPTIP0000001985799.417898.69
ENSG00000113360homo_sapiensENSP0000033984598.398896.2154rattus_norvegicusENSRNOP0000005063398.470596.2855
ENSG00000113360homo_sapiensENSP0000033984599.563399.1994prolemur_simusENSPSMP0000001243899.635899.2717
ENSG00000113360homo_sapiensENSP0000033984597.452795.7787microtus_ochrogasterENSMOCP0000001605898.167296.4809
ENSG00000113360homo_sapiensENSP0000033984557.132556.0408sorex_araneusENSSARP0000000407957.174156.0816
ENSG00000113360homo_sapiensENSP0000033984598.034995.8515peromyscus_maniculatus_bairdiiENSPEMP0000000083698.106395.9213
ENSG00000113360homo_sapiensENSP0000033984598.6997.3071bos_mutusENSBMUP0000001667498.618297.2364
ENSG00000113360homo_sapiensENSP0000033984597.816695.3421mus_spicilegusENSMSIP0000001749197.887895.4115
ENSG00000113360homo_sapiensENSP0000033984598.034996.4338cricetulus_griseus_chok1gshdENSCGRP0000100658897.821496.2237
ENSG00000113360homo_sapiensENSP0000033984595.196594.4687pteropus_vampyrusENSPVAP0000001241995.404894.6754
ENSG00000113360homo_sapiensENSP0000033984596.797795.0509myotis_lucifugusENSMLUP0000000235596.516794.775
ENSG00000113360homo_sapiensENSP0000033984591.120886.6812vombatus_ursinusENSVURP0001002728392.878388.3531
ENSG00000113360homo_sapiensENSP0000033984599.34598.7627rhinolophus_ferrumequinumENSRFEP0001000664099.34598.7627
ENSG00000113360homo_sapiensENSP0000033984599.417898.6172neovison_visonENSNVIP0000000581599.417898.6172
ENSG00000113360homo_sapiensENSP0000033984596.215494.9782bos_taurusENSBTAP0000006042798.804297.5336
ENSG00000113360homo_sapiensENSP0000033984599.053998.0349heterocephalus_glaber_femaleENSHGLP0000002653497.77396.7672
ENSG00000113360homo_sapiensENSP0000033984598.326198.3261rhinopithecus_bietiENSRBIP0000001808198.974498.9744
ENSG00000113360homo_sapiensENSP0000033984597.67196.7977canis_lupus_dingoENSCAFP0002002477597.884897.0095
ENSG00000113360homo_sapiensENSP0000033984598.908398.2533sciurus_vulgarisENSSVLP0000501278999.414898.7564
ENSG00000113360homo_sapiensENSP0000033984591.120886.6812phascolarctos_cinereusENSPCIP0000000706488.731484.4082
ENSG00000113360homo_sapiensENSP0000033984584.352382.6055procavia_capensisENSPCAP0000000683984.846383.0893
ENSG00000113360homo_sapiensENSP0000033984594.541593.2314nannospalax_galiliENSNGAP0000001675498.783397.4145
ENSG00000113360homo_sapiensENSP0000033984596.288294.9782bos_grunniensENSBGRP0000001238998.952997.6066
ENSG00000113360homo_sapiensENSP0000033984599.34598.3988chinchilla_lanigeraENSCLAP0000001905599.200698.2558
ENSG00000113360homo_sapiensENSP0000033984598.6997.1616cervus_hanglu_yarkandensisENSCHYP0000004000498.618297.0909
ENSG00000113360homo_sapiensENSP0000033984589.956389.1557catagonus_wagneriENSCWAP0000002000798.486197.6096
ENSG00000113360homo_sapiensENSP0000033984572.634672.198ictidomys_tridecemlineatusENSSTOP0000002517997.939297.3503
ENSG00000113360homo_sapiensENSP0000033984586.171884.7889otolemur_garnettiiENSOGAP0000000485696.103994.5617
ENSG00000113360homo_sapiensENSP0000033984599.781799.4178cebus_imitatorENSCCAP0000001899899.781799.4178
ENSG00000113360homo_sapiensENSP0000033984599.272298.3988urocitellus_parryiiENSUPAP0001000167899.344598.4705
ENSG00000113360homo_sapiensENSP0000033984598.398896.7977moschus_moschiferusENSMMSP0000001973598.327396.7273
ENSG00000113360homo_sapiensENSP0000033984599.781799.7817rhinopithecus_roxellanaENSRROP0000000801699.781799.7817
ENSG00000113360homo_sapiensENSP0000033984597.816695.706mus_pahariMGP_PahariEiJ_P002742297.887895.7757
ENSG00000113360homo_sapiensENSP0000033984596.724996.1426propithecus_coquereliENSPCOP0000003146898.153697.5628
ENSG00000113360homo_sapiensENSP0000033984541.557525.0364caenorhabditis_elegansF26E4.10a.152.578331.6759
ENSG00000113360homo_sapiensENSP0000033984558.224242.5764drosophila_melanogasterFBpp008792660.286444.0844
ENSG00000113360homo_sapiensENSP0000033984525.109219.7962ciona_intestinalisENSCINP0000000301577.181260.8501
ENSG00000113360homo_sapiensENSP0000033984545.123740.7569eptatretus_burgeriENSEBUP0000000930090.909182.1114
ENSG00000113360homo_sapiensENSP0000033984523.362418.8501eptatretus_burgeriENSEBUP0000002737845.33936.5819
ENSG00000113360homo_sapiensENSP0000033984580.640573.8719callorhinchus_miliiENSCMIP0000003508482.872175.9162
ENSG00000113360homo_sapiensENSP0000033984586.899680.6405latimeria_chalumnaeENSLACP0000000669488.641482.2569
ENSG00000113360homo_sapiensENSP0000033984586.026278.3843lepisosteus_oculatusENSLOCP0000001582184.428676.9286
ENSG00000113360homo_sapiensENSP0000033984579.767171.9796clupea_harengusENSCHAP0000004082083.409475.2664
ENSG00000113360homo_sapiensENSP0000033984580.78675.1092danio_rerioENSDARP0000008345086.113380.0621
ENSG00000113360homo_sapiensENSP0000033984576.855971.9068carassius_auratusENSCARP0000001497189.491583.7288
ENSG00000113360homo_sapiensENSP0000033984580.931674.3086carassius_auratusENSCARP0000006719086.335479.2702
ENSG00000113360homo_sapiensENSP0000033984582.314475.7642astyanax_mexicanusENSAMXP0000000573286.401879.5264
ENSG00000113360homo_sapiensENSP0000033984576.783171.0335ictalurus_punctatusENSIPUP0000003161182.615576.4291
ENSG00000113360homo_sapiensENSP0000033984582.751175.6914esox_luciusENSELUP0000007558380.752873.8636
ENSG00000113360homo_sapiensENSP0000033984582.678375.4003electrophorus_electricusENSEEEP0000004919185.285377.7778
ENSG00000113360homo_sapiensENSP0000033984582.823975.4731oncorhynchus_kisutchENSOKIP0000507489579.747772.6699
ENSG00000113360homo_sapiensENSP0000033984535.080131.0771oncorhynchus_kisutchENSOKIP0000510604873.141164.7951
ENSG00000113360homo_sapiensENSP0000033984582.678375.4003oncorhynchus_mykissENSOMYP0000002572080.169473.1122
ENSG00000113360homo_sapiensENSP0000033984525.982522.9985salmo_salarENSSSAP0000014881079.687570.5357
ENSG00000113360homo_sapiensENSP0000033984580.78674.0175salmo_salarENSSSAP0000005474183.647376.639
ENSG00000113360homo_sapiensENSP0000033984582.678375.2547salmo_truttaENSSTUP0000002062180.453373.2295
ENSG00000113360homo_sapiensENSP0000033984522.925820.5968salmo_truttaENSSTUP0000002627277.777869.8765
ENSG00000113360homo_sapiensENSP0000033984577.874871.1063gadus_morhuaENSGMOP0000004479278.676571.8382
ENSG00000113360homo_sapiensENSP0000033984566.448358.0786fundulus_heteroclitusENSFHEP0000000286677.176767.4556
ENSG00000113360homo_sapiensENSP0000033984582.096175.3275poecilia_reticulataENSPREP0000003295285.975678.8872
ENSG00000113360homo_sapiensENSP0000033984581.44174.3086oryzias_latipesENSORLP0000003111984.965877.5247
ENSG00000113360homo_sapiensENSP0000033984581.732274.3814oreochromis_niloticusENSONIP0000005900685.399277.7186
ENSG00000113360homo_sapiensENSP0000033984574.963667.1761haplochromis_burtoniENSHBUP0000003050284.150375.4085
ENSG00000113360homo_sapiensENSP0000033984582.823974.9636astatotilapia_callipteraENSACLP0000001816783.553675.6241
ENSG00000113360homo_sapiensENSP0000033984581.804975.0364sparus_aurataENSSAUP0001005890282.768875.9205
ENSG00000113360homo_sapiensENSP0000033984581.295574.9636lates_calcariferENSLCAP0001005887285.659578.9877
ENSG00000113360homo_sapiensENSP0000033984581.149975.837xenopus_tropicalisENSXETP0000009270185.179579.6028
ENSG00000113360homo_sapiensENSP0000033984591.557586.6812chrysemys_picta_belliiENSCPBP0000000052894.161789.1467
ENSG00000113360homo_sapiensENSP0000033984586.899681.441sphenodon_punctatusENSSPUP0000000890991.006185.2896
ENSG00000113360homo_sapiensENSP0000033984591.120885.7351crocodylus_porosusENSCPRP0000502394293.572588.0419
ENSG00000113360homo_sapiensENSP000003398459.606999.24309laticauda_laticaudataENSLLTP0000001741098.507594.7761
ENSG00000113360homo_sapiensENSP0000033984547.525540.1019laticauda_laticaudataENSLLTP0000001642180.418767.8571
ENSG00000113360homo_sapiensENSP0000033984530.567729.1121notechis_scutatusENSNSUP0000002630093.541289.0869
ENSG00000113360homo_sapiensENSP0000033984586.972379.8399pseudonaja_textilisENSPTXP0000002652488.913781.622
ENSG00000113360homo_sapiensENSP0000033984587.700182.0961anas_platyrhynchos_platyrhynchosENSAPLP0000000405593.122187.1716
ENSG00000113360homo_sapiensENSP0000033984590.829785.2256gallus_gallusENSGALP0001001505093.413287.6497
ENSG00000113360homo_sapiensENSP0000033984590.611485.1528meleagris_gallopavoENSMGAP0000000502793.188687.5749
ENSG00000113360homo_sapiensENSP0000033984590.538684.7162serinus_canariaENSSCAP0000000458493.113887.1257
ENSG00000113360homo_sapiensENSP0000033984590.538684.425parus_majorENSPMJP0000000250093.113886.8263
ENSG00000113360homo_sapiensENSP0000033984587.918582.0233anolis_carolinensisENSACAP0000000796791.238785.1208
ENSG00000113360homo_sapiensENSP0000033984558.442553.5662neolamprologus_brichardiENSNBRP0000000239887.759680.4372
ENSG00000113360homo_sapiensENSP0000033984585.589579.3304naja_najaENSNNAP0000001585190.600983.9753
ENSG00000113360homo_sapiensENSP0000033984576.419269.3595podarcis_muralisENSPMRP0000000804586.633778.6304
ENSG00000113360homo_sapiensENSP0000033984589.665284.2795geospiza_fortisENSGFOP0000002135293.830988.195
ENSG00000113360homo_sapiensENSP0000033984590.756984.7162taeniopygia_guttataENSTGUP0000000202593.338387.1257
ENSG00000113360homo_sapiensENSP0000033984585.225678.3115erpetoichthys_calabaricusENSECRP0000000758288.444181.2689
ENSG00000113360homo_sapiensENSP0000033984589.301383.115salvator_merianaeENSSMRP0000001155791.841385.479
ENSG00000113360homo_sapiensENSP0000033984581.368374.0902oryzias_javanicusENSOJAP0000004279384.761277.1797
ENSG00000113360homo_sapiensENSP0000033984569.21465.6477amphilophus_citrinellusENSACIP0000002495493.694688.867
ENSG00000113360homo_sapiensENSP0000033984583.406175.9825dicentrarchus_labraxENSDLAP0000505733484.763377.2189
ENSG00000113360homo_sapiensENSP0000033984559.898152.6201oryzias_sinensisENSOSIP0000002134981.485171.5842
ENSG00000113360homo_sapiensENSP0000033984591.266486.5357gopherus_evgoodeiENSGEVP0000500252093.862388.997
ENSG00000113360homo_sapiensENSP0000033984591.339286.4629chelonoidis_abingdoniiENSCABP0000001474092.688387.74
ENSG00000113360homo_sapiensENSP0000033984583.187876.1281seriola_dumeriliENSSDUP0000001510684.416577.2526
ENSG00000113360homo_sapiensENSP0000033984581.804974.5269cottoperca_gobioENSCGOP0000004762283.32175.9081
ENSG00000113360homo_sapiensENSP0000033984590.756985.444struthio_camelus_australisENSSCUP0000001217493.759488.2707
ENSG00000113360homo_sapiensENSP0000033984590.684184.9345anser_brachyrhynchusENSABRP0000001387193.263587.3503
ENSG00000113360homo_sapiensENSP0000033984520.232915.2111gasterosteus_aculeatusENSGACP0000000736365.105448.9461
ENSG00000113360homo_sapiensENSP0000033984517.831216.8122gasterosteus_aculeatusENSGACP0000000736794.961289.5349
ENSG00000113360homo_sapiensENSP0000033984581.804974.5269cynoglossus_semilaevisENSCSEP0000000218283.259375.8519
ENSG00000113360homo_sapiensENSP0000033984583.11576.4192myripristis_murdjanENSMMDP0000502275184.094377.3196
ENSG00000113360homo_sapiensENSP0000033984582.168974.9636sander_luciopercaENSSLUP0000001275384.190976.8083
ENSG00000113360homo_sapiensENSP0000033984590.320284.7162strigops_habroptilaENSSHBP0000500057592.889287.1257
ENSG00000113360homo_sapiensENSP0000033984591.557586.4629terrapene_carolina_triunguisENSTMTP0000000380294.302889.0555
ENSG00000113360homo_sapiensENSP0000033984546.579344.6143hucho_huchoENSHHUP0000008246293.294589.3586
ENSG00000113360homo_sapiensENSP0000033984532.678326.6376hucho_huchoENSHHUP0000008247862.885251.2605
ENSG00000113360homo_sapiensENSP0000033984581.222773.6536betta_splendensENSBSLP0000004500782.727975.0185
ENSG00000113360homo_sapiensENSP0000033984578.311572.7802pygocentrus_nattereriENSPNAP0000000567589.146682.85
ENSG00000113360homo_sapiensENSP0000033984581.950575.2547anabas_testudineusENSATEP0000004520283.038376.2537
ENSG00000113360homo_sapiensENSP0000033984545.633235.8806ciona_savignyiENSCSAVP0000001809074.731858.7604
ENSG00000113360homo_sapiensENSP0000033984583.333376.0553seriola_lalandi_dorsalisENSSLDP0000003300884.689377.2929
ENSG00000113360homo_sapiensENSP0000033984580.422173.9447labrus_bergyltaENSLBEP0000000868386.530979.5615
ENSG00000113360homo_sapiensENSP0000033984582.823974.818pundamilia_nyerereiENSPNYP0000000055484.609776.4312
ENSG00000113360homo_sapiensENSP0000033984582.678375.9098mastacembelus_armatusENSMAMP0000001875883.284576.4663
ENSG00000113360homo_sapiensENSP0000033984577.729371.1063oncorhynchus_tshawytschaENSOTSP0000509367680.361273.5139
ENSG00000113360homo_sapiensENSP000003398457.933047.7147acanthochromis_polyacanthusENSAPOP0000001684395.61492.9825
ENSG00000113360homo_sapiensENSP0000033984534.716231.8049acanthochromis_polyacanthusENSAPOP0000000142979.765973.0769
ENSG00000113360homo_sapiensENSP0000033984549.563343.5226acanthochromis_polyacanthusENSAPOP0000001206776.775767.4183
ENSG00000113360homo_sapiensENSP0000033984590.902585.3712aquila_chrysaetos_chrysaetosENSACCP0002002157293.48887.7994
ENSG00000113360homo_sapiensENSP0000033984582.896775.5459nothobranchius_furzeriENSNFUP0001504019785.832778.2215
ENSG00000113360homo_sapiensENSP0000033984582.387275.3275cyprinodon_variegatusENSCVAP0000002210184.667277.4121
ENSG00000113360homo_sapiensENSP0000033984583.260675.3275denticeps_clupeoidesENSDCDP0000006060385.245977.1237
ENSG00000113360homo_sapiensENSP0000033984583.260676.0553larimichthys_croceaENSLCRP0000506284984.42877.1218
ENSG00000113360homo_sapiensENSP0000033984583.042275.4003takifugu_rubripesENSTRUP0000005949084.331176.5706
ENSG00000113360homo_sapiensENSP0000033984588.937483.0422ficedula_albicollisENSFALP0000001343790.451584.456
ENSG00000113360homo_sapiensENSP0000033984576.783170.0146hippocampus_comesENSHCOP0000000658688.432580.637
ENSG00000113360homo_sapiensENSP0000033984579.767173.2169cyprinus_carpio_carpioENSCCRP0000009249684.437677.5039
ENSG00000113360homo_sapiensENSP0000033984577.874871.6157cyprinus_carpio_carpioENSCCRP0000008905285.32778.4689
ENSG00000113360homo_sapiensENSP0000033984590.829785.3712coturnix_japonicaENSCJPP0000501919493.413287.7994
ENSG00000113360homo_sapiensENSP0000033984571.324666.8122sinocyclocheilus_grahamiENSSGRP0000010408285.514880.1047
ENSG00000113360homo_sapiensENSP0000033984578.893772.4891sinocyclocheilus_grahamiENSSGRP0000007014783.900977.0898
ENSG00000113360homo_sapiensENSP0000033984582.823974.9636maylandia_zebraENSMZEP0000502613483.553675.6241
ENSG00000113360homo_sapiensENSP0000033984582.314475.4731tetraodon_nigroviridisENSTNIP0000001153783.161876.25
ENSG00000113360homo_sapiensENSP0000033984584.497877.6565paramormyrops_kingsleyaeENSPKIP0000003080587.622680.5283
ENSG00000113360homo_sapiensENSP0000033984583.187876.5648scleropages_formosusENSSFOP0001504266886.986380.0609
ENSG00000113360homo_sapiensENSP0000033984582.605575.6914leptobrachium_leishanenseENSLLEP0000001913182.545575.6364
ENSG00000113360homo_sapiensENSP0000033984582.387275.2547scophthalmus_maximusENSSMAP0000001310383.235376.0294
ENSG00000113360homo_sapiensENSP0000033984579.403272.0524oryzias_melastigmaENSOMEP0000000017982.464174.8299

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001530enables lipopolysaccharide binding1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0004525enables ribonuclease III activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IEAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0006364involved_in rRNA processing1IEAHomo_sapiens(9606)Process
GO:0010586involved_in miRNA metabolic process1IEAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IEAHomo_sapiens(9606)Process
GO:0014069located_in postsynaptic density1IEAHomo_sapiens(9606)Component
GO:0017151enables DEAD/H-box RNA helicase binding1IPIHomo_sapiens(9606)Function
GO:0031053involved_in primary miRNA processing3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0031054involved_in pre-miRNA processing1IBAHomo_sapiens(9606)Process
GO:0042803enables protein homodimerization activity1IDAHomo_sapiens(9606)Function
GO:0045589involved_in regulation of regulatory T cell differentiation1IEAHomo_sapiens(9606)Process
GO:0046332enables SMAD binding1IPIHomo_sapiens(9606)Function
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0050727involved_in regulation of inflammatory response1IEAHomo_sapiens(9606)Process
GO:0050829involved_in defense response to Gram-negative bacterium1IDAHomo_sapiens(9606)Process
GO:0050830involved_in defense response to Gram-positive bacterium1IDAHomo_sapiens(9606)Process
GO:0070412enables R-SMAD binding1IPIHomo_sapiens(9606)Function
GO:0070877part_of microprocessor complex2IBA,IDAHomo_sapiens(9606)Component
GO:0070878enables primary miRNA binding2IPI,NASHomo_sapiens(9606)Function
GO:0098978located_in glutamatergic synapse1IEAHomo_sapiens(9606)Component
GO:2000628involved_in regulation of miRNA metabolic process1IEAHomo_sapiens(9606)Process

Expression