Ensembl ID ENSG00000113360 Gene ID 29102 Accession 17904
Gene Symbol DROSHA Alias RN3;ETOHI2;RNASEN;RANSE3L;RNASE3L;HSA242976 Full Name drosha ribonuclease III
Position 5 : 31400494 - 31532196 Length 131703 bases Strand Minus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

ENSG00000113360 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000113360 DROSHA 1.15 6.68e-34 LUSC
ENSG00000113360 DROSHA 0.57 1.64e-17 LIHC
ENSG00000113360 DROSHA 1.00 2.55e-13 CHOL
ENSG00000113360 DROSHA 0.83 4.92e-25 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000113360 DROSHA esophageal cancer 17121874
ENSG00000113360 DROSHA tumor 17922911
ENSG00000113360 DROSHA tumor 18421256
ENSG00000113360 DROSHA tumors 18559093
ENSG00000113360 DROSHA tumor 20083228
ENSG00000113360 DROSHA cancer 20232482
ENSG00000113360 DROSHA colon cancer 20433755
ENSG00000113360 DROSHA tumor 20587524
ENSG00000113360 DROSHA tumor 20637737
ENSG00000113360 DROSHA lung cancer 20721975
ENSG00000113360 DROSHA Lung cancer 21102586
ENSG00000113360 DROSHA tumors 21205968
ENSG00000113360 DROSHA tumours 21533284
ENSG00000113360 DROSHA cancer 21766210
ENSG00000113360 DROSHA tumor 22187960
ENSG00000113360 DROSHA tumor 22492723
ENSG00000113360 DROSHA tumor 22546613
ENSG00000113360 DROSHA breast cancer 22639842
ENSG00000113360 DROSHA non-small cell lung cancer 23349018
ENSG00000113360 DROSHA tumor 23370771
ENSG00000113360 DROSHA testicular germ cell tumors 23547758
ENSG00000113360 DROSHA breast cancer 23629745
ENSG00000113360 DROSHA adrenocortical tumors 23671264
ENSG00000113360 DROSHA tumors 23921383
ENSG00000113360 DROSHA DLBCLs 24121164
ENSG00000113360 DROSHA tumours 24136150
ENSG00000113360 DROSHA Bladder Cancer 24312312
ENSG00000113360 DROSHA cancers 24325353
ENSG00000113360 DROSHA tumour 24386211
ENSG00000113360 DROSHA tumor 24839956
ENSG00000113360 DROSHA tumour 24909261
ENSG00000113360 DROSHA cancer 24909689
ENSG00000113360 DROSHA tumours 25190313
ENSG00000113360 DROSHA tumor 25197016
ENSG00000113360 DROSHA breast cancer 25390939
ENSG00000113360 DROSHA Wilms tumors 25670082
ENSG00000113360 DROSHA Wilms tumors 25670083
ENSG00000113360 DROSHA tumors 25676695
ENSG00000113360 DROSHA cancer 25709475
ENSG00000113360 DROSHA breast tumors 26141719
ENSG00000113360 DROSHA Colorectal Cancer 26147304
ENSG00000113360 DROSHA cancer 26156018
ENSG00000113360 DROSHA cancer 26203264
ENSG00000113360 DROSHA tumours 26635203
ENSG00000113360 DROSHA tumors 26646588
ENSG00000113360 DROSHA Wilms tumors 26655220
ENSG00000113360 DROSHA cancer 26688807
ENSG00000113360 DROSHA tumors 26802027
ENSG00000113360 DROSHA Wilms tumor 26925222
ENSG00000113360 DROSHA tumour 26934318
ENSG00000113360 DROSHA cancer 27313724
ENSG00000113360 DROSHA breast cancer 27380242
ENSG00000113360 DROSHA cancer 27957388
ENSG00000113360 DROSHA Tumour 28103887
ENSG00000113360 DROSHA laryngeal cancer 28155978
ENSG00000113360 DROSHA bladder cancer 28187437
ENSG00000113360 DROSHA lung cancer 28214904
ENSG00000113360 DROSHA cancer 28230864
ENSG00000113360 DROSHA cancer 28433598
ENSG00000113360 DROSHA tumors 28448850
ENSG00000113360 DROSHA tumors 28825729
ENSG00000113360 DROSHA cancer 28877962
ENSG00000113360 DROSHA cancer 28915552
ENSG00000113360 DROSHA cancer 28916654
ENSG00000113360 DROSHA gastric cancer 29156806
ENSG00000113360 DROSHA breast cancer 29333004
ENSG00000113360 DROSHA Cancer 29475968
ENSG00000113360 DROSHA cancer 29654164
ENSG00000113360 DROSHA tumours 29912901
ENSG00000113360 DROSHA tumor 30030436
ENSG00000113360 DROSHA cancer 30327290
ENSG00000113360 DROSHA Wilms tumor 30367465
ENSG00000113360 DROSHA cancer 30397354
ENSG00000113360 DROSHA cancer 30523565
ENSG00000113360 DROSHA cancer 30838030
ENSG00000113360 DROSHA breast cancer 30897768
ENSG00000113360 DROSHA thyroid tumors 30956758
ENSG00000113360 DROSHA tumor 31213844
ENSG00000113360 DROSHA cancer 31214494
ENSG00000113360 DROSHA tumor 31250375
ENSG00000113360 DROSHA tumor 31293964
ENSG00000113360 DROSHA cancer 31417090
ENSG00000113360 DROSHA tumor 31510013
ENSG00000113360 DROSHA cancer 31516620
ENSG00000113360 DROSHA tumors 31527943
ENSG00000113360 DROSHA tumors 31820118
ENSG00000113360 DROSHA gastric cancer 31966573
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000113360 DROSHA colorectal adenocarcinoma stop_gained 5.975% (68/1138) 2 entries
ENSG00000113360 DROSHA prostate adenocarcinoma missense_variant 5.089% (74/1454) 1 entry
ENSG00000113360 DROSHA kidney Wilms tumor stop_gained 8.154% (140/1717) 2 entries
ENSG00000113360 DROSHA basal cell carcinoma sequence_alteration 17.24% (10/58) 1 entry
ENSG00000113360 DROSHA colorectal adenocarcinoma sequence_alteration 5.975% (68/1138) 1 entry
ENSG00000113360 DROSHA basal cell carcinoma missense_variant 17.24% (10/58) 1 entry
ENSG00000113360 DROSHA prostate adenocarcinoma stop_gained 5.089% (74/1454) 1 entry
ENSG00000113360 DROSHA colorectal adenocarcinoma frameshift_variant 5.975% (68/1138) 2 entries
ENSG00000113360 DROSHA kidney Wilms tumor missense_variant 8.154% (140/1717) 5 entries
ENSG00000113360 DROSHA breast ductal adenocarcinoma sequence_alteration 11.13% (65/584) 1 entry
ENSG00000113360 DROSHA colorectal adenocarcinoma missense_variant 5.975% (68/1138) 3 entries
ENSG00000113360 DROSHA skin melanoma sequence_alteration 1.241% (12/967) 2 entries
ENSG00000113360 DROSHA lung adenocarcinoma missense_variant 2.921% (34/1164) 6 entries
ENSG00000113360 DROSHA Ovarian Endometrioid Adenocarcinoma sequence_alteration 22.22% (2/9) 1 entry
ENSG00000113360 DROSHA skin melanoma missense_variant 1.241% (12/967) 4 entries
ENSG00000113360 DROSHA cecum adenocarcinoma frameshift_variant 5.6% (7/125) 1 entry
ENSG00000113360 DROSHA clear cell renal carcinoma missense_variant 0.437% (6/1373) 1 entry
ENSG00000113360 DROSHA adenosquamous lung carcinoma missense_variant 18.18% (2/11) 1 entry
ENSG00000113360 DROSHA diffuse large B-cell lymphoma missense_variant 1.316% (4/304) 2 entries
ENSG00000113360 DROSHA Brain Stem Glioblastoma sequence_alteration 3.571% (2/56) 1 entry
ENSG00000113360 DROSHA prostate carcinoma sequence_alteration 3.286% (14/426) 1 entry
ENSG00000113360 DROSHA hepatocellular carcinoma missense_variant 1.333% (12/900) 1 entry
ENSG00000113360 DROSHA colon adenocarcinoma missense_variant 2.909% (21/722) 5 entries
ENSG00000113360 DROSHA colon adenocarcinoma sequence_alteration 2.909% (21/722) 1 entry
ENSG00000113360 DROSHA esophageal squamous cell carcinoma missense_variant 2.655% (18/678) 6 entries
ENSG00000113360 DROSHA small cell lung carcinoma missense_variant 0.6289% (2/318) 1 entry
ENSG00000113360 DROSHA squamous cell lung carcinoma missense_variant 3.15% (24/762) 1 entry
ENSG00000113360 DROSHA prostate adenocarcinoma frameshift_variant 5.089% (74/1454) 1 entry
ENSG00000113360 DROSHA melanoma missense_variant 4.95% (5/101) 3 entries
ENSG00000113360 DROSHA ovarian serous adenocarcinoma sequence_alteration 0.9709% (7/721) 1 entry
ENSG00000113360 DROSHA breast carcinoma missense_variant 0.6378% (9/1411) 1 entry
ENSG00000113360 DROSHA rectal adenocarcinoma missense_variant 1.357% (3/221) 2 entries
ENSG00000113360 DROSHA colon adenocarcinoma stop_gained 2.909% (21/722) 2 entries
ENSG00000113360 DROSHA cecum adenocarcinoma missense_variant 5.6% (7/125) 2 entries
ENSG00000113360 DROSHA esophageal squamous cell carcinoma sequence_alteration 2.655% (18/678) 1 entry
ENSG00000113360 DROSHA prostate carcinoma missense_variant 3.286% (14/426) 1 entry
ENSG00000113360 DROSHA ovarian serous adenocarcinoma missense_variant 0.9709% (7/721) 1 entry
ENSG00000113360 DROSHA colorectal adenocarcinoma conservative_inframe_deletion 5.975% (68/1138) 1 entry
ENSG00000113360 DROSHA HER2 Positive Breast Carcinoma missense_variant 14.81% (16/108) 1 entry
ENSG00000113360 DROSHA oral squamous cell carcinoma missense_variant 0.9756% (2/205) 2 entries
ENSG00000113360 DROSHA Merkel cell skin cancer missense_variant 13.33% (4/30) 1 entry
ENSG00000113360 DROSHA brain glioblastoma missense_variant 0.54% (5/926) 2 entries
ENSG00000113360 DROSHA female breast carcinoma missense_variant 2.247% (6/267) 1 entry
ENSG00000113360 DROSHA Merkel cell skin cancer sequence_alteration 13.33% (4/30) 1 entry
ENSG00000113360 DROSHA colon adenocarcinoma frameshift_variant 2.909% (21/722) 2 entries
ENSG00000113360 DROSHA gastric intestinal type adenocarcinoma missense_variant 4.706% (4/85) 2 entries
ENSG00000113360 DROSHA osteosarcoma sequence_alteration 0.8621% (1/116) 1 entry
ENSG00000113360 DROSHA ependymoma missense_variant 2.174% (1/46) 1 entry
ENSG00000113360 DROSHA Pleural Epithelioid Mesothelioma missense_variant 1.064% (1/94) 1 entry
ENSG00000113360 DROSHA Mantle cell lymphoma missense_variant 2.439% (1/41) 1 entry
ENSG00000113360 DROSHA pancreatic ductal adenocarcinoma stop_gained 3.971% (50/1259) 1 entry
ENSG00000113360 DROSHA chronic myelomonocytic leukemia stop_gained 3.704% (1/27) 1 entry
ENSG00000113360 DROSHA large cell lung carcinoma missense_variant 5.556% (1/18) 1 entry
ENSG00000113360 DROSHA lung adenocarcinoma sequence_alteration 2.921% (34/1164) 1 entry
ENSG00000113360 DROSHA prostate carcinoma stop_gained 3.286% (14/426) 1 entry
ENSG00000113360 DROSHA nasopharyngeal squamous cell carcinoma missense_variant 0.4184% (1/239) 1 entry
ENSG00000113360 DROSHA diffuse large B-cell lymphoma frameshift_variant 1.316% (4/304) 1 entry
ENSG00000113360 DROSHA bladder transitional cell carcinoma missense_variant 0.7299% (1/137) 1 entry
ENSG00000113360 DROSHA clear cell renal carcinoma sequence_alteration 0.437% (6/1373) 1 entry
ENSG00000113360 DROSHA Invasive Breast Carcinoma missense_variant 2.222% (1/45) 1 entry
ENSG00000113360 DROSHA angiosarcoma sequence_alteration 7.692% (1/13) 1 entry
ENSG00000113360 DROSHA metaplastic breast carcinoma missense_variant 3.922% (2/51) 1 entry
ENSG00000113360 DROSHA Cortisol-Producing Adrenal Cortex Adenoma missense_variant 0.8065% (1/124) 1 entry
ENSG00000113360 DROSHA anaplastic astrocytoma sequence_alteration 2.273% (1/44) 1 entry
ENSG00000113360 DROSHA prostate carcinoma frameshift_variant 3.286% (14/426) 1 entry
ENSG00000113360 DROSHA brain glioma frameshift_variant 11.11% (1/9) 1 entry
ENSG00000113360 DROSHA polycythemia vera missense_variant 2.083% (1/48) 1 entry
ENSG00000113360 DROSHA Kidney Oncocytoma missense_variant 3.125% (1/32) 1 entry
ENSG00000113360 DROSHA gastric intestinal type adenocarcinoma frameshift_variant 4.706% (4/85) 1 entry
ENSG00000113360 DROSHA esophageal adenocarcinoma missense_variant 5.251% (23/438) 1 entry
ENSG00000113360 DROSHA diffuse gastric adenocarcinoma sequence_alteration 1.266% (1/79) 1 entry
ENSG00000113360 DROSHA esophageal squamous cell carcinoma frameshift_variant 2.655% (18/678) 1 entry
ENSG00000113360 DROSHA B-cell acute lymphoblastic leukemia sequence_alteration 1.852% (1/54) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000113360 DROSHA MESO 0.018 high
ENSG00000113360 DROSHA SARC 0.0088 high
ENSG00000113360 DROSHA STAD 0.0088 low
ENSG00000113360 DROSHA CHOL 0.02 low
ENSG00000113360 DROSHA UCEC 0.00028 high
ENSG00000113360 DROSHA LGG 0.00079 low
ENSG00000113360 DROSHA READ 0.0073 low
ENSG00000113360 DROSHA KIRP 0.0092 high
ENSG00000113360 DROSHA LUAD 0.022 low
ENSG00000113360 DROSHA BRCA 0.017 high
ENSG00000113360 DROSHA COAD 0.00011 high
ENSG00000113360 DROSHA ESCA 0.038 low
ENSG00000113360 DROSHA KIRC 0.047 high
ENSG00000113360 DROSHA PRAD 0.03 low
ENSG00000113360 DROSHA BLCA 0.019 low
ENSG00000113360 DROSHA GBM 0.036 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000113360 DROSHA LUSC Amp 6.579995 0.337150 0.847200 0.750499
ENSG00000113360 DROSHA LUAD Amp 5.026378 0.203805 0.700450 0.606589
ENSG00000113360 DROSHA SKCM Amp 1.047724 0.131850 0.673863 0.247956