RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	CancerFlavivirusesSARS-COV-2Dengue
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	DataSet_01_109 DataSet_01_77 DataSet_02_144 DataSet_02_145

Description

Ensembl ID	ENSG00000112531	Gene ID	9444	Accession	21100
Symbol	QKI	Alias	QK;Hqk;QK1;QK3;hqkI	Full Name	QKI, KH domain containing RNA binding
Status	Confidence	Length	164593 bases	Strand	Plus strand
Position	6 : 163414000 - 163578592	RNA binding domain	KH_1 , STAR_dimer
Summary	The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000275262	KH_1	PF00013	2.4e-05	1
ENSP00000275262	STAR_dimer	PF16544	1.7e-26	2
ENSP00000354867	KH_1	PF00013	2.4e-05	1
ENSP00000354867	STAR_dimer	PF16544	1.7e-26	2
ENSP00000354951	KH_1	PF00013	2.3e-05	1
ENSP00000354951	STAR_dimer	PF16544	1.6e-26	2
ENSP00000355094	KH_1	PF00013	2.5e-05	1
ENSP00000355094	STAR_dimer	PF16544	1.8e-26	2
ENSP00000375973	KH_1	PF00013	2.3e-05	1
ENSP00000375973	STAR_dimer	PF16544	1.6e-26	2
ENSP00000408382	KH_1	PF00013	2.2e-05	1
ENSP00000408382	STAR_dimer	PF16544	1.6e-26	2
ENSP00000408775	KH_1	PF00013	2.3e-05	1
ENSP00000408775	STAR_dimer	PF16544	1.6e-26	2
ENSP00000437867	STAR_dimer	PF16544	1.3e-15	1
ENSP00000440599	KH_1	PF00013	7.6e-06	1
ENSP00000440991	KH_1	PF00013	6.5e-06	1
ENSP00000443690	KH_1	PF00013	3.9e-06	1

Showing 1 to 18 of 18 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
25843628	ChIRP.MS_PMID25843628_Hela_human	Hela	Ci Chu	2015 Apr 9	doi: 10.1016/j.cell.2015.03.025.?Epub 2015 Apr 2
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27040163	serIC_PMID27040163_Hs_K562	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
27040163	serIC_PMID27040163_Hs_K562.1	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
28431233	RIC_PMID28431233_Hs_microRNA		Thomas Treiber	2017 Apr 20	doi: 10.1016/j.molcel.2017.03.014
29636419	CARIC_PMID29636419_Hela_human	Hela	Xichen Bao	2018 Apr 24	doi: 10.1073/pnas.1718406115.?Epub 2018 Apr 10
30352994	eRIC_PMID30352994_Jurkat_human	Jurkat	Joel I Perez-Perri?	2018 Oct 23	doi: 10.1038/s41467-018-06557-8

Showing 1 to 10 of 25 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
17575274	The selective RNA-binding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiation.	Yuntao Chen	2007-08-10	The Journal of biological chemistry
19435871	MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents.	R Dawn Cochrane	2009-05-01	Molecular cancer therapeutics
21768773	E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulation.	Guodong Yang	2011-08-15	Cell cycle (Georgetown, Tex.)
21972111	Nonsense mutation-associated Becker muscular dystrophy: interplay between exon definition and splicing regulatory elements within the DMD gene.	M Kevin Flanigan	2011-03-01	Human mutation
22398723	The RNA-binding protein QKI5 is a direct target of C/EBPα and delays macrophage differentiation.	Haiyan Fu	2012-05-01	Molecular biology of the cell
23319046	The QKI-5 and QKI-6 RNA binding proteins regulate the expression of microRNA 7 in glial cells.	Yunling Wang	2013-03-01	Molecular and cellular biology
23321059	RNA-binding protein QKI regulates Glial fibrillary acidic protein expression in human astrocytes.	J Katarzyna Radomska	2013-04-01	Human molecular genetics
24799664	CAHM, a long non-coding RNA gene hypermethylated in colorectal neoplasia.	K Susanne Pedersen	2014-08-01	Epigenetics
25934039	Altered expression of neuroplasticity-related genes in the brain of depressed suicides.	B Fuchsova	2015-07-23	Neuroscience
26349458	An intriguing RNA species--perspectives of circularized RNA.	Ting Shen	2015-12-01	Protein & cell

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Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
No data available in table

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Gene Model

Click here to download ENSG00000112531's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
992	Body Height	8.25066069845004E-5	17903300
1005	Body Height	1.17594809259103E-5	17903300
1016	Body Height	4.40768165814731E-5	17903300
1017	Body Height	5.81981414238621E-5	17903300
1021	Body Height	4.40768165814731E-5	17903300
1022	Body Height	4.4458022995908E-5	17903300
1063	Body Height	3.62763234362795E-5	17903300
1064	Body Height	4.68117494687448E-5	17903300
2036	Body Weight	3.69127265951175E-5	17903300
2215	Body Weight Changes	2.22427764085245E-6	17903300

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GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000112531	rs9458859	6	163562826	Red blood cell count	30595370		EFO_0004305

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000112531's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000112531	homo_sapiens	ENSP00000366607	27.23	17.2144	homo_sapiens	ENSP00000355094	51.0264	32.2581
ENSG00000112531	homo_sapiens	ENSP00000281156	41.2607	31.2321	homo_sapiens	ENSP00000355094	42.2287	31.9648
ENSG00000112531	homo_sapiens	ENSP00000313829	33.1828	25.5079	homo_sapiens	ENSP00000355094	43.1085	33.1378
ENSG00000112531	homo_sapiens	ENSP00000348108	41.6185	29.7688	homo_sapiens	ENSP00000355094	42.2287	30.2053

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000112531	homo_sapiens	ENSP00000355094	78.5924	78.5924	nomascus_leucogenys	ENSNLEP00000013963	91.4676	91.4676
ENSG00000112531	homo_sapiens	ENSP00000355094	91.2023	89.1496	pan_paniscus	ENSPPAP00000030144	58.5687	57.2505
ENSG00000112531	homo_sapiens	ENSP00000355094	100	100	pongo_abelii	ENSPPYP00000019218	100	100
ENSG00000112531	homo_sapiens	ENSP00000355094	99.1202	98.827	pan_troglodytes	ENSPTRP00000085466	98.8304	98.538
ENSG00000112531	homo_sapiens	ENSP00000355094	99.1202	98.827	gorilla_gorilla	ENSGGOP00000037188	98.8304	98.538
ENSG00000112531	homo_sapiens	ENSP00000355094	99.1202	98.5337	ornithorhynchus_anatinus	ENSOANP00000035792	61.7916	61.426
ENSG00000112531	homo_sapiens	ENSP00000355094	97.3607	97.3607	sarcophilus_harrisii	ENSSHAP00000016606	88.0637	88.0637
ENSG00000112531	homo_sapiens	ENSP00000355094	69.2082	69.2082	notamacropus_eugenii	ENSMEUP00000007399	80.8219	80.8219
ENSG00000112531	homo_sapiens	ENSP00000355094	88.2698	87.0968	choloepus_hoffmanni	ENSCHOP00000005884	88.0117	86.8421
ENSG00000112531	homo_sapiens	ENSP00000355094	71.8475	71.5543	erinaceus_europaeus	ENSEEUP00000010982	83.6177	83.2765

Showing 1 to 10 of 211 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001570	involved_in vasculogenesis	1	IEA	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0003729	enables mRNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IEA	Homo_sapiens(9606)	Component
GO:0006397	involved_in mRNA processing	1	IEA	Homo_sapiens(9606)	Process
GO:0006417	involved_in regulation of translation	1	IEA	Homo_sapiens(9606)	Process
GO:0007286	involved_in spermatid development	1	IEA	Homo_sapiens(9606)	Process
GO:0008380	involved_in RNA splicing	1	IEA	Homo_sapiens(9606)	Process

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression